Patents Assigned to Board of Regents of the University of Nebraska
  • Nanofiber structures and methods of use thereof
    Patent number: 11318224
    Abstract: Coated and expanded, nanofiber structures are provided and methods of use thereof.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: May 3, 2022
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Jingwei Xie, Shixuan Chen, Mark Carlson
  • Healthcare provider interface for treatment option and authorization
    Patent number: 11322237
    Abstract: A healthcare provider user interface for treatment option and authorization is disclosed herein. In embodiments, a healthcare provider device includes a display coupled to one or more processors. The display includes a graphical user interface comprising one or more input interface display pages and one or more output interface display pages. The one or more input interface display pages may include one or more input boxes configured to receive information including patient demographic and physiological information, insurance information, past treatments, and one or more medical diagnoses. The one or more output interface display pages may include a treatment list generated based on the received information and a prior authorization form configured to receive one or more prior authorization input fields.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: May 3, 2022
    Assignee: Board of Regents of the University of Nebraska
    Inventor: Stephen Salzbrenner
  • Time-varying quantification of capacitive and resistive arterial blood flow
    Patent number: 11317889
    Abstract: Technology is described that can be used for continuous measurements of blood pressure and arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patients vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessment of the control of vascular resistance and capacitance in real time.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: May 3, 2022
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Irving H. Zucker, Ioannis Chatzizisis, Han-Jun Wang, Alicia M. Schiller, Peter Ricci Pellegrino
  • Compositions and methods for the delivery of therapeutics
    Patent number: 11311545
    Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: April 26, 2022
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Howard E. Gendelman, Xin-Ming Liu, Benson Edagwa
  • Antiviral prodrugs and nanoformulations thereof
    Patent number: 11311547
    Abstract: The present invention provides prodrugs and methods of use thereof.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: April 26, 2022
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Howard Gendelman, Benson Edagwa
  • Modified pigment epithelium-derived factor (PEDF) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection
    Patent number: 11261237
    Abstract: Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents, chemotherapy-protecting agents, and immune stimulating agents.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: March 1, 2022
    Assignees: Northwestern University, Board of Regents of the University of Nebraska
    Inventors: Jack Henkin, Olga Volpert, Serguei Vinogradov, Ignacio Melgar-Asensio
  • Methods and compositions for selective generation of dopaminergic precursors
    Patent number: 11261461
    Abstract: Provided are methods and compositions for transdifferentiation of a somatic cell, e.g., a fibroblast to a dopaminergic precursor, Specifically, provided are induced dopaminergic (iDP) cells, or master transcription factors (TFs) therefore, methods for making iDP cells, and methods and compositions for using them in, e.g., treating neurodegenerative diseases such as Parkinson's disease.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: March 1, 2022
    Assignees: Tongji University, Board of Regents of the University of Nebraska
    Inventors: Jialin Zheng, Changhai Tian
  • BIOMARKERS FOR TYPE 1 DIABETES
    Publication number: 20220057398
    Abstract: In various embodiments methods are provided for evaluating the likelihood of a subject progressing to type 1 diabetes. In certain embodiments the methods involve determining the level of CD57+, CD28?, CD127?, CD27?, CD8+ T cells (SLEC CD8 T cells) and the other populations shown in FIG. 10 and/or CCR7dim, CD45RA+, CD8+ T cells derived from a subject where an elevated level of the first populations above, and/or a reduced level of the CCR7dim, CD45RA+, CD8+ T cells as compared to the level(s) in a normal healthy control is an indicator that subject has a significant elevated risk for progression to type I diabetes.
    Type: Application
    Filed: September 11, 2019
    Publication date: February 24, 2022
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Nora E. Sarvetnick, Robert Z. Harms
  • Transesophageal echocardiography simulator
    Patent number: 11257397
    Abstract: A simulator system can be used to train personnel regarding transesophageal echocardiography (TEE) performance techniques. TEE is an ultrasonic imaging modality that can be used to capture images of a subject's heart. An imaging probe is inserted into the esophagus of the subject and positioned/aimed toward the subject's heart to capture the images. The TEE training system described is a system for ultrasonic diagnosis training (e.g., targeting the heart) which can be operated using an actual echocardiography machine used in clinic setting, and allows the practice of both acquisition and manipulation of images by the user so as to provide multiple aspects of learning 3D TEE.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 22, 2022
    Assignee: Board of Regents of the University of Nebraska
    Inventor: Nicholas Markin
  • GENE THERAPY FOR JUVENILE BATTEN DISEASE
    Publication number: 20220049272
    Abstract: Compositions and methods for the treatment of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Juvenile Batten Disease, are provided herein. In certain embodiments the compositions include but are not limited to adeno-associated viral (AAV) constructs, including self-complementary adeno-associated viral (sc-AAV) constructs, that express the human gene CLN3 (or a CLN3 cDNA).
    Type: Application
    Filed: December 22, 2020
    Publication date: February 17, 2022
    Applicants: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, OHIO STATE INNOVATION FOUNDATION
    Inventors: Tammy Kielian, Kevin Foust
  • Hall bar device for memory and logic applications
    Patent number: 11233192
    Abstract: A hall bar device for a memory or logic application can include a gate electrode, a boron-doped chromia layer on the gate electrode; and a hall bar structure with four legs on the boron-doped chromia layer. For a memory application, the hall bar device can be written to by applying a pulse voltage across the gate electrode and one leg of the hall bar structure in the absence of an applied magnetic field; and can be read from by measuring a voltage across the one leg of the hall bar structure and its opposite leg.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: January 25, 2022
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Christian Binek, Ather Mahmood, William Echtenkamp
  • Methods for Administration and Methods for Treating Cardiovascular Diseases with Resiniferatoxin
    Publication number: 20220000837
    Abstract: The present application provides methods for treating cardiovascular conditions. The methods can include administering a Transient Receptor Potential Vanilloid 1 (TRPV1) receptor agonist to an epidural space. The methods can be used to treat a variety of conditions such as hypertension, prehypertension, mild hypertension, severe hypertension, refractory hypertension, congestive heart failure and myocardial scarring.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 6, 2022
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Irving H. Zucker, Hanjun Wang
  • MEDICATION BOTTLE WITH ANTI-TAMPERING FEATURES
    Publication number: 20220000715
    Abstract: A medication bottle includes an outer container wall, an inner container wall and a fluid, such as an aversive liquid, located between the walls. In another aspect, the fluid is located within separate compartments or channels located between the walls where the walls contact or are secured to each other. A further aspect provides a removeable cap including multiple sensors, at least one of which is a biometric sensor.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 6, 2022
    Applicants: Board of Trustees of Michigan State University, Board of Regents of the University of Nebraska
    Inventors: Bahar Aliakbarian, Muhammad Rabnawaz, Susan E. Selke, Krystal Cheng, Arun Ross, Austin Cozzo, Anurag Chowdhury, Ali Tamayol, Carina Russell, Prem Chahal
  • ANTIMICROBIAL OZONE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20210400981
    Abstract: Antimicrobial aqueous ozone compositions and methods of use thereof are provided.
    Type: Application
    Filed: July 24, 2019
    Publication date: December 30, 2021
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: James E. Talmadge, Michael Draper, Holly Britton, Andrew M. Worlie, Evan D. Marlow
  • Method for diagnosing and treating Parkinson's disease via measurment of effector memory t-cells
    Patent number: 11209426
    Abstract: Methods and compositions for detecting and diagnosing Parkinson's disease are disclosed.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: December 28, 2021
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Howard E. Gendelman, R. Lee Mosley, Jessica A. Saunders
  • User-paced exercise equipment
    Patent number: 11185740
    Abstract: Disclosed herein are examples of user-paced exercise equipment, as well as related circuitry, methods, and computer-readable media. For example, disclosed herein is a user-paced treadmill, including a belt, a motor coupled to the belt, and control circuitry communicatively coupled to the motor. The control circuitry may be configured to change a velocity of the belt based at least in part on a body velocity and a leg swing velocity of a user of the user-paced treadmill.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: November 30, 2021
    Assignee: Board of Regents of the University Of Nebraska
    Inventors: William Denton, Molly Schieber, Casey Wiens
  • Phosphodiesterase inhibitors
    Patent number: 11180499
    Abstract: Provided herein are compounds and methods for modulating the phosphodiesterase PDE4. More particularly, provided are selective inhibitors PDE4 and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, inflammatory diseases, neurological diseases, neurodegenerative diseases, and addiction.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: November 23, 2021
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventor: Corey Hopkins
  • Biomarkers for resistance to porcine circovirus 2 associated disease
    Patent number: 11178859
    Abstract: The present disclosure provides compositions and methods for increasing resistance to PCV2 infection in pigs. The increased resistance may be the result of siRNA or genetic modification through CRISPR or a vectored virus targeting SNPs that are resistant to PCV2 infection.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: November 23, 2021
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Daniel Constantin Ciobanu, Lianna Rayne Walker, Taylor Benjamin Engle, Hiep Vu
  • Quick-release end effector tool interface
    Patent number: 11173617
    Abstract: The various embodiments herein relate to a coupling apparatus for a medical device having a coupler body, a cavity defined in the coupler body, a rotatable drive component disposed within the cavity and having at least two pin-receiving openings, and an actuable locking ring disposed around the cavity.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: November 16, 2021
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Shane Farritor, Thomas Frederick
  • Antiviral prodrugs and nanoformulations thereof
    Patent number: 11166957
    Abstract: The present invention provides prodrugs and methods of use thereof.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: November 9, 2021
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Howard Gendelman, Benson Edagwa