Abstract: An electronic low-frequency pulse patch of a one-piece structure is disclosed, which has a power supply and a circuit capable of outputting positive and negative current pulses concealed therein, and in which, without use of a flexible ribbon cable set and an additional fastener, a host unit and a coupling conductive patch unit assembly are joined together with the appearance to form a one-piece seamless water-proof structure for use as a self-adhesion patch device capable of generating a low-frequency pulse output.
Abstract: The present invention provides an RP system which can directly use hot melt polymers for fabricating porous 3D construct for cell culture and other biomedical applications based on a CAD design. To realize the direct use of polymer hot melt, the RP system uses a hot melt chamber which is mounted on a robotic dispensing ann or a XYZ motion control system. The hot melt chamber is equipped with a delivery mechanism to force the molten polymer passing through a nozzle. The extruded polymer thin filament deposits onto the positions according to the computer generated model, in a layer-by-layer fashion, similar to FDM. The present invention can use any type of thennal plastic polymer pellets, beads, particles, which are suitable for extrusion and injection molding, as well as composites of two or more different thermal plastic polymer blends, inorganic particle/thennal plastic composites.
Abstract: Disclosed herein are three-dimensional porous tubular scaffolds for cardiovascular, periphery vascular, nerve conduit, intestines, bile conduct, urinary tract, and bone repair/reconstruction applications, and methods and apparatus for making the same.
Abstract: Disclosed herein is an extract obtainable from Trigonella foenum-graecum. In particular, the extract is obtainable by a process comprising the steps of preparing a mixture of a plant material obtained from Trigonella foenum-graecum and liquid, incubating said mixture for at least 3 hours, heating of said mixture, and recovering a liquid extract from mixture. The extract is useful in the manufacture of various types of compositions, such as pharmaceutical compositions, disinfectant or preservation agents. The pharmaceutical may be used for the treatment or prevention of an inflammatory disease or an infectious condition.
Abstract: A method is disclosed for isolating both free and protein-associated DNA from bodily fluids, such as urine, saliva, serum, tears, sweat, cerebral spinal fluid, and plasma. The method comprises as a first step concentrating and isolating both the free DNA and the proteins present in the bodily fluid. The proteins are then disgested in order to release the formerly protein-associated DNA from the isolated proteins. Lastly, the free and formerly protein-associated DNA can be isolated and purified.
Abstract: The present invention relates to a diet product comprising an alginate in an aqueous dissolved or swelled form at a pH value causing the alginate not to gel.
Abstract: The present invention relates to a hybrid biomedical device formed from a prefabricated biomedical device and coated with an extracellular matrix coating which is produced by directly culturing mammalian cells on the prefabricated biomedical device. The purposes of applying such an ECM coating is to regulate the biological and cellular responses of a living tissue or a cellular environment that the hybrid biomedical device is intended to interact with. The ECM coating will provide necessary biological cues, biomechanical cues, structural cues, etc to regulate the biological and cellular responses of a living system. The invention further provides methods of making the hybrid biomedical device.
Type:
Application
Filed:
March 20, 2009
Publication date:
September 24, 2009
Applicant:
3D BIOTEK, LLC
Inventors:
Qing Liu, Wing K. Lau, Marika Katherine Bergenstock
Abstract: A method of using silicon carbide for removing adventitious materials such as endotoxins, prions, viruses and bacteria from water, buffers, aqueous solutions or biological preparations of DNA or proteins, or any combination thereof. The present invention provides for a method of removing adventitious materials from a fluid by passing the fluid through a column or filter bed comprised of silicon carbide particles, or by passing the fluid through a silicon carbide slurry. The method reduces at least 90% of bacteria and endotoxins. It is an economical, reproducible and regenerable process for removing adventitious materials from various fluids.
Abstract: The present invention relates to a three dimensional construct formed from non-biodegradable and non-cytotoxic polymers that provide an internal and external space for living cells to attach, proliferate and differentiate. The construct is composed of polymer struts and/or fibers which are joined together in a designed 3 dimensional pattern. The 3 dimensional cell culture construct (cell culture insert) is intended to be used together with cell/tissue culture plate, tissue culture flask, bioreactor and the like under normal cell culture conditions. The invention further provides methods of making the 3 dimensional cell culture construct. Finally, the invention provides kits comprising one or more 3 dimensional porous cell culture construct in a package together with other cell culture supplies, such as tissue culture plate and flasks.
Abstract: A method of using silicon carbide for removing adventitious materials such as endotoxins, prions, viruses and bacteria from water, buffers, aqueous solutions or biological preparations of DNA or proteins, or any combination thereof. The present invention provides for a method of removing adventitious materials from a fluid by passing the fluid through a column or filter bed comprised of silicon carbide particles, or by passing the fluid through a silicon carbide slurry. The method reduces at least 90% of bacteria and endotoxins. It is an economical, reproducible and regenerable process for removing adventitious materials from various fluids.
Abstract: A multi-layered microcapsule containing one or more active ingredients and process for preparing the same is disclosed. The multi-layered microcapsule comprises an inner solid microparticle core, typically composed of a biodegradable polymer, and having one or more alternating layers of polymer, active ingredient or polymer/active ingredient mixtures to produce a multi-layered microcapsule wherein the polymer or active ingredient in each layer may be the same or different or have the same or different concentration of the polymer or active ingredient in other layers.
Abstract: Methods and compositions to induce opioid drug independence in opioid drug dependent individuals comprising administering opioid agonists and/or antagonists encapsulated in biodegradable polymer microspheres in a dosage formulation.
Abstract: Purification methods are provided for proteins and peptides, employing silicon carbide to bind the proteins or peptides. The methods may also be used to recover and purify recombinantly expressed proteins sequestered in inclusion bodies. The method for purifying a protein or peptide comprises contacting a solution containing the protein or peptide with silicon carbide at a binding pH for the protein or peptide to allow the protein or peptide to bind to the silicon carbide; and eluting the protein or peptide from the silicon carbide.
Abstract: The invention disclosed is particularly directed to a process for the purification of DNA, and is especially useful for the isolation of biologically active plasmid DNA. The process is initiated by binding the DNA to silicon carbide particles, either in the presence or absence of chaotropic agents. The bound DNA is subsequently eluted from the resin in low salt buffer or water. The resulting purified DNA is substantially free of proteins and is shown to be biologically active. The scope and diversity of the process is demonstrated here since this process can be used for the isolation of RNA and genomic DNA as well as the purification of PCR products and isolation of DNA from agarose gel slices.
Abstract: The invention disclosed is particularly directed to a process for the purification of DNA, and is especially useful for the isolation of biologically active plasmid DNA. The process is initiated by binding the DNA to silicon carbide particles, either in the presence or absence of chaotropic agents. The bound DNA is subsequently eluted from the resin in low salt buffer or water. The resulting purified DNA is substantially free of proteins and is shown to be biologically active. The scope and diversity of the process is demonstrated here since this process can be used for the isolation of RNA and genomic DNA as well as the purification of PCR products and isolation of DNA from agarose gel slices.
Abstract: A slide lock device is provided for releasably locking a patient positioning mold to a base for accurate and repeatable radiation therapy. The slide lock device includes a rail secured to the base and a tab slidably mounted on the rail for overlapping engagement with the frame of the patient positioning mold. The tab locks the mold against vertical and lateral movement relative to the base in a quick and easy manner. A plurality of holes in the rail allow adjustable positioning of the mold through the use of indexing pins.
Abstract: A moldable vacuum cushion for positioning a patient during radiation therapy treatment includes an indexing bar with indexing pins to allow the attached cushion to be quickly, easily, accurately, and repeatably indexed on a baseplate or treatment table. The indexing bar may be releasably mounted on a frame member fixed to the cushion or may be directly mounted on the cushion.
Type:
Grant
Filed:
August 11, 1997
Date of Patent:
November 10, 1998
Assignee:
Biotek
Inventors:
Todd M. Hauger, Loren G. Kamstra, Vincent S. Hursh