Patents Assigned to Board of Trustees, Michigan State University
  • Patent number: 10730958
    Abstract: A method to convert at least a majority of native cellulose I? to cellulose IIII in pretreated or untreated densified biomass is disclosed. The densified biomass (cellulosic or lignocellulosic) is pretreated with anhydrous liquid ammonia or liquid ammonia comprising a solution of at least 80% ammonia. The pretreating can be performed at a temperature from about 4° C. to about 140° C. and a pressure from about 14.7 to about 200 psi. In one embodiment, the densified cellulosic converting pretreatment process is followed by lignin extraction (LE). The total moisture content of the densified biomass and the solution is 30% or less and a weight ratio of liquid ammonia to the densified biomass is from about 0.3:1 to about 2:1. Various products and systems are also disclosed.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: August 4, 2020
    Inventors: Venkatesh Balan, Leonardo da Costa Sousa
  • Publication number: 20200230238
    Abstract: A method of exciting an organic salt in a cell is provided. The method includes contacting the cell with a composition including the organic salt, the organic salt having a photoactive ion and a counterion. The cell uptakes the organic salt, the organic salt is substantially free of a coating within the cell, and the organic salt is non-toxic to the cell in the dark. The method also includes exposing the cell to light having a first wavelength, wherein the organic salt absorbs the light having the first wavelength and the photoactive ion becomes excited.
    Type: Application
    Filed: August 8, 2018
    Publication date: July 23, 2020
    Inventors: Richard R. LUNT, Sophia Y. LUNT, Deanna BROADWATER, Margaret YOUNG, Matthew BATES
  • Patent number: 10713540
    Abstract: A system and method is provided that utilizes deep learning, including convolutional neural networks, to identify subject objects in unconstrained user images such as unknown pills. An image of, e.g., a pill, may be captured and subsequently processed using deep learning models to identify the pill. The deep learning models may be optimized to have a small footprint (in terms of computational and memory resources) suitable for a resource-limited device such as a smartphone while retaining a high object recognition accuracy. Each such model may also be run on modified versions of the unconstrained image, for example on color, greyscale, and gradient images, to focus the models on different distinguishing features of the object.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: July 14, 2020
    Inventors: Mi Zhang, Kai Cao, Xiao Zeng
  • Publication number: 20200212643
    Abstract: A laser apparatus includes an optic dispersion compensator. In another aspect, an optic (40, 45) uses phase wrapping to compress or stretch a laser pulse. A further aspect includes an apparatus and method for binary-phase compression of stretched laser pulses. In yet another aspect, a single monolithic transmissive or reflective optic (40, 45) provides compression or stretching of a laser pulse using a sinusoidal pattern for introducing binary steps. Another aspect provides a stretching or compressing optic (40, 45) for retarding a phase of multiple frequency regions of a laser pulse by a factor of 2? or less. Still another aspect employs a volume grating or multi-layer mirror including phase wrapping to obtain discontinuous phase jumps in a laser pulse compressor (45) or stretcher (40). Methods of using or making the laser apparatus are also provided.
    Type: Application
    Filed: August 29, 2018
    Publication date: July 2, 2020
    Applicant: Board of Trustees of Michigan State University
    Inventors: Marcos DANTUS, Vadim LOZOVOY
  • Publication number: 20200200068
    Abstract: A diesel engine employs a turbulent jet ignition system and method. In another aspect, diesel fuel and air are premixed prior to introduction of the mixture into a main engine combustion chamber. A further aspect employs a turbocharger compressor to boost air pressure into a main piston combustion chamber and/or an ignition pre-chamber for missing with a heavy fuel, such as diesel.
    Type: Application
    Filed: July 26, 2018
    Publication date: June 25, 2020
    Applicant: Board of Trustees of Michigan State University
    Inventors: Harold SCHOCK, Guoming ZHU
  • Patent number: 10687863
    Abstract: The disclosure relates to a surgical system and related methods to facilitate reduction and fixation of sacro-iliac luxations/fractures (SIL/F) in small animals, for example dogs and cats. In another aspect, the disclosure relates to an aiming device and related methods providing accurate, reliable, and safe fixation of SIL/F in such small animals. The surgical system includes a work surface, an articulatable and lockable reduction arm mounted to the work surface, a reduction handle mounted to the reduction arm; an articulatable and lockable fixation arm mounted to the work surface, a fixation drill guide mounted to the fixation arm, and an image acquisition unit directed toward the work surface. The surgical system provides enhanced safety to surgical personnel using the system in terms of reduced exposure to harmful radiation form the image acquisition unit.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: June 23, 2020
    Inventor: Loic M. Dejardin
  • Patent number: 10686205
    Abstract: An electrochemical cell comprising an anode electrode, a cathode electrode and a reference electrode electronically connected to each other; a first biocatalyst comprising a consolidated bioprocessing organism (e.g., a cellulomonad or clostridium or related strains, such as Cellulomonas uda (C. uda), Clostridium lentocellum (C. lentocellum), Acetivibrio celluloyticus (A. cellulolyticus) Clostridium cellobioparum (C. cellobioparum), alcohol-tolerant C. cellobioparum, alcohol-tolerant C. uda, and combinations thereof) capable of fermenting biomass (e.g., cellulosic biomass or glycerin-containing biomass) to produce a fermentation byproduct; and a second biocatalyst comprising an electricigen (e.g., Geobacter sulfurreducens) capable of transferring substantially all the electrons in the fermentation byproduct (e.g., hydrogen, one or more organic acids, or a combination thereof) to the anode electrode to produce electricity is disclosed.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: June 16, 2020
    Inventors: Gemma Reguera, Allison Speers, Jenna Young
  • Patent number: 10667709
    Abstract: An implantable device is provided. The implantable device includes a flexible polymeric substrate that extends through an aperture in an electrically conductive material to form an anchor that partially covers the electrically conductive material. Methods for fabricating the implantable device are also provided.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: June 2, 2020
    Assignees: Board of Trustees of Michigan State University, Fraunhofer USA
    Inventors: Wen Li, Bin Fan, Robert Rechenberg, Michael Becker, Cory Rusinek
  • Publication number: 20200169275
    Abstract: A multiband sensing system includes an active multiband sensing unit configured to transmit a radio frequency (RF) signal in multiple bands and communicate with a network. The active multiband sensing unit includes at least one transmitting antenna configured to transmit the RF signal. The multiband sensing system includes a passive multiband sensing unit including at least one receiving antenna configured to receive the RF signal, an acoustic actuator powered by the received RF signal including an actuating sensor element configured to actuate in response to receiving extracted modulated information of the RF signal, and an acoustic detector. The acoustic detector includes a detector transmitting antenna configured to backscatter a new frequency band signal to the active multiband sensing unit and a detector sensor element configured to sense data. The sensed data is modulated over the received RF signal to produce the new frequency band signal.
    Type: Application
    Filed: November 26, 2019
    Publication date: May 28, 2020
    Applicant: Board of Trustees of Michigan State University
    Inventors: Premjeet CHAHAL, Deepak KUMAR, Saikat MONDAL, Saranraj KARUPPUSWAMI
  • Patent number: 10666306
    Abstract: A technique is presented for correcting phase distortion in a digital wireless transmitter. The technique includes: receiving an RF signal in an analog domain by a digital-to-RF modulator; amplitude modulating, the RF signal in accordance with a digital input code; and introducing delay in a signal path traversed by the RF signal before the digital-to-RF modulator using a delay circuit. The duration of the delay depends upon the value of the digital input code and substantially cancels out the phase distortion introduced by the digital wireless transmitter.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: May 26, 2020
    Assignee: Board of Trustees of Michigan State University
    Inventors: Sangmin Yoo, Si-Wook Yoo
  • Patent number: 10658560
    Abstract: Thermoelectric materials based on tetrahedrite structures for thermoelectric devices and methods for producing thermoelectric materials and devices are disclosed.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 19, 2020
    Assignees: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Donald T. Morelli, Xu Lu, Vidvuds Ozolins
  • Patent number: 10656062
    Abstract: The disclosure relates to an irreversible dosimetric shock-detection substrate as well as related articles and methods. The shock-detection substrate incorporates a plurality of microcapsules serving as an irreversible means for detecting impact on the substrate. A shock above a characteristic threshold level experienced by the substrate induces an irreversible detectable change associated with the microcapsules upon shock-induced rupture. The irreversible detectable change provides a tamper-proof and non-electronic means for detecting a shock or impact. The shock-detection substrates can be incorporated into a variety of articles and used in a variety of settings, for example to monitor personal safety, to monitor article integrity, to monitor the end of the useful life of the shock-detection substrate itself, or in any other setting where it is desirable to irreversibly detect and/or localize a shock event.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: May 19, 2020
    Inventors: Marcos Dantus, Gary J. Blanchard, Sheryl Blanchard
  • Patent number: 10653679
    Abstract: The present disclosure provides, among other things, compositions and methods useful for inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted with active or latent bacterial infections. The compositions described herein are also useful for decontaminating surfaces (e.g., surgical tools or implants).
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: May 19, 2020
    Assignee: Board of Trustees of Michigan State University
    Inventors: Robert Abramovitch, Benjamin K. Johnson, Christopher J. Colvin
  • Patent number: 10645886
    Abstract: The disclosure relates to a plant growth apparatus and related system to grow and maintain plants under controlled biotic conditions, for example to grow axenic (microbe-free) plants, gnotobiotic (defined microbiota) plants, and holoxenic (complex, or undefined microbiota) plants. This system allows aseptic bottom irrigation with water, soluble nutrients, chemicals, and/or microbiota. Plants can be inverted for dipping and/or vacuum infiltration. The system also allows for passive (gravity) drainage, thereby allowing for gas exchange and preventing root anoxia. A variety of plant growth substrates can be used within the plant growth apparatus as a plant growth medium. The plant growth apparatus, containing the growth substrate medium, can be completely flushed via the drainage port to remove potential toxic byproducts of the sterilization processes. The entire system is suitably constructed using autoclavable material.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 12, 2020
    Inventors: James Kremer, James M. Tiedje, Sheng-Yang He
  • Publication number: 20200138305
    Abstract: Current oscillometric devices for monitoring central blood pressure (BP) maintain the cuff pressure at a constant level to acquire a pulse volume plethysmography (PVP) waveform and calibrate it to brachial BP levels estimated with population average methods. A physiologic method was developed to further advance central BP measurement. A patient-specific method was applied to estimate brachial BP levels from a cuff pressure waveform obtained during conventional deflation via a nonlinear arterial compliance model. A physiologically-inspired method was then employed to extract the PVP waveform from the same waveform via ensemble averaging and calibrate it to the brachial BP levels. A method based on a wave reflection model was thereafter employed to define a variable transfer function, which was applied to the calibrated waveform to derive central BP.
    Type: Application
    Filed: July 12, 2018
    Publication date: May 7, 2020
    Applicants: Board of Trustees of Michigan State University, University of Maryland
    Inventors: Ramakrishna MUKKAMALA, Keerthana NATARAJAN, Jin-Oh HAHN
  • Publication number: 20200136165
    Abstract: A redox flow battery includes a cathode, an anode, a charge-carrying electrolyte, and an (a) oxidized and a (b) reduced form of an active material. The active material has the following formula: (D)-(L)-(A)-[(L)-(A)]V-DZ(F1) or (D)-(L)-(A)-(L-D)X (F2). In these formulae, each D is covalently bonded to an L, each L is covalently bonded to an A, x is a number from 0 to 5, v is a number from 0 to 5 and z is 0 or 1. D is an electron donor compound, L is a linker, and A is an electron acceptor compound. Each of D, L, and A has a particular structure.
    Type: Application
    Filed: July 20, 2018
    Publication date: April 30, 2020
    Applicant: Board of Trustees of Michigan State University
    Inventor: Thomas F. Guarr
  • Patent number: 10637508
    Abstract: Systems and methods provide for one or more server computers communicatively coupled to a network and configured to: generate a code construction for a file, including layers, each at a different code rate; calculate optimized code parameters, including storage efficiency, error-correction capability parameters, and constraints on error patterns; use the plurality of layers and optimized parameters to encode the file on a physical storage media; detect an error on the physical storage media; identify an error location within a first layer encoded at a first code rate; mark the error location as an erasure; and identify the erasure and a second error location for a second error location within a second layer, higher than the first layer, encoded at a second code rate.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: April 28, 2020
    Inventors: Jian Ren, Jian Li, Tongtong Li
  • Patent number: 10633749
    Abstract: The disclosure relates to an electrolyzer reactor suitable for the reduction of organic compounds. The reactor includes a membrane electrode assembly with freestanding metallic meshes which serve both as metallic electrode structures for electron transport as well as catalytic surfaces for electron generation and organic compound reduction. Suitable organic compounds for reduction include oxygenated and/or unsaturated hydrocarbon compounds, in particular those characteristic of bio-oil (e.g., alone or a multicomponent mixtures). The reactor and related methods provide a resource- and energy-efficient approach to organic compound reduction, in particular for bio-oil mixtures which can be conveniently upgraded at or near their point of production with minimal or no transportation.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: April 28, 2020
    Inventors: James E. Jackson, Chun Ho Lam, Christopher M. Saffron, Dennis J. Miller
  • Patent number: 10627415
    Abstract: Compositions and methods for measuring C-peptide binding by cells, including cells expressing Glut1, using a C-peptide binding facilitator, such as an albumin. Such methods include incubating the cell with a known amount of C-peptide and a C-peptide binding facilitator, and determining the amount of C-peptide bound to the incubated cells. Also provided are methods for detecting, monitoring, and/or treating immune-mediated diseases, such as multiple sclerosis (MS), using method of the present technology for measuring C-peptide binding by cells obtained from a human or other animal subject.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 21, 2020
    Assignee: Board of Trustees of Michigan State University
    Inventor: Dana Spence
  • Patent number: 10619234
    Abstract: An alloy and method for producing an alloy is presented. The Titanium alloy has Ti-xCr-yFe-zAl, where 16>x>10, 4>y>0, and 6>z>0, where the alloy is subjected to strain at a temperature between 250 and 500 degrees C. A portion of the Titanium alloy is converted from a first phase to a second phase.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: April 14, 2020
    Assignee: Board of Trustees of Michigan State University
    Inventors: Carl Boehlert, Vahid Khademi