Abstract: Molecules that interact with the NKT cell antigen receptor and its counterpart antigen presenting molecule, but which inhibit the NKT cell immune function, are administered to a patient. Conditions of particular interest include the treatment of systemic lupus erythematosus (SLE), cancer, atherosclerosis, and allergic disease. In some embodiment of the invention, the inhibitory agent is an anergizing glycolipid, for example ?-galactosylceramide. Pharmaceutical formulations of such glycolipids are provided, and find use in the treatment of diseases involving undesirable NKT cell activation.
Type:
Grant
Filed:
February 1, 2010
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Samuel Strober, Everett Hurteau Meyer, Dale T. Umetsu
Abstract: Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.
Type:
Grant
Filed:
January 11, 2012
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Garry P. Nolan, Erin F. Simonds, Sean C. Bendall
Abstract: Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, device surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide.
Type:
Grant
Filed:
May 28, 2009
Date of Patent:
March 25, 2014
Assignees:
State of Oregon by and through the State Board of Higher Education on behalf of Porland State University, State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
Inventors:
Mingdi Yan, Olof Ramström, Li-Hong Liu, Xin Wang, Michael M. Lerner, Tosapol Maluangnont
Abstract: An optical sensor, a method of configuring an optical sensor, and a method of using an optical sensor are provided. The optical sensor includes an optical loop having a length and a laser source optically coupled to the loop. The laser source has a coherence length. Light from the source is transmitted to the loop as a first signal and a second signal counterpropagating along the loop. The optical paths of the first signal and the second signal are substantially reciprocal with one another and the first signal and the second signal are combined together after counterpropagating through the loop to generate a third signal. A ratio of the coherence length to the length of the loop is greater than 1.
Type:
Grant
Filed:
March 25, 2013
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Michael J. F. Digonnet, Shanhui Fan, Seth Lloyd
Abstract: Short hairpin RNA (shRNA) interference therapy targeting hypoxia inducible factor—lot (HIF-1 ?) prolyl-4-hydroxylase protein (HIF-PHD2) is used for treatment of myocardial ischemia. This treatment can be followed noninvasively by molecular imaging. Provided are compositions comprising novel vectors encoding shRNA targeting the HIF-1? and asparaginyl hydroxylase genes. The vectors encoding shRNA are also useful for the treatment of cardiac diseases, peripheral vascular diseases and decubitis ulcers.
Type:
Grant
Filed:
September 15, 2009
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Joseph C. Wu, Mei Huang, Amato J. Giaccia, Denise Chan
Abstract: Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated. By counting the number of sequence tags mapped to a predefined window in each chromosome, the over- or under-representation of any chromosome in maternal plasma DNA contributed by an aneuploid fetus can be detected. This method does not require the differentiation of fetal versus maternal DNA. The median count of autosomal values is used as a normalization constant to account for differences in total number of sequence tags is used for comparison between samples and between chromosomes.
Type:
Grant
Filed:
May 6, 2011
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Hei-Mun Christina Fan, Stephen R. Quake
Abstract: An autonomic conductivity restoration system includes a solid conductor and a plurality of particles. The particles include a conductive fluid, a plurality of conductive microparticles, and/or a conductive material forming agent. The solid conductor has a first end, a second end, and a first conductivity between the first and second ends. When a crack forms between the first and second ends of the conductor, the contents of at least a portion of the particles are released into the crack. The cracked conductor and the released contents of the particles form a restored conductor having a second conductivity, which may be at least 90% of the first conductivity.
Type:
Grant
Filed:
June 20, 2011
Date of Patent:
March 25, 2014
Assignee:
Board of Trustees of the University of Illinois
Inventors:
Benjamin J. Blaiszik, Susan A. Odom, Mary M. Caruso, Aaron C. Jackson, Marta B. Baginska, Joshua A. Ritchey, Aaron D. Finke, Scott R. White, Jeffrey S. Moore, Nancy R. Sottos, Paul V. Braun, Khalil Amine
Abstract: The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular components. Additional embodiments relate to procedures in which various of the devices are used cooperatively. Certain embodiments of the medical devices are robotic in vivo devices.
Type:
Grant
Filed:
November 26, 2008
Date of Patent:
March 25, 2014
Assignee:
Board of Regents of the University of Nebraska
Inventors:
Shane M. Farritor, Amy Lehman, Mark Rentschler
Abstract: Control of a digital communication system having a plurality of communication lines on which signals are transmitted and received is implemented using a variety of methods and systems. According to one embodiment of the present invention, a method is implemented where the signals are affected by interference during transmission and each of the communication lines has at least one transmitter and at least one receiver. A model is created of the interference characteristics due to the signals carried on the communication lines. Interference characteristics for a line are determined based on the model and actual signals carried on other communication lines different from the line for which the characteristics are being determined. Actual interference is compensated for on the communication line using the determined interference characteristics.
Type:
Grant
Filed:
June 19, 2012
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Georgios Ginis, Wei Yu, Chaohuang Zeng, John M. Cioffi
Abstract: Provided are solar cells, photovoltaics and related methods for making solar cells, wherein the solar cell is made of ultrathin solar grade or low quality silicon. In an aspect, the invention is a method of making a solar cell by providing a solar cell substrate having a receiving surface and assembling a printable semiconductor element on the receiving surface of the substrate via contact printing. The semiconductor element has a thickness that is less than or equal to 100 ?m and, for example, is made from low grade Si.
Type:
Grant
Filed:
September 24, 2009
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
John A. Rogers, Angus A. Rockett, Ralph Nuzzo, Jongseung Yoon, Alfred Baca
Abstract: A practical and environmentally-friendly method, i.e. the high temperature-mechanical mixing by using an internal mixing device and a two-roll open milling device is used to produce the carbon blacks-free electrically conductive sulfur-vulcanised rubber blends of solid poly(butadiene-co-acrylonitrile) and solid sulfonic acid doped polyaniline. The addition of sulfur vulcanization system does not affect the electrical properties of the vulcanised blends. All vulcanised blends prepared by using this method show useful electrical conductivities up to the order of 10?2 S/cm, good tensile strengths up to 18.0 MPa and colorable with the addition of a whitening agent. As a result, they have good potential to be used for manufacturing any antistatic products, electrostatic discharge or dissipative products and electromagnetic or radio frequency interferences shielding products.
Abstract: Disclosed embodiments concern solution deposition of at least a first inorganic compound on a substrate, typically for production of electronic devices, such as solution deposition of metal salts, including halides, carbonyls, acetates, sulfates, phosphates, carbonates, and mixtures thereof. Solutions may be deposited using any suitable process, particularly inkjet printing or spin coating. The method can involve depositing only a first solution, depositing a first solution plural times, or deposition of plural different solutions. Furthermore, the method may involve simultaneous or serial deposition of two or more solutions. The method may further comprise post deposition processing the deposited material, such as thermal annealing, oxidation processes, reduction processes, exchange reactions, and combinations thereof.
Type:
Grant
Filed:
November 29, 2006
Date of Patent:
March 25, 2014
Assignee:
State of Oregon acting by and through the State Board of Higher Education action on Behalf of Oregon State University
Abstract: The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.
Type:
Grant
Filed:
August 14, 2009
Date of Patent:
March 25, 2014
Assignees:
Board of Regents, The University of Texas System, Southern Methodist University
Inventors:
Santosh R. D'Mello, Edward R. Biehl, Haribabu Ankati, Shashidhar Kumar Akubathini
Abstract: Methods and compositions are provided for detecting molecular translocations, particularly protein translocations within and between sub-cellular compartments, using at least two components that exhibit a localization-dependent difference in complementation activity. In particular, alpha-complementing ?-galactosidase fragments are provided. These ?-galactosidase reporter fragments display significantly enhanced enzymatic activity when one fragment is localized in a membrane. Methods for carrying out no-wash ELISA assays based on the reporter component system are also provided.
Type:
Grant
Filed:
September 20, 2011
Date of Patent:
March 25, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A new variety of smooth cordgrass identified as ‘LA11-101’ is disclosed as being genetically different from ‘Vermilion’, the only other smooth cordgrass variety for the northern Gulf of Mexico, and as having rapid establishment and growth in natural brackish and saline marsh environments, and excellent seed set and germination.
Type:
Application
Filed:
September 20, 2012
Publication date:
March 20, 2014
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Carrie Ann Knott, Michael David Materne, Herry Sutjahjo Utomo, Prasanta Kumar Subudhi, Niranjan Baisakh, Stephen Alan Harrison
Abstract: A new variety of smooth cordgrass identified as ‘LA11-103’ is disclosed as being genetically different from ‘Vermilion’, ‘LA11-101’, and ‘LA11-102’, as having rapid establishment and growth in natural brackish and saline marsh environments, and excellent seed set and germination.
Type:
Application
Filed:
September 20, 2012
Publication date:
March 20, 2014
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Carrie Ann Knott, Michael David Materne, Herry Sutjahjo Utomo, Prasanta Kumar Subudhi, Niranjan Baisakh, Stephen Alan Harrison
Abstract: A new variety of smooth cordgrass identified as ‘LA11-102’ is disclosed as being genetically different from ‘Vermilion’ and ‘LA11-101’ and as having rapid establishment and growth in natural brackish and saline marsh environments, and excellent seed set and germination.
Type:
Application
Filed:
September 20, 2012
Publication date:
March 20, 2014
Applicant:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
Inventors:
Carrie Ann Knott, Michael David Materne, Herry Sutjahjo Utomo, Prasanta Kumar Subudhi, Niranjan Baisakh, Stephen Alan Harrison
Abstract: Provided herein are methods of inducing psychosis in animals using light-responsive opsins and methods of identifying or screening compounds that may be useful in treating psychosis.
Type:
Application
Filed:
November 4, 2011
Publication date:
March 20, 2014
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Karl Deisseroth, Vikaas Sohal, Lisa Gunaydin
Abstract: Described herein are compact regular programmable fabrics for improved logic density, yield, reliability, performance and power consumption compared with existing programmable fabric based VLSI design. Programmable fabrics facilitate technology transition from current silicon lithographic VLSI design to future non-silicon self-assembled nanoscale device based VLSI design.
Type:
Application
Filed:
November 2, 2011
Publication date:
March 20, 2014
Applicant:
Board of Regents of the University of Texas System
Abstract: A nanocomposite material comprises polyethylene terephthalate (PET) as a base polymer and a nanoparticle that increases the strength of the base polymer.
Type:
Application
Filed:
May 3, 2012
Publication date:
March 20, 2014
Applicant:
THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY