Abstract: Provided are methods for monitoring the progression of Parkinson's Disease, and methods for monitoring or determining the effectiveness of therapeutics for the treatment of Parkinson's Disease, as well as methods for treatment thereof, by assessing one or more biomarkers, such as NF-?B and/or calcineurin.

Abstract: A system for controlling exercise equipment based on user pace and motion analysis is disclosed. The system includes a control unit communicatively coupled with a center of mass (COM) sensor and one or more additional sensors. The COM sensor is configured to track a position of a body of a user on the exercise equipment over time. The one or more additional sensors are configured to track off-center movements of the user over time. The control unit is configured to modulate an adjustable parameter of the exercise equipment based on a plurality of measurements of the user's body position and off-center movements collected by the COM sensor and the one or more additional sensors over time.

Abstract: Systems and methods are described for treating distal radius fractures using a plating system. In an aspect, a distal radius plating system includes a volar plate body for interfacing with a volar side of a distal portion of a radius bone. The volar plate body has a volar head portion extending from the volar plate body and terminating at a distal edge, the volar head portion including a first set of apertures to receive fixation fasteners therethrough to fix to the radius bone. The distal radius plating system also includes a radial longitudinal portion extending from a radial edge of the volar plate body to interface with the radial styloid of the radius bone while the volar plate body is positioned on the volar side of the distal portion of the radius bone.

Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.

Abstract: An apparatus for collecting a nasal specimen includes a device body with a nozzle at a distal end of the device body. The nozzle is configured to interface with a nasal cavity. The apparatus further includes an irrigation path and a collection path within the device body. The collection path may be separate from the irrigation path. The irrigation path is configured to direct a fluid from an irrigation chamber into the nasal cavity in order to dislodge a sample from the nasal cavity. When the fluid flows back out of the nasal cavity, the collection path is configured to direct at least a portion of the fluid and the sample dislodged from the nasal cavity into a collection chamber.

Abstract: Described are methods of treating or preventing a virus in a subject comprising administering ozonides to the subject.

Abstract: Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.

Abstract: Coated and expanded, nanofiber structures are provided and methods of use thereof.

Abstract: Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.

Abstract: Aspects of the present disclosure relate to systems and methods for analyzing a tumor, and more specifically, analyzing a tumor to identify a biological aggressiveness of the tumor. One example method for tumor analysis includes: receiving one or more input features associated with a geometric shape of a tumor, the one or more input features including at least a value indicating a circularity of the tumor; determining, via a machine learning component, a characteristic of the tumor based on the one or more input features, the characteristic being indicative of patient survivability; and outputting an indication of the characteristic.

Abstract: A surgical loupes head strap is disclosed. The surgical loupes head strap may include a first monofilament and a second monofilament coupled by at least one sleeve. The surgical loupes head strap may further include a first coupler with a first hole and a second hole, where the first hole is configured to surround and couple to a first end of the first monofilament, and the second hole is configured to surround and couple to at least a portion of a first surgical loupes headgear temple. The surgical loupes head strap may further include a second coupler with a first hole and a second hole, where the first hole is configured to surround and couple to a first end of the second monofilament, and the second hole is configured to surround and couple to at least a portion of a second surgical loupes headgear temple.

Abstract: Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.

Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.

Abstract: Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.

Abstract: Systems and methods for treating and inhibiting wound infections employ a hydrogel ionic circuit (HIC)-based device for therapeutic iontophoresis and/or biofilm debridement. The HIC-based device includes: a first chamber containing a salt solution; a second chamber containing a therapeutic or buffer solution, the second chamber being configured to interface with a surface overlaying a target region; a hydrogel membrane separating the first chamber from the second chamber; and an electrode configured to apply an electrical current to the first chamber of the working device to induce an ion current in the salt solution, wherein the ion current acts on the second chamber to iontophoretically transport therapeutic molecules across the surface overlaying the target region and/or debride biofilm at the surface overlaying the target region.

Abstract: Technology is described that can be used for continuous measurements of blood pressure and arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patient's vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessment of the control of vascular resistance and capacitance in real time.

Abstract: The various embodiments herein relate to systems, devices, and/or methods relating to surgical procedures, and more specifically for accessing an insufflated cavity of a patient and/or positioning surgical systems or devices into the cavity.

Abstract: Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The stent graft defines a lumen therethrough. In a particular embodiment, a first balloon is disposed around an outer periphery of the stent graft, a second balloon is disposed around the outer periphery of the stent graft and spaced apart from the first balloon, and a third balloon is disposed within the stent graft lumen between the first balloon and the second balloon. The third balloon can be inflated to fully or partially occlude the lumen. The first and second balloons can be individually inflated to fully or partially shunt blood flow from a blood vessel through the stent graft. In some embodiments, sensors and an automated control unit are included to automate the operations of the endovascular device.

Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.