Abstract: Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.
Type:
Application
Filed:
October 18, 2023
Publication date:
March 7, 2024
Applicant:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Matthew S. BOGYO, Martijn VERDOES, Leslie OFORI, Nimali P. WITHANA
Abstract: Many embodiments of the invention include systems and methods for evaluating motion from a video, the method includes identifying a target individual in a set of one or more frames in a video, analyzing the set of frames to determine a set of pose parameters, generating a 3D body mesh based on the pose parameters, identifying joint positions for the target individual in the set of frames based on the generated 3D body mesh, predicting a motion evaluation score based on the identified join positions, providing an output based on the motion evaluation score.
Type:
Grant
Filed:
May 19, 2021
Date of Patent:
March 5, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ehsan Adeli-Mosabbeb, Mandy Lu, Kathleen Poston, Juan Carlos Niebles
Abstract: Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.
Type:
Grant
Filed:
November 5, 2020
Date of Patent:
March 5, 2024
Assignees:
The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
Inventors:
Andrew Yang, Anton Wyss-Coray, Kyle Brewer
Abstract: Methods are provided for the treatment of cancer by administering a mitochondrial uncoupler in a dose effective to increase differentiation of the cancer cells, which may be provided in a combination with a retinoic acid to differentiate the cancer cells. The effect on the targeted cancer cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used. The cancer may be resistant to retinoic acid.
Type:
Grant
Filed:
December 3, 2021
Date of Patent:
March 5, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: An apparatus includes a substrate, at least one type of tuning material, and a composite material. The substrate has an interface surface or material that manifests, in response to light in a color spectrum, a particular color and a first thermal load. The particular color is associated with the first thermal load. The at least one type of tuning material manifests, in response to light in the color spectrum, the particular color and a second thermal load. The particular color is associated with the second thermal load. The first thermal load is different from the second thermal load. The composite material includes the interface surface or material and the at least one type of tuning material. The composite material manifests, in response to light in the color spectrum, the particular color and a tuned thermal load which is different than the first thermal load and the second thermal load.
Type:
Grant
Filed:
March 29, 2019
Date of Patent:
March 5, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: In certain examples, methods and semiconductor structures are directed to an apparatus including a photon emitter such as an LED which operates over an emission wavelength range and a photo-voltaic device arranged relative to the photon emitter to provide index-matched optical coupling between the photo-voltaic device and the photon emitter for an emission wavelength range of the photon emitter.
Type:
Grant
Filed:
December 3, 2021
Date of Patent:
March 5, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Shanhui Fan, Bo Zhao, Sid Assawaworrarit, Parthiban Santhanam, Meir Orenstein
Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
Type:
Application
Filed:
October 26, 2023
Publication date:
February 29, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
Type:
Grant
Filed:
December 14, 2021
Date of Patent:
February 27, 2024
Assignees:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
Abstract: An anode includes: (1) a current collector; and (2) an interfacial layer disposed over the current collector. The interfacial layer includes an ion-conductive organic network including anionic coordination units, organic linkers bonded through the anionic coordination units, and counterions dispersed in the ion-conductive organic network.
Type:
Grant
Filed:
October 2, 2019
Date of Patent:
February 20, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Zhenan Bao, Zhiao Yu, Dawei Feng, Min Ah Lee, Yi Cui, Allen Pei
Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.
Type:
Grant
Filed:
December 22, 2022
Date of Patent:
February 20, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Irving L. Weissman, Agnieszka Czechowicz, Deepta Bhattacharya, Daniel Kraft
Abstract: A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.
Type:
Grant
Filed:
November 11, 2021
Date of Patent:
February 20, 2024
Assignees:
The Board of Trustees of the Leland Stanford Junior University, U.S. Government as represented by the Department of Veterans Affairs
Inventors:
Tianjia Jessie Ge, Simon Conti, Joseph C. Liao, Kunj Raju Sheth, Shan X. Wang
Abstract: Square symmetric composite laminate structures, and sub-modules thereof, are provided, along with methods of forming the same. The square symmetric laminate structures include two or more sub-laminate modules, each comprising: a first ply set consisting of a first ply layer oriented at a first angle and a second ply layer oriented at a second angle, a first sum of the first and second angles being ninety degrees; and a second ply set consisting of a third ply layer oriented at a third angle and a fourth ply layer oriented at a fourth angle, a second sum of the third and fourth angles being ninety degrees; wherein the second ply layer is positioned adjacent the third ply layer and the second and third ply layers are both positioned intermediate the first and fourth ply layers, thereby defining a double-double helix arrangement of the respective ply layers. Associated methods are also provided.
Type:
Grant
Filed:
July 14, 2022
Date of Patent:
February 20, 2024
Assignee:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Stephen W. Tsai, Dan Wang, Antonio Miravete
Abstract: In certain examples, methods and semiconductor structures are directed to multilayered structures including TMD (transition metal dichalcogenide material or TMD-like material and a polymer-based layer which is characterized as exhibiting flexibility. A first layer including a TMD-based material (e.g., an atomic-thick layer including TMD) or TMD-like material is provided or grown on a surface which in certain instances may be a rigid platform or substrate. A plurality of electrodes are provided on or as part of the first layer, and another layer or film including polymer is applied to cover the first layer and the electrodes. The other layer is integrated with the TMD material or TMD-like material and the first layer, and the other layer provides a flexible substrate such as when released from the exemplary rigid platform or substrate.
Type:
Grant
Filed:
June 19, 2020
Date of Patent:
February 20, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Systems, methods, and kits for enhancing mRNA translation are disclosed. Some embodiments describe expression constructs for producing a peptide and include a translational enhancer. Additional embodiments describe methods for producing a peptide using a construct including a translational enhancer. Certain embodiments further enhance mRNA stability.
Type:
Application
Filed:
May 11, 2021
Publication date:
February 8, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A coated cathode material includes a cathode active material and an interfacial layer coating the cathode active material. The interfacial layer includes a lithium-containing fluoride which includes at least one additional metal different from lithium.
Type:
Grant
Filed:
May 10, 2018
Date of Patent:
February 6, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Disclosed herein are systems, methods, and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand.
Type:
Grant
Filed:
June 22, 2018
Date of Patent:
February 6, 2024
Assignee:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Thomas J. Wandless, Ling-Chun Chen, Yusaku Miyamae
Abstract: Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.
Type:
Grant
Filed:
July 5, 2018
Date of Patent:
February 6, 2024
Assignees:
The Johns Hopkins University, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Dax Fu, Chengfeng Merriman, Hongjie Dai, Hao Wan
Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
February 6, 2024
Assignees:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors:
Anton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi