Patents Assigned to Board of Regents of the University of Nebraska
  • Survival predictor for diffuse large B cell lymphoma
    Patent number: 9970059
    Abstract: The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: May 15, 2018
    Assignees: The United States of America, as represented by the Secretary, Department of Human Services, Arizona Board of Regents on behalf of the University of Arizona, Queen Mary University of London, Board of Regents of the University of Nebraska, Oslo University Hospital HF, Oregon Health & Science University, University of Rochester, Hospital Clinic de Barcelona, Universitat de Barcelona, British Columbia Cancer Agency Branch, Julius-Maximilians-University of Würzburg
    Inventors: Lisa Rimsza, Andrew T. Lister, Wing C. Chan, Dennis Weisenburger, Jan Delabie, Erlend B. Smeland, Harald Holte, Stein Kvaloy, Rita M. Braziel, Richard I. Fisher, Pedro Jares, Armando Lopez-Guillermo, Elias Campo Guerri, Elaine S. Jaffe, Georg Lenz, Wyndham H. Wilson, George Wright, Sandeep S. Dave, Louis M. Staudt, Randy D. Gascoyne, Joseph M. Connors, Hans-Konrad Muller-Hermelink, Andreas Rosenwald, German Ott
  • DNA EDITING USING SINGLE-STRANDED DNA
    Publication number: 20180127787
    Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.
    Type: Application
    Filed: December 1, 2017
    Publication date: May 10, 2018
    Applicants: Board of Regents of the University of Nebraska, Tokai University
    Inventors: Channabasavaiah B. Gurumurthy, Hiromi Miura, Masato Ohtsuka
  • MAGNETOELECTRIC MEMORY CELLS WITH DOMAIN-WALL-MEDIATED SWITCHING
    Publication number: 20180130511
    Abstract: A magnetoelectric memory cell with domain-wall-mediated switching is implemented using a split gate architecture. The split gate architecture allows a domain wall to be trapped within a magnetoelectric antiferromagnetic (MEAF) active layer. An extension of this architecture applies to multiple-gate linear arrays that can offer advantages in memory density, programmability, and logic functionality. Applying a small anisotropic in-plane shear strain to the MEAF can block domain wall precession to improve reliability and speed of switching.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 10, 2018
    Applicants: Board of Regents of the University of Nebraska, The John Hopkins University, Intel Corporation
    Inventors: KIRILL D. BELASHCHENKO, OLEG TCHERNYSHYOV, ALEXEY KOVALEV, DMITRI E. NIKONOV
  • Creatine oral supplementation using creatine hydrochloride salt
    Patent number: 9962352
    Abstract: The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 8, 2018
    Assignees: Vireo Systems, Inc., Board of Regents of the University of Nebraska
    Inventors: Donald W. Miller, Jonathan L. Vennerstrom, Mark C. Faulkner
  • Methods, systems, and devices for surgical access and procedures
    Patent number: 9956043
    Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various actuation system embodiments, including fluid actuation systems, drive train actuation systems, and motorless actuation systems. Additional embodiments include a reversibly lockable tube that can provide access for a medical device to a patient's cavity and further provides a reversible rigidity or stability during operation of the device. Further embodiments include various operational components for medical devices, including medical device arm mechanisms that have both axial and rotational movement while maintaining a relatively compact structure. medical device winch components, medical device biopsy/stapler/clamp mechanisms, and medical device adjustable focus mechanisms.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: May 1, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Michael Farritor, Mark Rentschler, Amy Lehman, Stephen R. Platt, Jeff Hawks
  • Analogs of C5a and methods of using same
    Patent number: 9895411
    Abstract: Materials and methods for treating and preventing an infection or disease, and for directly killing microorganisms, using carboxy-terminal C5a analogs, are provided.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: February 20, 2018
    Assignees: SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Sam D. Sanderson, Joy Arlene Phillips, Edward Leroy Morgan, Marilyn Louise Thoman, Tamsin Sheen, Kelly S. Doran, Elizabeth Louise Virts, Tammy Kielian, Mark Hanke
  • Fluid Jet Arterial Surgical Device
    Publication number: 20180042630
    Abstract: A catheter mounted arterial surgical tool has a body with a fluid jet prong extending from a distal end of the body along a prong axis that is parallel to and laterally offset from a body axis. A fluid passage extends through the fluid jet prong to an outlet that points laterally relative to the prong axis. A deflector anvil extends from the distal end of the body along a deflector axis that is parallel to and offset from the body axis. The deflector anvil has a face that faces toward the fluid jet prong and is impinged by a fluid jet discharged from the outlet. A pair of guide wire holes extend from the proximal to the distal end of the body parallel to the body axis for receiving guide wires to enable the body to slide along the guide wires.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 15, 2018
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Jason N. MacTaggart, Nicholas Y. Phillips, Amy R. Mantz, Alexey Kamenskly
  • NON-NEUROINVASIVE VIRUSES AND USES THEREOF
    Publication number: 20180044643
    Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
    Type: Application
    Filed: March 4, 2016
    Publication date: February 15, 2018
    Applicants: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)
    Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
  • System and method for monitoring pleural fluid
    Patent number: 9888870
    Abstract: The disclosure is directed to intrapleural air leak detection and monitoring. According to various embodiments of the disclosure, an air leak may be detected utilizing at least one sensor to determine whether fluid extracted from a pleural cavity of a patient includes carbon dioxide and/or a second substance. The second substance may be a foreign substance inhaled by the patient to confirm presence of the air leak. The air leak may be further monitored over a period of time by collecting temporally successive measurements associated with detected concentrations of carbon dioxide. Therefore, tissue damage and recovery may be assessed according to objectively collected criteria.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 13, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Dimitrios Miserlis, Kim Cluff, Abby M. Kelly, Suzanne J. Higgins, Max H. Twedt
  • Methods, systems, and devices relating to force control surgical systems
    Patent number: 9888966
    Abstract: The various embodiments herein relate to robotic surgical systems and devices that use force and/or torque sensors to measure forces applied at various components of the system or device. Certain implementations include robotic surgical devices having one or more force/torque sensors that detect or measure one or more forces applied at or on one or more arms. Other embodiments relate to systems having a robotic surgical device that has one or more sensors and an external controller that has one or more motors such that the sensors transmit information that is used at the controller to actuate the motors to provide haptic feedback to a user.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 13, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Thomas Frederick, Kearney Lackas, Joe Bartels, Jacob Greenburg
  • Multifunctional operational component for robotic devices
    Patent number: 9883911
    Abstract: The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular components. Additional embodiments relate to procedures in which various of the devices are used cooperatively. Certain embodiments of the medical devices are robotic in vivo devices.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: February 6, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane M Farritor, Amy Lehman, Mark Rentschler
  • METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS
    Publication number: 20180011106
    Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
    Type: Application
    Filed: June 22, 2017
    Publication date: January 11, 2018
    Applicants: The United States of America, as represented by he Secretary, Department of Health and Human Servi, Board of Regents of the University of Nebraska, University of Rochester, Arizona Board of Regents on Behalf of the University of Arizona, Universitat de Barcelona, Fundacio Clinic, Hospital Clinic de Barcelona, Julius-Maximilians-University of Wurzburg, British Columbia Cancer Agency Branch, Oslo University Hospital HF, Queen Mary and Westfield College, University of London
    Inventors: Louis M. Staudt, George Wright, Sandeep Dave, Bruce Tan, John I. Powell, Wyndham Wilson, Elaine S. Jaffe, Wing C. Chan, Timothy C. Greiner, Dennis Weisenburger, James Armitage, Kai Fu, Richard I. Fisher, Lisa M. Rimsza, Thomas Miller, Thomas Grogan, Elias Campo Guerri, Silvia M. Bea, Itziar Salaverria, Armando Lopez-Guillermo, Emilio Montserrat, Victor Moreno, Andreas Zetti, German Ott, Hans-Konrad Muller-Hermelink, Andreas Rosenwald, Julie Vose, Randy Gascoyne, Joseph Connors, Erlend B. Smeland, Stein Kvaloy, Harald Holte, Jan Delabie, T. Andrew Lister
  • Cancer biomarkers and methods of use thereof
    Patent number: 9850313
    Abstract: Methods and compositions for treating cancer, particularly breast cancer, are disclosed.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: December 26, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Vimla Band, Hamid Band, Sameer Mirza
  • Creatine ester anti-inflammatory compounds and formulations
    Patent number: 9833427
    Abstract: The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form of creatine. The biologically active creatine inhibits the production of chemical mediators, released during an inflammatory response, which are important components in the inflammatory response and the inflammation and pain resulting from physical or chemical trauma to cells and tissue.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: December 5, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Donald W. Miller, Samuel C. Augustine, Jon C. Wagner, Thomas L. McDonald, Dennis H. Robinson
  • Compositions and methods for the delivery of therapeutics
    Patent number: 9808428
    Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: November 7, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Howard E. Gendelman, Xin-Ming Liu
  • Nanofiber Structures and Methods of Synthesis and Use Thereof
    Publication number: 20170296703
    Abstract: Three dimensional nanofiber structures are provided and methods of production thereof.
    Type: Application
    Filed: September 29, 2015
    Publication date: October 19, 2017
    Applicant: The Board of Regents of the University of Nebraska
    Inventors: Jingwei Xie, Jiang Jiang
  • Compositions and methods for gene therapy
    Patent number: 9789205
    Abstract: Compositions and methods for transferring a nucleic acid to a target cell using an immune system cell are provided.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: October 17, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Alexander Kabanov, Elena Batrakova, Vivek Mahajan, Matthew J. Haney
  • Methods and compositions for inhibiting diseases of the central nervous system
    Patent number: 9782464
    Abstract: Methods and compositions for treating central nervous system diseases and disorders are disclosed.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: October 10, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Howard E. Gendelman, R. Lee Mosley, Ashley D. Reynolds
  • Fluid jet arterial surgical device
    Patent number: 9782195
    Abstract: A catheter mounted arterial surgical tool has a body with a fluid jet prong extending from a distal end of the body along a prong axis that is parallel to and laterally offset from a body axis. A fluid passage extends through the fluid jet prong to an outlet that points laterally relative to the prong axis. A deflector anvil extends from the distal end of the body along a deflector axis that is parallel to and offset from the body axis. The deflector anvil has a face that faces toward the fluid jet prong and is impinged by a fluid jet discharged from the outlet. A pair of guide wire holes extend from the proximal to the distal end of the body parallel to the body axis for receiving guide wires to enable the body to slide along the guide wires.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: October 10, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Jason N. Mactaggart, Nicholas Y. Phillips, Amy R. Mantz, Alexey Kamenskly
  • Robotic surgical devices, systems, and related methods
    Patent number: 9770305
    Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: September 26, 2017
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Erik Mumm, Philip Chu, Nishant Kumar, Jason Dumpert, Yutaka Tsutano