Patents Assigned to Board of Regents, The University of
  • Esters of 2-deoxy-monosaccharides with anti proliferative activity
    Patent number: 11925654
    Abstract: Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: March 12, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Waldemar Priebe, Marcin Cybulski, Izabela Fokt, Stanislaw Skora, Charles Conrad, Timothy Madden
  • miRNA biogenesis in exosomes for diagnosis and therapy
    Patent number: 11926824
    Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: March 12, 2024
    Assignees: Board of Regents, The University of Texas System, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Raghu Kalluri, Sónia Melo
  • Flexible microfluidic meshwork for glaucoma surgery
    Patent number: 11925579
    Abstract: The invention provides for novel glaucoma surgical devices comprising a microfluidic meshwork. The meshwork comprises interconnected, cellular-dimensioned microfluidic channels. Excess fluid in the eye can be drained and diffused through the microfluidic channels. The meshwork is porous and highly flexible, affording mechanical compliance similar to that of eye tissue. The meshwork minimizes foreign body reactions to the implant, decreasing fibrosis and capsule formation.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: March 12, 2024
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Chong Xie, Lan Luan, Ying Han
  • Regulation of eIF4E activity for migraine therapy
    Patent number: 11925642
    Abstract: The present disclosure provides a method of preventing, treating, or inhibiting migraine in a subject, by administering to the subject an amount of first therapeutic selected from cercosporamide, eFT508, or 4EGI-1 sufficient to prevent, treat, or inhibit said migraine. The present disclosure further provides a composition including at least two of cercosporamide. eFT508, or 4EGI-1, both in an amount sufficient to prevent, treat, or inhibit migraine in a subject and a pharmaceutically acceptable carrier. The present disclosure further provides a composition including at least one of cercosporamide, eFT508, or 4EGI-1 and at least one additional migraine therapeutic, both in an amount sufficient to prevent, treat, or inhibit migraine in a subject, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: March 12, 2024
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Greg Dussor, Jacob E. Lackovic
  • PREDICTION AND TREATMENT OF IMMUNOTHERAPEUTIC TOXICITY
    Publication number: 20240077496
    Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.
    Type: Application
    Filed: June 21, 2023
    Publication date: March 7, 2024
    Applicant: The Board of Regents of The University of Texas System
    Inventors: David E. Gerber, Edward Wakeland, Quan Li, Saad Khan, Jason Y. Park, Xin Luo, Yang Xie
  • Prefusion-stabilized hMPV F proteins
    Patent number: 11919927
    Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.
    Type: Grant
    Filed: April 6, 2023
    Date of Patent: March 5, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jason McLellan, Ching-Lin Hsieh, Scott Rush, Nianshuang Wang
  • Steerable intra-luminal medical device
    Patent number: 11918766
    Abstract: The disclosure provides a flexible, narrow medical device (such as a micro-catheter or a guidewire) that is controllably moved and steered through lumens of a body. The medical device may include an electrically-actuatable bendable portion at a distal end, which may be provided by a polymer electrolyte layer, electrodes distributed about the polymer electrolyte layer, and electrical conduits coupled to the electrodes, such that the polymer electrolyte layer deforms asymmetrically in response to an electrical signal through one or more conduits. The disclosure further includes a controller for moving the device into and out of bodily lumens and for applying the electrical signal for steering the device. The device further includes methods of preparing the polymer electrolyte layer in tubular shape.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: March 5, 2024
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Daniel H. Kim, Dong Suk Shin, Viljar Palmre
  • T cell receptors for immunotherapy
    Patent number: 11919937
    Abstract: Provided are T cell receptors (TCR) and TCR variable regions that can selectively bind the T-cell leukemia/lymphoma 1 (TCL1) oncoprotein. The TCR may be utilized in various therapies, such as autologous TCL1-TCR adoptive T cell therapy, to treat a cancer, such as a B-cell malignancy or a solid tumor expressing TCL1. Methods for expanding a population of T cells that target TCL1 are also provided.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: March 5, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jinsheng Weng, Kelsey Moriarty, Sattva S. Neelapu
  • Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration
    Patent number: 11918646
    Abstract: Described herein are dry immunogenic compositions and methods of freezing aluminum-containing vaccines such that when converted into a dried powder, the dry composition can be readily administered without loss of activity. Also described are methods of intranasal administering dry immunogenic compositions comprising antigens and aluminum adjuvants.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: March 5, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Zhengrong Cui, Sachin G. Thakkar
  • Method and apparatus for assisting a heart
    Patent number: 11918799
    Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: March 5, 2024
    Assignees: Board of Regents, The University of Texas System, Cardio Vol, LLC
    Inventors: John Porterfield, Jonathan W. Valvano, Clay Heighten, Anil Kottam, Marc David Feldman, Aleksandra Borisovna Gruslova, Drew R. Nolen
  • USE OF SDHA AS A PROGNOSTIC MARKER AND THERAPEUTIC TARGET IN UVEAL MELANOMA
    Publication number: 20240068047
    Abstract: Provided herein are methods for identifying expression of SDHA, MIF, and or monosomy 3 or disomy 3 status in sample to identify the sample as high-risk melanoma and/or the sensitivity to oxidative phosphorylation inhibitors. Also provided herein are methods for treating monosomy 3 uveal melanoma by administering a SDHA inhibitor in combination with an oxidative phosphorylation inhibitor.
    Type: Application
    Filed: September 7, 2023
    Publication date: February 29, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventors: Chandrani CHATTOPADHYAY, Janos ROSZIK
  • COMPOSITIONS AND METHODS FOR TREATMENT OF CHRONIC LUNG DISEASES
    Publication number: 20240067713
    Abstract: Methods for treating, reducing, ameliorating or inhibiting symptoms idiopathic pulmonary fibrosis (IPF) or interstitial pneumonia, comprising administering to a subject in need of an effective amount of a) multiple EGF-like-domains-9 (MEGF9) or a biologically active fragment thereof; b) uncoordinated receptor 5A (UNC5A) or a biologically active fragment thereof; c) dolichyl-phosphate beta-glucosyltransferase (ALG5) or a biologically active fragment thereof; d) a combination of two or three of a)-c); e) an antibody specifically binding to a); f) an antibody specifically binding to b); g) an antibody specifically binding to c); h) a combination of two or three of e)-g); or i) a combination of at least one of a)-c) and at least one of e)-g). Pharmaceutical compositions and processes for making and using the compositions are also disclosed.
    Type: Application
    Filed: October 5, 2023
    Publication date: February 29, 2024
    Applicant: Board of Regents, The University of Texas System
    Inventor: Sreerama SHETTY
  • Method of treating osteoarthritis by administering an anti-connexin 43 antibody
    Patent number: 11912762
    Abstract: Methods for identifying compounds that positively regulate connexin 43 hemichannels.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: February 27, 2024
    Assignee: Board of Regents of the University of Texas System
    Inventors: Jean X. Jiang, Manuel A. Riquelme, Sumin Gu
  • Upper-body robotic exoskeleton
    Patent number: 11911330
    Abstract: A robotic exoskeleton including a back portion providing at least two degrees of freedom, two shoulder portions, each shoulder portion providing at least five degrees of freedom, two elbow portions, each elbow portion providing at least one degree of freedom, and two forearm portions, each forearm portion providing at least one degree of freedom.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: February 27, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ashish Warren Deshpande, Bongsu Kim
  • Thermostable reverse transcriptase
    Patent number: 11912991
    Abstract: Embodiments of the disclosure concern methods and compositions related to generation and/or use of proofreading reverse transcriptases, including those that are thermophilic or hyperthermophilic. The disclosure encompasses specific recombinant polymerases and their use. In some embodiments, the polymerases are utilized for RNA sequencing in the absence of generation of a cDNA intermediate.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: February 27, 2024
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Andrew Ellington, Jared Ellefson, Jimmy Gollihar
  • Methods of treating metastasis, including inhibiting bone cancer metastasis, by administering an antibody which binds connexin 43 (Cx43) hemichannel
    Patent number: 11912758
    Abstract: Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: February 27, 2024
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jean X. Jiang, Zhiqiang An, Ningyan Zhang, Wei Xiong, Manuel A. Riquelme, Sumin Gu, Naomi Ledene Sayre
  • Method and apparatus for assisting a heart
    Patent number: 11911602
    Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: February 27, 2024
    Assignees: Board of Regents, The University of Texas System, Cardio Vol, I.LC
    Inventors: Jonathan W. Valvano, John Porterfield, Clay Heighten, Anil Kottam, Marc David Feldman, Aleksandra Borisovna Gruslova, Drew R. Nolen
  • Mechanically over-damped actuators having adjustable stiffness
    Patent number: 11911897
    Abstract: In one embodiment, a mechanically over-damped actuator includes an output link comprising a lever and a torsion spring associated with the lever, wherein the lever has an initial equilibrium position and is pivotable about a pivot axis, wherein the spring opposes pivoting of the lever away from its initial equilibrium position such that the spring tends to return the lever to the equilibrium position.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: February 27, 2024
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Amir Jafari
  • Highly specific tissue imaging
    Patent number: 11913883
    Abstract: A method of imaging comprises disposing a population of first targeting ultrasound-switchable fluorophores and a population of second non-targeting ultrasound-switchable fluorophores in an environment; detecting a first photoluminescence signal emitted by the population of first targeting fluorophores, and a second photoluminescence signal emitted by the population of second non-targeting fluorophores; determining a photoluminescence property of the population of second non-targeting fluorophores from the second photoluminescence signal; and using the determined photoluminescence property of the population of second non-targeting fluorophores to deconvolute the first photoluminescence signal into the population of first targeting fluorophores bound and unbound to a first target binding element in the environment.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: February 27, 2024
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Baohong Yuan
  • On-board tool tracking system and methods of computer assisted surgery
    Patent number: 11911117
    Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
    Type: Grant
    Filed: September 4, 2022
    Date of Patent: February 27, 2024
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera