Patents Assigned to Board of Trustees of the Leland Stanford Junior University
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Publication number: 20240249799Abstract: Systems and methods for cell typing in accordance with embodiments of the invention are illustrated. One embodiment includes a cell typing system, including a processor, and a memory, the memory containing a cell typing application that configures the processor to obtain single cell ribonucleic acid sequencing (scRNA-seq) data generated from a single cell, generate a two-dimensional (2D) image includes a grid of pixels referred to as a GenoMap, where each pixel describes a gene-gene interaction based upon the scRNA-seq data, provide the 2D image to a convolutional neural network (CNN), obtain a cell classification of the single cell from the CNN, and provide the cell classification via a display.Type: ApplicationFiled: January 12, 2024Publication date: July 25, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Md Tauhidul Islam, Lei Xing
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Publication number: 20240245646Abstract: The present invention is directed to a method for preventing and/or treating aging-related cognitive impairment in the central nervous system. The method comprises administering to a subject in need thereof a Ppangela activator 2-(4-tert-butylphenyl)-1H-benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, in an effective amount. A preferred route of administration is oral administration.Type: ApplicationFiled: November 29, 2023Publication date: July 25, 2024Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Khoa Dinh NGUYEN, Edgar G. ENGLEMAN
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Publication number: 20240249426Abstract: A method for dynamic modeling and manipulation of multi-object scenes is described. The method includes using object-centric neural implicit scattering functions (OSFs) as object representations in a model-predictive control (MPC) framework for the multi-object scenes. The method also includes modeling a per-object light transport to enable compositional scene re-rendering under object rearrangement and varying lighting conditions. The method further includes applying inverse parameter estimation and graph neural network (GNN) dynamics models to estimate initial object poses and a light position in the multi-object scene. The method also includes manipulating an object perceived in the multi-object scene according to the applying of the inverse parameter estimation and the GNN dynamics models.Type: ApplicationFiled: December 13, 2023Publication date: July 25, 2024Applicants: TOYOTA RESEARCH INSTITUTE, INC., TOYOTA JIDOSHA KABUSHIKI KAISHA, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Stephen TIAN, Yancheng CAI, Hong-Xing YU, Sergey ZAKHAROV, Katherine LIU, Adrien David GAIDON, Yunzhu LI, Jiajun WU
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Patent number: 12044757Abstract: Limited physical access to target organs of patients inside an MRI scanner is a major obstruction to real-time MRI-guided interventions. Traditional teleoperation technologies are incompatible with the MRI environment and although several solutions have been explored, a versatile system that provides high-fidelity haptic feedback and access deep inside the bore remains a challenge. A passive and nearly frictionless MRI-compatible hydraulic teleoperator is provided designed for in-bore biopsies. A needle driver translates a needle in insertion and retraction directions via a clutch mechanism. A needle holder grips the needle via a retraction lock when the clutch mechanism of the needle driver releases the needle to hold a position of the needle during reposition of the needle driver.Type: GrantFiled: November 12, 2020Date of Patent: July 23, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Samuel Frishman, Mark R. Cutkosky
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Patent number: 12047018Abstract: In certain examples, methods and semiconductor structures are directed to operation of a piezoelectric-based device (e.g., a DC-DC converter) and such operation may involve selectively switching inputs of the piezoelectric-based device at a modulation frequency and, in response, decoupling of the modulation frequency from output power delivered by the piezoelectric-based device. In some examples, the inputs of the piezoelectric-based device are selectively switched to cause decoupling the modulation frequency from output power delivered by the piezoelectric-based device and/or cause operation of the piezoelectric-based device without spurious mode operation.Type: GrantFiled: October 6, 2022Date of Patent: July 23, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric Stolt, Juan M. Rivas-Davila, Weston D. Braun
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Patent number: 12046439Abstract: The embodiments provide a thermionic emission device and a method for tuning a work function in a thermionic emission device is provided. The method includes illuminating an N type semiconductor material of a first member of a thermionic emission device, wherein a work function of the N type semiconductor material is lowered by the illuminating. The method includes collecting, on one of the first member or a second member of the thermionic emission device, electrons emitted from one of the first member or the second member.Type: GrantFiled: November 30, 2021Date of Patent: July 23, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Daniel Riley, Kunal Sahasrabuddhe, Igor Bargatin, Jared Schwede, Zhixun Shen, Nicholas A Melosh
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Publication number: 20240239958Abstract: A polymer is the reaction product of a substituted or unsubstituted 2,3-dihydrofuran, a substituted or unsubstituted 2,3-dihydropyran, or a mixture of any two or more thereof with a substituted or unsubstituted cycloalkenyl monomer, or a mixture of any two or more thereof, in the presence of a ring-opening metathesis catalyst. In some embodiments, the substituted or unsubstituted cycloalkenyl monomer is a substituted or unsubstituted norbornene monomer.Type: ApplicationFiled: March 31, 2022Publication date: July 18, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: J. D. FEIST, Yan XIA
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Publication number: 20240239891Abstract: Provided herein are Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR) constructs and related compositions, kits, methods of use and methods of production. REULR constructs comprise a variable domain heavy chain antibody (VHH) specific for a E3 Ubiquitin Ligase, and a VHH specific for a target protein, where in the E3 Ubiquitin Ligase and the target protein are different. REULR constructs described here target proteins associated with many maladies, but especially cancer.Type: ApplicationFiled: May 19, 2022Publication date: July 18, 2024Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Kenan Christopher GARCIA, Dirk Hubert SIEPE
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Patent number: 12036979Abstract: Aspects of the disclosure relate to a dynamic distance estimation output platform that utilizes improved computer vision and perspective transformation techniques to determine vehicle proximities from video footage. A computing platform may receive, from a visible light camera located in a first vehicle, a video output showing a second vehicle that is in front of the first vehicle. The computing platform may determine a longitudinal distance between the first vehicle and the second vehicle by determining an orthogonal distance between a center-of-projection corresponding to the visible light camera, and an intersection of a backside plane of the second vehicle and ground below the second vehicle. The computing platform may send, to an autonomous vehicle control system, a distance estimation output corresponding to the longitudinal distance, which may cause the autonomous vehicle control system to perform vehicle control actions.Type: GrantFiled: May 24, 2022Date of Patent: July 16, 2024Assignees: ALLSTATE INSURANCE COMPANY, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Juan Carlos Aragon, Derek Phillips, Regina Madigan, Sunil Chintakindi, Mykel Kochenderfer
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Patent number: 12036314Abstract: Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined gel structure in situ. Such gels can serve as cellular or acellular lamellar substitutes to reconstruct corneal stroma, facilitate matrix remodeling, and support multilayered re-epithelialization of wounded corneal stromal tissue, as well delivery vehicles for cells, biomolecules, and/or pharmaceutical agents to wound sites throughout the body.Type: GrantFiled: June 27, 2019Date of Patent: July 16, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: David Myung, Sarah Hull, Sarah Heilshorn, Christopher Lindsay, Christopher Madl, Hyun Jong Lee
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Patent number: 12037402Abstract: Methods are provided for targeting cells for depletion, including, without limitation, cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity; and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS and BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.Type: GrantFiled: August 25, 2021Date of Patent: July 16, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Irving L. Weissman, Stephen Willingham, Doris Po Yi Ho, Piero D. Dalerba, Kelly Marie McKenna, Jens-Peter Volkmer
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Patent number: 12040848Abstract: Described herein are methods of making and using and apparatus for wirelessly communicating data and providing power, particularly from a location exterior to a body and to an implantable device disposed within a body with tissue. The described embodiments provide apparatus and methods for efficiently transfer data and power between an external transceiver and an (implanted) biomedical device. The method is to modulate power carrier, which wirelessly powers the device, using an asynchronous modulation scheme, such as amplitude shift keying (ASK) modulation, with minimal modulation depth in order to not disrupt the power flow. The digital data is encoded in the pulse width, eliminating the need for synchronization to the power carrier signal and further minimizing the power consumption necessary for data transfer. Additionally, a reverse backscatter method for obtaining data from the implant is described that has flexible, low power operation.Type: GrantFiled: August 23, 2022Date of Patent: July 16, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Anatoly Anatolievich Yakovlev, Daniel Pivonka, Ada Shuk Yan Poon, Teresa H. Meng
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Patent number: 12039723Abstract: A method for enhancing a near-infrared fluorescence image includes providing a NIR fluorescence image produced by detecting light in the NIR-I or NIR-IIa windows emitted by fluorophores; and inputting the NIR fluorescence image to a convolutional neural network to produce as output a translated image, where the convolutional neural network is trained using a set of NIR-I or NIR-IIa fluorescence images and a set of NIR-IIb fluorescence images. Preferably, the convolutional neural network is a U-Net.Type: GrantFiled: September 11, 2021Date of Patent: July 16, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Hongjie Dai, Zhuoran Ma
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Publication number: 20240233861Abstract: Embodiments herein describe systems and methods to determine RNA structure and uses thereof. Many embodiments utilize one or more machine learning models to determine an RNA structure. In various embodiments, the machine learning model is trained using experimentally determined RNA structures. Certain embodiments identify one or more ligands or drugs that bind to an RNA structure, which can be used to treat an individual for a disease, disorder, or infection. Various embodiments determine structure of other molecules, including DNA, proteins, small molecules, etc. Further embodiments determine interactions between multiple molecules and/or molecule types (e.g., RNA-RNA interactions, RNA-DNA interactions, DNA-protein interactions, etc.Type: ApplicationFiled: May 20, 2022Publication date: July 11, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Raphael Townshend, Stephan Eismann, Andrew Watkins, Rhiju Das, Ron O. Dror
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Publication number: 20240231182Abstract: Systems and methods for shaping temporal and amplitude profiles of optical pulses in accordance with embodiments of the invention are illustrated. One embodiment includes at least two laser emitters where each emitter configured to generate at least two input optical pulses, a pulse-shaping device configured to apply dispersions of different orders on each of the at least two input pulses, and a nonlinear crystal where the at least two input pulses applied with dispersions combine to emit an output optical pulse having an angular frequency that is the sum of the angular frequencies of the at least two input pulses.Type: ApplicationFiled: January 11, 2024Publication date: July 11, 2024Applicants: The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior University, Colorado School of MinesInventors: Sergio Carbajo Garcia, Randy Lemons, Charles Durfee
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Publication number: 20240226337Abstract: Embodiments herein describe systems and methods to enhance RNA stability and uses thereof. Many embodiments alter the sequence of an RNA therapeutic molecule (e.g., vaccines) to encode for a variant peptide while maintaining and/or increasing stability of the RNA therapeutic.Type: ApplicationFiled: July 1, 2021Publication date: July 11, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Rhiju Das, Hannah K. Wayment-Steele
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Patent number: 12031146Abstract: Methods and compositions are provided for editing the genome of a cell without the use of an exogenously supplied nuclease. Aspects of the methods include contacting a cell with a targeting vector comprising nucleic acid sequence to be integrated into the target locus, where the cell is not also contacted with a nuclease. In addition, reagents, devices and kits thereof that find use in practicing the subject methods are provided.Type: GrantFiled: May 17, 2021Date of Patent: July 9, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Adi Barzel, Mark A. Kay
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Patent number: 12029686Abstract: Precise concentric, symmetric, and repeatable circular scoring (cutting) of Descemet's membrane is made possible by a handheld surgical ophthalmic device. The precision of the cut is provided by a stabilizing point on a stabilizing arm as well the anchoring insertion point at the limbus. Stabilization through the insertion point and the stabilizing arm provides a two-point fixation thereby establishing a cutting plane. The cutting plane allows for precise depth of cut whereas the rotating blade's consistent radius allows for circularity of the cut. The stabilization arm fixates on tissue, and is then removed when the procedure is completed. Consistent torque and contact pressure of the cutting blade is provided through rotational control via the depression of a button on a handle thereby removing the need to “free-hand” the desemetorhexis.Type: GrantFiled: March 15, 2022Date of Patent: July 9, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Michael Mbagwu, David Buickians, David Myung
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Patent number: 12032266Abstract: Provided is a phase modulator including an antenna pattern, a lower reflective layer spaced apart from the antenna pattern in a vertical direction, a spacer provided between the antenna pattern and the lower reflective layer, and a phase shift pattern included in the spacer, the phase shift pattern including a phase shift material.Type: GrantFiled: July 9, 2021Date of Patent: July 9, 2024Assignees: SAMSUNG ELECTRONICS CO., LTD., The Board of Trustees of the Leland Stanford Junior UniversityInventors: Junghyun Park, Yifei Wang, Mark L. Brongersma
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Patent number: 12031183Abstract: Methods of deconvolving a feature profile of a physical system are provided herein. The present method may include: optimizing a regression between a) a feature profile of a first plurality of distinct components and b) a reference matrix of feature signatures for a second plurality of distinct components, wherein the feature profile is modeled as a linear combination of the reference matrix, and wherein the optimizing includes solving a set of regression coefficients of the regression, wherein the solution minimizes 1) a linear loss function and 2) an L2-norm penalty function; and estimating the fractional representation of one or more distinct components among the second plurality of distinct components present in the sample based on the set of regression coefficients. Systems and computer readable media for performing the subject methods are also provided.Type: GrantFiled: December 19, 2018Date of Patent: July 9, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Aaron M. Newman, Arash Ash Alizadeh