Patents Assigned to Board of Trustees of the University
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Patent number: 11624060Abstract: The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.Type: GrantFiled: February 9, 2018Date of Patent: April 11, 2023Assignees: The Board of Trustees of the University of Arkansas, The Kitasato InstituteInventors: Joshua Sakon, Jeffrey Roeser, Ryan Bauer, Katarzyna Janowska, Keisuke Tanaka, Osamu Matsushita, Kentaro Uchida
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Publication number: 20230109627Abstract: Provided herein are methods of making a high-quality quantum dot (QD), including by providing anion precursor chemistry that enables chemical modulation of precursor reactivity, thereby, allowing independent optimization of reaction temperature and precursor reactivity to systematically grow high quality QDs and by providing specially configured tunable precursors and related chemistry to facilitate separate reaction pathways for nucleation and growth, thereby accessing heat-up based synthesis of high-quality QD, including core-shell QDs. The methods may include providing a base-QD and a first anion or cation precursor having a composition comprising an anion or a cation element, respectively, and a modification agent. At least one add-layer is grown on the base-QD at a growth temperature, thereby making the high-quality QD comprising the base-QD and the at least one add-layer. At least one add-layer may have a composition comprising an add-layer cation element and an add-layer anion element.Type: ApplicationFiled: November 13, 2020Publication date: April 6, 2023Applicant: The Board of Trustees of The University of IllinoisInventors: Hee-Sun HAN, Joonhyuck PARK
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Patent number: 11620574Abstract: A great deal of time and computational resources may be used when developing a machine learning or other data processing workflow. This can be related to the need to re-compute the workflow in response to adjustments to the workflow parameters, in order to assess the benefit of such adjustments so as to develop a workflow that satisfies accuracy or other constraints. Embodiments herein provide time and computational savings by selectively storing and re-loading intermediate results of steps of a data processing workflow. For each step of the workflow, during execution, a decision is made whether to store the intermediate results of the step. Thus, these embodiments can offer storage savings as well as processing speedups when repeatedly re-executing machine learning or other data processing workflows during workflow development.Type: GrantFiled: December 4, 2019Date of Patent: April 4, 2023Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLNOISInventors: Aditya G Parameswaran, Stephen Macke, Doris Suiyi Xin
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Patent number: 11621689Abstract: A piezoelectric thin film (PTF) is located above a carrier substrate. The PTF may be Z-cut LiNbO3 thin film adapted to propagate an acoustic wave in at least one of a first mode excited by an electric field oriented in a longitudinal direction along a length of the PTF or a second mode excited by the electric field oriented at least partially in a thickness direction of the PTF. A first interdigitated transducer (IDT) is disposed on a first end of the PTF. The first IDT is to convert a first electromagnetic signal, traveling in the longitudinal direction, into the acoustic wave. A second IDT is disposed on a second end of the PTF with a gap between the second IDT and the first IDT. The second IDT is to convert the acoustic wave into a second electromagnetic signal, and the gap determines a time delay of the acoustic wave.Type: GrantFiled: October 16, 2020Date of Patent: April 4, 2023Assignee: The Board of Trustees of the University of llllinoisInventors: Ruochen Lu, Tomas Manzaneque Garcia, Yansong Yang, Songbin Gong
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Patent number: 11618919Abstract: The present invention relates to an ultrasensitive assay platform for the detection of nucleic acids such as microRNAs (miRNAs), which are important biomarker for diseases including cancer. The platform allows high throughput detection of multiple nucleic acid sequences miRNAs on the single-molecule level using fluorescence labeling, molecular barcoding, and flow based detection and multiparametric data analysis.Type: GrantFiled: May 22, 2020Date of Patent: April 4, 2023Assignee: The Board of Trustees of the University of IllinoisInventors: Andrew Smith, Lucas David Smith
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Patent number: 11620108Abstract: A random number generation system may generate one or more random numbers based on the repeated programming of a memory, such as a flash memory. As an example, a control system may repeatedly store a sequence to a block of flash memory to force a plurality of cells into a random state such that, at any given instant, the values in the cells may be random. The control system may identify which of the cells contain random values and then generate based on the identified values a number that is truly random.Type: GrantFiled: May 17, 2019Date of Patent: April 4, 2023Assignee: Board of Trustees of the University of Alabama for and on behalf of the University of Alabama in HuntsvilleInventors: Biswajit Ray, Aleksander Milenkovic
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Publication number: 20230096431Abstract: A method of rapidly forming an elastomer with tunable properties is described herein. The method includes preparing a monomer solution comprising a catalyst and one or more monomers including 1,5-cyclooctadiene (COD). The one or more monomers may further include dicyclopentadiene (DCPD), and each of the COD and the DCPD may be present in the monomer solution at a predetermined volume percentage. A region of the monomer solution is activated to initiate an exothermic polymerization reaction and generate a self-propagating polymerization front, which moves through the monomer solution and polymerizes the one or more monomers. Thus, an elastomer having predetermined properties is rapidly formed.Type: ApplicationFiled: March 10, 2021Publication date: March 30, 2023Applicant: The Board of Trustees of the University of IllinoisInventors: Nancy R. Sottos, Jeffrey S. Moore, Leon M. Dean, Qiong Wu, Omar Alshangiti
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Patent number: 11612598Abstract: Compositions and methods relating to induction of cell death such as in cancer cells are disclosed. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds in connection with modification of procaspases such as procaspase-3 are disclosed. In various embodiments, the compounds and compositions are capable of activation of procaspase-3.Type: GrantFiled: December 21, 2018Date of Patent: March 28, 2023Assignee: The Board of Trustees of the University of IllinoisInventors: Paul J. Hergenrother, Karson S. Putt, Quinn P. Peterson, Valerie Fako
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Patent number: 11615152Abstract: Systems, devices, computer-implemented methods, and/or computer program products that facilitate event schema induction from unstructured or semi-structured data. In one example, a system can comprise a processor that executes computer executable components stored in memory. The computer executable components can comprise a schema component and a retrieval component. The schema component can derive an event schema for a document corpus using parsing results obtained from the document corpus. The retrieval component can populate a response to a query with a document of the document corpus using events extracted from the query and the document using the event schema.Type: GrantFiled: April 6, 2021Date of Patent: March 28, 2023Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Rajarshi Haldar, Yu Deng, Lingfei Wu, Ruchi Mahindru, Julia Constanze Hockenmaier, Sinem Guven Kaya
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Publication number: 20230086727Abstract: According to an aspect of the present disclosure, a method executed by an information processing apparatus in order to cause a neural network to learn a Tth task corresponding to a Tth learning set is provided. The method includes: for each of a plurality of units, determining an importance degree of the unit in the Tth task; for each of a plurality of layers, determining dissimilar tasks from among a first task to a (T?1)th task, the dissimilar tasks being not similar to the Tth task in terms of behaviors in the layer; and in learning that uses the Tth learning set, suppressing updating of weight parameters of the plurality of units included in the plurality of layers in accordance with importance degrees in the dissimilar tasks determined for each of the plurality of layers.Type: ApplicationFiled: September 22, 2021Publication date: March 23, 2023Applicants: KDDI Research, Inc., THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Tatsuya Konishi, Mori Kurokawa, Bing Liu, Gyuhak Kim, Zixuan Ke
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Publication number: 20230070016Abstract: A system for charging a battery includes three sub-modules, each receiving a respective phase of a three-phase alternating current (AC) signal. The three sub-modules cooperate to transform the respective phases of the three-phase AC signal to a direct current (DC) signal by passing the respective phases of the three-phase AC signal through a respective semiconductor device configured to discontinuously modulate the respective phase of the three-phase AC signal to convert it to a DC signal provided to the battery to charge the battery.Type: ApplicationFiled: November 10, 2022Publication date: March 9, 2023Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Sudip K. Mazumder, Moien Mohamadi, Nikhil Kumar
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Patent number: 11596329Abstract: The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.Type: GrantFiled: May 12, 2020Date of Patent: March 7, 2023Assignees: The Board of Trustees of the University of Illinois, Northwestern UniversityInventors: John A. Rogers, Jungil Choi, Sungbong Kim
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Patent number: 11600329Abstract: A system performs analog memory sanitization by forcing voltage levels in memory cells to substantially the same voltage level so that they are indistinguishable regardless of the data that has been previously stored in the cells. In some embodiments, a special programming operation for sanitizing a plurality of memory cells forces the charge in the cells to approximately the same voltage level by increasing the voltage level of all cells regardless of the data currently stored in the cells. As an example, each cell may be programmed to a logical high bit value (e.g., a “0”) by increasing the charge in each cell to a voltage level that is greater than the voltage level for writing the same logical bit value in a normal programming operation. Thus, after the programming operation is performed, the voltage levels of cells storing one logical bit value (e.g., a “0”) prior to the programming operation may be indistinguishable from voltage levels of cells storing a different logical bit value (e.g.Type: GrantFiled: March 19, 2021Date of Patent: March 7, 2023Assignee: Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in HuntsvilleInventor: Biswajit Ray
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Patent number: 11601442Abstract: A system associated with detecting a cyber-attack and reconstructing events associated with a cyber-attack campaign, is disclosed. The system performs various operations that include receiving an audit data stream associated with cyber events. The system identifies trustworthiness values in a portion of data associated with the cyber events and assigns provenance tags to the portion of the data based on the identified trustworthiness values. An initial visual representation is generated based on the assigned provenance tags to the portion of the data. The initial visual representation is condensed based on a backward traversal of the initial visual representation in identifying a shortest path from a suspect node to an entry point node. A scenario visual representation is generated that specifies nodes most relevant to the cyber events associated with the cyber-attack based on the identified shortest path. A corresponding method and computer-readable medium are also disclosed.Type: GrantFiled: August 19, 2019Date of Patent: March 7, 2023Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Ramasubramanian Sekar, Junao Wang, Md Nahid Hossain, Sadegh M. Milajerdi, Birhanu Eshete, Rigel Gjomemo, V. N. Venkatakrishnan, Scott Stoller
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Patent number: 11597945Abstract: Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.Type: GrantFiled: June 26, 2020Date of Patent: March 7, 2023Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Ioannis Tzanetakis, Jing Zhou
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Patent number: 11592113Abstract: The present disclosure describes one or more embodiments of a device for localized flow control. The device includes a plunger configured to slide along a longitudinal axis; a gate connecting to a proximal end of the plunger and configured to slide with the plunger; a spacer disposed along the longitudinal axis and on a same side with the gate relative to the plunger; a soft tube disposed in a gap between the spacer and a proximal end of the gate; and a plunger controller configured to slide the plunger between a closed position and an open position. In response to the plunger at the open position, the device is at an open state configured to allow a flow in the soft tube, and in response to the plunger at the closed position, the device is at a closed state configured to cut off the flow in the soft tube.Type: GrantFiled: March 3, 2020Date of Patent: February 28, 2023Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Yang Zhang, Long Zhou
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Patent number: 11591640Abstract: A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample.Type: GrantFiled: May 24, 2021Date of Patent: February 28, 2023Assignee: The Board of Trustees of the University of IllinoisInventors: Brian T. Cunningham, Yue Zhuo, Brendan Harley, Ji Sun Choi, Thibault Marin, Yi Lu
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Patent number: 11594816Abstract: An antenna includes a piezoelectric disc. The antenna further includes a first electrode disposed on a first surface of the piezoelectric disc and a second electrode disposed on a second surface of the piezoelectric disc that is opposite to the first surface. The first electrode and the second electrode are to receive a time-varying voltage to excite a mechanical vibration in the piezoelectric disc, and the piezoelectric disc is to radiate electromagnetic energy at a particular frequency responsive to the mechanical vibration.Type: GrantFiled: March 9, 2021Date of Patent: February 28, 2023Assignee: The Board of Trustees of the University of IllinoisInventors: Ahmed Hassanien, Michael Breen, Ming-Huang Li, Songbin Gong
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Patent number: 11583626Abstract: The present invention is directed to a multi-angulated catheter and methods of using the multi-angulated catheter. The multi-angulated catheter is so dimensioned as to facilitate accessing the left ventricle from an arm of a patient. The multi-angulated catheter generally includes in order: (a) a coiled end; (b) a first straight portion having a first straight portion length; (c) a first shaft including a distal end connected to the first straight portion and a proximal end opposite the distal end, the first shaft and the first straight portion defining a first obtuse angle, the first shaft having a first shaft length; and (d) a second shaft connected to the first shaft on said proximal end. The catheter is flexible so as to afford being straightened when it is advanced over a guide wire. The catheter resiliently returns to a multi-angulated position after the guide wire is withdrawn.Type: GrantFiled: November 4, 2019Date of Patent: February 21, 2023Assignees: The Board of Trustees of the University of Illinois, The US Government Represented by the Department of Veteran AffairsInventor: Mladen I. Vidovich
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Patent number: PP35017Abstract: A new and distinct peach tree named ‘Whitewater’ which originated from a hand-pollinated cross of ‘White County’ (female parent; U.S. Plant Pat. No. 17,742) x ‘Souvenirs’ peach (male parent; U.S. Plant Pat. No. 26,920) is provided. This new peach tree cultivar can be distinguished by its white, low-acid, slow-melting flesh, early-season ripening, attractive appearance, postharvest performance, and resistance to bacterial spot disease.Type: GrantFiled: December 14, 2021Date of Patent: March 7, 2023Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: John R. Clark, Margaret Worthington