Patents Assigned to Bioscience, Inc.
  • Immunoregulatory agents
    Patent number: 10106546
    Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 23, 2018
    Assignee: Flexus Biosciences, Inc.
    Inventors: Hilary Plake Beck, Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, James Aaron Balog, David K. Williams, Jay A. Markwalder, Emily Charlotte Cherney, Weifang Shan, Audris Huang
  • Vaccines and compositions against
    Patent number: 10105412
    Abstract: Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: October 23, 2018
    Assignees: Genocea Biosciences, Inc., Chidlren's Medical Center Corporation
    Inventors: Todd Gierahn, Richard Malley
  • Microfluidic methods for manipulating DNA
    Patent number: 10105702
    Abstract: Techniques are provided for generating, manipulating, and measuring fluidic droplets in mixed phase systems based on establishing transient continuities between otherwise spatially separated phases. In certain methods of the invention, electrodes in contact with the continuous phases allow electrical monitoring of continuity or proximity of separated phases as a means to characterize droplets. In other methods of the invention, fluidic continuity provides a means for generating droplets, injecting or extracting the contents of droplets, and sorting droplets. Chemical techniques are also provided that use these droplet-based methods, or others, to quantify and identify nucleic acids through incorporation into hydrogel particles. The nucleic acids are entrapped either actively by chemical incorporation during gel polymerization or passively by chain entanglement.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: October 23, 2018
    Assignee: Lariat Biosciences, Inc.
    Inventor: Jonathan W. Larson
  • Methods for affinity maturation-based antibody optimization
    Patent number: 10101333
    Abstract: Provided herein is a rational method of affinity maturation to evolve the activity of an antibody or portion thereof based on the structure/affinity or activity relationship of an antibody. The resulting affinity matured antibodies exhibit improved or optimized binding affinity for a target antigen.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: October 16, 2018
    Assignee: Taurus Biosciences, Inc.
    Inventors: Vaughn Smider, Helen Hongyuan Mao
  • Engineered nucleic acid-targeting nucleic acids
    Patent number: 10100333
    Abstract: The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide sequences that form scaffolds and nucleic acid binding proteins. Nucleic acid sequences encoding the engineered polynucleotide sequences that form scaffolds, as well as expression cassettes, vectors and cells comprising such polynucleotide sequences, are described. A variety of methods for making and using the engineered polynucleotide sequences that form scaffolds are also disclosed.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: October 16, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Paul Daniel Donohoue, Andrew Paul May
  • ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE
    Publication number: 20180289741
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human T cell receptor alpha constant region gene. The present disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells.
    Type: Application
    Filed: October 5, 2016
    Publication date: October 11, 2018
    Applicant: Precision BioSciences, Inc.
    Inventors: Michael G. Nicholson, James Jefferson Smith, Derek Jantz, Victor Bartsevich, Daniel T. MacLeod, Jeyaraj Antony
  • Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene
    Patent number: 10093900
    Abstract: Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: October 9, 2018
    Assignee: Precision BioSciences, Inc.
    Inventors: Derek Jantz, James Jefferson Smith, Michael G. Nicholson, Daniel T. MacLeod, Jeyaraj Antony, Victor Bartsevich
  • Anti-IL31 antibodies for veterinary use
    Patent number: 10093731
    Abstract: Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced conditions in companion animals, such as canines, felines, and equines.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: October 9, 2018
    Assignee: Kindred Biosciences, Inc.
    Inventors: Shyr Jiann Li, Lam Nguyen, Hangjun Zhan
  • Immunostimulatory compositions and uses thereof
    Patent number: 10093712
    Abstract: The present invention provides novel immune-stimulatory polypeptides, and methods for their use and identification.
    Type: Grant
    Filed: October 10, 2011
    Date of Patent: October 9, 2018
    Assignee: Susavion Biosciences, Inc.
    Inventors: Laura L. Eggink, Valerie Jacobs, Kenneth Hoober
  • Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene
    Patent number: 10093899
    Abstract: Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: October 9, 2018
    Assignee: Precision BioSciences, Inc.
    Inventors: Derek Jantz, James Jefferson Smith, Michael G. Nicholson, Daniel T. MacLeod, Jeyaraj Antony, Victor Bartsevich
  • ANTIMICROBIAL COATINGS FOR MEDICAL DRESSINGS AND DRY ANTIMICROBIAL MEDICAL DRESSINGS THEREFROM
    Publication number: 20180280201
    Abstract: Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N a titanium (IV) species, a 1,2-diol, an ?-hydroxy acid, a ?-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.
    Type: Application
    Filed: March 28, 2018
    Publication date: October 4, 2018
    Applicant: Allied Bioscience, Inc.
    Inventors: Craig Grossman, Gavri Grossman, Daniel Moros, Misagh Alipour, Jie Fang
  • ANTIMICROBIAL COATINGS FOR MEDICAL IMPLEMENTS AND MEDICAL DEVICES
    Publication number: 20180280582
    Abstract: The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an ?-hydroxy acid, ?-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.
    Type: Application
    Filed: March 28, 2018
    Publication date: October 4, 2018
    Applicant: Allied Bioscience, Inc.
    Inventors: Craig Grossman, Gavri Grossman, Daniel Moros, Misagh Alipour, Jie Fang
  • Determination of fertility potential from the oxidation-reduction potential of a biological sample
    Patent number: 10088466
    Abstract: Methods and systems for measuring and using the oxidation-reduction potential (ORP) of a biological sample are provided. The system generally includes a test strip and a readout device for determining the ORP. The measured ORP is then used to determine characteristics relating to the fertility of the sample or the subject from which the sample was derived. Some characteristics that can be determined include the quality of a sperm sample, an oocyte or a fertilized egg. The measured ORP value can also be used to determine the specific characteristics of a spermatozoa sample, such as the morphology of the spermatozoa, the motility of the spermatozoa, the number of cells in the sample and the concentration of the cells in the sample. Knowledge of such characteristics and fertility potential can be used to identify individuals that might benefit from specific fertility treatments.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 2, 2018
    Assignee: Aytu BioScience, Inc.
    Inventors: Raphael Bar-Or, David Bar-Or, Leonard T. Rael, Kimberly B. Bjugstad, Ashok Agarwal, Rakesh Sharma, Sajal Gupta
  • Use and identification of biomarkers for gastrointestinal diseases
    Patent number: 10087488
    Abstract: The described invention relates to the identification of biomarkers for gastrointestinal diseases and provides methods utilizing the biomarkers for in drug discovery, monitoring of treatment efficacy, and diagnostics. The invention further provides methods for identifying a therapeutic target to treat ulcerative colitis, colorectal cancer, and Crohn's disease.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: October 2, 2018
    Assignee: AlfaGene Bioscience, Inc.
    Inventor: Asit Panja
  • HYDROGEL PARTICLES WITH TUNABLE OPTICAL PROPERTIES AND METHODS FOR USING THE SAME
    Publication number: 20180275040
    Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell. In this regard, the hydrogel particles provided herein in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
    Type: Application
    Filed: June 16, 2017
    Publication date: September 27, 2018
    Applicant: Slingshot Biosciences, Inc.
    Inventors: Jeffrey KIM, Oliver LIU, Jeremy AGRESTI, Anh Tuan NGUYEN
  • HEPATITIS B CORE PROTEIN MODULATORS
    Publication number: 20180273520
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Application
    Filed: September 15, 2016
    Publication date: September 27, 2018
    Applicants: Assembly Bioscience, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: William Turner, Lee Daniel Arnold, Hans Maag, Mark Bures
  • HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS
    Publication number: 20180273521
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Application
    Filed: April 27, 2018
    Publication date: September 27, 2018
    Applicants: Indiana University Research and Technology Corporationt, Assembly Biosciences, Inc.
    Inventors: William W. Turner, JR., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
  • Composition of hair oil for stimulation of hair growth, control of hairfall, dandruff and infections thereof
    Patent number: 10080717
    Abstract: An improved composition of hair oil for stimulation of hair growth, control of hair fall, dandruff and infections thereof. The composition of hair oil comprising active ingredients of Capric Caprylic Tri-Glycerides (CCTG), Mineral oil, Coconut Oil, Ylang Ylang Oil, Di-propylene Glycol, Centella Asiatica Extract and Butylated Hydroxy Toulene. The composition of hair oil supports the hair growth and relaxation of the scalp. The composition of hair oil also effectively reduces/remove dandruff and thereby control hair fall in the subject (e.g., not limiting to male/female human). The composition of hair oil additionally demonstrates the properties of cooling effect, darkening of hair and promotion of hair upon continuous use of the hair oil by the subjects. The proposed composition is alternatively used to reduce/remove Psoriasis.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: September 25, 2018
    Assignee: Indfrag Biosciences Inc.
    Inventors: Philip Samuel, Boobalarasu Nadar, Roshni Raj
  • Production of modified fatty acids in plants through rDNA targeted integration of heterologous genes
    Patent number: 10081815
    Abstract: The present invention relates to transgenic plants comprising a plurality of nucleic acids heterologous to said plant, each of said nucleic acid comprising a coding sequence operably linked to one or more regulatory elements for directing expression of said coding sequence in said plant, said nucleic acid being stably integrated at or adjacent to rDNA sequences, or a seed, organ, tissue, part or cell thereof, or a descendant of said plant, seed, organ, tissue, part or cell; methods of producing the transgenic plants; and methods of producing oil using the transgenic plants.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: September 25, 2018
    Assignee: Agrisoma Biosciences Inc.
    Inventors: Steven Fabijanski, Michael Lindenbaum, Ping Fu, Elizabeth-France Marillia
  • Systems and methods for treating bacterial infection
    Patent number: 10080751
    Abstract: Therapeutic methods, kits, dosing regimens and uses of a medicament comprising iclaprim are provided, for example, for the treatment of bacterial infection. The administration of iclaprim in a fixed amount can achieve a Cmax(ss) below about 800 ng/mL, a T>MIC of between about 30% to about 95% and a ratio of AUC/MIC of about 20 to about 85, and the bacterial infection can be treated. The fixed amount can be about 70 mg to about 100 mg. The bacterial infection treated may be caused, or related to, drug-resistant bacteria including S. pneumoniae, H. influenzae, S. aureus, K. pneumoniae and M. catarrhalis. The bacterial infection may manifest as a skin and skin structure infection, pneumonia, asthma, emphysema and/or other adverse pulmonary conditions.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: September 25, 2018
    Assignee: Motif Biosciences Inc.
    Inventor: David Huang