Patents Assigned to Board of Regents of the University of Nebraska
  • Methods, systems, and devices relating to surgical end effectors
    Patent number: 10350000
    Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: July 16, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Tom Frederick, Joe Bartels
  • Quick-release end effectors and related systems and methods
    Patent number: 10342561
    Abstract: The various embodiments disclosed herein relate to arms or forearms of medical devices that are configured to couple with quick-release end effectors, quick-release end effectors for use with such medical devices, and arms or forearms coupled to such quick-release end effectors. Certain forearms and end effectors have magnetic couplings, while others have mechanical couplings, and further implementations have both magnetic and mechanical couplings.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: July 9, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Jeff Shasho, Alan Bachman, Kenneth Blier
  • Creatine oral supplementation using creatine hydrochloride salt
    Patent number: 10342771
    Abstract: The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: July 9, 2019
    Assignees: Vireo Systems, Inc., Board of Regents of the University of Nebraska
    Inventors: Donald W. Miller, Jonathan L. Vennerstrom, Mark C. Faulkner
  • Medical inflation, attachment and delivery devices and related methods
    Patent number: 10335024
    Abstract: The various embodiments disclosed herein relate to procedural space maintenance devices, medical device positioning devices, and devices that provide both procedural space maintenance and device positioning. Further embodiments relate to medical device insertion and/or retraction devices.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: July 2, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Mark Rentschler, Shane Farritor
  • Methods of estimating a position of a rotor in a motor under transient and systems thereof
    Patent number: 10333439
    Abstract: At least one example embodiment discloses a method of estimating a position of a rotor in a motor. The method includes obtaining a current regulation quality index based on a current command and a measured current, determining an estimated position of the rotor based on the current regulation quality index and position estimation data and controlling the motor based on the estimated position of the rotor.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: June 25, 2019
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, DEERE & COMPANY
    Inventors: Long Wu, Yue Zhao, Wei Qiao
  • Robotic surgical devices and related methods
    Patent number: 10307199
    Abstract: The present invention relates to robotic surgical devices. More specifically, the present invention relates to robotic surgical devices that can be inserted into a patient's body and can be positioned within the patient's body.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: June 4, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Amy Lehman, Nathan A. Wood, Mark Rentschler, Jason Dumpert, Dmitry Oleynikov
  • EVALUATION OF MANTLE CELL LYMPHOMA AND METHODS RELATED THERETO
    Publication number: 20190153539
    Abstract: The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
    Type: Application
    Filed: April 20, 2017
    Publication date: May 23, 2019
    Applicants: The United States of America, as represented by the secretary, Dep. of Health and Human Service, British Columbia Cancer Agency Branch, Julius-Maximilians - University of Würzburg, Oregon Health and Science University, Hospital Clinic de Barcelona, Universitat de Barcelona, Oslo University Hospital HF, Board of Regents of the University of Nebraska, The Cleveland Clinic Foundation, Mayo Foundation for Medical Education and Research
    Inventors: Louis M. Staudt, David William Scott, George W. Wright, Andreas Rosenwald, Pau Abrisqueta, Rita Braziel, Elias Campo Guerri, Wing C. Chan, Joseph M. Connors, Jan Delabie, Diego Villa, Kai Fu, Randy D. Gascoyne, Timothy Greiner, Elaine S. Jaffe, Pedro Jares, Anja Mottok, German Ott, Lisa M. Rimsza, Graham Slack, Dennis Weisenburger, Erlend B. Smeland, James Robert Cook
  • On-board tool tracking system and methods of computer assisted surgery
    Patent number: 10219811
    Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: March 5, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera
  • Single site robotic device and related systems and methods
    Patent number: 10219870
    Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: March 5, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Jack Mondry, Shane Farritor, Eric Markvicka, Thomas Frederick, Joe Bartels
  • Controlled-release peptide compositions and uses thereof
    Patent number: 10220002
    Abstract: Controlled-release formulations of carboxy-terminal C5a analogs (such as sustained-release formulations of the analogs), and their use in methods for treating and preventing an infection or a disease such as cancer, for directly killing microorganisms, for vaccine preparation, for inducing an immune response and for targeting antigen-presenting cells and other cells bearing a C5a receptor, are provided.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 5, 2019
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Joseph A. Vetro, Sam D. Sanderson
  • Creatine ester anti-inflammatory compounds and formulations
    Patent number: 10206897
    Abstract: The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form of creatine. The biologically active creatine inhibits the production of chemical mediators, released during an inflammatory response, which are important components in the inflammatory response and the inflammation and pain resulting from physical or chemical trauma to cells and tissue.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: February 19, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Donald W. Miller, Samuel C. Augustine, Jon C. Wagner, Thomas L. McDonald, Dennis H. Robinson
  • GENE THERAPY FOR JUVENILE BATTEN DISEASE
    Publication number: 20190032078
    Abstract: Compositions and methods for the treatment of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Juvenile Batten Disease, are provided herein. In certain embodiments the compositions include but are not limited to adeno-associated viral (AAV) constructs, including self-complementary adeno-associated viral (sc-AAV) constructs, that express the human gene CLN3 (or a CLN3 cDNA).
    Type: Application
    Filed: December 16, 2015
    Publication date: January 31, 2019
    Applicants: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, OHIO STATE INNOVATION FOUNDATION
    Inventors: Tammy Kielian, Kevin Foust
  • Anti-microbial peptides and coatings
    Patent number: 10144767
    Abstract: Antimicrobial peptides and methods of use are provided.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: December 4, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventor: Guangshun Wang
  • System and methods for ventilation through a body cavity
    Patent number: 10124126
    Abstract: A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles. Through circulation of oxygen microbubbles through the body cavity, oxygen and carbon dioxide exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen-intake restricting injury and/or failure may be achieved through use of the invented system and methods.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: November 13, 2018
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Mark A. Borden, Benjamin S. Terry
  • Polyethylene Glycol-Conjugated Glucocorticoid Prodrugs and Compositions and Methods Thereof
    Publication number: 20180318318
    Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.
    Type: Application
    Filed: November 12, 2016
    Publication date: November 8, 2018
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Dong Wang, Fang Yuan, Zhenshan Jia, Xiaobei Wang
  • Robotic surgical devices, systems, and related methods
    Patent number: 10111711
    Abstract: The embodiments relate to various medical device components, including components that are incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: October 30, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Tyler Wortman, Kyle Strabala, Ryan McCormick, Amy Lehman, Dmitry Oleynikov
  • On-board tool tracking system and methods of computer assisted surgery
    Patent number: 10105149
    Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 23, 2018
    Assignees: Board of Regents of the University of Nebraska, Trak Surgical, Inc.
    Inventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera, David Scott Saunders
  • Magnetoelectric memory cells with domain-wall-mediated switching
    Patent number: 10090034
    Abstract: A magnetoelectric memory cell with domain-wall-mediated switching is implemented using a split gate architecture. The split gate architecture allows a domain wall to be trapped within a magnetoelectric antiferromagnetic (MEAF) active layer. An extension of this architecture applies to multiple-gate linear arrays that can offer advantages in memory density, programmability, and logic functionality. Applying a small anisotropic in-plane shear strain to the MEAF can block domain wall precession to improve reliability and speed of switching.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 2, 2018
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, THE JOHN HOPKINS UNIVERSITY, INTEL CORPORATION
    Inventors: Kirill D. Belashchenko, Oleg Tchernyshyov, Alexey Kovalev, Dmitri E. Nikonov
  • On-board tool tracking system and methods of computer assisted surgery
    Patent number: 10080617
    Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 25, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera
  • Modified pigment epithelium-derived factor (PEDF) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection
    Patent number: 10081668
    Abstract: Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents, chemotherapy-protecting agents, and immune stimulating agents.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: September 25, 2018
    Assignees: Northwestern University, Board of Regents of the University of Nebraska
    Inventors: Jack Henkin, Olga Volpert, Serguei Vinogradov, Ignacio Melgar-Asensio