Abstract: A method for the electrochemical remediation of a metal species comprises flowing a contaminated solution comprising a metal species to be removed through an electrochemical cell that includes a working electrode and a counter electrode spaced apart from the working electrode. The working electrode comprises a conductive substrate or current collector with a polymeric coating thereon, where the polymeric coating comprises a semiconducting or redox-active polymer. A reducing potential is applied to the electrochemical cell, thereby inducing the metal species from the contaminated solution to deposit onto the working electrode. After depositing the metal species, a recovery solution is flowed through the electrochemical cell. An oxidizing potential is applied to the electrochemical cell, thereby stripping the metal species from the working electrode and recovering the metal species in the recovery solution.

Abstract: Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: A tissue adhesion prevention hydrogel is provided and engineered with essential features for maintaining separation between tissues and organs in any part of the body, thus preventing adhesion formation, are their shear-thinning, viscoelasticity, and rapid self-healing. A method of using the tissue adhesion prevention hydrogel for tissue adhesion prevention is also provided. A method of interposing the tissue adhesion prevention in between tissue layers for tissue adhesion prevention is further provided.

Abstract: A catalyst structure includes: (1) a substrate; (2) a catalyst layer on the substrate; and (3) an adhesion layer disposed between the substrate and the catalyst layer. In some implementations, an average thickness of the adhesion layer is about 1 nm or less. In some implementations, a material of the catalyst layer at least partially extends into a region of the adhesion layer. In some implementations, the catalyst layer is characterized by a lattice strain imparted by the adhesion layer.

Abstract: The present invention provides compositions and methods for selectively treating a cancer or tumor utilizing an effective amount of a vegetable oil-derived polyol or hydrogel particles comprising a vegetable oil-derived polyol. In some embodiments, the cancer is a gynecologic cancer, specifically an ovarian cancer. In other aspects, the present invention provides a method of targeting and imaging various tumors and/or tumor associated macrophages (TAMs).

Abstract: Disclosed are electrochemical devices, such as lithium ion battery electrodes, lithium ion conducting solid-state electrolytes, and solid-state lithium ion batteries including these electrodes and solid-state electrolytes. Also disclosed are methods for making such electrochemical devices.

Abstract: The invention relates to a system, method, and computer program for estimating binding affinity that is purely physics-based, highly accurate, computationally efficient, and applicable to drugs of any size and proteins of any flexibility level. In one aspect, a method for physics-based binding affinity estimation is disclosed. The method includes the step of creating a unified simulation for a ligand and a target molecule, where the unified simulation includes a plurality of replicas that are each associated with four restraints along four variables. The method also includes the steps of exchanging data for the four variables between a subset of the replicas and performing a single non-parametric reweighting analysis with the data to estimate an absolute binding free energy for the ligand and target molecule.

Abstract: Embodiments herein describe systems and methods to enhance RNA stability and uses thereof. Many embodiments alter the sequence of an RNA therapeutic molecule (e.g., vaccines) to encode for a variant peptide while maintaining and/or increasing stability of the RNA therapeutic.

Abstract: Chiral redox-polymers that have been enabled for electrochemically-controlled enantioselective interactions. Supramolecular chirality was leveraged for enhancing recognition toward target enantiomers. Chiral redox-metallopolymers were synthesized based on Ugi's amine-inspired chiral monomers, and their enantioselective recognition toward ionic enantiomers, such as tryptophan and naproxen, is demonstrated, with higher enhancement provided by a chiral redox-polymer over a single-site, chiral building block. 2D nuclear magnetic resonance spectroscopy and solid-state circular dichroism support supramolecular chirality resulting from the intramolecular interaction between the ferrocene and the alkyl group in the backbone. The chiral redox-metallopolymers can be used as a platform for electrochemically-modulated enantioselective interactions toward a range of amino acids and pharmaceutical carboxylates.

Abstract: Compositions and methods are provided for treating fibrosis in a mammal by administering a therapeutic dose of a pharmaceutical composition.

Abstract: Various embodiments relate to a method for producing a metal-organic framework (MOF) having a desired redox conductivity and including redox-active linkers, having ?-alkyl-ferrocene groups, via de novo solvothermal synthesis. Various embodiments relate to a metal-organic framework (MOF) linker comprising an ?-alkyl-ferrocene group. Various embodiments relate to a metal-organic framework (MOF), having a first plurality of redox-active linkers, each having an ?-alkyl-ferrocene group. The MOF according to various embodiments, may further have one or more redox-inactive linkers. Various embodiments relate to materials, apparatuses, and components that include the MOF according to various embodiments. For example, various embodiments relate to thin-films, bulk powders, or electrodes.

Abstract: Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.

Abstract: Improved resolution of a time-varying optical measurement is provided with optical intensity modulator(s) having a bandwidth greater than that of the detector array(s). The modulator configuration can have high photon collection efficiency, e.g. by using polarization modulation to split the incident light into several time-gated channels.

Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

Abstract: A traffic monitoring system has a controller and sensors placed in or on roads such that vehicles pass over or near the sensors, thereby casting shadows on the sensors as they pass. The sensors may be configured to detect the shadows, and a controller may be configured to determine any of a variety of information about the passing vehicles based on the detected shadows. For example, the controller may count the number of vehicles that pass, determine a speed of each passing vehicle, and determine a length of each passing vehicle. The sensors can be relatively inexpensive so that a relatively large number of sensors can be used to monitor a large area at a relatively low cost. In some embodiments, solar cells are used to power the sensors, and if desired, the solar cells may be used as the sensors for detecting the shadows of the vehicles being monitored.

Abstract: A method and a system for managing power resources. One or more measurements received from one or more sensors communicatively coupled to at least one processor are processed. The sensors monitor and measure at least one of: one or more operational parameters associated with operation of at least one equipment, one or more external parameters associated with an environment of the equipment, and one or more power parameters associated with a power consumption by the equipment. Based on the processed one or more measurements, one or more future operational parameters associated with an operation of the are determined. The operation of the equipment is controlled using the determined future operational parameters.

Abstract: A yeast-containing dough that is used to form a leavened dough product having a desired degree of leavening is initially formed as two separate dough subcomponents that, when combined, leavens through a fermentation reaction process to form a dough having the desired degree of leavening. The first dough subcomponent includes a leavening activator, flour, salt and water, while the second dough component includes a biological leavening agent, flour, and water. When combined, the leavening agent reacts in the presence of the biological leavening activator through a fermentation process to form the dough having a desired degree of leavening, which can then be heated to a temperature exceeding a viability temperature of the leavening activator to terminate the fermentation process and form the leavened dough product. The dough can also be combined with at least one non-dough component to form the leavened dough product.

Abstract: In certain aspects, the present invention provides methods for inducing a stable gene modification of a target nucleic acid via homologous recombination in a primary cell, such as a primary blood cell and/or a primary mesenchymal cell. In certain other aspects, the present invention provides methods for enriching a population of genetically modified primary cells having targeted integration at a target nucleic acid. The methods of the present invention rely on the introduction of a DNA nuclease such as a Cas polypeptide and a homologous donor adeno-associated viral (AAV) vector into the primary cell to mediate targeted integration of the target nucleic acid. Also provided herein are methods for preventing or treating a disease in a subject in need thereof by administering to the subject any of the genetically modified primary cells or pharmaceutical compositions described herein to prevent the disease or ameliorate one or more symptoms of the disease.

Abstract: Embodiments pertain to a system with a first surface and a second surface operational to associate with one another, where at least one of the first surface and the second surface includes an adhesive layer and a graphite layer positioned on the adhesive layer, and where the graphite layer reduces friction between the first surface and the second surface while the adhesive layer maintains the position of the graphite layer on at least the first surface and the second surface. Additional embodiments pertain to methods of modifying a system that includes a first surface and a second surface by applying an adhesive material to at least one of the first surface and the second surface to form an adhesive layer on at least one of the first surface and the second surface; and applying a graphite material onto the adhesive layer to form a graphite layer on the adhesive layer.