Abstract: A two-dimensional liquid chromatography (2D-LC) apparatus and method of its use, the apparatus constructed with (1) a first dimension (first-D) having at least one first chromatography column, (2) at least one multi-port stream selector in fluid communication with the at least one first chromatography column for receiving an effluent therefrom, and (3) a second dimension (second-D) having a plurality of second chromatography columns, each second chromatography column in fluid communication with a corresponding port of the at least one multi-port stream selector for receiving an effluent fraction of the effluent from the at least one first chromatography column, thereby enabling simultaneous chromatographic separation by the plurality of second chromatography columns of a set of multiple effluent fractions outputted from the at least one first chromatography column.
Type:
Grant
Filed:
March 6, 2018
Date of Patent:
August 4, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: Variant peptides of calcitonin gene-related peptide alpha (?CGRP), calcitonin gene-related peptide beta (?CGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high binding affinity and agonistic or antagonistic activity for at least one receptor complex of CLR:RAMP1, CLR:RAMP2, and CLR:RAMP3. Also disclosed are methods of use of the variant peptides in therapeutic treatments.
Type:
Grant
Filed:
October 4, 2019
Date of Patent:
July 28, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: Disclosed are synthetic peptides and peptide compositions, including peptide conjugates, that can ameliorate and/or block the cytotoxicity of Clostridium difficile toxin B(TcdB), and methods of their use for inhibiting the activity of Clostridium difficile toxin B(TcdB) and protecting against damage during Clostridium difficile toxin B(TcdB) disease, and/or for use as cell penetrating peptides for enhancing the delivery of particular heterogenous molecules into cells.
Type:
Grant
Filed:
September 2, 2016
Date of Patent:
July 14, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: A distillation system having a plurality of chambers, an input conduit connected to each chamber to deliver an aqueous fluid to each chamber; a pressure reducing valve connected to the input conduit; a waste output conduit connected to a waste collection compartment of each chamber; and condensate output conduit connected to a condensate collection compartment of each chamber. An evaporation wall of each chamber is constructed to maintain an evaporation surface temperature that is greater than a condensation surface temperature of a condensation wall of each chamber. The aqueous fluid forms a fluid coating, which moves down the evaporation wall. A saturation pressure differential is created as water from the aqueous fluid evaporates from the evaporation wall and condenses on the condensation wall forming an aqueous condensate, which moves down the condensation wall and is collected as an aqueous distillate in the condensate collecting compartment.
Type:
Grant
Filed:
October 30, 2018
Date of Patent:
July 7, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.
Type:
Grant
Filed:
May 28, 2013
Date of Patent:
May 5, 2020
Assignees:
AGENUS INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Inventors:
Donald F. Hunt, Andrew Norris, Ann Michelle English, Jeffrey Shabanowitz, William H. Hilderbrand, Oriana E. Hawkins
Abstract: Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.
Type:
Application
Filed:
December 20, 2017
Publication date:
April 2, 2020
Applicants:
The Board of Regents of the University of Texas System, The Board of Regents of the University of Oklahoma System
Inventors:
Susan L MOOBERRY, Andrew J ROBLES, April L RISINGER, Robert H CICHEWICZ, Salkat HALDAR, Peter HOUGHTON
Abstract: The present disclosure provides, in various embodiments, immunogenic mutants of cholesterol-dependent cytolysins, such as pneumolysin, which have reduced hemolytic activity and reduced pore-forming activity in comparison to their wild type protein. The present disclosure also provides, in various embodiments, nucleic acids which encode such mutants, and methods of the use of such mutants.
Type:
Grant
Filed:
November 20, 2015
Date of Patent:
February 18, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: Novel materials, material deposition methods, and devices used to generate electrical power from thermal radiators based on thermophotovoltatic (TPV) operating principles using group IV-VI alloys and materials are disclosed. A semiconductor structure comprising (N) stacked junctions, each junction formed of a IV-VI semiconductor alloy and each of said N junctions having a bandgap, where N is an integer and N>1 is disclosed. The semiconductor structure is configured to capture electromagnetic radiation having wavelengths from about 1 ?m to about 7 ?m. TPV devices comprising the novel semiconductor structure and methods of making the novel structures and devices are also disclosed.
Type:
Grant
Filed:
December 2, 2014
Date of Patent:
January 28, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: A surgical cleaning tool and method of cleaning a surgical tool. The surgical cleaning tool includes a shaft, a handle and an end portion. The shaft has a distal end and a proximal end. The handle is attached to the distal end of the shaft The end portion is connected to the proximal end of the shaft, wherein the end portion has an outer surface, an inner cavity, an inner surface, at least one cleaning element connected to at least a portion of the inner surface, and an opening in a wall portion of the end portion, wherein the opening allows access to the cleaning element in the inner cavity of the end portion.
Type:
Grant
Filed:
November 24, 2015
Date of Patent:
January 21, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Inventors:
Nilesh Vasan, Michael Petri, Andrew Stewart, Patrick Stevens, Rannyu Ngoran, Jonathan Schick, Derrick Jones
Abstract: A dual linear polarized dipole antenna (and arrays of such antennas) having high isolation between ports. The antenna may include a pair of crossed (collocated) bent (angled) dipole antenna elements which are excited by a unique dual-polarized feeding structure. The antenna elements may be printed. Stripline feeding along with substantially symmetrical and substantially identical radiative (e.g., “radiating”) elements results in high level of port isolation. Sub-ground planes may be positioned about the stripline on both sides of a balun block to limit or reduce parasitic stripline radiation, thereby improving polarization purity. Polarization purity may be additionally reinforced by a principal ground plane which isolates the radiative elements from the baluns. The antennas and antenna arrays may be used, for example, for weather observation and air surveillance.
Type:
Grant
Filed:
July 18, 2018
Date of Patent:
January 7, 2020
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: Compounds having inhibitory activity against retinaldehyde dehydrogenases (RALDHs). The compounds can be used, for example, to inhibit synthesis of retinoic acid for the treatment of refractive error disorders such as myopia, and as infertility treatments by inhibiting spermatogenesis.
Type:
Grant
Filed:
September 16, 2016
Date of Patent:
December 31, 2019
Assignees:
The Board of Regents of the University of Oklahoma, Oklahoma Medical Research Foundation
Inventors:
Jody A. Summers, Angelica R. Harper, Tim Mather, Anthony Burgett, Anh Thi Quynh Le
Abstract: Mutant mammalian RPE65 proteins and portions thereof, and nucleic acids encoding the mutants, for use in treating a condition related to retinal degeneration in a subject, the mutant mammalian RPE65 proteins or portions thereof having isomerohydrolase activity. A gene therapy method of treating a condition related to retinal degeneration in a mammalian subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of a vector comprising a nucleic acid encoding a mutant mammalian RPE65 protein or a portion thereof. A method of treating a condition related to retinal degeneration in a subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of at least one of a mutant mammalian RPE65 protein or a portion thereof.
Type:
Grant
Filed:
July 27, 2015
Date of Patent:
December 3, 2019
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: Variant peptides of calcitonin gene-related peptide alpha (?CGRP), calcitonin gene-related peptide beta (?CGRP), and adrenomedullin (AM) are disclosed, wherein the variant peptides have high binding affinity and agonistic or antagonistic activity for at least one receptor complex of CLR:RAMP1, CLR:RAMP2, and CLR:RAMP3. Also disclosed are methods of use of the variant peptides in therapeutic treatments.
Type:
Grant
Filed:
May 13, 2016
Date of Patent:
November 5, 2019
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: Compositions and methods for treating various cardiovascular disorders include targeted delivery of glutamate for impairing a targeted portion of the autonomic nervous system (ANS). Targeted delivery may be via direct injection into the targeted portion of the ANS or via vascular injection of magnetically-targetable nanoparticles.
Type:
Grant
Filed:
August 25, 2017
Date of Patent:
September 3, 2019
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: Stable CNT dispersions having a combination of polymeric dispersants, including at least one first dispersant and at least one second dispersant, wherein the second dispersant is stable under saline conditions, and methods of using the CNT dispersions in subterranean formations for enhancing oil recovery therefrom.
Type:
Grant
Filed:
September 25, 2015
Date of Patent:
August 13, 2019
Assignee:
The Board of Regents of the University of Oklahoma
Inventors:
Mohannad J. Kadhum, Daniel E. Resasco, Jeffrey H. Harwell, Ben Shiau, Daniel P. Swatske
Abstract: A method of using NMR to estimate pore connectivity in a shale formation by estimating organic pore connectivity in a first sample of the shale formation and inorganic pore connectivity in a second sample of the shale formation based on uptake of brine and hydrocarbon phases. Porosity partitioning of the shale formation may be estimated with a third sample of the shale formation.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
July 23, 2019
Assignee:
The Board of Regents of the University of Oklahoma
Inventors:
Ali Ousseini Tinni, Carl Sondergeld, Chandra Rai
Abstract: Primer and/or probe sets and arrays for determining microRNA (miRNA) expression signatures that are specific to doublecortin-like kinase 1 (DCLK1) activity, and methods of their use, are disclosed.
Type:
Application
Filed:
May 18, 2017
Publication date:
July 18, 2019
Applicant:
The Board of Regents of the University of Oklahoma
Inventors:
Courtney W. HOUCHEN, Nathaniel WEYGANT, Dongfeng QU, Randal MAY, Parthasarathy CHANDRAKESAN
Abstract: System and method relates to measuring separation rate of water from water-in-crude oil emulsions at elevated temperature. The system includes an electrolytic interface (conductivity) cell comprising a plurality of capacitance/conductance probes disposed at different heights in a fluid stream disposed within the interface cell and an analyzer. Logic of the analyzer determines the separation rate based on signals received from the plurality of capacitance/conductance probes in the interface cell that are coupled to monitor the fluid stream. Methods for making and using the system are also disclosed.
Type:
Grant
Filed:
July 17, 2015
Date of Patent:
June 25, 2019
Assignees:
PHILLIPS 66 COMPANY, BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Inventors:
Moniraj Ghosh, Brian P. Grady, Jeffrey H. Harwell, James A. Miles