Patents Assigned to Biosensors International Group, Ltd.
  • Patent number: 11046711
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: June 29, 2021
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Patent number: 10835722
    Abstract: The present disclosure describes an angioplasty balloon catheter having a retractable sheath and a flexible tip attached to the distal end of the sheath. The flexible tip is made of an elastomeric plastic that is capable of returning to its original shape after being expanded multiple times. The tip allows for the sheath to be retractable and the balloon inflated multiple times to treat or expand different locations within the vessel. Because the tip returns to its original shape each time, the tip is less likely to damage the vessel wall when the sheath is repositioned in the vessel, and also is easier to retract through a guide-catheter.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: November 17, 2020
    Assignee: Biosensors International Group, Ltd.
    Inventors: Roseann Ward, Eugene Serina, Emilio Crisolo
  • Patent number: 10597406
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: March 24, 2020
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Patent number: 10576242
    Abstract: A catheter having a multilumenal tube surrounded by a slotted hypotube is provided. The catheter has a tube holder that houses the multilumenal tubing and slidably engages the hypotube, and has internal passages configured to receive one of more tubes from the multilumenal tube. The multilumenal tubing separates into one or more tubings, each comprising a lumen, such that the tubings exit the tube holder at different locations. The slotted hypotube slidably engages a key in the tube holder that prevents the multilumenal tubing from rotating relative to the tube holder and the one of more tubings that separate from the multilumenal tubing. Advantages provided by the slotted hypotube/tube holder assembly are described.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: March 3, 2020
    Assignee: Biosensors International Group, Ltd.
    Inventors: Eric Jones, Eugene Serina, Roseann Ward, Emilio Crisolo
  • Patent number: 10456508
    Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: October 29, 2019
    Assignee: Biosensors International Group, Ltd.
    Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
  • Patent number: 10202402
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 12, 2019
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Patent number: 10166373
    Abstract: The present disclosure describes an angioplasty balloon catheter having a retractable sheath and a flexible tip attached to the distal end of the sheath. The flexible tip is made of an elastomeric plastic that is capable of returning to its original shape after being expanded multiple times. The tip allows for the sheath to be retractable and the balloon inflated multiple times to treat or expand different locations within the vessel. Because the tip returns to its original shape each time, the tip is less likely to damage the vessel wall when the sheath is repositioned in the vessel, and also is easier to retract through a guide-catheter.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: January 1, 2019
    Assignee: Biosensors International Group, Ltd.
    Inventors: Roseann Ward, Eugene Serina, Emilio Crisolo
  • Publication number: 20180000431
    Abstract: An N-M tomography system comprising: a carrier for the subject of an examination procedure; a plurality of detector heads; a carrier for the detector heads; and a detector positioning arrangement operable to position the detector heads during performance of a scan without interference or collision between adjacent detector heads to establish a variable bore size and configuration for the examination. Additionally, collimated detectors providing variable spatial resolution for SPECT imaging and which can also be used for PET imaging, whereby one set of detectors can be selectably used for either modality, or for both simultaneously.
    Type: Application
    Filed: September 19, 2017
    Publication date: January 4, 2018
    Applicant: Biosensors International Group, Ltd.
    Inventors: Nathaniel ROTH, Yoel ZILBERSTIEN, Shlomo BEN-HAIM, Benny ROUSSO
  • Patent number: 9802216
    Abstract: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elements.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: October 31, 2017
    Assignee: Biosensors International Group, Ltd.
    Inventors: Ivan Vecerina, Vinh Pham
  • Patent number: 9598439
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: March 21, 2017
    Assignee: BIOSENSORS INTERNATIONAL GROUP, LTD.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Patent number: 9579424
    Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 28, 2017
    Assignee: Biosensors International Group, Ltd.
    Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
  • Publication number: 20170007193
    Abstract: A method for predefining a set of radioactive-emission measurement views, for radioactive-emission imaging after an administration of a radiopharmaceutical, the method being tailored to a specific body structure and optimized with respect to the information gained about the body structure and based on modeling body-structure, based on its geometry and anatomical constraints, which limit accessibility to the body structure.
    Type: Application
    Filed: June 16, 2016
    Publication date: January 12, 2017
    Applicant: Biosensors International Group, Ltd.
    Inventors: Michael NAGLER, Eli DICHTERMAN, Yoel ZILBERSTIEN, Ran RAVHON, Omer ZIV, Benny ROUSSO, Shlomo BEN-HAIM
  • Patent number: 9511385
    Abstract: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stem elements.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: December 6, 2016
    Assignee: BIOSENSORS INTERNATIONAL GROUP, LTD.
    Inventors: Ivan Vecerina, Vinh Pham
  • Patent number: 9434744
    Abstract: The present invention provides improved processes for obtaining rapamycin derivatives including Biolimus A9.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: September 6, 2016
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik
  • Patent number: 9370333
    Abstract: A method for predefining a set of radioactive-emission measurement views, for radioactive-emission imaging after an administration of a radiopharmaceutical, the method being tailored to a specific body structure and optimized with respect to the information gained about the body structure and based on modeling body-structure, based on its geometry and anatomical constraints, which limit accessibility to the body structure.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: June 21, 2016
    Assignee: Biosensors International Group, Ltd.
    Inventors: Michael Nagler, Eli Dichterman, Yoel Zilberstein, Ran Ravhon, Omer Ziv, Benny Rousso, Shlomo Ben-Haim
  • Patent number: 9316743
    Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: April 19, 2016
    Assignee: Biosensors International Group, Ltd.
    Inventors: Benny Rousso, Shlomo Ben-Haim, Ran Ravhon, Yoel Zilberstein, Simona Ben-Haim, Nathaniel Roth
  • Patent number: 9275451
    Abstract: A method for analyzing a functional map of at least one tissue of a patient. The method comprises managing a plurality of functional maps each being associated with a plurality of first biological activity indications, receiving a functional map which is associated with a plurality of second biological activity indications, identifying a matching set of the managed functional maps by matching between the plurality of first and second biological activity indications, and using the matching set for a member of a group consisting of: an image data acquisition, a diagnosis of the received functional map, a classification of the received functional map.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: March 1, 2016
    Assignee: Biosensors International Group, Ltd.
    Inventors: Shlomo Ben-Haim, Benny Rousso
  • Patent number: 9168159
    Abstract: Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: October 27, 2015
    Assignee: Biosensors International Group, Ltd.
    Inventors: Shih-Horng Su, Fuh-Sheng Chen, Debashis Dutta
  • Patent number: 9101501
    Abstract: Disclosed is a stent that is useful for treating a vascular bifurcation, the stent having a plurality of segments extending coaxially end to end along a longitudinal axis of the stent from a first end to a second end of the stent, each segment having a plurality of struts extending in a zig-zag pattern around the circumference of the stent, wherein the stent is expandable from reduced diameter to an expanded diameter, the second end of the stent having a larger diameter than the first end when expanded; and an eyelet integrally formed with the segment positioned adjacent the second end, and configured to receive a radiopaque marker therein. The stent provides an improvement over prior stents for treating a vascular bifurcation by allowing the stent to be deployed in the widened transitional zone of a bifurcation such that the second end of the stent is accurately positioned at the carina.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: August 11, 2015
    Assignee: Biosensors International Group, Ltd.
    Inventors: Jean-Claude Laborde, Robert John Elicker, Brett Trauthen, Jacques Seguin
  • Patent number: 9040016
    Abstract: A method of radioimaging a myocardial perfusion, the method including in sequence: administering to a subject a low dose of a first radiopharmaceutical; subjecting the subject to a physical stress; administering to the subject at a peak of said physical stress a medium or high dose of a second radiopharmaceutical; and immediately radioimaging using a 3D non-coincidence imaging method a heart of the subject, thereby radioimaging a myocardial perfusion.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: May 26, 2015
    Assignee: Biosensors International Group, Ltd.
    Inventors: Benny Rousso, Dalia Dickman, Shlomo Ben-Haim, Simona Ben Haim