Patents Assigned to Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
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Patent number: 12163128Abstract: The invention is directed generally to oligonucleotide compositions for the treatment of DNA repeat expansion diseases. The invention also relates to oligonucleotides directed to subunits of the DNA mismatch repair system.Type: GrantFiled: June 1, 2020Date of Patent: December 10, 2024Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Edward L. Grabczyk, Kayla T. Fuselier
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Patent number: 12149673Abstract: A system and method are provided for reconstructing 3-D point cloud. A light source generates light that is received by a polarization field generator, which generates a polarization field that illuminates the target object being imaged such that each outgoing ray has a unique polarization state. A camera captures images of the illuminated target object and the captured images are received by a processor that: (1) performs a polarization field decoding algorithm that decodes the polarization field to obtain a set of incident rays; (2) performs a camera ray decoding algorithm to obtain a set of camera rays; (3) performs a ray-ray intersection algorithm that determines intersection points where the incident rays and the camera rays intersect; and (4) performs a 3-D reconstruction algorithm that uses the set of incident rays, the set of camera rays and the intersection points to reconstruct a 3-D point cloud of the target object.Type: GrantFiled: April 24, 2023Date of Patent: November 19, 2024Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Jinwei Ye, Jie Lu
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Patent number: 12129373Abstract: Disclosed herein is a self-healing asphalt binder composition comprising i) an asphalt binder, ii) an oxetane substituted polysaccharide, and iii) a polyurethane, as well as asphalts comprising said self-healing asphalt binder and an asphalt mixture. Also disclosed are methods of making the self-healing asphalt binder.Type: GrantFiled: January 31, 2022Date of Patent: October 29, 2024Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AGRICULTURAL AND MECHANICAL COLLEGEInventors: Sharareh Shirzad, Marwa M. Hassan
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Patent number: 12132303Abstract: The present disclosure provides a DC mechanical circuit breaker that can utilize two switches, one of which can generate zero-crossing with an alternate oscillatory circuit for the other one, which can be a conventional zero-crossing-based AC breaker and can be used in the main circuit. This is different from the conventional single-switch commute-and-absorb method currently used. The present disclosure shows that disclosed circuit breaker improves the fault current extinction and significantly reduces the voltage rate-of-change while creating the current zero-crossing faster compared to the available technology. Thus, disclosed circuit breaker is capable of interrupting high DC currents with minimal arc through a less expensive AC circuit breaker. Simulation and hardware results are provided to show the efficiency of the disclosed circuit breaker.Type: GrantFiled: February 16, 2023Date of Patent: October 29, 2024Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Shahab Mehraeen, Sudipta Sen
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Publication number: 20240352424Abstract: The invention relates to a method of producing a tendon neotissue from a population of adipose-derived stem cells (ASCs) subjected to mechanical and biological stimulations in a bioreactor system. The tendon neotissues are effective as implants to treat tendon or ligament injury in a subject. The invention also relates to a customized bioreactor useful for producing a tri-dimensional engineered tissue.Type: ApplicationFiled: April 22, 2024Publication date: October 24, 2024Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Mandi J. LOPEZ, Takashi TAGUCHI
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Patent number: 12085575Abstract: This invention is directed to compositions and methods for detecting proteinopathies.Type: GrantFiled: March 29, 2021Date of Patent: September 10, 2024Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventor: Shyamal D. Desai
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Patent number: 12070463Abstract: Provided are compositions that include a platelet-activating factor antagonist, pharmaceutical compositions including the platelet-activating factor antagonist, methods of treating a modulating the proliferation of a glioma or a pathological condition resulting from patient having a glioma.Type: GrantFiled: January 10, 2020Date of Patent: August 27, 2024Assignees: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE, UNIVERSIDAD DE ALCALĂInventors: Nicolas G. Bazan, Alberto E. Musto, Julio Alvarez-Builla
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Patent number: 12064432Abstract: The present disclosure provides compositions comprising a lyn kinase activator and TRPM8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, Syndrome X, obesity, prediabetes, type II diabetes, type I diabetes; treating hypercholesterolemia, hypertension, coronary heart disease, diabetic neuropathy, lipodystrophy, diabetic retinopathy, erectile dysfunction, kidney disease, dyslipidemia, dyslipoproteinemia, a peroxisome proliferator activated receptor-associated disorder, septicemia, a thrombotic disorder, or pancreatitis; inducing the beiging of adipocytes; and preventing pancreatic beta cell degeneration.Type: GrantFiled: November 23, 2022Date of Patent: August 20, 2024Assignees: Melior Pharmaceuticals I, Inc., Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical CollegeInventors: Andrew G. Reaume, Weina Cong, Frank Greenway, Ann Coulter
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Patent number: 12049233Abstract: A system and method are disclosed for overheight vehicle impact avoidance and incident detection. A detection subsystem of the system determines whether an incoming vehicle is clear to pass, depending at least on its height. The detection subsystem relies on distance sensors located along the freeway to detect the highest point of the vehicle and outputs an indication of whether the vehicle can pass. A warning subsystem receives the indication that a vehicle is overheight and provides a warning indication to the driver about the vehicle's inability to pass an upcoming structure. The warning subsystem may also perform a variety of other tasks, such as, for example, logging a variety of information about the vehicle and the incident, sending data about the incident locally to a central command, and generating reports.Type: GrantFiled: June 15, 2020Date of Patent: July 30, 2024Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: George Z. Voyiadjis, Aly Mousaad Aly, Jin-Woo Choi
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Publication number: 20240238268Abstract: Therapeutics and methods treating Alzheimer's disease or a pre-Alzheimer's disease condition in a patient comprising administering a pharmaceutical composition containing a therapeutically effective dose therapeutic, wherein the therapeutic contains a PRMT4 inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof. According to a further embodiment, the PRMT4 inhibitor is one of TP-064 and SCFFBXO9.Type: ApplicationFiled: September 9, 2022Publication date: July 18, 2024Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Hung Wen (Kevin) Lin
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Patent number: 12023454Abstract: A device and method are disclosed for intravenous cannulation. The device employs a spring to precisely and accurately control the force and velocity imparted to a piercing needle, with mechanical constraints built into the device to precisely and accurately control the distance through which the piercing needle travels. A sheathed-needle configuration is used with an outer, echogenic needle that can be seen via ultrasound; and an inner needle used to pierce the vein. The operator releases the piercing needle with a controlled velocity, controlled force, and controlled travel distance. The device reduces the human error and complications that have previously been associated with manually piercing a vein for cannulation.Type: GrantFiled: October 14, 2019Date of Patent: July 2, 2024Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Jacob Bursavich, Benjamin Seago, Logan Daigle
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Patent number: 12011508Abstract: In one aspect, the disclosure relates to compositions, methods, and devices pertaining to polymeric nanoparticle compositions (pNP), pNP compositions comprising a therapeutic agent, devices comprising a drug-coated balloon comprising a disclosed pNP comprising a therapeutic agent, and methods for treating peripheral artery disease using the disclosed compositions and devices. In further aspects, the pNP comprises a poly (lactic-co-glycolic) acid possessing a positive charge for firm attachment to the balloon matrix, followed by adhesion to the negatively charged bilayer of the vascular wall. In still further aspects, the therapeutic agent comprises a resveratrol or derivative thereof, a quercetin or derivative thereof, or combinations thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: GrantFiled: February 1, 2019Date of Patent: June 18, 2024Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Tammy Renee Dugas, Cristina Sabliov, Carlos Astete
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Publication number: 20240188522Abstract: Male-sterile EGMS rice lines, both conventional and herbicide-tolerant, and their Fi hybrids are disclosed. The EGMS lines can produce Fi hybrids with high yield, desirable agronomic traits, and good milling characteristics.Type: ApplicationFiled: April 15, 2022Publication date: June 13, 2024Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: James H. Oard, Democrito Banay Rebong ll
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Publication number: 20240189321Abstract: A method of treating prostate cancer in a patient comprising administering to the patient a pharmaceutical composition including a first therapeutic including a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, and a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof.Type: ApplicationFiled: November 15, 2023Publication date: June 13, 2024Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Arrigo DeBenedetti, Siddhant Bhoir, Vibha Singh, Javeena Hussain, Rupesh Chikhale, Richard Bryce, Sivapriya Kirubakaran
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Patent number: 11992013Abstract: A composition and method for killing feral hogs: a bait that is attractive to hogs is mixed with a lethal amount of sodium nitrite, along with sufficient base to inhibit decomposition of the sodium nitrite. At sufficiently high pH, encapsulation of the sodium nitrite is not required to inhibit decomposition. In the absence of substantial decomposition, the sodium nitrite itself is not aversive to the pigs, and may even enhance acceptance of the baits by the pigs. Optionally, an anti-emetic compound is added to the mixture to reduce the likelihood the bait will be vomited. Optionally, an additional toxicant such as luteolin is added to the mixture.Type: GrantFiled: June 8, 2023Date of Patent: May 28, 2024Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Glen Gentry, John Pojman, Baylen Thompson
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Patent number: 11974988Abstract: This invention is directed to neuroprotective compositions and methods of using the same to treat neurodegenerative diseases.Type: GrantFiled: November 16, 2020Date of Patent: May 7, 2024Assignees: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jeffrey Erickson, Heike Wulff, Heesung Shim, Vikrant Singh, Latika Singh
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Patent number: 11964387Abstract: A concentric tube steerable device includes a plurality of tubes having a nested, concentric configuration. The tubes include an outer tube and an inner tube that extends coaxially within the outer tube. The inner tube terminates at a tip, and a pose of the tip is effectuated through individual or collective rotation or translation of the tubes about a tube axis. The concentric tube steerable device includes an actuator for rotating at least one tube about a respective tube axis, and a translator for translating at least one tube along a respective tube axis. Each tube includes a precurved portion and a corresponding axis of precurvature. For at least one tube, a flexural rigidity of the tube along its axis of precurvature is less than a flexural rigidity of the tube along a second axis that is perpendicular to the axis of precurvature, thereby improving stability of the tube.Type: GrantFiled: June 24, 2022Date of Patent: April 23, 2024Assignees: University of Tennessee Research Foundation, Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Daniel Caleb Rucker, Hunter Bryant Gilbert
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Publication number: 20240115588Abstract: Oral formulations comprising one or more proteasome inhibitors for use as a treatment of coronavirus infection in a subject. Also disclosed are the use of such for the treatment or prevention of SARS-CoV-2 infection in humans.Type: ApplicationFiled: February 1, 2022Publication date: April 11, 2024Applicants: Board of Supervisors of Louisiana state University and Agricultural and Mechanical College, Skymount Medical US lnc.Inventors: Adam Bess, Frej Knut Gosta BERGLIND, Supratik MUKHOPADHYAY, Kishor M. WASAN, Chris GALLIANO, Michal BRYLINSKI, Stephania CORMIER, Allan ADER, Nicholas GRIGGS, Janet GOULD, Tiffany CHO, Julia ABRAMOV, Peter HNIK
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Patent number: 11953501Abstract: This invention comprises compositions and methods to determine the prognosis of necrotizing enterocolitis.Type: GrantFiled: February 4, 2020Date of Patent: April 9, 2024Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventor: Sunyoung Kim
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Patent number: 11953408Abstract: The present disclosure provides for sampling instruments and methods of collecting sample particles. The sampling instrument can include a high-pressure pulsed valve coupled to a gas flow system to displace a sample from a surface. Also included can be a voltage supply coupled to a voltage switch, a suction device, a sample collector, and a collection filter. To collect a sample, extractive particles can be deposited onto a sample present on a substrate. At least a portion of the sample becomes coupled to a portion of the extractive particles to form sample particles. High-pressure gas can be discharged at the sample, thereby aerosolizing a portion of the sample particles to disperse aerosolized sample particles. A portion of the aerosolized sample particles can be collected onto a collection filter to form a collected sample.Type: GrantFiled: May 13, 2022Date of Patent: April 9, 2024Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Kermit King Murray, Fabrizio Donnarumma, Jamira Stephenson