Abstract: Systems and methods are provided for enabling users to work with TimeML annotations and perform advanced temporal analysis, offering a comprehensive suite of features. Systems and methods of embodiments allow users to parse TimeML annotations, construct TimeML graphs, and execute the timeline extraction (TLEX) algorithm to effect complete timeline extraction. An algorithm can be incorporated for increasing connectivity in temporal graphs, which identifies graph disconnectivity and recommends links based on temporal reasoning, thereby enhancing the coherence of the graph representation. Also, a built-in validation algorithm can be included, ensuring compliance with TimeML annotation guidelines.

Abstract: The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided.

Abstract: This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help restore heart function. According to certain embodiments, a fluid-induced shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for the regenerative repair of diseases, such as diseased heart tissues. Therefore, compositions comprising the exosomes derived from stem cells and methods of treating a degenerative disease by administering the exosomes isolated from stem cells are also provided.

Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.

Abstract: Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.

Abstract: Provided herein are ultraviolet light blocking compositions composed of an active agent containing a phage, phage particle, or other functional component thereof, or another viral particle, or other functional component thereof, in addition to one or more secondary agents useful for application to skin, in industrial or domestic settings, or in agriculture.

Abstract: Disclosed herein are compositions comprising a polymer and a metabolic inhibitor, as well as a method of using the composition to modulate an immune response. The composition may be produced in the form of a synthetic tissue for provision in a subject. The composition or synthetic tissue may further comprise additional therapeutic agents.

Abstract: A method and system for removing smeared pixels from an image includes obtaining a plurality of training images of a scene from different poses, forming a point cloud of the scene having a plurality of pixels and a depth, and rendering a first pixel in a first reference frame to a second reference frame. The method includes comparing a depth difference of the first depth and the second depth, determining whether the pixel is valid or smeared based on the depth difference, associating a label with the pixel corresponding to valid or smeared, training a classifier with the pixel and the label to form a trained classifier, obtaining an image to be classified at the classifier and classifying the pixels in the image as valid or smeared and removing smeared pixels from the image to form a cleaned image.

Abstract: The invention relates to a process for treating livestock (e.g., gestating dams) exposed to toxic forage, such as endophyte-infected tall fescue or ryegrass, using a melatonin composition. The composition can include an active ingredient that includes melatonin having a concentration of up to about 250 ?g/kg body weight of the livestock and an agriculturally acceptable carrier. The process can administer melatonin as a prophylactic or therapeutic for livestock consuming toxic forage or as a prophylactic or therapeutic for offspring of gestating dams that consume toxic forage.

Abstract: Embodiments pertain to a neurostimulation system operable for providing fascicular nerve fiber stimulation to one or more nerves of a subject. The neurostimulation systems may include: (1) one or more electrodes operational to associate with at least one fascicular nerve fiber region of a subject; (2) a stimulator in electrical communication with the electrodes and operational to provide one or more electrical pulses to the electrodes to stimulate at least one fascicular nerve fiber region; and (3) a signal processing unit in electrical communication with the electrodes and the stimulator, and operational to measure on-target and off-target activation by the stimulated electrodes. Further embodiments pertain to methods of providing at least one fascicular nerve fiber stimulation to one or more nerves of a subject by utilizing the disclosed neurostimulation systems. The stimulation may achieve intrafascicular selectivity.

Abstract: Disclosed herein is a stripline interconnect system for high-frequency signal transmission. The interconnect is positioned within a recessed area of a substrate, enabling a reduced height. Included in this design is a dielectric ramp, manufactured on the substrate, that facilitates a smooth transition from transmission dielectric to height of the wafer. Formed using aerosol jet printing, a center conductor extends from the substrate, traverses the dielectric ramp, and connects to wafer pads. To provide for electromagnetic confinement and reduce external interferences, a dielectric is printed over the center conductor, forming an arch, which is subsequently shielded with a printed metal covering. This design provides for reduced insertion and reflection losses, low dispersion, and increased signal isolation. This stripline interconnect is of particular interest for applications desiring precise high-frequency signal transmission between integrated circuit wafers and external circuitry.

Abstract: 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.

Abstract: Aspects of this disclosure relate to driving a capacitive micromachined ultrasonic transducer (CMUT) with a pulse train of unipolar pulses. The CMUT may be electrically excited with a pulse train of unipolar pulses such that the CMUT operates in a continuous wave mode. In some embodiments, the CMUT may have a contoured electrode.

Abstract: Porous electrically conductive graphene/carbon nanofiber bio-scaffolds can be fabricated having a Youngs modulus and electrical conductivity that both match typical values for brain tissue. Such scaffolds have been tested and found to provide improved differentiation of stem cells into functional neural cells relative to conventional scaffolds. In preferred embodiments, neural cell differentiation in conductive graphene/carbon nanofiber scaffolds is promoted by an applied electrical stimulus.

Abstract: This disclosure enables the generation and patterning of color centers with nanometer-scale spatial control in a variety of materials in repeatable fashion and without the use of radiation. Embodiments in accordance with the present disclosure employ a layer of vacancy-injection material disposed on a host-material, where the vacancy-injection material forms a compound with host-material atoms at elevated temperatures. During compound formation, lattice vacancies are generated in the host material and diffuse within the substrate lattice to bond with impurity atoms, thereby forming color centers. High-resolution lithographic patterning of the vacancy-injection film and the short diffusion lengths of the lattice vacancies enables nanometer-level spatial control over the lateral positions of the color centers. Furthermore, the depth of the color centers in the substrate can be controlled by controlling the coating material, thickness, anneal time, and anneal temperature.

Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.

Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP? construct comprising an antibody recruiting molecule linked to one or more pHLIP? peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.

Abstract: A method of treating and attenuating L-DOPA-induced dyskinesia, comprising administering an effective dose of at least one pharmacological agent, e.g., vilazodone, having serotonin-specific reuptake inhibition (SSRI) and serotonin receptor 1A (5-HT1AR) partial agonism activity, in conjunction with L-DOPA. Other agents, such as an L-DOPA decarboxylase inhibitor, e.g., carbidopa, or other adjunct treatments may also be provided.

Abstract: The present disclosure provides methods and compositions for genetically modifying hematopoietic stem and progenitor cells (HSPCs), in particular by replacing the HBB locus in the HSPCs with a transgene encoding alpha globin.

Abstract: Imidazotetrazines were designed to evade resistance by O6-methylguanine DNA methyltransferase (MGMT) while retaining suitable hydrolytic stability, allowing for effective prodrug activation and biodistribution. One compound, called TABZ, exhibits activity against cancer cells irrespective of MGMT expression and MMR status. TABZ has comparable blood-brain barrier penetrance and comparable hematological toxicity relative to TMZ, while also matching its maximum tolerated dose (MTD) in mice when dosed once-per-day over five days. The activity of TABZ is independent of the two principal mechanisms suppressing the effectiveness of TMZ, making it a promising new candidate for the treatment of GBM, especially those that are TMZ resistant.