Patents Assigned to Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
  • Patent number: 10393726
    Abstract: The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid substrate, a plurality of spaced support structures within said bioreactor chamber and attached to the solid substrate, and one or more capture molecules immobilized to some or all of said plurality of spaced support structures, said one or more capture molecules suitable to bind to a portion of a target nucleic acid molecule in a sample. The device also comprises one or more nanotubes defined by the solid substrate and fluidically coupled to the bioreactor chamber.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 27, 2019
    Assignees: The University of North Carolina at Chapel Hill, Cornell University, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Steven A. Soper, Francis Barany, Sunggook Park, Michael Murphy, Collin J. McKinney, John William Efcavitch, Mateusz Hupert
  • Patent number: 10392394
    Abstract: Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties. The compounds may be utilized in dental and/or medical applications, including dental composites, dentures, bonding agents, sealants, resins and medical devices.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: August 27, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Xiaoming Xu
  • Publication number: 20190254987
    Abstract: Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Iuliu Hatieganu University of Medicine and Pharmacy
    Inventors: Cristina M. Sabliov, Carlos E. Astete, Ede Bodoki, Oliviu Vostinaru, Ovidiu Ciprian Samoila, Elena Dinte
  • Publication number: 20190256634
    Abstract: A sealant composition and method for its manufacture are disclosed. A two-way shape memory polymer (2W-SMP) sealant expands upon cooling and contracts upon heating, and thus provides improved sealing for pavements and other structures. The base resin for the sealant is polybutadiene with a high cis content.
    Type: Application
    Filed: February 19, 2019
    Publication date: August 22, 2019
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Lu Lu, Jinbao Cao, Guoqiang Li
  • Patent number: 10376566
    Abstract: An intervention for sleep disorders comprises: collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines improves tryptophan availability and sleep quality, and allows individuals to sleep better with fewer side effects. The composition promotes high-quality, deep sleep.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: August 13, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Jack N. Losso, Jose Daniel Estrada Andino
  • Patent number: 10376618
    Abstract: A thoracic catheter system comprises a flexible thoracic catheter for inserting into a thoracic cavity of a human. A distal end of the thoracic catheter has a plurality of apertures. A proximate end of the thoracic catheter is designed to extend out of the thoracic cavity. A three way valve is one of fused with and removably attached to the proximal end of the thoracic catheter.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: August 13, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Alireza Hamidian Jahromi, David Hilton Ballard, Jeffery Adam Weisman, Horacio Ruben Vincent D'Agostino
  • Publication number: 20190231902
    Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.
    Type: Application
    Filed: June 21, 2017
    Publication date: August 1, 2019
    Applicants: University of Florida Research Foundation, Incorporated, Board of Supervisors of Louisiana State University & Agricultural & Mechanical College
    Inventors: David C. Bloom, Alfred S. Lewin, Donna M. Neumann, Zachary L. Watson, Sonal Sanjeev Tuli, Gregory Scott Schultz
  • Publication number: 20190233429
    Abstract: A method of treating a disease condition in a mammal comprising administering a pharmacologically effective amount of a therapeutic, wherein the therapeutic includes a bioisosteres of caffeic acid. A pharmaceutical composition for treating a disease condition in a mammal comprising a first therapeutic that includes a bioisosteres of caffeic acid, wherein the condition may be breast cancer, and the pharmaceutical composition may include a second therapeutic for the disease condition that is not a bioisosteres of caffeic acid.
    Type: Application
    Filed: January 28, 2019
    Publication date: August 1, 2019
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Brian Salvatore
  • Patent number: 10363117
    Abstract: A dental implant including a base, a central shaft and a shock absorber spacing and allowing limited movement between the base and the central shaft. The shock absorber may also contain a plurality of flex struts. The dental implant may further include an index collar covering an upper portion in the base.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: July 30, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Gulshan Neville Sunavala-Dossabhoy, Kevin McCarthy
  • Publication number: 20190210922
    Abstract: A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and a means for molecular scale healing is disclosed; the composition has the ability to resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer serves to bring surfaces of a structural defect into approximation, whereafter use of the means for molecular scale healing allowed for movement of the healing means into the defect and thus obtain molecular scale healing. The means for molecular scale healing can be a thermoplastic such as fibers, particles or spheres which are used by heating to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. Compositions of the invention have the ability to not only close macroscopic defects, but also to do so repeatedly even if another wound/damage occurs in a previously healed/repaired area.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Guoqiang Li, Harper Meng
  • Patent number: 10328422
    Abstract: Catalysts are disclosed having metal oxide support structures and acidic reaction sites. The reaction sites may be according to the general formula MxOyAlBrzX]?H+ where x is one or two; y is one or two; z is one or two; X is selected from Br or Cl; M is Al or Si and one or more of M, O and Al has a molecular bond with the metal oxide support structure.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: June 25, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: James J. Spivey, Kunlun Ding, Swarom Kanitkar
  • Patent number: 10334685
    Abstract: An electroluminescent LED device comprising a hole transport layer, an electron transport layer, an active emissive layer between the hole transport layer and the electron transport layer, and carbon dots forming the active emissive layer.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: June 25, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Weiyong Yu, Yu Zhang
  • Patent number: 10328147
    Abstract: Embodiments of nucleic acids comprise a nucleotide sequence encoding a live-attenuated chimeric Herpes Simplex Virus Type-1 (HSV-1) VC2 virus and a nucleotide sequence encoding a heterologous polypeptide operably linked to a promoter. The nucleotide sequence encoding the heterologous polypeptide can be operably linked to a promoter encoding the glycoprotein D (gD) of Equine Herpesvirus-1 (EHV-1) or a fragment thereof. Also provided is a live-attenuated recombinant Herpes Simplex Virus Type-1 (HSV-1) VC2 virus comprising a nucleotide sequence encoding a nucleotide sequence encoding a heterologous polypeptide operably linked to a promoter.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 25, 2019
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventor: Konstantin G. Kousoulas
  • Patent number: 10327661
    Abstract: A method for determining an increased risk of death of a patient includes receiving ECG data of the patient generated during a first time period; receiving EEG data of the patient generated during the first time period; composing a feature of the ECG data and a feature of the EEG data over a common time frame and determining a statistical measure of association between the ECG data and the EEG data; and determining whether the degree of association exceeds a predetermined threshold, thereby indicating whether an increased risk is present.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: June 25, 2019
    Assignees: Louisiana Tech Research Corporation, Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Leonidas D. Iasemidis, Ioannis Vlachos, Albert Edward Glasscock
  • Patent number: 10307441
    Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: June 4, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher Kevil, Anthony Giordano, Douglas R Flanagan, Panayiotis P Constantinides
  • Patent number: 10307750
    Abstract: Catalysts useful in transforming biomass to bio-oil are disclosed, as are methods for making such catalysts, and methods of transforming biomass to bio-oil. The catalysts are especially useful for, but are not limited to, microwave- and induction-heating based pyrolysis of biomass, solid waste, and other carbon containing materials into bio-oil. The catalysts can also be used for upgrading the bio-oil to enhance fuel quality.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: June 4, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Dorin Boldor, Daniel Hayes
  • Publication number: 20190153130
    Abstract: The present invention provides compositions, methods and kits for the temporal control induction time for a polymerization reaction.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: John Anthony Pojman
  • Patent number: 10292943
    Abstract: Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: May 21, 2019
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Cristina M. Sabliov, Carlos E. Astete, Ede Bodoki, Oliviu Vostinaru, Ovidiu Ciprian Samoil{hacek over (a)}, Elena Dinte
  • Publication number: 20190127625
    Abstract: Bentonite (or other clay) water-based drilling fluids incorporating functionalized cellulose nanocrystals are disclosed. Cellulose nanocrystals are modified with tailored surface charges or tailored levels of salt-tolerant polymer grafting, and combined with bentonite (or other clay) nanoplatelets in an aqueous suspension. Thermal performance of drilling fluids can also be enhanced by surface grafting of thermally functional polymers onto cellulose nanocrystals.
    Type: Application
    Filed: October 31, 2018
    Publication date: May 2, 2019
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Qinglin Wu, Meichun Li
  • Publication number: 20190111105
    Abstract: The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as insulin resistance.
    Type: Application
    Filed: December 19, 2018
    Publication date: April 18, 2019
    Applicants: Ipsen Pharma S.A.S., Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Heather A. HALEM, Michael DeWitt CULLER, Andrew A. BUTLER