Patents Assigned to Board of Regents of the University of Nebraska
  • Patent number: 10821178
    Abstract: Compositions and methods for preventing, ameliorating or treating biofilm infections are provided, including biofilms comprising at least one Pseudomonad or Staphylococcus, such as S. aureus. The biofilm infections may be associated with artificial joints, prostheses or implants.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 3, 2020
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventor: Tammy Kielian
  • Publication number: 20200323771
    Abstract: There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.
    Type: Application
    Filed: June 24, 2020
    Publication date: October 15, 2020
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Irving H. Zucker, Hanjun Wang
  • Patent number: 10799620
    Abstract: Nanofiber structures are provided along with methods of production and methods of use.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: October 13, 2020
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Jingwei Xie, Shixuan Chen, Bernard Timothy Baxter
  • Patent number: 10779851
    Abstract: A catheter mounted arterial surgical tool has a body with a fluid jet prong extending from a distal end of the body along a prong axis that is parallel to and laterally offset from a body axis. A fluid passage extends through the fluid jet prong to an outlet that points laterally relative to the prong axis. A deflector anvil extends from the distal end of the body along a deflector axis that is parallel to and offset from the body axis. The deflector anvil has a face that faces toward the fluid jet prong and is impinged by a fluid jet discharged from the outlet. A pair of guide wire holes extend from the proximal to the distal end of the body parallel to the body axis for receiving guide wires to enable the body to slide along the guide wires.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: September 22, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Jason N. MacTaggart, Nicholas Y. Phillips, Amy R. Mantz, Alexey Kamenskiy
  • Patent number: 10772718
    Abstract: There is described an arteriovenous fistula stent, having a tubular body comprising a series of sinusoidal shaped struts along the length of the tubular body. A plurality of curvilinear connectors extend between and are attached to adjacent struts wherein a first end of a connector is attached to a distal face of a proximal strut apex and a second end of a connector is attached to a proximal face of a distal strut apex. A pair of unconnected strut apexes are between pairs of connected apexes. When the tubular body is in a stowed configuration a proximal aperture and a distal aperture are circular and when the tubular body is in a deployed configuration the distal aperture is oblong or ovoid. There is also described a method for inserting a stent for use in creation of an arteriovenous fistula by identifying a candidate artery and a candidate vein and dissecting the candidate vein. Next, inserting a stent into the vein and creating a breach in the candidate artery at a desired angle and location.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: September 15, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventor: Marius C. Florescu
  • Patent number: 10758386
    Abstract: Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The stent graft defines a lumen therethrough. In a particular embodiment, a first balloon is disposed around an outer periphery of the stent graft, a second balloon is disposed around the outer periphery of the stent graft and spaced apart from the first balloon, and a third balloon is disposed within the stent graft lumen between the first balloon and the second balloon. The third balloon can be inflated to fully or partially occlude the lumen. The first and second balloons can be individually inflated to fully or partially shunt blood flow from a blood vessel through the stent graft. In some embodiments, sensors and an automated control unit are included to automate the operations of the endovascular device.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 1, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Jason N. MacTaggart, Alexey Kamenskiy
  • Patent number: 10743949
    Abstract: The various embodiments herein relate to robotic surgical systems and devices that use force and/or torque sensors to measure forces applied at various components of the system or device. Certain implementations include robotic surgical devices having one or more force/torque sensors that detect or measure one or more forces applied at or on one or more arms. Other embodiments relate to systems having a robotic surgical device that has one or more sensors and an external controller that has one or more motors such that the sensors transmit information that is used at the controller to actuate the motors to provide haptic feedback to a user.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: August 18, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Tom Frederick, Kearney Lackas, Joe Bartels, Jacob Greenburg
  • Patent number: 10729643
    Abstract: There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: August 4, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Irving H. Zucker, Hanjun Wang
  • Patent number: 10723764
    Abstract: Anti-microbial peptides and methods of use are provided.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: July 28, 2020
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventor: Guangshun Wang
  • Patent number: 10697975
    Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: June 30, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Board of Regents of the University of Nebraska, University of Rochester, Arizona Board of Regents on behalf of the University of Arizona, Universitat de Barcelona, Fundacio Clinic, Hospital Clinic de Barcelona, Julius-Maximilians-University of Würzburg, British Columbia Cancer Agency Branch, Oslo University Hospital HF, Queen Mary and Westfield College, University of London
    Inventors: Louis M. Staudt, George Wright, Sandeep Dave, Bruce Tan, John I. Powell, Wyndham Wilson, Elaine S. Jaffe, Wing C. Chan, Timothy C. Greiner, Dennis Weisenburger, James Armitage, Kai Fu, Richard I. Fisher, Lisa M. Rimsza, Thomas Miller, Thomas Grogan, Elias Campo Guerri, Silvia M. Bea, Itziar Salaverria, Armando Lopez-Guillermo, Emilio Montserrat, Victor Moreno, Andreas Zettl, German Ott, Hans-Konrad Muller-Hermelink, Andreas Rosenwald, Julie Vose, Randy Gascoyne, Joseph Connors, Erlend B. Smeland, Stein Kvaloy, Harald Holte, Jan Delabie, T. Andrew Lister
  • Patent number: 10695137
    Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various actuation system embodiments, including fluid actuation systems, drive train actuation systems, and motorless actuation systems. Additional embodiments include a reversibly lockable tube that can provide access for a medical device to a patient's cavity and further provides a reversible rigidity or stability during operation of the device. Further embodiments include various operational components for medical devices, including medical device arm mechanisms that have both axial and rotational movement while maintaining a relatively compact structure. medical device winch components, medical device biopsy/stapler/clamp mechanisms, and medical device adjustable focus mechanisms.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: June 30, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Mark Rentschler, Amy Lehman, Stephen Platt, Jeff Hawks
  • Patent number: 10633643
    Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
    Type: Grant
    Filed: May 14, 2016
    Date of Patent: April 28, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Benjamin J. Pavlik, Paul Blum, Kevin Van Cott
  • Patent number: 10624704
    Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: April 21, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Erik Mumm, Philip Chu, Nishant Kumar, Jason Dumpert, Yutaka Tsutano
  • Publication number: 20200105364
    Abstract: In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 2, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, British Columbia Cancer Agency Branch, Mayo Foundation for Medical Education and Research, Julius-Maximilians-University of Würzburg, Board of Regents of the University of Nebraska, Oslo University Hospital HF, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut D? Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Robert Bosch Gesellschaft fuer medizinische Forschung mbH, Oregon Health & Science University, City of Hope, The Cleveland Clinic Foundation
    Inventors: Louis M. Staudt, Christian Steidl, Anja Mottok, George W. Wright, David William Scott, Lisa M. Rimsza, Andreas Rosenwald, Randy Gascoyne, Timothy Greiner, Dennis Weisenburger, Erlend B. Smeland, Jan Delabie, Elias Campo Guerri, German Ott, Rita Braziel, Elaine S. Jaffe, Kai Fu, Wing C. Chan, Joo Song, James R. Cook
  • Patent number: 10603121
    Abstract: The various embodiments disclosed herein relate to improved robotic surgical systems, including robotic surgical devices having improved arm components and/or biometric sensors, contact detection systems for robotic surgical devices, gross positioning systems and devices for use in robotic surgical systems, and improved external controllers and consoles.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: March 31, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Thomas Frederick, Joe Bartels, Eric Markvicka, Jack Mondry
  • Publication number: 20200099379
    Abstract: Logic circuits constructed with magnetoelectric (ME) transistors are described herein. A ME logic gate device can include at least one conducting device, for example, at least one MOS transistor; and at least one ME transistor coupled to the at least one conducting device. The ME transistor can be a ME field effect transistor (ME-FET), which can be can be an anti-ferromagnetic spin-orbit read (AFSOR) device or a non-AFSOR device. The gates and logic circuits described herein can be included as standard cells in a design library. Cells of the cell library can include standard cells for a ME inverter device, a ME minority gate device, a ME majority gate device, a ME full adder, a ME XNOR device, a ME XOR device, or a combination thereof.
    Type: Application
    Filed: September 24, 2019
    Publication date: March 26, 2020
    Applicants: Board of Regents of the University of Nebraska, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Intel Corporation
    Inventors: Nishtha SHARMA, Andrew MARSHALL, Peter A. DOWBEN, Dmitri E. NIKONOV
  • Publication number: 20200085842
    Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 19, 2020
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Dong Wang, Fang Yuan, Zhenshan Jia, Xiaobei Wang
  • Patent number: 10591468
    Abstract: In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldheyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 17, 2020
    Assignee: Board of Regents of The University of Nebraska
    Inventors: Geoffrey M. Thiele, Daniel R. Anderson, Michael J. Duryee
  • Patent number: 10577617
    Abstract: The impact of plastid size change in both monocot and dicot plants has been examined. In both, when plastid size is increased there is an increase in biomass relative to the parental lines. Thus, provided herein are methods for increasing the biomass of a plant, comprising decreasing the expression of at least one plastid division protein in a plant. Optionally, the level of chlorophyll in the plant is also reduced.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: March 3, 2020
    Assignees: The Board of Trustees of the University of Illinois, The United States of America, as Represented by the Secretary of Agriculture, The Board of Regents of the University of Nebraska, The University of Florida Research Foundation, Incorporated
    Inventors: Aleel K. Grennan, Donald R. Ort, Stephen Patrick Moose, Damla D. Bilgin, Thomas Clemente, Fredy Altpeter, Stephen P. Long
  • Patent number: D892330
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: August 4, 2020
    Assignee: The Board of Regents of the University of Nebraska
    Inventor: Daniel Firestone