Patents Assigned to Biosciences, Inc.
  • CELL MAINTAINER FOR AUTOLOGOUS CELL THERAPY PRODUCTION
    Publication number: 20240228936
    Abstract: In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.
    Type: Application
    Filed: December 13, 2023
    Publication date: July 11, 2024
    Applicant: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • REMOVABLE CIRCULAR NOZZLE FOR FLOW CYTOMETERS
    Publication number: 20240226872
    Abstract: A circular nozzle assembly is disclosed. A cuvette nozzle subsystem (assembly) for flow cytometry systems is disclosed including a cuvette assembly and a circular nozzle assembly selectively engaged with the cuvette assembly. The cuvette assembly includes a cuvette having a pocket and a flow channel, and a receptacle coupled within the pocket to the cuvette. The receptacle has a through-hole with a tapered conical portion and a circular cylindrical portion. The circular nozzle assembly includes an o-ring gasket coupled to a nozzle body with a flow channel. A tapered conical portion of the nozzle body engages the tapered conical portion of the through-hole to align the respective flow channels of the cuvette and the nozzle body together.
    Type: Application
    Filed: October 20, 2023
    Publication date: July 11, 2024
    Applicant: CYTEK BIOSCIENCES, INC.
    Inventor: Mikhail Blinkov
  • Virus-like particle conjugates for diagnosis and treatment of tumors
    Patent number: 12029794
    Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: July 9, 2024
    Assignees: Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Serv.
    Inventors: Elisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
  • 5-membered heteroaryl carboxamide compounds for treatment of HBV
    Patent number: 12030869
    Abstract: The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.
    Type: Grant
    Filed: November 17, 2022
    Date of Patent: July 9, 2024
    Assignee: ASSEMBLY BIOSCIENCES, INC.
    Inventors: Simon Nicolas Haydar, Leping Li, Mark G. Bures, Roopa Rai, Lynne Bannen, Michael Walker
  • VIRUS-LIKE PARTICLE CONJUGATES FOR DIAGNOSIS AND TREATMENT OF TUMORS
    Publication number: 20240216527
    Abstract: The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
    Type: Application
    Filed: March 14, 2024
    Publication date: July 4, 2024
    Applicants: Aura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Serv.
    Inventors: Elisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
  • Autoflowering markers
    Patent number: 12024712
    Abstract: Provided herein is the identification and markers and genes associated with day-neutral autoflowering in plants and their use in selecting plants, including Cannabis plants, having autoflowering activity. The markers are useful for breeding autoflowering plants by obtaining nucleic acids, detecting one or more markers that indicate autoflowering activity, and establishing plant lines having such characteristics. Also provided are methods of editing plants to establish plant lines having autoflowering allelic variations.
    Type: Grant
    Filed: February 5, 2022
    Date of Patent: July 2, 2024
    Assignee: Phylos Bioscience, Inc.
    Inventors: Erica Bakker, Alisha Holloway, Kristen Waterman
  • Isoquinoline derivatives, methods of synthesis and uses thereof
    Patent number: 12024521
    Abstract: Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as amyotrophic lateral sclerosis. These compounds and pharmaceutical compositions are also useful as antivirals and antimicrobial agents.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: July 2, 2024
    Assignee: Prosetta Biosciences, Inc.
    Inventors: Kumarapandian Paulvannan, Dennis Solas, Anatoliy Kitaygorodskyy, Vishwanath R. Lingappa
  • Methods and systems for screening using microcapillary arrays
    Patent number: 12024705
    Abstract: High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be isolated, and cells expressing the variant proteins of interest can be characterized. Also provided are systems for performing the disclosed screening methods.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: July 2, 2024
    Assignee: XCELLA Biosciences, Inc.
    Inventors: Jennifer R. Cochran, Bob Chen, Spencer Caleb Alford
  • METHOD AND SYSTEM FOR PERFORMING CELL OPERATIONS USING A VERIFIABLE DATA STRUCTURE
    Publication number: 20240214210
    Abstract: A method and system for performing operations on cells in an instrument wherein the performance of operations on cell samples is controlled and data relating to the operations is generated, a unique identifier is associated with the instrument, the generated data is encrypted with a key corresponding to the unique identifier and a hash of one of the generated data and the encrypted generated data is created to enable verification of the integrity thereof. The hash is stored for later verification of data.
    Type: Application
    Filed: April 7, 2022
    Publication date: June 27, 2024
    Applicant: THRIVE BIOSCIENCE, INC.
    Inventor: Alan BLANCHARD
  • DEVICE, METHOD AND APPARATUS FOR CONTROLLING HUMIDITY IN AN INCUBATOR
    Publication number: 20240209304
    Abstract: A device, method and apparatus for controlling humidity in a cell incubator. The device includes a thermally conductive block having a water exuding surface, an electrical heater attached to the block and receptive of electrical energy to heat the block, at least one fan for blowing gas to be humidified over the surface of the block, at least humidity sensor attached at least downwind of the block, a controllable pump connectable to a source of water for supplying water to the exuding surface of the block and a controller receptive of output signals from the at least one humidity sensor and connected to the pump for controlling the pump based upon the output signals from the at least one humidity sensor to obtain a desired level of humidity.
    Type: Application
    Filed: April 26, 2022
    Publication date: June 27, 2024
    Applicant: THRIVE BIOSCIENCE, INC.
    Inventor: Alan BLANCHARD
  • Product, system and method for an improved fertilizer
    Patent number: 12017966
    Abstract: A product, system and method for an improved plant fertilizer made from harvested skimmate from a reservoir filed with a reduced sodium, artificial ocean water solution and live fish that produce fish excrement (reclaimed as skimmate). The skimmate contains a reduced concentration of sodium as a result of being harvested from a reduced sodium aquatic solution. The harvested skimmate is mixed with one or more additives to produce an improved fertilizer that may be certified as organic.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: June 25, 2024
    Assignee: FOOP ORGANIC BIOSCIENCES, INC.
    Inventors: Laurence J. Footer, Jonathan V. Goslin
  • Host-targeted pan-respiratory antiviral small molecule therapeutics
    Patent number: 12017997
    Abstract: Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as, for example, those caused by any viral family causing respiratory viral disease, including specifically coronaviruses and influenza viruses.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: June 25, 2024
    Assignee: Prosetta Biosciences, Inc.
    Inventors: Vishwanath R. Lingappa, Kumarapandian Paulvannan
  • Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids
    Patent number: 12018301
    Abstract: The present disclosure relates to recombinant polypeptides that have olivetolic acid cyclase activity, nucleic acids encoding these recombinant polypeptides, recombinant host cells that produce these recombinant polypeptides, and compositions comprising the recombinant polypeptides, nucleic acids, and/or recombinant host cells. The present disclosure also relates to uses of these recombinant polypeptides, nucleic acids encoding them, and recombinant host cells comprising them, in methods for the preparation of cannabinoids and cannabinoid precursors.
    Type: Grant
    Filed: June 20, 2023
    Date of Patent: June 25, 2024
    Assignees: WILLOW BIOSCIENCES, INC., EPIMERON USA, INC.
    Inventors: Trish Choudhary, Xueyang Feng, Thanh Nguyen, Matthew Workentine
  • LOX enzyme inhibiting methods and compositions
    Patent number: 12016864
    Abstract: This invention relates to LOX enzyme-inhibiting compounds in accordance with Formula I or Formula II, or a pharmaceutically acceptable salt or hydrate thereof: and pharmaceutical compositions comprising the compounds. Such compounds and compositions can be useful in treating a variety of conditions, diseases, and disorders including, but not limited to, fibrotic disorders, proliferative disorders, cardiovascular disorders, acute and chronic inflammatory disorders, primary and metastatic cancer, pulmonary conditions, ocular diseases, and neurological and neuropsychiatric conditions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: June 25, 2024
    Assignee: Anovia Biosciences, Inc.
    Inventors: Michael Clare, Juan Du, Xiang Li, Ronggang Liu
  • ENGINEERED MEGANUCLEASES THAT TARGET HUMAN MITOCHONDRIAL GENOMES
    Publication number: 20240200046
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in combination with mitochondrial transit peptides in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been modified or edited.
    Type: Application
    Filed: April 22, 2022
    Publication date: June 20, 2024
    Applicants: Precision BioSciences, Inc., University of Miami
    Inventors: Carlos T. Moraes, James Jefferson Smith, Derek Jantz, Ginger H. Tomberlin, John Morris, Wendy Shoop
  • MODIFIED B-TYPE NATRIURETIC PEPTIDE
    Publication number: 20240199716
    Abstract: Provided is a modified B-type natriuretic peptide (BNP) comprising a covalently attached polymer comprising amino acids, where the polymer inhibits degradation and/or elimination of the BNP in a subject, and where the modified BNP retains vasorelaxant activity. Nucleic acid molecules encoding the above-described modified BNP, as are vectors comprising the nucleic acid molecules, and cells comprising the vector. Methods of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition that can be treated with a natriuretic, diuretic or vasorelaxant is also provided. The methods comprise administering the above modified BNP to the subject. Further provided is method of preparing the above-described modified BNP.
    Type: Application
    Filed: November 14, 2023
    Publication date: June 20, 2024
    Applicant: Antlia BioScience, Inc.
    Inventors: Nigel Shankley, Brian Johnson, Sarkis Barret Kalindjian, Lars Friedrich
  • Sirtuin modulating compounds and applications thereof
    Patent number: 12012370
    Abstract: In one aspect, compounds modulating sirtuin activity are described herein. Sirtuin modulation by compounds described herein includes sirtuin activation and sirtuin inhibition. Modulation of sirtuin activity includes sirtuin activation and/or sirtuin inhibition. In some embodiments, a sirtuin modulating compound and/or salt thereof is of Formula I described herein.
    Type: Grant
    Filed: December 29, 2022
    Date of Patent: June 18, 2024
    Assignee: CODAGEN BIOSCIENCES, INC.
    Inventors: Célina Reverdy, Gaetan Gitton, Xiangying Guan, Indranil Adhya, Rama Krishna Dumpati, Samir Roy, Santu Chall, Anisha Ghosh, Gauthier Errasti, Thomas Delacroix, Raj Chakrabarti
  • Bicyclic compounds as androgen receptor modulators
    Patent number: 12012398
    Abstract: Provided herein are compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: June 18, 2024
    Assignee: NIDO BIOSCIENCES, INC.
    Inventors: Bakary-Barry Toure, Mark Andrew Gallop
  • Substituted pyrazolo[1,5-a]pyrazines for spinal muscular atrophy
    Patent number: 12012410
    Abstract: A prophylactic or therapeutic agent for spinal muscular atrophy according to the present invention includes a compound represented by the formula (I) or a salt thereof: the variables are described herein.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 18, 2024
    Assignee: REBORNA BIOSCIENCES, INC.
    Inventors: Koji Fuji, Takeshi Yamasaki, Shunya Suzuki, Koji Ono, Hiroki Takahagi
  • Chip imaging module array
    Patent number: D1034575
    Type: Grant
    Filed: January 1, 2020
    Date of Patent: July 9, 2024
    Assignee: PATTERN BIOSCIENCE, INC.
    Inventors: William W. Hunter, Scot B. Herbst, Jonathan D. Isom