Patents Assigned to Board of Trustees of the Leland Stanford Junior University
  • Publication number: 20220142477
    Abstract: Methods to compute gestational age and time to delivery utilizing temporal alignment methods and applications thereof are described. Generally, systems utilize analyte measurements collected at one or more time points to determine a gestational age and time to delivery, which can be used as a basis to perform interventions and treat individuals. Computational models trained utilizing temporal alignment of analyte measurements can be used to determine gestational age and time to delivery.
    Type: Application
    Filed: November 8, 2021
    Publication date: May 12, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Liang Liang, Rajanala Samyak, Robert Tibshirani, Trevor Hastie, Michael P. Snyder
  • Publication number: 20220143012
    Abstract: The invention provides a macromolecule-supported compound of formula (I) or (II). Macromolecule-supported compounds of the invention, comprising macromolecular support linked to one or more TLR agonists, are recognized by TLRs (e.g., TLR7 and/or TLR8) with high affinity providing utility in therapeutics, diagnostics, and chemical assays. The invention further provides compositions comprising and methods of treating cancer with the macromolecule-supported compounds.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 12, 2022
    Applicants: Bolt Biotherapeutics, Inc., The Board of Trustees of The Leland Stanford Junior University
    Inventors: Shelley Erin Ackerman, Michael N. Alonso, David Dornan, Justin Kenkel, Romas Kudirka, Arthur Lee, Brian Safina, Matthew Zhou, Edgar George Engleman
  • Patent number: 11324963
    Abstract: Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: May 10, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Amit Etkin, Corey Keller, Wei Wu
  • Patent number: 11325123
    Abstract: Control of fluid flow in a fluidic network is provided by controlling phase transitions of a phase-change material between a liquid phase and a non-fluid phase. The phase-change material is disposed at ports of the fluidic network where the fluidic network is in communication with an ambient. This advantageously provides control of pressure-driven flow within the fluidic network without altering properties of fluids within the fluidic network.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: May 10, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anita Rogacs, Juan G. Santiago
  • Patent number: 11326265
    Abstract: A corrosion resistant anode is provided for oxygen evolution reaction in water including chloride ions. The anode includes: (1) a substrate; (2) a passivation layer coating the substrate; and (3) an electrocatalyst layer coating the passivation layer. Polyanion adjusted alkaline seawater electrolyte for hydrogen generation by electrolysis is also provided.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: May 10, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Michael J. Kenney, Hongjie Dai, Yun Kuang, Yongtao Meng
  • Publication number: 20220135964
    Abstract: Systems and methods for assessing mRNA in vivo and/or in vitro stability are disclosed. Some embodiments methods obtain RNA indexed or barcoded RNA molecules which are then tested against various conditions including stability inside of cells, stability in cell lysate, and stability in solution (e.g., for storage and/or transportation). Additional embodiments describe methods to determine degradation points with single base resolution.
    Type: Application
    Filed: November 12, 2021
    Publication date: May 5, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Maria Barna, Kathrin Leppek, Gun Woo Byeon
  • Publication number: 20220139497
    Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
    Type: Application
    Filed: November 16, 2021
    Publication date: May 5, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Publication number: 20220137149
    Abstract: System, methods, and other embodiments described herein relate to improving the estimation of battery life. In one embodiment, a method includes measuring electrochemical data of a battery cell associated with an electrochemical reaction triggered by a test during a diagnostic cycle. The method also includes determining a feature associated with the degradation of the battery cell from the electrochemical data. The method also includes predicting an end-of-life (EOL) of the battery cell by using the feature in a machine learning (ML) model.
    Type: Application
    Filed: March 31, 2021
    Publication date: May 5, 2022
    Applicants: Toyota Research Institute, Inc., The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of Technology
    Inventors: William C. Chueh, Bruis van Vlijmen, William E. Gent, Vivek Lam, Patrick K. Herring, Chirranjeevi Balaji Gopal, Patrick A. Asinger, Benben Jiang, Richard Dean Braatz, Xiao Cui, Gabriel B. Crane
  • Publication number: 20220127624
    Abstract: The present disclosure describes systems and methods capable of fixing atmospheric nitrogen into bio-available nitrogenous compounds, including ammonia. Embodiments of the present disclosure are directed to synthetic DNA constructs encoding genes to allow release of bio-available nitrogenous compounds in nitrogen fixing diazotrophic organisms. Many of these constructs encode these genes in inducible and constitutive means, such that inducible embodiments can be activated at select times. Additional embodiments are directed to genetically engineered diazotrophs utilizing these constructs to produce bio-available nitrogenous compounds. Further embodiments are directed to methods to create these constructs and organisms as well as to use these constructs and organisms.
    Type: Application
    Filed: February 5, 2020
    Publication date: April 28, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tim Schnabel, Elizabeth Sattely
  • Publication number: 20220125886
    Abstract: Compositions and methods for treating diabetes are disclosed. In particular, the invention relates to co-formulations of amylin analogues with insulin analogues for treatment of diabetes.
    Type: Application
    Filed: February 12, 2020
    Publication date: April 28, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric A. APPEL, Bruce A. BUCKINGHAM, David M. MAAHS, Caitlin MAIKAWA, Gillie Agmon ROTH
  • Patent number: 11313933
    Abstract: A diffusion-weighted magnetic resonance imaging (MRI) method acquires MRI scan data from a multi-direction, multi-shot, diffusion-weighted MRI scan, and jointly reconstructs from the MRI scan data 1) magnitude images for multiple diffusion-encoding directions and 2) phase images for multiple shots and multiple diffusion-encoding directions using an iterative reconstruction method. Each iteration of the iterative reconstruction method comprises a gradient calculation, a phase update to update the phase images, and a magnitude update to update the magnitude images. Each iteration minimizes a cost function comprising a locally low-rank (LLR) regularization constraint on the magnitude images from the multiple diffusion-encoding directions.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 26, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Yuxin Hu
  • Patent number: 11312753
    Abstract: Embodiments of the invention are generally directed to lignin-modifying enzymes and systems and methods of their manufacture. In many embodiments, the lignin-modifying enzymes are lignin-degrading enzymes capable of breaking down lignin into component parts that are usable for other purposes. Several embodiments are directed to systems for producing lignin-modifying enzymes in vivo, including in yeast and/or plant species, and certain embodiments are directed to methods of creating these systems, including transfecting the species to produce lignin-modifying enzymes.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: April 26, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nikita A. Khlystov, Elizabeth Sattely
  • Patent number: 11308645
    Abstract: Methods to quantify motion of a human or animal subject during a magnetic resonance imaging (MRI) exam are provided. In particular, these algorithms make it possible to track head motion over an extended range by processing data obtained from multiple cameras. These methods make current motion tracking methods more applicable to a wider patient population.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jakob Ehrl, Julian Maclaren, Murat Aksoy, Roland Bammer
  • Patent number: 11308661
    Abstract: Multi-shot diffusion-weighted magnetic resonance imaging acquires multiple k-space segments of diffusion-weighted MRI data, estimates reconstructed multi-shot diffusion weighted images, and combines the estimated images to obtain a final reconstructed MRI image. The estimation of images iteratively calculates updated multi-shot images from the multiple k-space segments and current multi-shot images using a convex model without estimating motion-induced phase, constructs multiple locally low-rank spatial-shot matrices from the updated multi-shot images, and calculates current multi-shot images from spatial-shot matrices.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Bruce L. Daniel, Brian A. Hargreaves, Yuxin Hu, Evan G. Levine
  • Patent number: 11306309
    Abstract: Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: April 19, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies
    Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
  • Patent number: 11305133
    Abstract: We provide a novel technique for coupling focused ultrasound into the brain. The ultrasound beam can be used for therapy or neuro-modulation. We excite a selected Lamb wave mode in the skull that mode converts into longitudinal waves in the brain. The benefits of our approach is in improved efficiency, reduction in heating of the skull, and the ability to address regions in the brain that are close or far from the skull.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Butrus T. Khuri-Yakub, Kamyar Firouzi
  • Patent number: 11306244
    Abstract: Intrinsic broadband white-light emitting phosphors and a solution-state method for producing them are disclosed. Emitters in accordance with the present invention include layered perovskite-based phosphors that comprise metals and halides and have an emission spectrum that spans the entire visible-light spectrum.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Emma Rose Dohner, Hemamala Indivari Karunadasa
  • Publication number: 20220115692
    Abstract: A battery includes: 1) an anode; 2) a cathode; and 3) a solid or gel electrolyte disposed between the anode and the cathode, wherein the electrolyte includes a supramolecular polymer formed of, or including, molecules crosslinked through dynamic bonds, and each of the molecules includes an ionic ally conductive domain.
    Type: Application
    Filed: January 17, 2020
    Publication date: April 14, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David George Mackanic, Xuzhou Yan, Yi Cui, Zhenan Bao
  • Publication number: 20220110694
    Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.
    Type: Application
    Filed: October 12, 2021
    Publication date: April 14, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Adi Maron-Katz
  • Patent number: 11299770
    Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the oligonucleotide, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 12, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nikolay Samusik, Garry P. Nolan, Yury Goltsev