Abstract: In one embodiment of the present disclosure, a device is disclosed comprising a macroscopic thermal body and an extraction structure that is electromagnetically-coupled to the thermal emitting area of the thermal body. The macroscopic thermal body having a thermal emitting area, and the extraction structure configured and arranged to facilitate emission from, or receipt to the thermal emitting area that exceeds a theoretical, Stefan-Boltzmann, emission limit for a blackbody having the same thermal emitting area as the thermal body.
Type:
Application
Filed:
March 14, 2013
Publication date:
April 17, 2014
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Zongfu Yu, Nicholas Sergeant, Torbjorn Skauli, Gang Zhang, Hailiang Wang, Shanhui Fan
Abstract: The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.
Type:
Application
Filed:
September 30, 2013
Publication date:
April 17, 2014
Applicant:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Mehdi Javanmard, Sam Emaminejad, Janine Mok, Michael N. Mindrinos
Abstract: Described herein are methods and compositions for high efficiency transfection of siRNA into a cell population. Such methods and compositions utilize a low voltage pre-conditioning pulse to modulate the efficiency of siRNA transfection. In some embodiments, the methods and compositions permit spatial and temporal control of siRNA transfection efficiency within a population of cells. The disclosed methods and compositions, in some embodiments, are amenable to high throughput applications such as siRNA library-based phenotypic screening.
Abstract: Contaminant mass collection in saturated sedimentary environments for bioavailability determination. A casing includes a screen between the environment that is subject to sampling, such as a saturated sediment and the device itself. The casing includes a water intake zone, a pump, and sorptive media. The water intake zone, the pump, the screen and the sorptive media, are all operably linked in sequence. The screened casing is secured to form an in situ device; the screen is in fluid communication with the water intake zone and excludes endemic sediments and aquatic life. The in situ device is deployed in the saturated sedimentary environment. The pump operates to concentrate analytes from the selected environment in the sorptive media, where the concentrated analytes include the analyte mass of time-weighted fluid samples.
Abstract: Certain embodiments are directed to methods of identifying a subject having a higher risk of prostate cancer recurrence. The methods can include the step of measuring levels of one or more of FLIP, transcription factor Sp1, and transcription factor Sp3 in a prostate sample from the subject, wherein elevated levels of FLIP, transcription factor Sp1, and transcription factor Sp3 identify a subject as high risk for prostate cancer recurrence.
Type:
Application
Filed:
September 11, 2013
Publication date:
April 17, 2014
Applicant:
The Board of Regents of the University of Texas System
Inventors:
Addanki Pratap Kumar, Izhar Singh Batth, Rita Ghosh, Roble Bedolla, Ian M. Thompson
Abstract: The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorrophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.
Type:
Application
Filed:
December 13, 2013
Publication date:
April 17, 2014
Applicant:
Board of Regents of the Nevada System of Higher Education, on behald of the University of Nevada,
Inventors:
Suk-Wah Tam-Chang, Kenneth W Hunter, Nelson G Publicover
Abstract: A magnetic oxide-quantum dot nanocomposite and methods of synthesizing it. In one embodiment, the magnetic oxide-quantum dot nanocomposite has at least one magnetic oxide nanoparticle coated with a silica (SiO2) shell and terminated with at least one thiol group (—SH), and at least one CdSe/ZnS quantum dot linked with the at least one SiO2-coated magnetic oxide nanoparticle via the at least one thiol group. In one embodiment, the at least one magnetic oxide nanoparticle comprises at least one iron oxide (Fe3O4) nanoparticle.
Type:
Grant
Filed:
March 25, 2011
Date of Patent:
April 15, 2014
Assignee:
Board of Trustees of The University of Arkansas
Inventors:
Alexandru S. Biris, Yang Xu, Daoyuan Wang
Abstract: The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections.
Type:
Grant
Filed:
September 2, 2009
Date of Patent:
April 15, 2014
Assignees:
University of Maryland, Baltimore, Arizona Board of Regents A Body Corporate of the State of Arizona
Inventors:
Mark E. Shirtliff, Rebecca A. Brady, Jeffrey G. Leid, Timothy L. Vail, Jennifer M. Kofonow
Abstract: Posterior spinal stabilization devices that engage vertebral structures of at least two verterbrae and increase the stability between the two vertebrae. In some embodiments the stabilization devices engage laminae of at least two vertebrae. The devices can be adapted, however, to engage at least one of a variety of vertebral structures (e.g., spinous process, lamina, transverse process, etc.) of a plurality of vertebrae to decrease vertebral motion between at least two vertebrae.
Type:
Grant
Filed:
October 30, 2008
Date of Patent:
April 15, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: An apparatus and method for generating co-registerable images for processing is disclosed. The apparatus includes a dichroic filter that splits an electro-magnetic beam into first and second split beams, and a mirror that reflects the second split beam. The dichroic filter and the first and second split beams are arranged to direct the first and second split beams, respectively, along substantially parallel but non overlapping paths.
Type:
Grant
Filed:
October 29, 2012
Date of Patent:
April 15, 2014
Assignee:
The Board of Regents for Oklahoma State University
Abstract: Methods and apparatus for storing information or energy. An array of nano vacuum tubes is evacuated to a pressure below 10?6 Torr, where each nano vacuum tube has an anodic electrode, a cathodic electrode spaced apart from the anodic electrode, and an intervening evacuated region. An excess of electrons is stored on the cathodic electrode.
Type:
Grant
Filed:
October 20, 2010
Date of Patent:
April 15, 2014
Assignee:
The Board of Trustees of the University of Illinois
Abstract: The present invention relates to the preparation of hyperpolarized 89Y. Hyperpolarized 89Y may be used as nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) agents for sensitive detection and imaging.
Type:
Grant
Filed:
October 9, 2009
Date of Patent:
April 15, 2014
Assignee:
The Board of Regents of The University of Texas System
Inventors:
Zoltan Kovacs, Matthew E. Merritt, A. Dean Sherry
Abstract: An electromagnetic system having a reaction mass with a field winding embedded therein, a base plate having an inner annular surface and an outer annular surface, and an armature winding coupled to at least a portion of the inner annular surface and at least a portion of the outer annular surface of an upper end portion of the base plate. In operation, directing an electric current in at least one of the field winding and the armature winding causes at least one of the base plate and the reaction mass to move relative to each other. The electromagnetic system can be used for seismic exploration and vibroseis applications, among other uses.
Type:
Grant
Filed:
March 16, 2010
Date of Patent:
April 15, 2014
Assignee:
Board of Regents, The University of Texas System
Inventors:
Ray Zowarka, John Uglum, Jim Upshaw, Charles Penney, Hsing-Pang Liu, Stephen Manifold, Kent Davey, Bryan Bunkowski, David Prater
Abstract: A calorimeter device includes various components located on a common substrate. A first (calorimeter) integrated chip device is located on the substrate. This first device has a first microfluidic channel that has first side and a second side. A first heat sensing circuit is located on the first side of the first channel and a second heat sensing circuit is located on the second side of the channel, opposite the first side and facing the first heat sensing circuit. A second integrated chip device is located on the substrate and proximal to the first device. The second device includes a second microfluidic channel having a third side and fourth side. A third heat sensing circuit is located on the third side of the second channel. A fourth heat sensing circuit is located on the fourth side of the channel, opposite the third side and facing the third heat sensing circuit.
Type:
Grant
Filed:
May 25, 2012
Date of Patent:
April 15, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior Univerity
Abstract: A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.
Type:
Grant
Filed:
October 12, 2012
Date of Patent:
April 15, 2014
Assignees:
MicroTransponder, Inc., The Board of Regents, The University of Texas System
Inventors:
Michael P. Kilgard, Navzer Engineer, David Michael Pierce, Robert L. Rennaker
Abstract: Image data is processed to facilitate focusing and/or optical correction. According to an example embodiment of the present invention, an imaging arrangement collects light data corresponding to light passing through a particular focal plane. The light data is collected using an approach that facilitates the determination of the direction from which various portions of the light incident upon a portion of the focal plane emanate from. Using this directional information in connection with value of the light as detected by photosensors, an image represented by the light is selectively focused and/or corrected.
Type:
Grant
Filed:
August 26, 2013
Date of Patent:
April 15, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ren Ng, Patrick Hanrahan, Marc S. Levoy, Mark A. Horowitz
Abstract: Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.
Type:
Grant
Filed:
November 18, 2011
Date of Patent:
April 15, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: This invention relates to methods for optimizing a golf swing by measuring and providing feedback on a combination of various key parameters of a subject's movement to both generate more power and reduce injury.
Type:
Grant
Filed:
July 27, 2012
Date of Patent:
April 15, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Jessica Rose, David W. Meister, Amy L. Ladd, Katherine M. Steele
Abstract: A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.
Type:
Grant
Filed:
May 1, 2007
Date of Patent:
April 15, 2014
Assignees:
Johns Hopkins University, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Corinne Bright, Rachel Bright, Eric Churchill, Kam W. Leong, Daria Mochly-Rosen