Patents Assigned to Biosensors International Group, Ltd.
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Patent number: 8676292Abstract: Apparatus for radiation based imaging of a non-homogenous target area having distinguishable regions therein, comprises: an imaging unit configured to obtain radiation intensity data from a target region in the spatial dimensions and at least one other dimension, and an image four-dimension analysis unit analyzes the intensity data in the spatial dimension and said at least one other dimension in order to map the distinguishable regions. The system typically detects rates of change over time in signals from radiopharmaceuticals and uses the rates of change to identify the tissues. In a preferred embodiment, two or more radiopharmaceuticals are used, the results of one being used as a constraint on the other.Type: GrantFiled: January 23, 2007Date of Patent: March 18, 2014Assignee: Biosensors International Group, Ltd.Inventors: Benny Rousso, Michael Nagler
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Patent number: 8657870Abstract: Implant release apparatus includes a connector connecting a lead having an electrolytically erodible portion and a restraint that restrains the implant. In one embodiment, the connector can include or comprise a nonconductive member.Type: GrantFiled: June 26, 2009Date of Patent: February 25, 2014Assignee: Biosensors International Group, Ltd.Inventors: Roman Turovskiy, Thuan Ngo, Matthew L Davis
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Publication number: 20140037541Abstract: A method for imaging is providing, including administering a teboroxime species to an adult human subject, administering T1-201-thallous chloride to the subject performing a teboroxime species SPECT imaging procedure of the teboroxime species on a region of interest (ROI) of the subject, and, after administering the teboroxime species, performing a T1-201-thallous chloride SPECT imaging procedure of the T1-201-thallous chloride on the ROI. Administering the teboroxime species and the T1-201-thallous chloride and performing the teboroxime species and the T1-201-thallous chloride SPECT imaging procedures comprise administering the teboroxime species and the T1-201-thallous chloride and performing the teboroxime species and the T1-201-thallous chloride SPECT imaging procedures during a time period having a duration of no more than 30 minutes. Other embodiments are also described.Type: ApplicationFiled: June 10, 2013Publication date: February 6, 2014Applicant: BIOSENSOR INTERNATIONAL GROUP LTD.Inventors: Benny Rousso, Dalia Dickman
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Patent number: 8644910Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.Type: GrantFiled: July 19, 2006Date of Patent: February 4, 2014Assignee: Biosensors International Group, Ltd.Inventors: Benny Rousso, Dalia Dickman, Yael Nir, Michael Nagler, Zohar Bronshtine, Shankar Vallabhajosula, Shlomo Ben-Haim, Simona Ben-Haim
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Patent number: 8620679Abstract: Apparatus is provided for use with at least one labeled radiopharmaceutical agent, the apparatus including a container (22) containing the at least one labeled radiopharmaceutical agent, and a portable computer-communcatable data carrier (120, 24) associated with the container (22), the data (120, 24) containing imaging protocol information for use with the at least one labeled radiopharmaceutical agent. Other embodiments are also described.Type: GrantFiled: October 31, 2007Date of Patent: December 31, 2013Assignee: Biosensors International Group, Ltd.Inventors: Benny Rousso, Shlomo Ben-Haim, Haim Melman, Zohr Bronshtine, Yoel Zilberstein, Michael Nagler, Dalia Dickman, Einav Omer
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Patent number: 8620046Abstract: A method for predefining a set of radioactive-emission measurement views, for radioactive-emission imaging after an administration of a radiopharmaceutical, the method being tailored to a specific body structure and optimized with respect to the information gained about the body structure and based on modeling body-structure, based on its geometry and anatomical constraints, which limit accessibility to the body structure.Type: GrantFiled: January 8, 2012Date of Patent: December 31, 2013Assignee: Biosensors International Group, Ltd.Inventors: Michael Nagler, Eli Dichterman, Yoel Zilberstein, Ran Ravhon, Omer Ziv, Benny Rousso, Shlomo Ben-Haim
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Patent number: 8615405Abstract: Apparatus is provided for use with at least one labeled radiopharmaceutical agent, the apparatus including a container (22) containing the at least one labeled radiopharmaceutical agent, and a portable computer-communicatable data carrier (120, 24) associated with the container (22), the data carrier (120, 24) containing imaging protocol information for use with the at least one labeled radiopharmaceutical agent. Other embodiments are also described.Type: GrantFiled: October 31, 2007Date of Patent: December 24, 2013Assignee: Biosensors International Group, Ltd.Inventors: Benny Rousso, Shlomo Ben-Haim, Haim Melman, Zohar Bronshtine, Yoel Zilberstien, Michael Nagler, Dalia Dickman, Einav Omer
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Patent number: 8610075Abstract: A method for cardiac imaging is provided, including administering to an adult human subject an amount of a teboroxime species having a radioactivity of less than 5 mCi at a time of administration, and performing a SPECT imaging procedure of a cardiac region of interest (ROI) of the subject. Other embodiments are also described.Type: GrantFiled: November 13, 2007Date of Patent: December 17, 2013Assignee: Biosensors International Group Ltd.Inventors: Benny Rousso, Dalia Dickman, Yael Nir
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Patent number: 8603157Abstract: A device and method for treating pathological narrowing of fluid-carrying conduits of the human body (such as blood vessels) in an area of a bifurcation is disclosed. In particular, a stent system comprising a pair of dissimilar stents, one of which is particularly suited for treating a widened portion of a blood vessel immediately proximal to a bifurcation. A stent delivery system including a handpiece adapted to selectively deliver the stents is also disclosed.Type: GrantFiled: June 22, 2007Date of Patent: December 10, 2013Assignee: Biosensors International Group, Ltd.Inventors: Jacques Seguin, Robert John Elicker, Jean-Claude Laborde
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Patent number: 8606349Abstract: A method of imaging, comprising: (a) providing an isotope at a low dosage in a body of a patient; (b) receiving radiation generated by said isotope from said body using a radiation camera; and (c) reconstructing a 3D distribution of said isotope from said received radiation, wherein the dosage is less than ? of a standard dose set forth in Table 5.Type: GrantFiled: October 31, 2007Date of Patent: December 10, 2013Assignee: Biosensors International Group, Ltd.Inventors: Benny Rousso, Shlomo Ben-Haim, Michael Nagler, Omer Ziv, Ran Ravhon, Dalia Dickman, Yoel Zilberstein, Eli Dichterman, Simona Ben-Haim, Shankar Vallabhajosula, Daniel Berman, Zohar Bronshtine, Ziv Popper, Nir Weissberg, Nathaniel Roth, Haim Melman
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Publication number: 20130308749Abstract: A system of performing a volumetric scan. The system comprises a surface of positioning a patient in a space parallel thereto, a plurality of extendable detector arms each the detector arm having a detection unit having at least one radiation detector, and an actuator which moves the detection unit along a linear path, and a gantry which supports the plurality of extendable detector arms around the surface so that each the linear path of each respective the extendable detector arm being directed toward the space.Type: ApplicationFiled: July 22, 2013Publication date: November 21, 2013Applicant: Biosensors International Group, Ltd.Inventors: Yoel Zilberstein, Nathaniel Roth, Benny Rousso, Shlomo Ben-Haim
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Patent number: 8579954Abstract: Medical devices and methods for delivery or implantation of prostheses within hollow body organs and vessels or other luminal anatomy are disclosed. The subject technologies may be used in the treatment of atherosclerosis in stenting procedures or be used in variety of other procedures. The systems may employ a self expanding stent restrained by one or more members released by an electrolytically erodable latch. Such release means do not connect directly to the implant, though one or more portions may contact it.Type: GrantFiled: January 27, 2006Date of Patent: November 12, 2013Assignee: Biosensors International Group, Ltd.Inventor: David Licata
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Patent number: 8573150Abstract: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elements.Type: GrantFiled: November 14, 2008Date of Patent: November 5, 2013Assignee: Biosensors International Group, Ltd.Inventors: Ivan Vecerina, Vinh Pham
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Patent number: 8565860Abstract: A radioactive emission probe in communication with a position tracking system and the use thereof in a variety of systems and methods of medical imaging and procedures, are provided. Specifically, wide aperture collimation—deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactivity emitting source, by scanning the radioactivity emitting source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. Furthermore, an imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.Type: GrantFiled: July 10, 2003Date of Patent: October 22, 2013Assignee: Biosensors International Group, Ltd.Inventors: Yoav Kimchy, Roni Amrami, Yona Bouskila, Udi Antebi, Nick Sidorenko, Gal Ben-David, Yoel Zilberstein
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Patent number: 8545550Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: GrantFiled: July 24, 2012Date of Patent: October 1, 2013Assignee: Biosensors International Group, Ltd.Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Patent number: 8492725Abstract: A system of performing a volumetric scan. The system comprises a surface of positioning a patient in a space parallel thereto, a plurality of extendable detector arms each the detector arm having a detection unit having at least one radiation detector, and an actuator which moves the detection unit along a linear path, and a gantry which supports the plurality of extendable detector arms around the surface so that each the linear path of each respective the extendable detector arm being directed toward the space.Type: GrantFiled: December 24, 2012Date of Patent: July 23, 2013Assignee: Biosensors International Group Ltd.Inventors: Yoel Zilberstein, Nathaniel Roth, Benny Rousso, Shlomo Ben-Haim
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Patent number: 8481946Abstract: A method for cardiac imaging is provided, including administering to an adult human subject an amount of a teboroxime species having a radioactivity of less than 5 mCi at a time of administration, and performing a SPECT imaging procedure of a cardiac region of interest (ROI) of the subject. Other embodiments are also described.Type: GrantFiled: November 13, 2007Date of Patent: July 9, 2013Assignee: Biosensors International Group Ltd.Inventors: Benny Rousso, Dalia Dickman, Yael Nir
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Publication number: 20130150952Abstract: A biodegradable polymer stent with radiopacity and a method of making and using a stent with enhanced mechanical strength and/or controlled degradation for use in a bodily lumen is described.Type: ApplicationFiled: February 12, 2013Publication date: June 13, 2013Applicant: Biosensors International Group Ltd.Inventor: Biosensors International Group Ltd.
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Patent number: 8414814Abstract: A biodegradable polymer stent with radiopacity and a method of making and using a stent with enhanced mechanical strength and/or controlled degradation for use in a bodily lumen is described.Type: GrantFiled: October 4, 2010Date of Patent: April 9, 2013Assignee: Biosensors International Group, Ltd.Inventors: Shih-Horng Su, Debashis Dutta
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Publication number: 20130035754Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-Iactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: ApplicationFiled: October 9, 2012Publication date: February 7, 2013Applicant: Biosensors International Group, Ltd.Inventors: John E. SHULZE, Ronald E. BETTS, Douglas R. SAVAGE