Patents Assigned to Board of Trustees of the Leland Stanford Junior University
  • Publication number: 20240382528
    Abstract: The present disclosure provides methods and compositions for genetically modifying hematopoietic stem and progenitor cells (HSPCs), in particular by correcting a JAK2V617F mutation in the HSPCs.
    Type: Application
    Filed: October 4, 2022
    Publication date: November 21, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew H. Porteus, Michael Kyle Cromer
  • Patent number: 12146826
    Abstract: A device for detecting optical chirality includes a metasurface composed of a biperiodic array of nanodisks in the form of a checkerboard array [300], where the nanodisks have diameters d±?/2 such that adjacent nanodisks [302, 304] have diameters that differ by an offset ?. The nanodisks are composed of a dielectric material that is transparent and has a refractive index greater than 2 at a predetermined operational ultraviolet wavelength. The nanodisks have a width-to-height aspect ratio d/h tuned to produce spectral overlap of electric dipole and magnetic dipole modes of incident circularly polarized ultraviolet light.
    Type: Grant
    Filed: November 8, 2020
    Date of Patent: November 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jennifer A. Dionne, Jack Hu, Michelle Solomon, Mark Lawrence
  • Patent number: 12144862
    Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.
    Type: Grant
    Filed: May 23, 2023
    Date of Patent: November 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric A. Appel, Joseph L. Mann, John Klich, Catherine M. Kasse
  • Publication number: 20240378432
    Abstract: Systems, methods, and other embodiments described herein relate to specialized hardware accelerators for deep learning tasks. In one embodiment, a system includes a first waveguide and a second waveguide. The first waveguide is spaced from the second waveguide. The system includes a first phase tuning component, a second phase tuning component, and a signal mixing component. The first phase tuning component includes a first ring resonator that is coupled to the first waveguide. The second phase tuning component includes a second ring resonator that is coupled to the second waveguide. The signal mixing component includes at least a third ring resonator and a fourth ring resonator. The third ring resonator is coupled to the first waveguide and the fourth ring resonator is coupled to the second waveguide. Further, the third ring resonator and the fourth ring resonator are coupled to each other.
    Type: Application
    Filed: May 11, 2023
    Publication date: November 14, 2024
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the Leland Stanford Junior University, Toyota Jidosha Kabushiki Kaisha
    Inventors: Jiahui Wang, Shanhui Fan, Sean P. Rodrigues, Ercan Mehmet Dede
  • Patent number: 12144100
    Abstract: A hadron therapy system that provides 3D scanning and rapid delivery of a high dose. Such systems can include a hadron source and accelerator with an RF energy modulator and an RF deflector that operate in combination to provide 3D scanning of a targeted tissue. The systems can include a permanent magnet quadrupole for magnification of the beam. The systems can include high energy hadron sources that utilize a multi-cell, multi-klystron design that achieves scanning of high energy hadron beams, for example a fixed energy of 200 MeV protons. Such systems can provide full irradiation of a liter scale tumor within one second or less.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: November 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sami G. Tantawi, Emilio Nanni, Zenghai Li, Cecile Limborg-Deprey
  • Patent number: 12139749
    Abstract: Methods and apparatus for direct detection of chemical reactions are provided. Electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: November 12, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nader Pourmand, Miloslav Karhanek, Ronald W. Davis
  • Patent number: 12133771
    Abstract: This disclosure relates to combined frequency and angle compounding for speckle reduction in ultrasound imaging. Such combined frequency and angle compounding can result in a multiplicative speckle reduction compared to using either frequency compounding or angle compounding alone. Compounding methods of this disclosure can make use of the full aperture of the ultrasound probe when acquiring individual images, hence there can be no compromise in resolution. In disclosed embodiments, ultrasound images can be obtained while an ultrasound probe is moving and the relative position and orientation of the ultrasound images can be determined from a measurement of the position and orientation of the ultrasound probe. Certain embodiments can correct for the movement and distortion of an object being imaged during the image acquisition.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: November 5, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, THORLABS, INC.
    Inventors: Yilei Li, Steven Chu, Noah Yuzo Toyonaga, James Y Jiang, Alex E. Cable
  • Patent number: 12133893
    Abstract: A stable injectable collagen-based hydrogel delivery platform and method is provided to obtain the viscosity, post-injection stability and mechanical properties needed of an injectable collagen matrix via incorporating alginate and calcium sulfate (CaSO4) into the matrix. The hydrogel (Alg/Col hydrogel) is shear-thinning, injectable through commercially available needles and stable right after injection.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: November 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yunzhi Yang, Seyedsina Moeinzadeh
  • Patent number: 12135300
    Abstract: A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: November 5, 2024
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Garry P. Nolan, Sean C. Bendall, Robert M. Angelo
  • Patent number: 12136473
    Abstract: Methods of performing experimental treatments on a cohort of subjects are provided. A predictive model can be utilized to predict progression of a medical disorder or relevant imaging biomarker. The predicted medical disorder progression can be utilized as a control to determine whether an experimental treatment has an effect on the progression of the medical disorder. In some instances, the enrollment of subjects within a control group for clinical experiment is eliminated or reduced.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: November 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Greg Zaharchuk
  • Publication number: 20240361522
    Abstract: A dual ring resonator including a base substrate, and a silicon oxide layer positioned on the base substrate having a first waveguide, a primary ring resonator optically coupled to the first waveguide, a second waveguide, and a secondary ring resonator optically coupled to the primary ring resonator and the second waveguide. The dual ring resonator further includes at least one heater disposed partially on the primary ring resonator, and a trench within at least the silicon oxide layer and surrounding at least a portion of the first waveguide and the second waveguide.
    Type: Application
    Filed: April 28, 2023
    Publication date: October 31, 2024
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the Leland Stanford Junior University, Toyota Jidosha Kabushiki Kaisha
    Inventors: Ercan M. Dede, Sean P. Rodrigues, Jiahui Wang, Shanhui Fan
  • Publication number: 20240358719
    Abstract: Methods and formulations of treatment for menstrual complications, gestational complications, and to prolong gestation are described. Treatments include administration of a compound related to regulation of gestational progress or uterine contractions.
    Type: Application
    Filed: March 31, 2021
    Publication date: October 31, 2024
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Trustees of Boston University
    Inventors: Liang Liang, Michael P. Snyder, Cristina M. Alvira, David N. Cornfield, Lihua Ying, John K. Snyder
  • Publication number: 20240359009
    Abstract: Systems and methods for calibration of retinal prosthetics in accordance with embodiments of the invention are illustrated. A closed loop calibration process is described whereby a multi-electrode stimulation regime can be calibrated to a given user's retina. Multi-electrode stimulation can provide increased stimulation selectivity, but significantly increases complexity. Systems and methods described herein provide computational steps that significantly reduce the amount of trials and computation required in order to achieve clinically viable selectivity, making closed-loop calibration of retinal prosthetics possible in significantly less time than open-loop calibration.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 31, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eduardo Jose Chichilnisky, Praful K. Vasireddy, Nishal Pradeepkumar Shah
  • Publication number: 20240350797
    Abstract: Chronic non-healing wounds represent a major source of morbidity for patients, and a significant economic burden. Current wound care treatments are passive and are unable to adapt to changes in the wound environment in real time. By integrating multimodal sensors and adding stimulators in a bandage, physiological monitoring is possible and provides an opportunity for active intervention into the complex wound environment. Here, we develop a battery-free flexible bioelectronic system consisting of wirelessly powered, closed-loop, autonomous sensing and stimulation circuits with tissue-interfacing tough conducting hydrogel electrodes for robust signal transduction, on-demand adhesion, and detachment.
    Type: Application
    Filed: August 26, 2022
    Publication date: October 24, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yuanwen JIANG, Artem TROTSYUK, Zhenan BAO, Geoffrey GURTNER, Simiao NIU
  • Publication number: 20240352450
    Abstract: Embodiments herein describe systems and methods to determine nucleic acid thermodynamics and uses thereof. Many embodiments utilize a sequencing chip, such as an Illumina flow cell as a high-throughput platform for performing massively parallel melt curve determination. In many embodiments, nucleic acid molecules possessing a region that forms a secondary structure are affixed to a sequencing chip and hybridized with one or more labeled oligonucleotides. As the secondary structure denatures, changes in fluorescence can be measured to determine a melt curve of specific sequences.
    Type: Application
    Filed: August 29, 2022
    Publication date: October 24, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hannah K. Wayment-Steele, Eesha Sharma, Rhiju Das, William J. Greenleaf, Anthony Ho, Winston Becker, Yuxi Ke
  • Publication number: 20240350307
    Abstract: A retina clip in accordance with embodiments of the invention are illustrated. One embodiment includes a retina clip including an outer ring having a means of retention against the retina, and an inner platform configured to hold a payload against the retina of an eye, where the inner platform is suspended from the inner ring via several springs. In many embodiments, the springs are flexures. The springs can be modified to generate a desired deflection based on a given payload attached to the inner platform. In numerous embodiments, the payload is a microelectrode array used as part of a retinal prosthetic.
    Type: Application
    Filed: April 22, 2024
    Publication date: October 24, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eduardo Jose Chichilnisky, Ruwan Amila Silva, Martin Breidenbach, Knut Skarpaas, VIII, Marco Oriunno
  • Patent number: 12121404
    Abstract: A device for manipulating tissue at a vessel includes an elongated member having a proximal end and a distal end, a guide member at the distal end of the elongated member, the guide member having a blunt distal tip for engagement against an interior wall of the vessel, and a tissue cutting device at the distal end of the elongated member, wherein the tissue cutting device has a sharp tip that is proximal to the blunt distal tip of the guide member.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: October 22, 2024
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Fletcher T. Wilson, Rhunjay James Yu
  • Publication number: 20240341607
    Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
    Type: Application
    Filed: April 23, 2024
    Publication date: October 17, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Keith Sudheimer
  • Patent number: 12115383
    Abstract: Provided herein are, for example, systems and methods of diagnosing and treating depression, in which a transcranial magnetic stimulation (TMS) therapy is administered to a subject in need thereof and measuring a TMS evoked response in the subject, are provided. The systems and methods allow tailoring or optimizing of a treatment protocol for maximal individual benefit, thereby providing an individualized and optimized treatment protocol for psychiatric disorders such as depression.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: October 15, 2024
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Amit Etkin, Corey Keller, Wei Wu
  • Patent number: 12117530
    Abstract: A laser beam steering system is disclosed which includes a laser source which produces a pulsed laser light beam with a frequency comb spectrum, a first metasurface configured to i) directly receive the pulsed laser and ii) directly generate a diffracted pulsed laser output at different frequencies with a beam at a center frequency normal to the first metasurface; and a second metasurface configured to i) directly receive the diffracted pulsed laser output and ii) to focus onto different foci at a focal plane, light propagating from the focal plane leads to generation of one or more optical beams that are controlled in space and time.
    Type: Grant
    Filed: July 4, 2023
    Date of Patent: October 15, 2024
    Assignees: Purdue Research Foundation, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Amr Mohammad E. A. Shaltout, Vladimir M. Shalaev, Mark L. Brongersma