Patents Assigned to Board of Trustees of The Leland Stanford Jr. University
  • Patent number: 12171661
    Abstract: Devices and methods are provided for fatigue testing a medical device, e.g., an annuloplasty ring, using a cam rotatably mounted relative to a base and one or more sets of mounts on the base for securing opposite ends of the medical device. For example, each set of mounts may include a stationary mount on the base, a sliding mount on the base adjacent the cam, and a follower slidably mounted to the sliding mount that contacts the cam such that the follower reciprocates along a horizontal axis as the cam rotates about a vertical axis. The follower and stationary mount include connectors to secure opposite ends, respectively, of a medical device such that rotation of the cam causes the follower to reciprocate and apply tensile and/or compressive loads to fatigue test the medical device.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: December 24, 2024
    Assignee: The Board of Trustees of the Leland Stanford, Jr. University
    Inventors: Matthew Park, Annabel M. Imbrie-Moore, Yuanjia Zhu, Joseph Woo
  • Patent number: 12121220
    Abstract: A multi-wavelength surgical system is provided using an endoscope sensitive in the short-wave infrared region which allows exploration of different areas of the skull base for CSF leaks. The device includes an LED box with multiple wavelengths including allowing excitation of ICG with 785-808 nm, enhancing the water absorption from 1200-1550 nm and above 1800 nm and incorporating white light to allow for surgical navigation. Because CSF is 99% water having a large absorption in the SWIR band around 1200-1550 nm and above 1800 nm, the system and method should be an effective means of diagnosis without the need for intrathecal fluorescein.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: October 22, 2024
    Assignee: The Board of Trustees of the Leland Stanford, Jr. University
    Inventors: Tulio A. Valdez, Mahbuba Tusty, David Huland, Oliver Bruns
  • Patent number: 11806230
    Abstract: Systems and methods are provided for altering the shape of a target tissue structure of a subject, e.g., a nasal septum or other nasal tissue that include securing a first end of a shaping element to tissue adjacent the structure; manipulating the tissue to alter a shape of the structure; and applying a force to the shaping element to maintain the altered shape of the structure.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: November 7, 2023
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: James Kintzing, McCutcheon Brandon, Nayak Jayakar
  • Patent number: 11550802
    Abstract: An example method of displaying a data visualization includes displaying a graphical user interface that includes three distinct regions, and receiving user actions to associate two different fields with two different shelves. The method also includes generating, in accordance with the received user actions, data marks to be displayed in a data visualization, each data mark corresponding to a respective retrieved tuple of data from a multidimensional database, where (i) each data mark has an x-position defined according to data for a first field in the respective tuple and (ii) each data mark has a y-position defined according to data for a second field in the respective tuple. The method also includes displaying a data visualization that includes the generated data marks.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: January 10, 2023
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Patent number: 11550803
    Abstract: An example method of displaying a data visualization includes displaying a plurality of selectable fields and receiving user selections of two different fields from the plurality of selectable fields. The method also includes generating, in accordance with the received user selections, data marks to be displayed in a data visualization, each data mark corresponding to a respective retrieved tuple of data from a multidimensional database, where (i) each data mark has an x-position defined according to data for a first field in the respective tuple and (ii) each data mark has a y-position defined according to data for a second field in the respective tuple. The method also includes displaying the data visualization that includes the generated data marks.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: January 10, 2023
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Patent number: 11352422
    Abstract: Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 7, 2022
    Assignees: VIB VZW, Vrije Univeriteit Brussel, Board of Trustees Leland Stanford Jr University
    Inventors: Jan Steyaert, Toon Laeremans, Els Pardon, Brian Kobilka, Aashish Manglik
  • Patent number: 11162954
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: November 2, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel, Board of Trustees Leland Stanford Jr University
    Inventors: Jan Steyaert, Els Pardon, Soren G. F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Patent number: 11162953
    Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: November 2, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel, Board of Trustees of Leland Stanford Jr University
    Inventors: Jan Steyaert, Els Pardon, Soren G. F. Rasmussen, Juan Jose Fung, Brian Kobilka, Toon Laeremans
  • Patent number: 11067836
    Abstract: A multi-stack graphene structure includes a graphene stack that includes graphene layers including amorphous graphene and thin film dielectric layers. The graphene layers include amorphous graphene. The graphene layers and the thin dielectric layers are alternately stacked on one another. The multi-stack graphene structure also includes an electric field former configured to apply an electric field to the graphene layers.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: July 20, 2021
    Assignees: SAMSUNG ELECTRONICS CO., LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY
    Inventors: Wonjae Joo, Juhyung Kang, Soojin Kim, Mark L. Brongersma, Shanhui Fan
  • Patent number: 10816828
    Abstract: A multi-stack graphene structure includes a graphene stack that includes graphene layers including amorphous graphene and thin film dielectric layers. The graphene layers include amorphous graphene. The graphene layers and the thin dielectric layers are alternately stacked on one another. The multi-stack graphene structure also includes an electric field former configured to apply an electric field to the graphene layers.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: October 27, 2020
    Assignees: SAMSUNG ELECTRONICS CO., LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY
    Inventors: Wonjae Joo, Juhyung Kang, Soojin Kim, Mark L. Brongersma, Shanhui Fan
  • Patent number: 10545977
    Abstract: An exemplary method of displaying a data visualization includes retrieving a dataset that includes a plurality of fields and displaying a graphical user interface with a plurality of shelves. The method further includes receiving user actions to: (i) associate a first field with a first shelf, and (ii) associate a second field with a second shelf; displaying, in accordance with the received user actions, a data visualization, where each data mark has a first size defined according to a default position of a displayed slidable affordance; and receiving an additional user action that moves the slidable affordance from the default position to a user-defined position. In response to receiving the additional user action, the method further includes updating the data visualization, where each data mark included in the updated data visualization has a second size, different from the first size, defined according to the user-defined position of the slidable affordance.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: January 28, 2020
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Patent number: 10528582
    Abstract: An exemplary method of displaying a data visualization includes displaying a graphical user interface that includes three distinct regions, and receiving user actions to associate three different fields with three different shelves, including a shelf that defines colors of data marks. The method also includes generating, in accordance with the received user actions, data marks to be displayed in a data visualization, each data mark corresponding to a respective retrieved tuple of data from a multidimensional database, where (i) each data mark has an x-position defined according to data for a first field in the respective tuple, (ii) each data mark has a y-position defined according to data for a second field in the respective tuple, and (iii) each data mark has a color assigned according to data for a third field in the respective tuple. The method also includes displaying a data visualization that includes the generated data marks.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 7, 2020
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Patent number: 10528583
    Abstract: A method is performed at a computer. The computer retrieves a dataset having a plurality of fields, including a first field and a second field. The computer displays a graphical user interface, including a first region displaying the plurality of fields from the dataset, a second region having a plurality of shelves determined according to a user-selected data visualization type, and a third region for displaying one or more data visualizations. The computer receives user actions to drop the first field on a first shelf and to drop the second field on a second shelf. The first and second shelves define positional attributes of data marks. The computer displays a data visualization in the third region. Each data mark has a position in the data visualization determined according to the first shelf, a data value for the first field, the second shelf, and a data value for the second field.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: January 7, 2020
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Patent number: 10528584
    Abstract: An example method of displaying a data visualization includes displaying a graphical user interface that includes three distinct regions, and receiving user actions to associate two different fields with two different shelves. The method also includes generating, in accordance with the received user actions, data marks to be displayed in a data visualization, each data mark corresponding to a respective retrieved tuple of data from a multidimensional database, where (i) each data mark has an x-position defined according to data for a first field in the respective tuple and (ii) each data mark has a y-position defined according to data for a second field in the respective tuple. The method also includes displaying a data visualization that includes the generated data marks.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: January 7, 2020
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Publication number: 20190384074
    Abstract: A multi-stack graphene structure includes a graphene stack that includes graphene layers including amorphous graphene and thin film dielectric layers. The graphene layers include amorphous graphene. The graphene layers and the thin dielectric layers are alternately stacked on one another. The multi-stack graphene structure also includes an electric field former configured to apply an electric field to the graphene layers.
    Type: Application
    Filed: August 30, 2019
    Publication date: December 19, 2019
    Applicants: SAMSUNG ELECTRONICS CO., LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY
    Inventors: Wonjae JOO, Juhyung KANG, Soojin KIM, Mark L. BRONGERSMA, Shanhui FAN
  • Patent number: 10355216
    Abstract: According to example embodiments, a method includes dispersing carbon nanotubes in a mixed solution containing a solvent, the carbon nanotubes, and a dispersant, the carbon nanotubes including semiconducting carbon nanotubes, the dispersant comprising a polythiophene derivative including a thiophene ring and a hydrocarbon sidechain linked to the thiophene ring. The hydrocarbon sidechain includes an alkyl group containing a carbon number of 7 or greater. The hydrocarbon sidechain may be regioregularly arranged, and the semiconducting carbon nanotubes are selectively separated from the mixed solution. An electronic device includes semiconducting carbon nanotubes and the foregoing described polythiophene derivative.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: July 16, 2019
    Assignees: Samsung Electronics Co., Ltd., The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Young-jun Park, Jong-min Kim, Hang-woo Lee, Zhenan Bao
  • Patent number: 10324945
    Abstract: A method of displaying data visualizations includes retrieving a dataset from a multidimensional database, where the dataset includes a plurality of fields, including first and second fields, and the first field is a data hierarchy that includes multiple subfields. The method further includes displaying a GUI with a first region displaying the plurality of fields (with the first field in a collapsed state), a second region with a plurality of shelves, and a third region. In response to receiving a user action to display the first field in an expanded state, the method displays the first field and the multiple subfields in a hierarchical structure. The method receives additional user actions to: (i) associate a first subfield of the plurality with a first shelf, and (ii) associate the second field with a second shelf, and then displays, in accordance with the user actions, a data visualization in the third region.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 18, 2019
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Publication number: 20180323376
    Abstract: A polymer includes a first repeating unit and a second repeating unit forming a main chain, the first repeating unit including at least one first conjugated system, and the second repeating unit including at least one second conjugated system and a multiple hydrogen bonding moiety represented by Chemical Formula 1.
    Type: Application
    Filed: July 12, 2018
    Publication date: November 8, 2018
    Applicants: Samsung Electronics Co., Ltd., The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Jong Won CHUNG, Sangyoon LEE, Zhenan BAO, Simon RONDEAU-GAGNE, Bob C. SCHROEDER, Jinyoung OH, Yu-Cheng CHIU, Franziska LISSEL
  • Patent number: 10042901
    Abstract: An exemplary method of generating a plurality of data visualizations comprises displaying a graphical user interface that includes a schema information region and a data visualization region. The method further includes receiving user actions to associate first, second, and third fields included in the schema information region with a plurality of shelves of the data visualization region. The method further includes generating a plurality of data visualizations in the data visualization region in accordance with the received user actions, each data visualization includes a plurality of data marks corresponding to a respective retrieved tuple of data having the first, second, and third fields. Moreover, each of the data marks has an x-position and y-position defined according to data for the first and second fields, respectively. In addition, each of the data visualizations corresponds to a respective unique value of the third field, and is displayed in a respective pane.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: August 7, 2018
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan
  • Patent number: 10042517
    Abstract: An exemplary method of generating a chart matrix comprises outputting a user interface (UI) comprising a row header UI section, a column header UI section, and a grid header UI section in a headers UI section, outputting a chart matrix defined by associating a first data dimension corresponding to a data dimension placed in a first position in the row header with a row edge of the chart matrix, and a second data dimension corresponding to a data dimension placed in a first position in the column header with a column edge of the chart matrix, outputting two or more charts nested within each of two or more cells of the chart matrix, providing a user option to perform a drill operation on a selected member displayed in the chart matrix, and outputting, in response to the user input to perform the drill operation, a modified chart matrix.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: August 7, 2018
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Chris Stolte, Diane L. Tang, Patrick Hanrahan