Patents Assigned to Board of
  • miRNA FOR TREATING CANCER AND FOR USE WITH ADOPTIVE IMMUNOTHERAPIES
    Publication number: 20170312304
    Abstract: In some aspects, miRNA for the treatment of cancer are provided. In some embodiments, a miRNA (e.g., miR-124, miR-142, and/or miR-138) may be used to promote or enhance immune destruction of a cancer, or reduce the immune suppression of the cancer, in a subject. In other aspects, the miRNA may be used in, or in combination with, an adoptive immunotherapy.
    Type: Application
    Filed: May 9, 2017
    Publication date: November 2, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Amy HEIMBERGER, Jun WEI
  • Methods and systems of making nanostructures
    Patent number: 9801829
    Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making nanostructures (e.g., nanoparticles, nanofibers), systems for making nanostructures, and the like.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: October 31, 2017
    Assignees: University of Florida Research Foundation, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Peng Guo, Charles R. Marin, Yaping Zhao, Richard N. Zare
  • Methods and compositions for determining a graft tolerant phenotype in a subject
    Patent number: 9803241
    Abstract: Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least 5 genes in a sample from the subject, e.g., a blood sample, is assayed to obtain a gene expression result for the at least 5 genes. The obtained gene expression result for the at least 5 genes is then employed to determine whether the subject has a graft tolerant phenotype. Also provided are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: October 31, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Minnie M. Sarwal, Li Li
  • Smartphone-based asset management system
    Patent number: 9805331
    Abstract: A method of tracking an inventory of objects via a mobile communications device includes acquiring an image of one or more of the objects via the mobile communications device, which also collects a location of the mobile communications device while acquiring the image of the one or more of the objects. The location and image are transferred from the mobile communications device to a remote server via a wireless network, such that the one or more of the objects are identified at the server based on the image, and the location and identity of the one or more objects are stored on a database associated with the server.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: October 31, 2017
    Assignees: DEUTSCHE TELEKOM AG, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Cheng-Hsin Hsu, Kyu-Han Kim, Jatinder Pal Singh, David M. Chen, Sam Tsai, Bernd Girod
  • Lipocationic polymers and uses thereof
    Patent number: 9801944
    Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 31, 2017
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Daniel J. Siegwart, Jing Hao, Kejin Zhou, Jason Miller, Petra Kos, Lian Xue
  • Methyl butenol synthase
    Patent number: 9803186
    Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: October 31, 2017
    Assignee: Board of Trustees of Michigan State University
    Inventors: Dennis Gray, Thomas D Sharkey
  • Wireless communication methods, systems, and computer program products
    Patent number: 9806791
    Abstract: A method, wireless device and computer program product for expanding the coverage of a cellular network. A wireless device (e.g., cellular telephone) is able to communicate with a base station in a cell of the cellular network over a non-cellular interface via another wireless device in a cell through the use of multi-hopping. A wireless device may request permission to communicate with the base station over a non-cellular interface via hopping off another wireless device when its signal strength is below a threshold. Alternatively, a wireless device may receive a request to communicate with the base station over a non-cellular interface via hopping off the wireless device that sent the request when that wireless device has excess capacity in its bandwidth with the base station.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: October 31, 2017
    Assignee: Board Of Regents, The University Of Texas System
    Inventors: Vidur Bhargava, Sriram Vishwanath, Jubin Jose
  • Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
    Patent number: 9801863
    Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: October 31, 2017
    Assignees: Case Western Reserve University, Board of Regents of the Univeristy of Texas System
    Inventors: Sanford Markowitz, Amar Desai, Stanton Gerson, Joseph Ready
  • Fiber optic directional sensor with wide-field optical field expanding element and method
    Patent number: 9804251
    Abstract: A fiber optic directional sensor has a substantially hemispherical dome surface and a substantially flat surface. The sensor is formed from a plurality of optical fibers fused to one another, and each optical fiber extends from the dome surface to the flat surface. One end of each optical fiber is substantially perpendicular to the sensor's dome surface, and the opposite end of the fiber is substantially perpendicular to the sensor's flat surface such that an end face of the fiber is substantially tangent to the dome surface, and another end face of the fiber is substantially tangent to the flat surface. The sensor further includes an optical element which expands the field of view of the sensor and chromatically controls the incoming light. Using the sensor, light from projectiles, such as missiles, bullets, and other weaponry, can be detected, and the locations of the projectiles can be determined.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: October 31, 2017
    Assignee: Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
    Inventor: Patrick John Reardon
  • Diagnostic method for pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorder associated with streptococci infection (PANDAS)
    Patent number: 9804171
    Abstract: The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) in an individual. These include enzyme linked immunosorbent assays (ELISAs) to measure antibody titers against neuronal antigens present in the brain; the neuronal antigens include lysoganglioside, tubulin, dopamine receptor D1, dopamine receptor D2, serotonin receptor 5HT2A, and serotonin receptor 5HT2C. Antibody titers against at least four of these neuronal antigens are required in the present methods; preferably antibody tiers against all of these neuronal antigens are measured. A final assay is used to quantify calcium/calmodulin-dependent protein kinase activity using a neuronal cell line.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: October 31, 2017
    Assignees: The Board of Regents of the University of Oklahoma, Moleculera Labs, Inc., National Institutes of Health
    Inventors: Phina Madeleine Cunningham, Craig David Shimasaki, Susan E. Swedo, Christine Kirvan
  • Variable imaging arrangements and methods therefor
    Patent number: 9807287
    Abstract: Various approaches to imaging involve selecting directional and spatial resolution. According to an example embodiment, images are computed using an imaging arrangement to facilitate selective directional and spatial aspects of the detection and processing of light data. Light passed through a main lens is directed to photosensors via a plurality of microlenses. The separation between the microlenses and photosensors is set to facilitate directional and/or spatial resolution in recorded light data, and facilitating refocusing power and/or image resolution in images computed from the recorded light data. In one implementation, the separation is varied between zero and one focal length of the microlenses to respectively facilitate spatial and directional resolution (with increasing directional resolution, hence refocusing power, as the separation approaches one focal length).
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 31, 2017
    Assignee: Board of Trustees of the Leland Stanford Junior University
    Inventors: Yi-Ren Ng, Patrick M. Hanrahan, Mark A. Horowitz, Marc S. Levoy
  • All-optical proteretic photonic integrated device
    Patent number: 9806697
    Abstract: An apparatus and a method for a design and a simulation of an all-optical proteretic bi-stable device. The proteresis is a reversed hysteresis with an interesting characteristic which increases the oscillation frequency of a feed-back system with a relaxation dynamics by reducing the feed-back delay. The calculation of the bi-stable device parameters, a simulation of the theoretical device, and a simulation of the all-optical device are given. Applications of the proteretic device in ultra-high speed oscillations are also disclosed.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 31, 2017
    Assignee: Board of Trustees, Southern Illinois University
    Inventors: Mohammad R. Sayeh, Nima Davoudzadeh Mahboub Sedigh, Mohamad Tafazoli Mehrjerdi
  • Method for creating topographical patterns in polymers via surface energy patterned films and the marangoni effect
    Patent number: 9804494
    Abstract: Using a broadband light source and a photomask, surface energy gradients can be directly transferred into polymer films. The Marangoni effect causes high surface energy regions to rise upon heating the film. This leads to the formation of three-dimensional topography that can be locked in by quenching the polymer by cooling.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: October 31, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Christopher J. Ellison, Joshua M. Katzenstein, Dustin W. Janes
  • Branched siloxanes and methods for synthesis
    Patent number: 9802968
    Abstract: The present invention describes branched and functionalized siloxanes and methods for making such compounds. The compounds have a variety of uses. One preferred application is as novel planarizing material for lithogaphy, in which case functionalized branched siloxane, such as an epoxy-modified branched siloxane is particularly useful.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: October 31, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: C. Grant Willson, Tsuyoshi Ogawa, Michael B Jacobsson
  • Lipid substitution on aminoglycoside based polymers: plasmid delivery, anticancer drug delivery and transgene expression
    Patent number: 9801954
    Abstract: A method to form a lipid-containing aminoglycoside-based polymer, where the method includes reacting an aminoglycoside with a diepoxide to form an aminoglycoside-based polymeric material, and then reacting the aminoglycoside-based polymeric material with an acyl chloride to form the lipid-containing aminoglycoside-based polymer.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 31, 2017
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Kaushal Rege, Bhavani Miryala, Thrimoorthy Potta
  • Radioactive nanoparticles and methods of making and using the same
    Patent number: 9801962
    Abstract: In one aspect, radioactive nanoparticles are described herein. In some embodiments, a radioactive nanoparticle described herein comprises a metal nanoparticle core, an outer metal shell disposed over the metal nanoparticle core, and a metallic radioisotope disposed within the metal nanoparticle core or within the outer metal shell. In some cases, the radioactive nanoparticle has a size of about 30-500 nm in three dimensions. In addition, in some embodiments, the radioactive nanoparticle further comprises an inner metal shell disposed between the metal nanoparticle core and the outer metal shell. The metal nanoparticle core, outer metal shell, and inner metal shell of the radioactive nanoparticle can have various metallic compositions.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: October 31, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xiankai Sun, Yaowu Hao, Sina Moeendarbari
  • Materials and methods for rapid and specific detection of cocaine
    Patent number: 9804178
    Abstract: The invention pertains to a rapid and specific aptamer-based method for one-step cocaine detection with minimal reagent requirements based on an aptamer sensor that reports the presence of cocaine via the displacement and unquenching of a bound fluorophore molecule. In certain embodiments, the invention provides novel aptamers, which have reduced background fluorescence, bind a fluorophore molecule tightly, and show an increased signal gain in the presence of cocaine.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: October 31, 2017
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Daniel Roncancio, Haixiang Yu, Xiaowen Xu, Yi Xiao
  • HIF-2alpha INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS
    Publication number: 20170304300
    Abstract: The present disclosure relates to HIF-2? inhibitors and methods of making and using them for treating iron overload disorders. Certain compounds were potent in HIF-2? scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and reduced liver iron accumulation and serum iron parameters in both prophylactic and treatment mouse models.
    Type: Application
    Filed: September 25, 2015
    Publication date: October 26, 2017
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Richard Keith BRUICK, Yaomin CHEN, Julio Cesar Francisco RUIZ
  • REMOTE CONTROL AND CONCIERGE SERVICE FOR AN AUTONOMOUS TRANSIT VEHICLE FLEET
    Publication number: 20170308082
    Abstract: Methods and systems for assisting autonomous vehicles are provided. The methods and systems can help increase safety and consumer satisfaction with autonomous vehicles and help bridge the gap towards completely autonomy. A method for assisting autonomous vehicles can include providing an autonomous vehicle having sensory inputs and providing a remote control center having two-way communication with the autonomous vehicle. The autonomous vehicle can send its sensory input information to the control center and the control center can send control information to the autonomous vehicle.
    Type: Application
    Filed: February 10, 2017
    Publication date: October 26, 2017
    Applicant: The Florida International University Board of Trustees
    Inventors: Oliver Ullrich, Naphtali Rishe
  • Infravein Vasculature Visualization Device
    Publication number: 20170303848
    Abstract: Embodiments of the devices described herein are directed to a vein imaging system which adds user protection, variable positioning, and portability to an established imaging modality, near infrared (NIR) videography and videogrammetry.
    Type: Application
    Filed: April 26, 2017
    Publication date: October 26, 2017
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Kreg Zimmern, Kristen Hamalainen, Andrew Shiels, Sanjiv Patel, Teja Guda