Patents Assigned to Board of Regents of the University of Texas System
  • Continuous-time input-stage successive approximation register analog-to-digital converter
    Patent number: 11757461
    Abstract: The exemplified disclosure presents a successive approximation register analog-to-digital converter circuit that comprises a two-step (e.g., two-stage) analog-to-digital converter (ADC) that operates a 1st-stage successive approximation register (SAR) in the continuous time (CT) domain (also referred to as a “1-st stage CTSAR”) that then feeds a sampling operation location in the second stage. Without a front-end sampling circuit in the 1st-stage, the exemplary successive approximation analog-to-digital converter circuit can avoid high sampling noise associated with such sampling operation and thus can be configured with a substantially smaller input capacitor size (e.g., at least 20 times smaller) as compared to conventional Nyquist ADC with a front-end sample-and-hold circuit.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: September 12, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Linxiao Shen, Nan Sun
  • Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Patent number: 11753381
    Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: September 12, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard T. Lewis, Matthew Michael Hamilton, William J. Ray, Fernando Alvarez, Dana E. Pfaffinger, Naphtali Reyna, Jason Cross, Suyambu Kesava Vijayan Ramaswamy
  • Photoresponsive polymer coated optical fibers for water treatment
    Patent number: 11754778
    Abstract: A photoreactor including a reservoir configured to hold water, the reservoir defining an inlet and an outlet, and a multiplicity of optical fiber assemblies positioned in the reservoir. Each optical fiber assembly includes one or more optical fibers coated with a composition comprising a photoresponsive polymer and a light source optically coupled to the one or more optical fibers. The photoresponsive polymer undergoes a change from an initial state to an irradiated state when irradiated with light from the light source, and photoresponsive polymer in the irradiated state is adapted to bind an ion from the water.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: September 12, 2023
    Assignees: Arizona Board of Regents on behalf of Arizona State University, Board of Regents; The University of Texas System
    Inventors: Paul K. Westerhoff, Shahnawaz Sinha, Juan Noveron
  • Collection probe and methods for the use thereof
    Patent number: 11756778
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: September 12, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, John Lin, John Rector, Nitesh Katta, Aydin Zahedivash
  • Ultrasound transducer holder for vascular assessments during hyperemic blood flow
    Patent number: 11751843
    Abstract: An ultrasound transducer probe holder device comprising a support piece; a base connected to the support piece; a cylindrical orifice within the support piece; a housing extending from the orifice and defining a cavity; a sleeve for insertion within the orifice; and an adjustment screw fitted in the housing for contact with the sleeve. The device supports and maintains the position of an ultrasound transducer probe to provide for a hands-free application of the device during different modalities of exercise required to instigate hyperemic conditions while providing x, y, z, positional adjustments of the probe relative to the patient.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: September 12, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Francisco Morales Acuna, Luis A. Ochoa, Alvaro N. Gurovich
  • Magnetoelectric XNOR logic gate device
    Patent number: 11757449
    Abstract: A magneto-electric (ME) XNOR logic gate device includes a conducting device; and a ME-FET coupled to the conducting device. The ME-FET can be formed of a split gate; a first gate terminal coupled to a first portion of the split gate for receiving a first input signal; a second gate terminal coupled to a second portion of the split gate for receiving a second input signal; a source terminal coupled to a ground line; and a drain terminal coupled to the conducting device.
    Type: Grant
    Filed: May 29, 2022
    Date of Patent: September 12, 2023
    Assignees: BOARD OF REGENT'S OF THE UNIVERSITY OF NEBRASKA, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, INTEL CORPORATION
    Inventors: Nishtha Sharma Gaul, Andrew Marshall, Peter A. Dowben, Dmitri E. Nikonov
  • USE OF FATE MODULATORS TO IMPROVE NERVE REGENERATION
    Publication number: 20230279347
    Abstract: The present disclosure describes the use of ectopic SOX2 to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease, by reprogramming non-nerve cells into neuronal cells. In particular, the disclosure provides for the use of SOX2 therapy, optionally combined with neurogenic growth factors, to treat nerve deficit conditions.
    Type: Application
    Filed: October 28, 2022
    Publication date: September 7, 2023
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Chun-Li Zhang, Lei-Lei Wang, Yuhua Zou, Wenjiao Tai, Wenze Niu
  • Methods and platform for screening and selecting metabolites and their receptors
    Patent number: 11746374
    Abstract: Disclosed herein are methods and platforms using Receptor Compartmentalized Partnered Replication (CPR), in which the partner gene is a receptor, signal transduction pathway, or metabolic pathway that leads to the production of an effector molecule for the receptor or signal transduction pathway. The signal transduction pathway or receptor is coupled to the production of a thermostable polymerase. Emulsification of libraries of organisms with primers that can amplify the partner gene led to the selective amplification of those partner genes that were best able to produce the thermostable polymerase during thermal cycling of the emulsion.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: September 5, 2023
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, THE TEXAS A&M UNIVERSITY
    Inventors: Andrew Ellington, Jimmy Gollihar, Katy Kao, Elizabeth Gardner
  • Methods of cancer treatment and therapy using a combination of antibodies that bind glycosylated PD-L1
    Patent number: 11746152
    Abstract: Anti-cancer treatment and therapeutic methods are provided in which an antibody that binds specifically to glycosylated PD-L1 relative to unglycosylated PD-L1 and blocks binding of PD-L1 to PD-1 is administered to a subject in need in combination with an antibody that binds specifically to glycosylated PD-L1 relative to unglycosylated PD-L1, blocks binding of PD-L1 to PD-1 and also promotes internalization and degradation of PD-L1. The anti-cancer methods utilize antibodies that recognize specific epitopes on glycosylated PD-L1 protein, as well as antibodies that exhibit the IPD function of both blocking the binding of PD-L1 to PD-1 and also facilitating the internalization of PD-L1 on cells expressing PD-L1. Methods in which such antibody combinations are especially useful include cancer and tumor treatments and therapies in which the cancer or tumor is a PD-L1 positive cancer or tumor.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: September 5, 2023
    Assignees: STCUBE, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Stephen S. Yoo, Mien-Chie Hung, Chia-Wei Li, Seung-Oe Lim
  • Prediction and treatment of immunotherapeutic toxicity
    Patent number: 11747345
    Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: September 5, 2023
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: David E. Gerber, Edward Wakeland, Quan Li, Saad Khan, Jason Y. Park, Xin Luo, Yang Xie
  • Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
    Patent number: 11744926
    Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: September 5, 2023
    Assignee: Board Of Regents, The University Of Texas System
    Inventors: Sarah Mayes, Christine E. Schmidt
  • AUTOPHAGY AS A THERAPEUTIC TARGET FOR INTRACRANIAL ANEURYSM
    Publication number: 20230270715
    Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.
    Type: Application
    Filed: May 25, 2022
    Publication date: August 31, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Yanning Rui, Zhen Xu, John Hagan
  • Minimally invasive collection probe and methods for the use thereof
    Patent number: 11737671
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: August 29, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, Noah Giese, Nitesh Katta
  • Sealed isocyanates
    Patent number: 11739177
    Abstract: The present disclosure relates to sealed isocyanate resin compositions. The resin compositions may be used for additive manufacturing. One embodiment of the invention includes a photopolymerizable resin for additive manufacturing, the resin comprising: a blocked isocyanate; at least one monomer or oligomer; and a multifunctional nucleophile.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: August 29, 2023
    Assignees: Adaptive 3D Technologies, Board of Regents, The University of Texas System
    Inventors: Benjamin R. Lund, Walter Voit
  • Methods and compositions for treating chronic granulomatous disease
    Patent number: 11738053
    Abstract: The invention relates to a method of treating chronic granulomatous disease through Hematopoietic stem cell (HSC) transplantation. The method comprises the steps of administering stem cell mobilization agent to human such that the target stem cell population migrates from host niches into the subject's blood. The target stem cells are removed from blood and administering the therapeutic stem cells to human and said therapeutic stem cells are engineered to express gp91phox. The steps are repeated multiple times i.e. at least four times. The mobilization agents used in the invention are granulocyte-colony stimulating factor and AMD3100. The method of HSC transplantation is effective in treatment of chronic granulomatous disease.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: August 29, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Senlin Li, Robert A Clark, Cang Chen, Yang Li
  • Antimicrobial catheters
    Patent number: 11738119
    Abstract: Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: August 29, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joel Rosenblatt, Issam Raad
  • Methods, compositions, and devices for the occlusion of cavities and passageways
    Patent number: 11737761
    Abstract: Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: August 29, 2023
    Assignees: Applied Cardiovascular Solutions, LLC, Board of Regents, The University of Texas System
    Inventors: F. Javier Otero, Joseph J. Beaman, Krishnendu Roy, Andrew Zimbroff
  • Wiper assembly for imaging element cleaning apparatus
    Patent number: 11737661
    Abstract: Embodiments of the present invention are directed to providing an effective and reliable approach for cleaning an exposed surface of an imaging element (e.g., a lens) of apparatuses including but not limited to medical imaging instruments such as endoscopes and laparoscopes and the like. In the case of medical imaging instruments, cleaning apparatuses configured in accordance with embodiments the present invention can be cleaned while the distal end portion of the endoscope is in vivo. Such apparatuses have a cleaning member incorporated therein (e.g., a resilient polymeric wiper, a sponge, an absorbent pad or the like) that is used for cleaning the exposed surface of the imaging element. The apparatus is preferably adapted for being mounted on imaging apparatus but can also be entirely or partially integral with one or more components of the imaging apparatus or system of which it is a component.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: August 29, 2023
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, CLEARCAM INC.
    Inventors: Christopher Idelson, Christopher Rylander, Mitchell Ross Gilkey, James Landon Gilkey
  • Protonated dimeric ionic liquid to enhance performance of membrane assembly electrode (MEA)
    Patent number: 11731110
    Abstract: A protonated dimeric ionic liquid that enhances and improves the performance of a fuel cell catalyst. The protonated dimeric ionic liquid comprises 9?9?-(butane-1,4-diyl)bis(3,4,6,7,8,9-hexahydro-2H-pyrimido[1,2-a]pyrimidin-1-ium) 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate. Membrane electrode assemblies (MEAs) and polymer electrolyte membrane fuel cells (PEMFCs) employing the protonated dimeric ionic liquid are also disclosed.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: August 22, 2023
    Assignees: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Liang Wang, Hongfei Jia, Joan F. Brennecke, Oscar Morales Collazo, Hisao Kato
  • Molecular subtyping of small cell lung cancer to predict therapeutic responses
    Patent number: 11732306
    Abstract: Provided herein are methods for determining a subtype of a small cell lung cancer in a patient based on the express status of ASCL1, NEUROD1, and POU2F3, which are expressed in a mutually exclusive fashion. The subtype of the cancer can be used to determine the sensitivity of the cancer to certain anti-cancer therapies. As such, also provided are methods of treating patients having small cell lung cancer based on the subtyping results.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: August 22, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Carl M. Gay, Lauren A. Byers, John V. Heymach