Patents Assigned to Board of Trustees of the Leland Stanford Junior University
  • Publication number: 20240065564
    Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
    Type: Application
    Filed: October 26, 2023
    Publication date: February 29, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan Williams, Keith Sudheimer
  • Patent number: 11912998
    Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: February 27, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
  • Patent number: 11909050
    Abstract: An anode includes: (1) a current collector; and (2) an interfacial layer disposed over the current collector. The interfacial layer includes an ion-conductive organic network including anionic coordination units, organic linkers bonded through the anionic coordination units, and counterions dispersed in the ion-conductive organic network.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: February 20, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhenan Bao, Zhiao Yu, Dawei Feng, Min Ah Lee, Yi Cui, Allen Pei
  • Patent number: 11904589
    Abstract: Square symmetric composite laminate structures, and sub-modules thereof, are provided, along with methods of forming the same. The square symmetric laminate structures include two or more sub-laminate modules, each comprising: a first ply set consisting of a first ply layer oriented at a first angle and a second ply layer oriented at a second angle, a first sum of the first and second angles being ninety degrees; and a second ply set consisting of a third ply layer oriented at a third angle and a fourth ply layer oriented at a fourth angle, a second sum of the third and fourth angles being ninety degrees; wherein the second ply layer is positioned adjacent the third ply layer and the second and third ply layers are both positioned intermediate the first and fourth ply layers, thereby defining a double-double helix arrangement of the respective ply layers. Associated methods are also provided.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: February 20, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Stephen W. Tsai, Dan Wang, Antonio Miravete
  • Patent number: 11905333
    Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: February 20, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Irving L. Weissman, Agnieszka Czechowicz, Deepta Bhattacharya, Daniel Kraft
  • Patent number: 11908690
    Abstract: In certain examples, methods and semiconductor structures are directed to multilayered structures including TMD (transition metal dichalcogenide material or TMD-like material and a polymer-based layer which is characterized as exhibiting flexibility. A first layer including a TMD-based material (e.g., an atomic-thick layer including TMD) or TMD-like material is provided or grown on a surface which in certain instances may be a rigid platform or substrate. A plurality of electrodes are provided on or as part of the first layer, and another layer or film including polymer is applied to cover the first layer and the electrodes. The other layer is integrated with the TMD material or TMD-like material and the first layer, and the other layer provides a flexible substrate such as when released from the exemplary rigid platform or substrate.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: February 20, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Alwin S. Daus, Sam Vaziri, Eric Pop
  • Patent number: 11903969
    Abstract: Methods and compositions for modifying allogeneic donor ?? T cells for use in the treatment of high risk leukemias are provided.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: February 20, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew H. Porteus, Alice Bertaina, Volker Andreas Wiebking
  • Patent number: 11903666
    Abstract: A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: February 20, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, U.S. Government as represented by the Department of Veterans Affairs
    Inventors: Tianjia Jessie Ge, Simon Conti, Joseph C. Liao, Kunj Raju Sheth, Shan X. Wang
  • Publication number: 20240043835
    Abstract: Systems, methods, and kits for enhancing mRNA translation are disclosed. Some embodiments describe expression constructs for producing a peptide and include a translational enhancer. Additional embodiments describe methods for producing a peptide using a construct including a translational enhancer. Certain embodiments further enhance mRNA stability.
    Type: Application
    Filed: May 11, 2021
    Publication date: February 8, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Maria Barna, Kathrin Leppek
  • Patent number: 11892401
    Abstract: The present disclosure relates to novel boronic acid receptor compounds and their use in methods of quantifying a saccharide appearing in a sample. Provided are methods of measuring the concentration of a saccharide in a sample as well as methods of measuring the concentration of a halogenated saccharide in a sample. In certain aspects the sample is abiological sample and the methods further include correlating the measured concentration of saccharide in the biological sample to the gastrointestinal permeability in the individual. Disclosed are also kits for performing the above methods.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: February 6, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Angel Resendez, Sanjay Malhotra
  • Patent number: 11894546
    Abstract: A coated cathode material includes a cathode active material and an interfacial layer coating the cathode active material. The interfacial layer includes a lithium-containing fluoride which includes at least one additional metal different from lithium.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: February 6, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yi Cui, Jin Xie
  • Patent number: 11891634
    Abstract: Disclosed herein are systems, methods, and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: February 6, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Thomas J. Wandless, Ling-Chun Chen, Yusaku Miyamae
  • Patent number: 11892457
    Abstract: Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: February 6, 2024
    Assignees: The Johns Hopkins University, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Dax Fu, Chengfeng Merriman, Hongjie Dai, Hao Wan
  • Patent number: 11891442
    Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 6, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Anton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi
  • Publication number: 20240035095
    Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
    Type: Application
    Filed: October 4, 2023
    Publication date: February 1, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Patent number: 11884657
    Abstract: Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-heteroaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribavirin, and the like.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: January 30, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
    Inventors: Jeffrey S. Glenn, Michael A. Gelman, Brandon Tavshanjian, Kevan Shokat, Ingrid Choong, Mark Smith
  • Patent number: 11883226
    Abstract: An x-ray apparatus includes an x-ray source capable of producing an x-ray beam with a focal spot having a spatial shape that is selected to pre-amplify predetermined spatial frequencies exceeding half a cutoff frequency as compared to spatial frequencies below half the cutoff frequency; an x-ray detector capable of detecting the x-ray beam; and a processor adapted to reconstruct an image from the detected x-ray beam using a filter that compensates the pre-amplified predetermined spatial frequencies. The spatial shape comprises two or more disconnected regions that preferably have widths less than that of a nominal focal spot, combined widths greater than or equal to that of a nominal focal spot, and are separated by less than three times a width of a nominal focal spot.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: January 30, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Norbert J. Pelc, Adam S. Wang
  • Patent number: 11884937
    Abstract: The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: January 30, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Eduard Yakubov
  • Patent number: 11884956
    Abstract: A series of carbohydrate-dye conjugates, as well as a method for detection of pathogenic or other organisms (e.g., bacteria) using the same are provided. The carbohydrate-dye conjugate can be enzymatically incorporated into live and active (viable) bacteria of interest for facile detection of said bacteria. The conjugate incorporation is achieved by utilizing one or more of the enzymes that are endogenous to the bacteria of interest, which can incorporate the conjugate via the conjugate's carbohydrate. A detectable signal is produced by the conjugate's dye only upon incorporation into the bacteria of interest, due to the changes in the dye's local environment upon incorporation. The conjugate may be metabolically incorporated into the fatty outer membrane of a bacterial cell wall, which provides a distinctly hydrophobic environment for the conjugate's dye, causing it to produce a detectable signal.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: January 30, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Carolyn R. Bertozzi, Mireille Kamariza, Peyton Shieh
  • Patent number: 11885576
    Abstract: Various aspects as described herein are directed to a radiative cooling device and method for cooling an object. As consistent with one or more embodiments, a radiative cooling device includes a solar spectrum reflecting structure configured and arranged to suppress light modes, and a thermally-emissive structure configured and arranged to facilitate thermally-generated electromagnetic emissions from the object and in mid-infrared (IR) wavelengths.
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: January 30, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaswath Pattabhi Raman, Shanhui Fan, Eden Rephaeli