Patents Assigned to Board of Trustees
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Publication number: 20250255638Abstract: A system for creating an endoluminal valve from a blood vessel wall, includes: a tubular assembly having a longitudinal axis, a proximal end, a distal portion with a distal end, and a first lumen extending from the proximal end to a distal port located proximate the distal portion, the distal port located along the longitudinal axis, the distal portion having a supporting surface on a same side of the tubular assembly as the distal port, the supporting surface extending in a longitudinal direction and offset from a surface of the tubular assembly proximal the distal port and configured to contact the blood vessel wall; and a tissue dissection probe disposed within the first lumen, the tissue dissection probe having a fluid delivery lumen extending to a fluid delivery port located at a distal end of the tissue dissection probe, the tissue dissection probe configured to be inserted into the blood vessel wall.Type: ApplicationFiled: March 3, 2025Publication date: August 14, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Fletcher T. Wilson, Rhunjay J. Yu
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Patent number: 12385010Abstract: Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.Type: GrantFiled: October 31, 2024Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Zurab Siprashvili, Ngon T. Nguyen, M. Peter Marinkovich, Jean Tang, Alfred T. Lane, Paul A. Khavari
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Patent number: 12389052Abstract: New systems and methods allow for transmission of multiple types of content protocols over a unidirectional content delivery network, such as a television broadcast. Hardware and/or software used at the network transmission location (such as a television broadcast station) and hardware and/or software located at an endpoint (such as a home television, car infotainment system, or first responder location) allow for a native ATSC 1.0 signal to have embedded within it additional content that is not encoded as ATSC 1.0 content. The non-ATSC 1.0 content can be detected and segregated from ATSC 1.0 content so that the endpoint devices (such as a television receiver) will not attempt to render the non-ATSC 1.0 content (such as, e.g., ATSC 3.0 content or application specific content) as normal ATSC 1.0 programming. Instead, the non-ATSC 1.Type: GrantFiled: June 6, 2023Date of Patent: August 12, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Chandra Kotaru, Prabu David, Susanne Elkins
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Patent number: 12384875Abstract: Disclosed herein are ladder polymers comprising fused aromatic and non-aromatic rings. Also disclosed are the manufacture and use of these ladder polymers, e.g., in separation membranes, such as membrane for gas separation.Type: GrantFiled: October 23, 2020Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of TechnologyInventors: Holden Wan Hong Lai, Jun Myun Ahn, Yan Xia, Zachary P. Smith, Francesco M. Benedetti
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Patent number: 12383196Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.Type: GrantFiled: October 15, 2019Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, Board of Regents, The University of Texas System, The United States Government as represented by the Department of Veterans AffairsInventors: Amit Etkin, Madhukar Trivedi, Wei Wu
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Patent number: 12384023Abstract: Various implementations include a modular soft robot including a base, an arm coupled to the base, and an actuator. The arm includes a first surface and a second surface opposite and spaced apart from the first surface. The first surface defines a plurality of channels, each channel comprising a proximal end at the first surface and a distal end spaced apart from the proximal end. Each channel has a longitudinal axis extending therethrough. The actuator is configured to deform the arm.Type: GrantFiled: April 20, 2023Date of Patent: August 12, 2025Assignee: The Board of Trustees of The University of AlabamaInventors: Vishesh Vikas, Caitlin Freeman, Michael Maynard
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Patent number: 12385837Abstract: A photon peak event detection system accepts an analog output from a photon sensor, directly digitizes the analogy output and includes a graphics processing unit (GPU) programmed to conduct a photon peak event detection in real-time via a photon count program that analyzes the digitized photon sensor output in sampling periods each having at least three consecutive data points to determine a local maximum among the consecutive data points and compare the local maximum to one or more predetermined thresholds to determine whether or not a photon was received in each sampling period, the algorithm providing photon counts to a phasor analysis program in the GPU. The phasor analysis program calculates pixelwise fluorescence lifetime phasor data in real-time and sends the data to a central processing unit.Type: GrantFiled: June 9, 2022Date of Patent: August 12, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Stephen Boppart, Janet Sorrells, Rishyashring Raman Iyer
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Patent number: 12387816Abstract: Processes to identify a subset of trait-related genes and classify individuals are described. Generally, systems generate classification models which are used to identify the subset of trait-related genes and classify individuals. The classification models are also used in various applications, including developing research tools, performing diagnostics, and treating individuals.Type: GrantFiled: January 9, 2019Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Jingjing Li, Sai Zhang, Michael P. Snyder, Cuiping Pan, Philip S. Tsao
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Patent number: 12386807Abstract: Various disclosed embodiments pertain to a distributed audit trail system for use in a connected system including: a master unit to control a first aspect of the connected system and to create a blockchain light client and a distributed hash table (DHT); a first node to control a second aspect of the connected system; a second node to control a third aspect of the connected system; and one or more remote servers to form a blockchain full node, where the master unit, the first node, and the second node electronically communicate with each other through the DHT in order to form a combined audit trail, where the master unit creates a meta-hash of the software version of the software in the master unit, the first node, and the second node, system identification data, system sensor data, and system hardware configuration.Type: GrantFiled: October 5, 2021Date of Patent: August 12, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, Board of Trustees of Michigan State UniversityInventors: Gregory Falco, Joshua Siegel
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Publication number: 20250250582Abstract: Plant cells, plants, seeds and portions of plants modified or genetically engineered to have increased expression or activity of at least one protein selected from the group consisting of trehalose phosphate synthetase (TPS), trehalose phosphate phosphatase (TPP), Protein ALP1-like (At3g55350 or ALPL1), Glycosyltransferase 75D1 (UGT75D1), Cytochrome P450 709B2 (CYP709B2), Cytochrome P450 709B1 (CYP709B1) and Cytochrome P450 72A15 (CYP72A15) are provided herein. Also provided are methods of increasing plant resistance to herbicides and/or abiotic stress by increasing expression of at least one of trehalose phosphate synthetase (TPS), trehalose phosphate phosphatase (TPP), Protein ALP1-like (At3g55350 or ALPL1), Glycosyltransferase 75D1 (UGT75D1), Cytochrome P450 709B2 (CYP709B2), Cytochrome P450 709B1 (CYP709B1) or Cytochrome P450 72A15 (CYP72A15).Type: ApplicationFiled: January 3, 2025Publication date: August 7, 2025Applicant: The Board of Trustees of the University of ArkansasInventors: Christopher E. Rouse, Nilda Roma-Burgos, Gulabben Rangani
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Publication number: 20250250616Abstract: Provided are methods of analyzing target nucleic acids, the methods comprising, using the target nucleic acids as reagents and reporters as substrates, assaying enzyme kinetic parameters of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) endonucleases comprising guide RNAs (gRNAs) that hybridize with reference nucleic acids. In certain aspects, certain such methods comprise comparing a sequence of a target nucleic acid with a sequence of a reference nucleic acid. In some embodiments, such comparison is based on the rates of cleavage of the reporters at plurality of concentrations of the reporters. The kinetic parameters can also be the Michaelis-Menten constant (KM), the apparent turnover rate (K*cat), and/or the apparent catalytic efficiency (K*cat/KM). Kits for performing the methods of the disclosure are also provided.Type: ApplicationFiled: April 12, 2023Publication date: August 7, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Juan Santiago, Alexandre Avaro, Ashwin Ramachandran, Diego Huyke, Charles Blanluet
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Patent number: 12378577Abstract: The present disclosure relates to CRISPR-Cas10 systems and methods for phage genome editing.Type: GrantFiled: September 16, 2022Date of Patent: August 5, 2025Assignee: The Board of Trustees of The University of AlabamaInventor: Asma Hatoum
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Patent number: 12381418Abstract: An integrated circuit on a chip may include a plurality of capacitors that are connected in series and generate an AC noise signal. A selected bandwidth of the AC noise signal transmits through the series of capacitors as a first AC power signal. Respective rectifiers are positioned for receiving a positive cycle of the first AC power signal and a negative cycle of the first AC power signal. Output terminals are connected to the respective rectifiers and configured for connection to an off chip circuit. The capacitors may be fixed or variable gap capacitors.Type: GrantFiled: July 11, 2023Date of Patent: August 5, 2025Assignee: Board of Trustees of The University of ArkansasInventor: Paul Thibado
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Patent number: 12379331Abstract: In accordance with the invention, an X-ray amplitude analyzer grating adapted for use in an interferometric imaging system, the interferometric imaging system comprising an X-ray source and an X-ray detector with an X-ray fringe plane between the X-ray source and the X-ray detector, wherein an X-ray fringe pattern is formed at the X-ray fringe plane, wherein the X-ray amplitude analyzer grating is provided. The X-ray amplitude analyzer grating comprises a plurality of grating pixels across two dimensions of the X-ray amplitude analyzer grating, wherein each grating pixels of the plurality of grating pixels has a different pattern with respect to all adjacent grating pixels to the grating pixel so that all adjacent grating pixels do not have a same pattern as the grating pixel.Type: GrantFiled: September 4, 2020Date of Patent: August 5, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Max Yuen, Yao-Te Cheng, Paul Christopher Hansen, Lambertus Hesselink
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Patent number: 12377077Abstract: Methods of treatment and pharmaceutical formulations configured to treat primary and secondary mitochondrial dysfunction are provided. The methods and treatments use an agonist of AMPK. The agonist activates AMPK to activate ATP-producing pathways and inhibiting ATP-consuming pathways, thus allowing for the alleviation of symptoms associated with mitochondrial dysfunctions.Type: GrantFiled: December 31, 2019Date of Patent: August 5, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Tereza Moore, Tina M. Cowan, Gregory M. Enns, Mehrdad Shamloo, Michael J. Green, Alam Jahangir, Rolando E. Yanes
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Patent number: 12377396Abstract: Provided are systems and methods that can combine T cell receptor sequencing (TCRseq) and Assay for Transposase Accessible Chromatin using sequencing (ATAC-seq), and/or respective aspects thereof. Further provided are systems and methods that can combine ATAC-seq and perturbation sequencing (Perturb-seq), and/or respective aspects thereof.Type: GrantFiled: December 19, 2018Date of Patent: August 5, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Naresha Saligrama, Ansuman Satpathy, Howard Y. Chang, Mark M. Davis
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Patent number: 12378290Abstract: Methods for synthesizing nanowires are provided. Modified PilA peptides are used as peptide building blocks for synthesizing the nanowires. The method places the peptide building blocks in an assembly buffer with a hydrophobe. Addition of a hydrophobe and molecular crowding by evaporation of the assembly buffer triggers the self-assembly of the peptide building blocks into fibers. Multiple elongation cycles of addition of peptide building blocks, mixing and evaporation are conducted to promote elongation of the fibers and synthesis of nanowires. Electronic characterization of the synthesized nanowires is provided.Type: GrantFiled: October 9, 2023Date of Patent: August 5, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Gemma Reguera, Krista Marie Cosert
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Patent number: 12378278Abstract: The present disclosure relates to disaccharides with defined sulfation patterns, and oligosaccharide mimetics comprising the disaccharides as repeating units linked in a head to tail fashion. The present disclosure further relates to methods of making the same, and to methods of using the same to mediate cell proliferation, cell differentiation, amyloid plaque formation, anti-coagulation, and neuronal growth.Type: GrantFiled: September 21, 2020Date of Patent: August 5, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Xuefei Huang, Jicheng Zhang
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Patent number: 12380728Abstract: A method and system for fingerprint recognition includes generating a first set of feature embeddings for a first image at a feature extractor, generating a second set of feature embeddings for a second image at the feature extractor, generating a third set of embeddings at a first classification head from the first set of feature embeddings, generating a fourth set of embeddings at a second classification head from the first set of feature embeddings, generating a fifth set of embeddings at the first classification head from the second, set of feature embeddings, generating a sixth set of embeddings at the second classification head from the second set of feature embeddings, generating a first similarity score based on the third and fourth sets of embeddings and the fifth and sixth set of embeddings and generating a similarity indicator based on the first similarity score.Type: GrantFiled: January 31, 2024Date of Patent: August 5, 2025Assignee: Board of Trustees of Michigan State UniversityInventors: Anil K. Jain, Steven Grosz
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Patent number: RE50514Abstract: A method for treating a subject having a diseased or atrophic state of fibrotic tissue, kidney disease and associated nerve endings, or for promoting tissue regeneration in muscle tissue is accomplished through exposing the tissue with a laser light having a wavelength of about 400 nm to about 700 nm, or more preferably having a wavelength of about 405 nm, about 532 nm, about 635 nm, or a combination thereof. Subsequent to exposure, mesenchymal stem cells can be administered to the subject. After the administration of mesenchymal stem cells, the tissue is further exposed to laser light having a wavelength of about 400 nm to about 700 nm, or a laser light having a single wavelength of about 400 nm to about 700 nm. The mesenchymal cells can be interferon gamma activated.Type: GrantFiled: December 15, 2022Date of Patent: August 5, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Amelia Bartholomew, Megan O'Connor, Rachana Patil