Patents Assigned to Biotek
  • Patent number: 12226538
    Abstract: An aqua-ozone hygienization system is disclosed, including a tank configured to hold an item for treatment. The system enables user selection between three hygienization methods: a non-wetting atomized mist for deodorization, a wetting spray for disinfection, or an immersion for comprehensive purification, deodorization, and disinfection. A platform within the tank forms a water reservoir beneath it and provides a top surface for item placement. The system includes an electrochemical generator that produces ozonated concentrate liquid from water, supplied by a circulating pump drawing from the reservoir. A nozzle connected to the electrochemical generator is switchable between dispensing the ozonated concentrate liquid as either an atomized mist or spray. During operation, the liquid is either misted or sprayed onto the item, or accumulates on the platform to immerse the item, depending on the selected treatment method.
    Type: Grant
    Filed: September 18, 2024
    Date of Patent: February 18, 2025
    Assignee: Biotek Environmental Science Ltd
    Inventors: Gavin Hsu, Maxwell Hsu, Darren Simmons, Ivor J. J. Longo, H. Brock Kolls
  • Patent number: 12171914
    Abstract: The present invention relates to a system and method of deodorizing air using aqueous ozone as a catalyst. Water is delivered to an electrochemical ozone generator which forms aqueous ozone gas, oxygen gas, and hydrogen gas. The first treatment stage oxidizes airflow extracted from a surrounding environment by combining the airflow with the aqueous ozone gas, oxygen, and hydrogen forming an oxidized airflow. A second stage deodorizes the oxidized airflow to form a deodorized airflow with hydroxide molecules that are created by combining the oxidized airflow with ultraviolet light, titanium oxide particles, and sintered columnar manganese dioxide particles. Residual aqueous ozone gas is converted to oxygen by interaction with the titanium oxide particles and the sintered columnar manganese dioxide particles. The deodorized airflow is vented back to the surrounding environment with ozone gas at or below the human-safe permissible level.
    Type: Grant
    Filed: July 1, 2024
    Date of Patent: December 24, 2024
    Assignee: Biotek Environmental Science Ltd
    Inventors: Gavin Hsu, Maxwell Hsu, Darren Simmons, Ivor J. J. Longo, H. Brock Kolls
  • Publication number: 20240408055
    Abstract: The present invention relates to a use of a natural compound Anisomelic acid extracted from Anisomeles indica O. Kuntze in the preparation of pharmaceutical compositions for inhibiting the infection and replication of novel coronaviruses and the mutant strains (SARS-CoV-2 variants) thereof, the Anisomelic acid is a compound comprising a chemical structural Formula I, the pharmaceutical composition includes a safe and effective amount of Anisomelic acid, that is, the pharmaceutical composition is a combination of a safe and effective amount of Anisomelic acid and its pharmaceutically acceptable salt or carrier thereof.
    Type: Application
    Filed: October 21, 2021
    Publication date: December 12, 2024
    Applicants: Peking University Shenzhen Graduate School, CNS BIOTEK CORP., Gansu Evergreen Pharmaceuticals Co.,Ltd.
    Inventors: Zhen Yang, Yew-Min Tzeng, Jun-Min Quan, Qing Chang, Chi-Tai Yeh
  • Patent number: 12151055
    Abstract: The present invention relates to a system and method of deodorizing air using aqueous ozone as a catalyst. Water is delivered to an electrochemical ozone generator which forms aqueous ozone gas, oxygen gas, and hydrogen gas. The first treatment stage oxidizes airflow extracted from a surrounding environment by combining the airflow with the aqueous ozone gas, oxygen, and hydrogen forming an oxidized airflow. A second stage deodorizes the oxidized airflow to form a deodorized airflow with hydroxide molecules that are created by combining the oxidized airflow with ultraviolet light, titanium oxide particles, and sintered columnar manganese dioxide particles. Residual aqueous ozone gas is converted to oxygen by interaction with the titanium oxide particles and the sintered columnar manganese dioxide particles. The deodorized airflow is vented back to the surrounding environment with ozone gas at or below the human-safe permissible level.
    Type: Grant
    Filed: July 1, 2024
    Date of Patent: November 26, 2024
    Assignee: Biotek Environmental Science Ltd
    Inventors: Gavin Hsu, Maxwell Hsu, Darren Simmons, Ivor J. J. Longo, H. Brock Kolls
  • Patent number: 12084650
    Abstract: Provided is a composition for preserving cell-free nucleic acids and/or cells in a biological sample and methods for use thereof. The composition comprises at least one volume excluding polymer, at least one osmotic agent and at least one enzyme inhibitor. The composition optionally further comprises at least one metabolic inhibitor. Further, provided is a kit comprising the composition, preferably in a blood collection tube, or the components of the composition.
    Type: Grant
    Filed: April 20, 2023
    Date of Patent: September 10, 2024
    Assignee: Norgen Biotek Corp.
    Inventors: Taha Alexander Haj-Ahmad, Yousef Haj-Ahmad
  • Publication number: 20240287013
    Abstract: A method for asymmetric synthesis of (?)-Anisomelic Acid is provided in the present invention, a chiral compound (?)-Costunolide is used as a starting material, a key intermediate is obtained by a regioselective ozone decomposition reaction, then carbon chain extension is performed by a Horner-Wadsworth-Emmons (HWE) reaction and a Peterson olefination reaction, and a (?)-anisomelic acid fourteen-membered carbocyclic skeleton is constructed by a ring-closing metathesis (RCM) reaction, laying an important foundation for subsequent (?)-anisomelic acid biological activity research, in the synthesis route, various (?)-anisomelic acid analogs can also be obtained from the key intermediate, the reaction operations in the synthesis route are simple and the present invention can be widely popularized and used.
    Type: Application
    Filed: June 10, 2021
    Publication date: August 29, 2024
    Applicants: Peking University Shenzhen Graduate School, CNS BIOTEK CORP., Gansu Evergreen Pharmaceuticals Co.,Ltd.
    Inventors: Zhen Yang, Yew-Min Tzeng, Hai-Xin Yu, Nan Zheng, Chong-Guo Jiang
  • Patent number: 12023903
    Abstract: A method for thinning a fingerprint identification module includes the steps of: providing at least one fingerprint identification module, wherein the fingerprint identification module includes a glass substrate and a plurality of laminated fingerprint identification members; providing a protective layer on each laminated fingerprint identification member; providing a dissociable sealant around each laminated fingerprint identification member and the protective layer of the fingerprint identification module and being adhered to support plate to form a carrier plate to be etched; etching the carrier plate to be etched and allowing an etching solution to etch the glass substrate until a thickness to be thinned is etched to form a semi-finished carrier plate; dissociating the dissociable sealant of the semi-finished carrier plate to reduce its viscosity; and removing the support plate, the dissociable sealant and the protective layer to complete a finished product of the thinned fingerprint identification module
    Type: Grant
    Filed: May 19, 2022
    Date of Patent: July 2, 2024
    Assignees: RECO TECHNOLOGY CHENGDU CO., LTD, RECO BIOTEK CO., LTD
    Inventor: Chin-Feng Chung
  • Patent number: 12005438
    Abstract: An apparatus for collecting and combining a sample, and in particular, a biological sample, with a reagent, and uses thereof. The apparatus comprises a sample collection container and a complementary sealing cap. A sealed reagent reservoir containing a reagent, such as a preservative reagent, is provided in a lower portion of the collection container. A piercing insert is nested within the collection container, above the seal of the reagent reservoir. Following the collection of the sample into the collection container, the action of sealing the collection container with the cap causes the piercing insert to engage with and disrupt the seal on the reagent reservoir, thereby exposing the collected sample to the reagent.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: June 11, 2024
    Assignee: Norgen Biotek Corp.
    Inventor: Yousef Haj-Ahmad
  • Patent number: 11926810
    Abstract: A bioreactor includes a reservoir container for holding a liquid medium, a duct providing a flowpath in a generally vertical direction upward from the reservoir container, a plurality of fiber assemblies located within the duct, a top of which is higher than a top of the plurality of fiber assemblies, and a circulation system. The upper end of the duct comprises an overflow wall surrounded by a moat, a bottom of which is lower than a top of the overflow wall. The upper end of the duct and moat contact a pocket region that is bounded by a structure that is connected to the duct and that is isolated from fluid communication with an exterior of the pocket region. The liquid medium flows over the overflow wall within the pocket region, contacts gas in the pocket region, overflows into the moat and is removed therefrom by the circulation system.
    Type: Grant
    Filed: December 6, 2022
    Date of Patent: March 12, 2024
    Assignee: 3D Biotek, LLC
    Inventors: Zongsen Wang, Wing Lau, Faribourz Payvandi, Peng Yue, Azadeh Jadali, Peter Materna
  • Patent number: 11767522
    Abstract: Provided is a composition for preserving cell-free nucleic acids and/or cells in a biological sample and methods for use thereof. The composition comprises at least one volume excluding polymer, at least one osmotic agent and at least one enzyme inhibitor. The composition optionally further comprises at least one metabolic inhibitor. Further, provided is a kit comprising the composition, preferably in a blood collection tube, or the components of the composition.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: September 26, 2023
    Assignee: Norgen Biotek Corp.
    Inventors: Taha Alexander Haj-Ahmad, Yousef Haj-Ahmad
  • Publication number: 20230143813
    Abstract: A compound of Formula I compound—Ovatodiolide which is safe and effective to use in a pharmaceutical composition for inhibition of SARS-CoV-2 is provided. The pharmaceutical composition comprising a safe and effective amount of a compound of Formula I compound—Ovatodiolide or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier, which has great potential to treat SARS-CoV-2 induced COVID-19 based on a safe and effective amount of a compound of Formula I compound—Ovatodiolide.
    Type: Application
    Filed: April 17, 2020
    Publication date: May 11, 2023
    Applicants: Peking University Shenzhen Graduate School, CNS Biotek Corp., Gansu Evergreen Pharmaceuticals, Co., Ltd.
    Inventors: Zhen Yang, Yew-Min Tzeng, Linqi Zhang, Junmin Quan, Qing Chang, Qi Zhang, Chien-Ming Lee
  • Publication number: 20230112777
    Abstract: A bioreactor includes a reservoir container for holding a liquid medium, a duct providing a flowpath in a generally vertical direction upward from the reservoir container, a plurality of fiber assemblies located within the duct, a top of which is higher than a top of the plurality of fiber assemblies, and a circulation system. The upper end of the duct comprises an overflow wall surrounded by a moat, a bottom of which is lower than a top of the overflow wall. The upper end of the duct and moat contact a pocket region that is bounded by a structure that is connected to the duct and that is isolated from fluid communication with an exterior of the pocket region. The liquid medium flows over the overflow wall within the pocket region, contacts gas in the pocket region, overflows into the moat and is removed therefrom by the circulation system.
    Type: Application
    Filed: December 6, 2022
    Publication date: April 13, 2023
    Applicant: 3D Biotek, LLC
    Inventors: Zongsen Wang, Wing Lau, Faribourz Payvandi, Peng Yue, Azadeh Jadali, Peter Materna
  • Patent number: 11597665
    Abstract: A disinfection system device for producing ozone water directly in a water pipe system contains an electrolytic tap water ozonation generator and holder. The electrolytic tap water ozonation generator includes at least one anode sheet and at least one cathode sheet. The holder includes a base, and the base has a locking portion, an inflow orifice, an outflow orifice, a connection interface, and a damping valve. A flow switch is mounted above the base and has an intake, and a discharge orifice of the flow switch is communicated with the outflow orifice. A top of the base is connected with one of two lids, the other lid is connected with the first socket and a second socket, and the other lid accommodates a control panel. The number of the anode sheet(s) is n which is a natural number and n?1. The number of the cathode sheets is n+1.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: March 7, 2023
    Assignee: BIOTEK ENVIRONMENTAL SCIENCE LTD.
    Inventors: Ming-Yung Hsu, Gavin Hsu
  • Patent number: 11566215
    Abstract: A bioreactor for culturing of cells is described. Screens suitable as a cell growth scaffold may comprise crossed fibers. Screens may be contained loosely in a screen holder, which in turn may be contained inside a manifold assembly. A lower manifold, screen holder and upper manifold may have identical or similar interior open cross-sections. Flow of liquid medium can occur upwardly through the array of screens, then flowing over a weir in the presence of an air pocket, and into a moat and a pump. The screen holder may have slots whose exterior-facing ligaments are rounded, and may have grooves whose interior-facing edges are rounded. These components may be located inside an incubator suitable to maintain desired environmental conditions and cleanliness.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: January 31, 2023
    Assignee: 3D BIOTEK LLC
    Inventors: Zongsen Wang, Wing Lau, Faribourz Payvandi, Peng Yue, Azadeh Jadali, Peter Materna
  • Patent number: 11475694
    Abstract: The disclosure provides a touch recognition device, including a display device and manufacturing method thereof. The touch recognition device includes a substrate, a thin film transistor layer, a transparent conductive layer, a first metal layer, a piezoelectric material layer and a second metal layer. The transparent conductive layer is disposed on an end of the thin film transistor layer, and the transparent conductive layer includes a plurality of transparent electrodes. The first metal layer is adjacent to the plurality of transparent electrodes. The piezoelectric material layer is disposed on the transparent conductive layer and the first metal layer. The second metal layer is disposed on the piezoelectric material layer to achieve the effect of increasing voltage of signals and power of ultrasound.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: October 18, 2022
    Assignees: Reco Technology (Chengdu) Co., Ltd., Reco Biotek Co., Ltd.
    Inventors: Li-Ting Cheng, Shih-Chieh Huang
  • Patent number: 11417139
    Abstract: The present invention is a display device, comprising a display module, a fingerprint recognition module and a speaker module. The back of the display module is provided with a fingerprint recognition module and a speaker module. A common electrode layer is arranged between the fingerprint recognition module and the speaker module, so that the thickness of the display can be greatly reduced.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: August 16, 2022
    Assignees: RECO TECHNOLOGY (CHENGDU) CO., LTD, RECO BIOTEK CO., LTD
    Inventors: Sincheng Lin, Chungwu Liu
  • Publication number: 20220090169
    Abstract: Disclosed are methods and kits for improving global gene expression analysis for a population of RNA molecules derived from a human urine sample. In an embodiment, the method comprises the step of selectively depleting miR-10a-5p fragments from the population of RNA molecules or selectively blocking miR-10a-5p fragments within the RNA population. The miR-10a-5p depleted or miR-10a-5p blocked population of RNA can be used in a variety of global gene expression analysis protocols, including next generation sequencing. In a further embodiment, the method comprises selectively depleting or blocking miR-10b-5p fragments within the RNA population. The miR-10a-5p and/or miR-10b-5p depleted or blocked populations of RNA can also be used in global gene expression analysis protocols, including next generation sequencing.
    Type: Application
    Filed: December 8, 2021
    Publication date: March 24, 2022
    Applicant: Norgen Biotek Corp.
    Inventor: Yousef Haj-Ahmad
  • Publication number: 20220080404
    Abstract: An apparatus for collecting and combining a sample, and in particular, a biological sample, with a reagent, and uses thereof. The apparatus comprises a sample collection container and a complementary sealing cap. A sealed reagent reservoir containing a reagent, such as a preservative reagent, is provided in a lower portion of the collection container. A piercing insert is nested within the collection container, above the seal of the reagent reservoir. Following the collection of the sample into the collection container, the action of sealing the collection container with the cap causes the piercing insert to engage with and disrupt the seal on the reagent reservoir, thereby exposing the collected sample to the reagent.
    Type: Application
    Filed: September 14, 2021
    Publication date: March 17, 2022
    Applicant: Norgen Biotek Corp.
    Inventor: Yousef Haj-Ahmad
  • Patent number: 11208678
    Abstract: Disclosed are methods and kits for improving global gene expression analysis for a population of RNA molecules derived from a human urine sample. In an embodiment, the method comprises the step of selectively depleting miR-10a-5p fragments from the population of RNA molecules or selectively blocking miR-10a-5p fragments within the RNA population. The miR-10a-5p depleted or miR-10a-5p blocked population of RNA can be used in a variety of global gene expression analysis protocols, including next generation sequencing. In a further embodiment, the method comprises selectively depleting or blocking miR-10b-5p fragments within the RNA population. The miR-10a-5p and/or miR-10b-5p depleted or blocked populations of RNA can also be used in global gene expression analysis protocols, including next generation sequencing.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: December 28, 2021
    Assignee: Norgen Biotek Corp.
    Inventor: Yousef Haj-Ahmad
  • Publication number: 20210301811
    Abstract: An autoclaving microplate washing system for cells and non-adhering three-dimensional (3D) cell cultures includes one or more peristaltic pumps for controlling the dispensing of washing fluid and the evacuation of fluid from microwells to gently wash the cells.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 30, 2021
    Applicant: BIOTEK INSTRUMENTS, INC
    Inventors: Christopher MANY, Brad Larson, Byron Smith, Brian Struhammer