Patents Assigned to Bioscience, Inc.
  • Site specific chemically modified nanopore devices
    Patent number: 10234415
    Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 19, 2019
    Assignee: Electronic BioSciences, Inc.
    Inventors: Eric N. Ervin, John J. Watkins, Geoffrey A. Barrall
  • METHODS AND COMPOSITIONS FOR ATTENUATING GENE EXPRESSION MODULATING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES
    Publication number: 20190076458
    Abstract: Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
    Type: Application
    Filed: August 9, 2018
    Publication date: March 14, 2019
    Applicant: Selecta Biosciences, Inc.
    Inventor: Takashi Kei Kishimoto
  • HUMAN MILK COMPOSITIONS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190075808
    Abstract: The disclosure features human milk fortifier compositions, standardized human milk, and methods of making and using same. In one embodiment, a pasteurized human milk composition includes a human protein constituent of about 35-85 mg/mL; a human fat constituent of about 60-110 mg/mL; and a human carbohydrate constituent of about 60-140 mg/mL.
    Type: Application
    Filed: November 14, 2018
    Publication date: March 14, 2019
    Applicant: Prolacta Bioscience, Inc.
    Inventors: Elena M. MEDO, Martin L. LEE, David J. RECHTMAN, Joseph FOURNELL
  • METHODS FOR OBTAINING STERILE MILK AND COMPOSITIONS THEREOF
    Publication number: 20190075809
    Abstract: The disclosure provides a simple and effective methods for sterilization of milk without degradation or loss of biologically active agents in the milk and the products produced by such methods.
    Type: Application
    Filed: November 14, 2018
    Publication date: March 14, 2019
    Applicant: Prolacta Bioscience, Inc.
    Inventors: Elena M. MEDO, Armando MONTOYA, Martin LEE, David RECHTMAN
  • METHODS FOR PROVIDING POLYMERIC SYNTHETIC NANOCARRIERS FOR GENERATING ANTIGEN-SPECIFIC TOLERANCE IMMUNE RESPONSES
    Publication number: 20190076522
    Abstract: Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods. The synthetic nanocarrier compositions may also include antigen in some embodiments.
    Type: Application
    Filed: August 6, 2018
    Publication date: March 14, 2019
    Applicant: Selecta Biosciences, Inc.
    Inventors: David H. Altreuter, Aaron P. Griset, Roberto A. Maldonado
  • MULTIPLEX SLIDE PLATE DEVICE AND OPERATION METHOD THEREOF
    Publication number: 20190078140
    Abstract: A multiplex slide plate device and an operation method thereof are provided. The multiplex slide plate device includes a slide plate and a sacrificial layer. The slide plate has reaction vessels arranged in an array, an injection hole and an exhaust hole, wherein each of the reaction vessels has an opening portion and a bottom portion. The sacrificial layer has a microfluidic channel, wherein the microfluidic channel has an injection channel, a main channel and a distal channel connected to each other. The sacrificial layer is assembled to the slide plate, wherein the main channel faces the opening portion. A sample solution is injected into the injection channel, such that the sample solution flows from the injection channel through the main channel to the distal channel, wherein the sample solution loads into each of the reaction vessels while flowing through the main channel.
    Type: Application
    Filed: November 15, 2018
    Publication date: March 14, 2019
    Applicant: Quark Biosciences, Inc.
    Inventors: Chung-Fan Chiou, Cheng-Wey Wei, Yu Chang, Ming-Chuan Hsu
  • Engineered cascade components and cascade complexes
    Patent number: 10227576
    Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: March 12, 2019
    Assignee: Caribou Biosciences, Inc.
    Inventors: Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Stemberg
  • Non-replicative transduction particles and transduction particle-based reporter systems
    Patent number: 10227662
    Abstract: Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: March 12, 2019
    Assignee: GeneWeave Biosciences, Inc.
    Inventors: Diego Ariel Rey, Nikol de Forest, Heather Cox, Soni Shukla
  • Non-replicative transduction particles and transduction particle-based reporter systems
    Patent number: 10227663
    Abstract: Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles can be constructed from viruses and use viral transduction and replication systems. The reporter nucleic acid molecules include a reporter gene, such as a reporter molecule or selectable marker, for detecting target genes or cells. Methods and systems are provided for detection of cells and target nucleic acid molecules using the non-replicative transduction particles as reporter molecules.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: March 12, 2019
    Assignee: GeneWeave Biosciences, Inc.
    Inventors: Diego Ariel Rey, Nikol de Forest, Heather Cox, Soni Shukla
  • High contrast signal to noise ratio device components
    Patent number: 10228347
    Abstract: Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR).
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: March 12, 2019
    Assignee: Electronic BioSciences, Inc.
    Inventors: Geoffrey A. Barrall, Eric N. Ervin, Prithwish Pal
  • Heterocyclic modulators of lipid synthesis and combinations thereof
    Patent number: 10226449
    Abstract: Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: March 12, 2019
    Assignee: 3-V Biosciences, Inc.
    Inventors: Timothy Sean Heuer, Johan D. Oslob, Robert S. McDowell, Russell Johnson, Hanbiao Yang, Marc Evanchik, Cristiana A. Zaharia, Haiying Cai, Lily W. Hu, Gregory Duke, Yamini Ohol-Gupta, Marie O'Farrell
  • Sequence-specific detection and phenotype determination
    Patent number: 10227661
    Abstract: Disclosed herein are materials and methods for achieving sequence-specific organism detection and/or phenotype(s) using sequence-specific oligonucleotides. Also disclosed are related kits, cultures, and cells for detecting and/or phenotyping microorganisms in a sequence-specific manner.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 12, 2019
    Assignee: GeneWeave Biosciences, Inc.
    Inventor: Diego Ariel Rey
  • STABLE AQUEOUS FORMULATIONS OF ADALIMUMAB
    Publication number: 20190070294
    Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: November 1, 2018
    Publication date: March 7, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark Manning, Robert W. Payne
  • STABLE AQUEOUS FORMULATIONS OF ADALIMUMAB
    Publication number: 20190070293
    Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: November 1, 2018
    Publication date: March 7, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark Manning, Robert W. Payne
  • STABLE AQUEOUS FORMULATIONS OF ADALIMUMAB
    Publication number: 20190070292
    Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: November 1, 2018
    Publication date: March 7, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark Manning, Robert W. Payne
  • Selective amplification of overlapping amplicons
    Patent number: 10221448
    Abstract: The present invention relates to a scalable multiplex PCR method that can simultaneously amplify overlapping amplicons without the drawbacks of conventional multiplex PCR. The method selectively amplifying target nucleic acid fragments having an overlapping region. The method comprises the steps of: obtaining a first nucleic acid sequence comprising a first tag t2 and a first forward primer F1, obtaining a second nucleic acid sequence comprising a second tag t1 and a first reverse primer R1, obtaining a third nucleic acid sequence comprising the second tag t1 and a second forward primer F2, obtaining a fourth nucleic acid sequence comprising a third tag t3 and a second reverse primer R2, wherein each primer is a gene-specific primer; performing initial cycles of PCR; and then performing later cycles of PCR at higher annealing temperatures to obtain amplification products.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: March 5, 2019
    Assignee: Pillar Biosciences Inc.
    Inventors: Zhaohui Wang, Gang Song
  • Inhibiting the transient receptor potential A1 ion channel
    Patent number: 10221177
    Abstract: The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of their use for the treatment of pain, respiratory conditions, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: March 5, 2019
    Assignee: Hydra Biosciences, Inc.
    Inventors: Bertrand L. Chenard, Xinyuan Wu
  • STABLE AQUEOUS FORMULATIONS OF ADALIMUMAB
    Publication number: 20190060455
    Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Application
    Filed: November 1, 2018
    Publication date: February 28, 2019
    Applicant: Coherus Biosciences, Inc.
    Inventors: Mark Manning, Robert W. Payne
  • Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
    Patent number: 10215748
    Abstract: Use of impedance devices in methods of generating a time dependent cellular profiles (TCRP) for the modulation of oncogene addicted cells and comparing the impedance-based TCRP to controls or knowns to identify signature time dependent cellular profiles.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: February 26, 2019
    Assignee: ACEA Biosciences, Inc.
    Inventors: Yama A. Abassi, Li Zhao, Ning Ke, Xiaobo Wang, Xiao Xu
  • Radially tensioned wound or skin treatment devices and methods
    Patent number: 10213350
    Abstract: Devices, kits and methods described herein may be for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. An applicator and/or tensioning device may be used to apply a dressing to a subject. The applicator and/or tensioning device applies and/or maintains a strain in an elastic dressing, wherein at least some of the strain is out-of-plane or at a non-orthogonal, non-parallel and non-aligned orientation to other strains in the dressing.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: February 26, 2019
    Assignee: Neodyne Biosciences, Inc.
    Inventors: Jasper Jackson, William R. Beasley, John A. Zepeda, Richard T. Caligaris