Patents Assigned to Board of Regents of the University of Nebraska
  • Publication number: 20240156442
    Abstract: An apparatus for collecting a nasal specimen includes a device body with a nozzle at a distal end of the device body. The nozzle is configured to interface with a nasal cavity. The apparatus further includes an irrigation path and a collection path within the device body. The collection path may be separate from the irrigation path. The irrigation path is configured to direct a fluid from an irrigation chamber into the nasal cavity in order to dislodge a sample from the nasal cavity. When the fluid flows back out of the nasal cavity, the collection path is configured to direct at least a portion of the fluid and the sample dislodged from the nasal cavity into a collection chamber.
    Type: Application
    Filed: March 23, 2022
    Publication date: May 16, 2024
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Thang Nguyen, Michael Wadman, Wesley Zeger
  • Patent number: 11963945
    Abstract: Described are methods of treating or preventing a virus in a subject comprising administering ozonides to the subject.
    Type: Grant
    Filed: January 6, 2022
    Date of Patent: April 23, 2024
    Assignees: THE JOHNS HOPKINS UNIVERSITY, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Ravit Boger, Jonathan Vennerstrom
  • Patent number: 11950867
    Abstract: Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: April 9, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Joseph Palmowski, Shane Farritor
  • Patent number: 11951227
    Abstract: Coated and expanded, nanofiber structures are provided and methods of use thereof.
    Type: Grant
    Filed: April 4, 2022
    Date of Patent: April 9, 2024
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Jingwei Xie, Shixuan Chen, Mark Carlson
  • Patent number: 11946164
    Abstract: Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.
    Type: Grant
    Filed: July 19, 2022
    Date of Patent: April 2, 2024
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventor: Jingwei Xie
  • Publication number: 20240096493
    Abstract: Aspects of the present disclosure relate to systems and methods for analyzing a tumor, and more specifically, analyzing a tumor to identify a biological aggressiveness of the tumor. One example method for tumor analysis includes: receiving one or more input features associated with a geometric shape of a tumor, the one or more input features including at least a value indicating a circularity of the tumor; determining, via a machine learning component, a characteristic of the tumor based on the one or more input features, the characteristic being indicative of patient survivability; and outputting an indication of the characteristic.
    Type: Application
    Filed: September 18, 2023
    Publication date: March 21, 2024
    Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Matteo Ligorio, Rebecca Napier, William Gasper, Dario Ghersi
  • Patent number: 11934039
    Abstract: A surgical loupes head strap is disclosed. The surgical loupes head strap may include a first monofilament and a second monofilament coupled by at least one sleeve. The surgical loupes head strap may further include a first coupler with a first hole and a second hole, where the first hole is configured to surround and couple to a first end of the first monofilament, and the second hole is configured to surround and couple to at least a portion of a first surgical loupes headgear temple. The surgical loupes head strap may further include a second coupler with a first hole and a second hole, where the first hole is configured to surround and couple to a first end of the second monofilament, and the second hole is configured to surround and couple to at least a portion of a second surgical loupes headgear temple.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: March 19, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Donny Suh, James Hermsen
  • Patent number: 11911117
    Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
    Type: Grant
    Filed: September 4, 2022
    Date of Patent: February 27, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera
  • Patent number: 11911464
    Abstract: Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: February 27, 2024
    Assignees: Prommune, Inc., Board of Regents of the University of Nebraska
    Inventors: Paul Davis, Samer Al-Murrani
  • Patent number: 11909576
    Abstract: Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: February 20, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Tyler Wortman, Kyle Strabala, Ryan McCormick, Amy Lehman, Dmitry Oleynikov, Eric Markvicka
  • Publication number: 20240050735
    Abstract: Systems and methods for treating and inhibiting wound infections employ a hydrogel ionic circuit (HIC)-based device for therapeutic iontophoresis and/or biofilm debridement. The HIC-based device includes: a first chamber containing a salt solution; a second chamber containing a therapeutic or buffer solution, the second chamber being configured to interface with a surface overlaying a target region; a hydrogel membrane separating the first chamber from the second chamber; and an electrode configured to apply an electrical current to the first chamber of the working device to induce an ion current in the salt solution, wherein the ion current acts on the second chamber to iontophoretically transport therapeutic molecules across the surface overlaying the target region and/or debride biofilm at the surface overlaying the target region.
    Type: Application
    Filed: October 25, 2023
    Publication date: February 15, 2024
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Siwei Zhao, Fan Zhao
  • Patent number: 11896423
    Abstract: Technology is described that can be used for continuous measurements of blood pressure and arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patient's vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessment of the control of vascular resistance and capacitance in real time.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: February 13, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Irving H. Zucker, Ioannis Chatzizisis, Han-Jun Wang, Alicia M. Schiller, Peter Ricci Pellegrino
  • Patent number: 11883065
    Abstract: The various embodiments herein relate to systems, devices, and/or methods relating to surgical procedures, and more specifically for accessing an insufflated cavity of a patient and/or positioning surgical systems or devices into the cavity.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: January 30, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Thomas Frederick, Shane Farritor, Jack Mondry, Eric Markvicka, Dmitry Oleynikov, Jacob Greenburg
  • Patent number: 11857265
    Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.
    Type: Grant
    Filed: December 23, 2022
    Date of Patent: January 2, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Hani Haider, Osvaldo Andres Barrera
  • Patent number: 11857443
    Abstract: Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The stent graft defines a lumen therethrough. In a particular embodiment, a first balloon is disposed around an outer periphery of the stent graft, a second balloon is disposed around the outer periphery of the stent graft and spaced apart from the first balloon, and a third balloon is disposed within the stent graft lumen between the first balloon and the second balloon. The third balloon can be inflated to fully or partially occlude the lumen. The first and second balloons can be individually inflated to fully or partially shunt blood flow from a blood vessel through the stent graft. In some embodiments, sensors and an automated control unit are included to automate the operations of the endovascular device.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: January 2, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Jason N. MacTaggart, Alexey Kamenskiy
  • Patent number: 11839623
    Abstract: The present invention provides prodrugs and methods of use thereof.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: December 12, 2023
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Howard E. Gendelman, Benson Edagwa
  • Patent number: 11840540
    Abstract: Provided herein are compounds and methods for modulating the NF?B pathway. More particularly, provided are inhibitors of the NF?B pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: December 12, 2023
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Amarnath Natarajan, Sandeep Rana
  • Publication number: 20230390382
    Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles (WAEVs) for presenting HIV antigen domains. These WAEVs can be harnessed to deliver and present HIV antigens useful for vaccine development. Specifically, the disclosure provides a fusion protein comprising: (a) a WW-containing domain; (b) a transmembrane domain; and (c) an extracellular domain, wherein the extracellular domain is an HIV antigen domain. Further provided are sequences of each domain as well as methods of producing and using the fusion protein.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicants: President and Fellows of Harvard College, Board of Regents of the University of Nebraska
    Inventors: Quan Lu, Shi-Hua Xiang
  • Patent number: 11832871
    Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: December 5, 2023
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Tom Frederick, Joe Bartels
  • Patent number: D1006248
    Type: Grant
    Filed: March 23, 2022
    Date of Patent: November 28, 2023
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Thang Nguyen, Michael Wadman, Wesley Zeger