Patents Assigned to Board of Trustees of the Leland Stanford Junior University
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Publication number: 20250112247Abstract: A method of producing a conductive nanoporous support, comprises: (i) producing an inorganic template by mixing and subjecting to high-energy ball milling an inorganic material and a powder selected from a carbonaceous material, a polymer, or a metal oxide; and (ii) coating the inorganic template with metal nanoparticles to obtain the nanoporous support. The invention further relates to a conductive nanoporous support, an electrolytic electrode, or gas diffusion electrode and an electrolytic cell or fuel cell.Type: ApplicationFiled: September 30, 2024Publication date: April 3, 2025Applicants: The Board of Trustees of the Leland Stanford Junior University, Volkswagen AktiengesellschaftInventors: Marwa Atwa, Shicheng John Xu, Tim Goh, Friedrich B. Prinz, Gerold Huebner, Jonathan Edward Mueller, Marco Wiethop, Vedran Glavas, Lasse Schmidt
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Publication number: 20250110401Abstract: A photo-curable composition includes a fluorinated monomer including cross-linkable functional groups, and a photoinitiator. Manufacturing methods using the photo-curable composition are provided.Type: ApplicationFiled: November 22, 2022Publication date: April 3, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jia LIU, Yuxin LIU, Zhenan BAO
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Publication number: 20250107713Abstract: Systems and methods for treatment verification and re-treatment with iboga alkaloids in accordance with embodiments of the invention are illustrated. One embodiment includes obtaining a first arterial spin labeling (ASL) scan of a patient's brain pre-treatment with an iboga-alkaloid for a neuropsychiatric condition, obtaining a second ASL scan of the patient's brain post-treatment, measuring changes in regional cerebral blood flow (rCBF) in a left orbitofrontal cortex, left insula, right cingulate cortex, and left putamen of the patient's brain based on the first ASL scan and the second ASL scan, determining that the treatment succeeded when either (i) rCBF increased by at least 0.1 in the left orbitofrontal cortex, or (ii) rCBF increased by any amount in the left orbitofrontal cortex and in at least two of the left insula, right cingulate cortex, and left putamen, and determining that the treatment failed when it is not determined that the treatment succeeded.Type: ApplicationFiled: September 30, 2024Publication date: April 3, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ian Kratter, Nolan R. Williams, Azeezat Azeez, Malvika Sridhar, Manish Saggar
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Patent number: 12266444Abstract: A method for magnetic resonance imaging (MRI) tag tracking includes: synthetically generating tagged data from natural images combined with programmed tag motion and a full Bloch simulation; training a convolutional neural network (CNN) with the synthetically generated tagged data to generate grid tag motion paths; acquiring MRI images using a tagged imaging method; inputting the acquired images into the CNN to estimate motion paths of tracked points; and determining from the estimated motion paths a path of tag lines through the cardiac cycle from a set of tagged MRI images. The method can calculate strain curves from the estimated motion paths using Ecc derivation.Type: GrantFiled: January 19, 2021Date of Patent: April 1, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government As Represented By The Department Of Veteran AffairsInventors: Michael Loecher, Daniel B. Ennis
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Patent number: 12263350Abstract: The present disclosure provides light-responsive polypeptides, and nucleic acids comprising nucleotide sequences encoding the light-responsive polypeptides. The present disclosure provides methods, devices, and systems for controlling the activity of a cell expressing a light-responsive polypeptide of the present disclosure.Type: GrantFiled: January 10, 2020Date of Patent: April 1, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Karl A. Deisseroth, Yoon Kim, Hideaki Kato, Charu Ramakrishnan, Susumu Yoshizawa
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Patent number: 12263621Abstract: The present invention provides a metal mold and the method of making the metal mold for casting directional gecko-inspired adhesives that require deep, slanted features and an undercut wedge structure. The durable metal mold can be used for high quantities. In one example, compression molding is used to mass produce the adhesives. What normally takes 24 hours to produce now with compressing molding takes 5 minutes. Compression molding allows us to increase daily production from 1 adhesive patch to thousands per day.Type: GrantFiled: November 13, 2020Date of Patent: April 1, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Capella F. Kerst, Mark R. Cutkosky
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Publication number: 20250105357Abstract: A molecular design principle utilizes a steric hindrance effect to tune the solvation structures of Li+ ions. By substituting the methoxy groups on DME with larger-sized ethoxy groups, the resulting 1,2-diethoxyethane (DEE) has weaker solvation ability and consequently more anion-rich inner solvation shells, both of which enhance interfacial stability at cathode and anode. According to certain additional aspects, the present embodiments relate to a family of fluorinated-1,2-diethyoxyethane (fluorinated-DEE) molecules that are readily synthesized in large scales to use as the electrolyte solvents. Selected positions on 1,2-diethyoxyethane (DEE, distinct from the diethyl ether are functionalized with various numbers of fluorine atoms through iterative tuning, to reach a balance between CE, oxidative stability, and ionic conduction. Paired with 1.2 M lithium bis(fluorosulfonyl)imide (LiFSI), these fluorinated-DEE-based, single-salt single-solvent electrolytes are thoroughly characterized.Type: ApplicationFiled: October 21, 2022Publication date: March 27, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Yi CUI, Zhenan BAO, Yuelang CHEN, Zhiao YU, Yangju LIN
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Patent number: 12261287Abstract: A conformal graphene-encapsulated battery electrode material is formed by: (1) coating a battery electrode material with a metal catalyst to form a metal catalyst-coated battery electrode material; (2) growing graphene on the metal catalyst-coated battery electrode material to form a graphene cage encapsulating the metal catalyst-coated battery electrode material; and (3) at least partially removing the metal catalyst to form a void inside the graphene cage.Type: GrantFiled: November 23, 2020Date of Patent: March 25, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Yuzhang Li, Kai Yan, Zhenda Lu, Yi Cui
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Patent number: 12258399Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.Type: GrantFiled: August 12, 2021Date of Patent: March 25, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Stephen Willingham, Maureen Howard, Jie Liu, Ravindra Majeti, Susan Sweeney Prohaska, Anne Kathrin Volkmer, Jens-Peter Volkmer, Irving L. Weissman
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Patent number: 12258558Abstract: The disclosure is directed to methods and compositions for screening a library of aptamers for aptamers having a binding affinity to a target molecule. The methods and compositions described herein utilize a throughput approach that is able to simultaneously measure binding affinity and link the binding affinity to the identity (e.g., sequence) of the aptamer.Type: GrantFiled: June 4, 2019Date of Patent: March 25, 2025Assignees: CZ Biohub SF, LLC, The Board of Trustees of The Leland Stanford Junior UniversityInventors: Trevor Feagin, Diana Wu, Peter Mage, John Coller, Hyongsok Tom Soh
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Patent number: 12258403Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.Type: GrantFiled: February 3, 2023Date of Patent: March 25, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Stephen Willingham, Maureen Howard, Jie Liu, Ravindra Majeti, Susan Sweeney Prohaska, Anne K. Volkmer, Jens-Peter Volkmer, Irving L. Weissman
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Publication number: 20250090549Abstract: Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.Type: ApplicationFiled: December 4, 2024Publication date: March 20, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Helen M. BLAU, Andrew Tri Van HO, Adelaida R. PALLA
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Patent number: 12254691Abstract: Systems and methods for multi-view cooperative contrastive self-supervised learning, may include receiving a plurality of video sequences, the video sequences comprising a plurality of image frames; applying selected images of a first and second video sequence of the plurality of video sequences to a plurality of different encoders to derive a plurality of embeddings for different views of the selected images of the first and second video sequences; determining distances of the derived plurality of embeddings for the selected images of the first and second video sequences; detecting inconsistencies in the determined distances; and predicting semantics of a future image based on the determined distances.Type: GrantFiled: December 3, 2020Date of Patent: March 18, 2025Assignees: TOYOTA RESEARCH INSTITUTE, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Nishant Rai, Ehsan Adeli Mosabbeb, Kuan-Hui Lee, Adrien Gaidon, Juan Carlos Niebles
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Patent number: 12251404Abstract: Compositions and methods are provided for induction and maintenance of quiescence of stem cells.Type: GrantFiled: February 27, 2023Date of Patent: March 18, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Marco Quarta, Thomas A. Rando
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Patent number: 12252521Abstract: The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present disclosure can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.Type: GrantFiled: April 17, 2020Date of Patent: March 18, 2025Assignees: The Board of Trustees of the Leland Stanford Junior University, Vrije Universiteit Brussel, The Regens of the University of MichiganInventors: Jan Steyaert, Els Pardon, Toon Laeremans, Brian Kobilka, Soren G. F. Rasmussen, Sebastien Granier, Roger K Sunahara
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Publication number: 20250082730Abstract: Compositions and methods for treating hyperinsulinemic hypoglycemia, such as hyperinsulinemic hypoglycemia after bariatric surgery, are provided. In some embodiments, an effective amount of the glucagon-like peptide-1 receptor antagonist exendin(9-39) is subcutaneously administered twice per day.Type: ApplicationFiled: June 17, 2024Publication date: March 13, 2025Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Tracey L. MCLAUGHLIN, Colleen M. CRAIG
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Publication number: 20250082573Abstract: Compositions for treating ocular disease are disclosed herein. In some embodiments, the composition comprises a dynamic hydrogel comprising a polymer and a plurality of nanoparticles, wherein the polymer is non-covalently crosslinked with the plurality of nanoparticles. The dynamic hydrogel can also comprise an ocular therapeutic encapsulated by the dynamic hydrogel.Type: ApplicationFiled: September 17, 2024Publication date: March 13, 2025Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric Andrew Appel, Emily Louise Meany
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Publication number: 20250082969Abstract: Medical energy devices, systems, and methods that allows for treatment of systemic inflammatory disorders through modulation of neural activity.Type: ApplicationFiled: November 26, 2024Publication date: March 13, 2025Applicant: The Board of Trustees of The Leland Stanford Junior UniversityInventors: Nishant DOCTOR, Alexander SACKEIM
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Patent number: 12249401Abstract: The present disclosure provides systems and methods for analyzing a mixed population of cells. In particular, the present disclosure provides systems and methods for digital cytometry of a biological sample, digital analysis of a biological sample, digital purification of a biological sample, evaluation of a disease in an individual, and prediction of a clinical outcome of a disease therapy.Type: GrantFiled: July 19, 2018Date of Patent: March 11, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Aaron M. Newman, Arash Ash Alizadeh
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Patent number: 12249008Abstract: A method for diagnostic imaging reconstruction uses a prior image xpr from a scan of a subject to initialize parameters of a neural network which maps coordinates in image space to corresponding intensity values in the prior image. The parameters are initialized by minimizing an objective function representing a difference between intensity values of the prior image and predicted intensity values output from the neural network. The neural network is then trained using subsampled (sparse) measurements of the subject to learn a neural representation of a reconstructed image. The training includes minimizing an objective function representing a difference between the subsampled measurements and a forward model applied to predicted image intensity values output from the neural network. Image intensity values output from the trained neural network from coordinates in image space input to the trained neural network are computed to produce predicted image intensity values.Type: GrantFiled: September 14, 2022Date of Patent: March 11, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Liyue Shen, Lei Xing