Patents Assigned to Board of Regents, The University of
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Patent number: 12163961Abstract: A kit or composition for in situ simultaneously derivatization of 14 phenol and carboxylic acid metabolites of benzene, toluene, ethyl benzene, and xylene (BTEX) in a urine sample is disclosed. The derivatization imparts a positive charge to phenol and carboxylic acid for subsequent LC-MS analysis. Limit of detection reached part-per-trillion levels for o-Cresol and part-per-billion levels for the remaining BTEX metabolites. BTEX metabolites can be detected in less than 35 mins according to one embodiment of the invention. Methods, kits and compositions disclosed herein can be used for in situ simultaneous derivatization of phenol and carboxylic acid in aqueous solution in general.Type: GrantFiled: October 24, 2022Date of Patent: December 10, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Kevin Albert Schug, Yehia Zakaria Mahmoud Youssef Baghdady
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Patent number: 12163168Abstract: Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine-?-lyases comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes.Type: GrantFiled: October 25, 2019Date of Patent: December 10, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Everett Stone, Wei-Cheng Lu, Christos Karamitros
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Patent number: 12159467Abstract: A system for measuring surface deflection of a road includes a first stereo line-scan camera pair on a sensor rig and for capturing a first set of 3D images of a road surface; a second stereo line-scan camera pair on the sensor rig and for capturing a second set of 3D images of the road surface; at least one digital electro-optical (EO) camera rigidly attached to the sensor rig; an inertial measurement unit (IMU) detecting inertial forces acting upon the sensor rig; and a processor compensating for acceleration and vibration effects upon the sensor rig; and calculating the surface deflection of the road based on the first and second sets of 3D images. The processor utilizes imagery from the EO camera and inertial measurements from the IMU to produce 2D mosaics and 3D reconstructions of the road surface from the first and second sets of 3D images.Type: GrantFiled: July 10, 2024Date of Patent: December 3, 2024Assignees: Novateur Reserch Solutions, Board of Regents, The University of Texas SystemInventors: Zeeshan Rasheed, Khurram Hassan-Shafique, Maoxu Li, Nicholas Raphael Gans, Cody Lee Lundberg, Michael Edward Araujo
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Patent number: 12151062Abstract: Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.Type: GrantFiled: June 1, 2023Date of Patent: November 26, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Hugh D. C. Smyth, Robert O. Williams, III, Zachary Warnken, Yang Lu
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Patent number: 12140865Abstract: The present invention provides a method that utilizes an existing infrastructure such as atomic layer deposition or similar vapor-based deposition tool or metal salt solutions based infiltration to infiltrate certain metals or metal-based precursors into resist materials to enhance the performance of the resists for the advancement of lithography techniques.Type: GrantFiled: March 4, 2020Date of Patent: November 12, 2024Assignees: Brookhaven Science Associates, LLC, Board of Regents, The University of Texas System, The Research Foundation for The State University of New YorkInventors: Chang-Yong Nam, Aaron Stein, Ming Lu, Jiyoung Kim, Nikhil Tiwale, Su Min Hwang, Ashwanth Subramanian
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Patent number: 12139757Abstract: DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the first and second sequences to generate a consensus sequence of the dsDNA. By independently sequencing first and second strands the error probability of the consensus sequence approximates a multiplication of those of the first and second sequences.Type: GrantFiled: December 26, 2022Date of Patent: November 12, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Zbyszek Otwinowski, Dominika Borek
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Patent number: 12142805Abstract: A complementary metal-oxide-semiconductor (CMOS) device includes a metal oxide layer comprising anodic aluminum oxide (AAO) and one or more nanowires (NW) of an electrically conducting material each formed within a corresponding pore extending through the AAO from a first side of the layer to a second side of the layer opposite the first side, a first electrically conducting layer disposed on the first side of the metal oxide layer, and a second electrically conducting layer disposed on the second side of the metal oxide layer. The nanowires form a via electrically connecting first electrically conducting layer and the second electrically conducting layer.Type: GrantFiled: June 4, 2021Date of Patent: November 12, 2024Assignees: Regents of the University of Minnesota, Board of Regents, The University of Texas SystemInventors: Rhonda Franklin, Yali Zhang, Joseph Um, Bethanie Joyce Hills Stadler, Rashaunda Henderson
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Patent number: 12134702Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to gel-phase inks suitable for extrusion-based 3D printing and methods of making the same, as well as anisotropic hydrogels printed from the same. In another aspect, the disclosure relates to linear contractile elements constructed from the anisotropic hydrogels and 3D structures with programmed morphologies and motions comprising the linear contractile elements. In still another aspect, the disclosure relates to a process for preparing soft materials and a method to create 3D structures starting from the gel-phase inks disclosed herein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: GrantFiled: September 11, 2020Date of Patent: November 5, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Kyungsuk Yum, Amirali Nojoomi, Hakan Arslan
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Patent number: 12134648Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.Type: GrantFiled: March 14, 2019Date of Patent: November 5, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Michael A. Curran, Ashvin R. Jaiswal, Dongxing Zha, Carlo Toniatti, Bianka Prinz, Nadthakarn Boland, Eric Krauland
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Patent number: 12129836Abstract: A geothermal well includes a borehole formed in a geologic formation. The borehole includes a first portion extending from a first end to a second end and a second portion intersecting the first portion at a first depth. The second portion is exposed to the formation for heating a fluid flowing in the second portion. The well includes an outer string disposed in the first portion where a lower end of the outer string is disposed above the first depth. The well includes an inner string disposed though the outer string and an annulus formed between the inner string and the outer string. The well includes a choke fluidly coupled to at least one of the annulus or the inner string. The choke is configured to regulate return flow of the heated fluid to maintain surface backpressure above a boiling pressure of the heated fluid at surface.Type: GrantFiled: October 6, 2021Date of Patent: October 29, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Eric Van Oort, Pradeepkumar Ashok, Dongmei Chen
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Patent number: 12126467Abstract: Various embodiments provide for deep learning-based architectures and design methodologies for an orthogonal frequency division multiplexing (OFDM) receiver under the constraint of one-bit complex quantization. Single bit quantization greatly reduces complexity and power consumption in the receivers, but makes accurate channel estimation and data detection difficult. This is particularly true for OFDM waveforms, which have high peak-to average (signal power) ratio in the time domain and fragile subcarrier orthogonality in the frequency domain. The severe distortion for one-bit quantization typically results in an error floor even at moderately low signal-to-noise-ratio (SNR) such as 5 dB. For channel estimation (using pilots), various embodiments use novel generative supervised deep neural networks (DNNs) that can be trained with a reasonable number of pilots. After channel estimation, a neural network-based receiver specifically, an autoencoder jointly learns a precoder and decoder for data symbol detection.Type: GrantFiled: February 3, 2023Date of Patent: October 22, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Jeffrey Andrews, Eren Balevi
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Patent number: 12121525Abstract: We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.Type: GrantFiled: November 30, 2021Date of Patent: October 22, 2024Assignees: Sloan Kettering Institute for Cancer Research, Board of Regents, The University of Texas SystemInventors: Jimmy Andrew Rotolo, Richard N. Kolesnick, Renata Pasqualini, Wadih Arap
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Patent number: 12122874Abstract: Disclosed herein are catalyst systems useful for a wide range of ring opening polymerization processes. Epoxides, oxetanes, lactones and cyclic carbonates are all suitable substrates for the ring opening polymerization.Type: GrantFiled: July 30, 2019Date of Patent: October 22, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Nathaniel A. Lynd, Jennifer Imbrogno, Robert C. Ferrier
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Patent number: 12120740Abstract: A method, system, or computer program product to enhance the performance of multi-hop cellular networks or other wireless networks is provided. A wireless device (e.g., cellular telephone) is able to communicate with a base-station in a cell of the cellular network over a non-cellular interface via another wireless device in the cell through the use of multi-hopping. By enabling wireless devices to communicate with a base station in such a manner, the effective coverage area of the cellular network is expanded and the effective capacity of the cellular network is improved. Distributed routing, device management, adaptive scheduling, and distributed algorithms can be used to enhance the overall performance of multi-hop cellular networks.Type: GrantFiled: December 16, 2021Date of Patent: October 15, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Vidur Bhargava, Sriram Vishwanath, Jubin Jose
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Patent number: 12109349Abstract: The present disclosure includes methods, apparatuses, and systems for aspirating an airway of a patient. The apparatuses include a main body having a pump and a storage canister housing coupled to the main body and containing a storage container that is at least partially collapsible. In some configurations, the main body can include a pressure sensor, a controller in communication with the pressure sensor, and having a processor, a memory, and a power source in communication with the controller. The storage canister housing can include a first end coupled to the main body, and a second end having a weighted portion and configured to be coupled to the first end to permit free rotation, such that the second end gravitationally rotates.Type: GrantFiled: October 18, 2019Date of Patent: October 8, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Forhad Akhter, Austin R. Schoppe, Omar Navarro, Bruce Adams, Yusheng Feng, Robert Delorenzo, Robert L. Hood
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Publication number: 20240325383Abstract: Embodiments are directed to molecules for the treatment of Coronavirus infection, including SARS-COV-2 infection. In certain aspects the small molecule is administered via inhalation and/or intranasal administration.Type: ApplicationFiled: March 22, 2024Publication date: October 3, 2024Applicant: Board of Regents, The University of Texas SystemInventors: Alexander Bukreyev, Jia Zhou
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Publication number: 20240328040Abstract: Sheath-run artificial muscles (or SRAMs) are described in which the dimensional changes and/or modulus changes of a sheath on the surface of a twisted or coiled host yarn or fiber drives torsional and tensile actuation. The sheath-core artificial muscle includes a sheath on a coiled core yarn or fiber that has inserted twist, in which the sheath does not include a yam, the coiled core yarn or fiber includes a core yarn or fiber, the sheath can change volume, modulus, or a combination thereof when actuated by an influence source to drive actuation, and the influence source is selected from a group consisting of absorption processes, desorption processes, changes in temperature, changes in external pressure, changes in a magnetic field, changes in an electric field, exposures to actinic radiation, electrochemical charge and discharge, chemical reactions, and combinations thereof.Type: ApplicationFiled: June 6, 2024Publication date: October 3, 2024Applicant: Board of Regents, The University of Texas SystemInventors: Ray H. Baughman, Jiuke Mu, Monica Jung De Andrade, Shaoli Fang, Na Li, Carter S. Haines
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Publication number: 20240325456Abstract: Multipotent lung progenitor cells for lung regeneration are provided. Accordingly, there are provided methods of expanding in culture an isolated population of pulmonary cells, methods of qualifying suitability of an isolated population of pulmonary cells for administration to a subject in need thereof, and methods of generating an isolated population of pulmonary cells comprising selecting a cell population being double positive for expression of epithelial and endothelial cell markers. Also provided are isolated populations of pulmonary cells, pharmaceutical compositions comprising same and uses of same.Type: ApplicationFiled: June 7, 2024Publication date: October 3, 2024Applicants: Yeda Research and Development Co. Ltd., Board of Regents, The University of Texas SystemInventors: Yair REISNER, Chava ROSEN, Elias SHEZEN, Ran ORGAD, Irit MILMAN KRENTSIS, Xiaohua SU, Raj Kumar YADAV, Yangxi ZHENG
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Patent number: 12102313Abstract: A surgical retractor assembly for providing surgical exposure. The surgical retractor assembly consists of two frame segments connected by adjustable ratchet mechanisms to form a retractor frame. The ratchet mechanisms can be attached to tissue retractor blades that provide exposure of the wound when expanded, without the requirement of a direct connection/attachment to an operating table or bed frame. The tissue retractor blades are attached in a manner that is adjustable and facilitates the ability of the overall surgical retractor assembly to be raised or lowered with respect to the patient. The retractor frame also allows attachments of additional retractor blades or other surgical retractor accessories for additional surgical exposure.Type: GrantFiled: March 6, 2023Date of Patent: October 1, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Ramon Francisco Cestero, Justin Alexander Long, Clarence Lamar Long, Jeffrey Adam Long
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Publication number: 20240318535Abstract: Aspects of the subject technology relate to systems and methods of controlling a drill string having a steerable bit when drilling a wellbore through a substrate. A deterministic model of a directional behavior of the drill string is developed that includes a drill string state, one or more drill parameters associated with the drill string, and one or more substrate parameters associated with the substrate. A stochastic differential model of the directional behavior of the drill string is then developed by replacing the state and each of the parameters of the deterministic model with respective probability distributions and adding feedback. The stochastic differential model is reduced to a truncated stochastic model by substituting a predetermined number of terms of a generalized polynomial chaos expansion for each probability distribution and then evaluating the expectations.Type: ApplicationFiled: March 23, 2023Publication date: September 26, 2024Applicants: Halliburton Energy Services, Inc., Board of Regents, The University of Texas SystemInventors: Nazli DEMIRER, Robert P. DARBE, Alexander Mathew KELLER, Dongmei CHEN