Abstract: A smart (intelligent) textile that can control its porosity, shape, texture, loft, stiffness, or color by temperature change or moisture absorption by using polymer fiber torsional and tensile actuators. This temperature change can be due to a change in ambient temperature or by an external stimulus, such as electrothermal heating.
Type:
Grant
Filed:
March 21, 2017
Date of Patent:
October 3, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Özer Göktepe, Fatma Göktepe, Na Li, Shaoli Fang, Ray H. Baughman, Marcio Dias Lima, Carter S. Haines
Abstract: Provided herein are compounds of the formula (I): wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases or disorders, such as a bacterial infection.
Type:
Application
Filed:
March 23, 2021
Publication date:
September 28, 2023
Applicant:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Jonathan L SESSLER, Adam C. SEDGWICK, James Thomas BREWSTER, II, Axel STEINBRÜCK
Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.
Type:
Grant
Filed:
July 23, 2021
Date of Patent:
September 26, 2023
Assignees:
HEALTH RESEARCH, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Abstract: Provided herein are methods for identifying expression of SDHA, MIF, and or monosomy 3 or disomy 3 status in sample to identify the sample as high-risk melanoma and/or the sensitivity to oxidative phosphorylation inhibitors. Also provided herein are methods for treating monosomy 3 uveal melanoma by administering a SDHA inhibitor in combination with an oxidative phosphorylation inhibitor.
Type:
Grant
Filed:
October 25, 2018
Date of Patent:
September 26, 2023
Assignee:
Board of Regents, The University of Texas System
Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
Type:
Grant
Filed:
March 4, 2021
Date of Patent:
September 26, 2023
Assignee:
The Board of Regents of The University of Texas System
Inventors:
Qiang Cheng, Tuo Wei, Daniel J. Siegwart
Abstract: Disclosed herein are compositions and methods for reducing fluid loss in a well bore, methods for wellbore strengthening and increasing the integrity of the borehole of an oil or gas well. Also disclosed are methods for artificially increasing the temperature of a subsurface formation in the wellbore to increase the apparent wellbore strength. The mechanism for accomplishing this revolves around increasing fracture propagation pressure by actively manipulating thermal wellbore stresses.
Type:
Grant
Filed:
August 28, 2020
Date of Patent:
September 26, 2023
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Eric Van Oort, Besmir B. Hoxha, Ali Karimi Vajargah, Robert O. Williams, III, Hugh Smyth, Silvia Ferrati
Abstract: Provided herein are methods of manufacturing clinical grade exosomes derived from mesenchymal stem cells (MSCs). Further provided are methods of loading the exosomes with therapeutic agents, such as siRNA. Also provided herein are methods of treating diseases by administering the clinical grade exosomes.
Type:
Grant
Filed:
November 16, 2018
Date of Patent:
September 26, 2023
Assignee:
Board of Regents, The University of Texas System
Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.
Type:
Application
Filed:
January 12, 2023
Publication date:
September 21, 2023
Applicants:
Detect, Inc., Board of Regents, The University of Texas System
Inventors:
Spencer Glantz, Jonathan M. Rothberg, Xinghua Shi, Benjamin Rosenbluth, Jaymin Patel, William A. Hansen, Jonathan Naccache, Hope Kronman, Henry Kemble, Caixia Lv, Andrew Ellington, Sanchita Bhadra
Abstract: The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients.
Type:
Application
Filed:
January 6, 2023
Publication date:
September 21, 2023
Applicant:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
James B. BRUGAROLAS, Haley HILL, Tao WANG
Abstract: A magneto-electric (ME) majority gate device includes a conducting device and a plurality of ME transistors coupled to the conducting device. In one implementation, the plurality of ME transistors include a ME AND gate device with downward interface polarization, a ME-transmission gate device with downward interface polarization, and a ME-XNOR gate device. In another implementation, the plurality of ME transistors is five single-input ME-FETs.
Type:
Grant
Filed:
May 29, 2022
Date of Patent:
September 19, 2023
Assignees:
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, INTEL CORPORATION
Inventors:
Nishtha Sharma Gaul, Andrew Marshall, Peter A. Dowben, Dmitri E. Nikonov
Abstract: A method for fabricating patterns. An inverse optimization scheme is implemented to determine process parameters used to obtain a desired film thickness of a liquid resist formulation, where the liquid resist formulation includes a solvent and one or more non-solvent components. A substrate is covered with a substantially continuous film of the liquid resist formulation using one or more of the following techniques: dispensing discrete drops of a diluted monomer on the substrate using an inkjet and allowing the dispensed drops to spontaneously spread and merge, slot die coating and spin-coating. The liquid resist formulation is diluted in the solvent. The solvent is then substantially evaporated from the liquid resist formulation forming a film. A gap between a template and the substrate is then closed. The film is cured to polymerize the film and the substrate is separated from the template leaving the polymerized film on the substrate.
Type:
Grant
Filed:
August 3, 2017
Date of Patent:
September 19, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Sidlgata V. Sreenivasan, Shrawan Singhal, Ovadia Abed, Lawrence Dunn
Abstract: Antibody antigen binding domains which specifically binds human leptin comprises VH or VL CDR1, CDR2 and CDR3 sequences of an hLept antibody. The antibody antigen binding domains and antibodies thereof are useful to treat obesity and diabetes.
Type:
Grant
Filed:
December 16, 2020
Date of Patent:
September 19, 2023
Assignee:
Board of Regents, The University of Texas System
Inventors:
Zhiqiang An, Ningyan Zhang, Philipp E. Scherer, Shangang Zhao
Abstract: The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm?1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm?1.
Type:
Grant
Filed:
January 21, 2021
Date of Patent:
September 19, 2023
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Keith P. Johnston, Joshua Engstrom, Robert O. Williams, III
Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
Type:
Grant
Filed:
April 15, 2021
Date of Patent:
September 19, 2023
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.
Type:
Grant
Filed:
May 13, 2022
Date of Patent:
September 19, 2023
Assignee:
The Board of Regents of The University of Texas System
Inventors:
Robert F. Mattrey, Caroline De Gracia Lux, Jacques Lux, Zhenghong Gao, Carlos J. Brambila
Abstract: Embodiments of the disclosure encompass methods and compositions related to cell therapy treatment, including for cancer. In specific embodiments, the disclosure concerns adoptive cell therapy cancer treatment in which tumor-1 infiltrating lymphocytes and/or engineered T cells are modified to increase their efficacy as a cancer treatment. In specific cases, the cells are engineered for knock out of one or more genes, such as Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and/or programmed cell death protein 1 (PD-1).
Type:
Application
Filed:
July 23, 2021
Publication date:
September 14, 2023
Applicant:
Board of Regents, The University of Texas System
Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.
Type:
Application
Filed:
December 7, 2022
Publication date:
September 14, 2023
Applicant:
The Board of Regents of The University of Texas System
Inventors:
Edward K. Wakeland, David E. Gerber, Quanzhen Li, Shaheen Khan, Saad Khan, Yang Xie, Jason Y. Park, Farjana Fattah, Xin Luo
Abstract: The present disclosure provides methods for the identification, characterization and ranking of putative tau monomer stabilizing agents. Specifically, the disclosure provides methods for assessing the capability of a test compound to stabilize a tau monomer, methods of prioritizing a plurality of test compounds from a library identified as tau monomer stabilizing agents, methods of screening a test compound library to identify tau monomer stabilizing agents, and a kit providing the reagents to perform the described methods.
Type:
Application
Filed:
July 2, 2021
Publication date:
September 14, 2023
Applicant:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Marc I. DIAMOND, Jaime VAQUER-ALICEA, Gianna C. MAGGIORE
Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.
Type:
Grant
Filed:
April 14, 2021
Date of Patent:
September 12, 2023
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM