Patents Assigned to Board to Trustees of the Leland Stanford Junior University
  • Graphene hybrid materials, apparatuses, systems and methods
    Patent number: 9236197
    Abstract: Graphene based materials are provided in connection with various devices and methods of manufacturing. As consistent with one or more embodiments, an apparatus includes a graphene sheet and a single-crystal structure grown on the graphene sheet, with the graphene sheet and single-crystalline structure functioning as an electrode terminal. In various embodiments, the single-crystalline structure is grown on a graphene sheet, such as by using precursor particles to form nanoparticles at the distributed locations, and diffusing and recrystallizing the nanoparticles to form the single-crystal structure.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Hailiang Wang
  • High throughput system for isolation, growth, and detection of lipid inclusions in bacteria
    Patent number: 9234229
    Abstract: A method of high throughput growth and quantitative analysis of microorganisms is provided that includes providing a microtiter plate growth and gas delivery system having well plates disposed for growth of the microorganisms, and providing a spectroscopic screening system disposed to analyze lipid inclusions of the microorganisms.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric R. Sundstrom, Craig S. Criddle
  • Anion transport membrane
    Patent number: 9233345
    Abstract: An anion transport membrane is provided enabling efficient anion exchange across the membrane, which could be used in applications like fuel cells, water electrolyzers, or water filtration systems. The structural membrane morphology is based on a hydrophobic polysulfone membrane backbone and co-grafted thereon hydrophilic poly(ethylene glycol) grafts and anion conducting quaternary ammonium species. This structure defines a bi-continuous morphology with locally phase-separated hydrophobic-hydrophilic domains, and a co-localization of the anion conducting quaternary ammonium species with respect to the hydrophilic poly(ethylene glycol) grafts enabling efficient and continuous ion transport channels for facilitating anion transport.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Steve S. He, Curtis W. Frank
  • Methods for treating depression using NCAM peptide mimetics
    Patent number: 9234242
    Abstract: The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: January 12, 2016
    Assignee: THE BOARD OF THE TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Huda Akil, Stanley J. Watson, Cortney Turner, William E. Bunny, Edward G. Jones, Richard M. Myers, Alan F. Schatzberg
  • Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha V beta 3 integrin
    Patent number: 9234021
    Abstract: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jennifer R. Cochran, Adam Silverman, Douglas Jones, Niv Papo
  • Supramolecular functionalization of graphitic nanoparticles for drug delivery
    Patent number: 9233166
    Abstract: Disclosed are nanoparticles, such as carbon nanotubes or other graphitic sheet materials having extended aromatic surfaces, which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a “drug”) to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer or adsorption of an amphiphilic molecule to render them stable in suspension. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Zhuang Liu, Xiaolin Li, Xiaoming Sun
  • Minicircle DNA vector preparations and methods of making and using the same
    Patent number: 9233174
    Abstract: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: January 12, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhi-Ying Chen, Mark A. Kay
  • Closure device and method
    Patent number: 9232947
    Abstract: Devices and methods for treatment of prolapsed hemorrhoidal arteries is disclosed. The devices can identify the hemorrhoid and ligate the artery without causing significant pain or distension of the rectum. The artery can be identified with ultrasound. The ligation can be performed using energy and/or mechanical structures, such as clips or rubber bands.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: January 12, 2016
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Jacob S. Brenner, Gregory A. Magee, Ruey Feng Peh, Erika I. Palmer
  • DEVICE AND METHOD FOR RAPID ASPIRATION AND COLLECTION OF BODY TISSUE FROM WITHIN AN ENCLOSED BODY SPACE
    Publication number: 20160000991
    Abstract: Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Applicant: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Daniel KRAFT, James HOLE
  • Including fiducial markers in radiation therapy planning to facilitate real-time position monitoring during treatment delivery
    Patent number: 9227085
    Abstract: An inverse planning method that is capable of controlling the appearance of the implanted fiducial(s) in segmented IMRT fields for cine MV or combined MV/kV image-guided IMRT is provided. The method for radiation treatment includes computing a radiation treatment plan and delivering beams to a target in accordance with the radiation treatment plan, where computing the radiation treatment plan includes introducing a penalty in an inverse planning objective function optimization calculation to discourage or avoid blockage of one or more fiducials in optimized multi-leaf collimator (MLC) apertures.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: January 5, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yunzhi Ma, Paul J. Keall, Lei Xing
  • Charge perturbation detection system for DNA and other molecules
    Patent number: 9228971
    Abstract: Methods and apparatus for direct detection of chemical reactions are provided. Electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: January 5, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nader Pourmand, Miloslav Karhanek, Ronald W. Davis
  • Methods and compositions for treating or preventing narcotic withdrawal symptoms
    Patent number: 9226918
    Abstract: This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: January 5, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Gary Peltz, David Clark, Lawrence Chu
  • Methods for modulating the expression and aggregation of a CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
    Patent number: 9226935
    Abstract: This invention provides a method for modulating the expression of a first gene in a cell wherein the first gene is one containing more than 36 CAG trinucleotide repeats and encoding a protein that form polyglutamine-mediated protein aggregation. Suppression of the first gene is achieved by reducing the expression of SPT4 gene or SUPT4H gene. It can also be achieved by inhibiting the formation of a Spt4/Spt5 complex or a Supt4h/Supt5h complex. Also provided is a method for identifying an agent useful for modulating the expression and aggregation of CAG-expanded gene product, or treating a polyglutamine disease such as Huntington's disease.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: January 5, 2016
    Assignees: NATIONAL YANG MING UNIVERSITY, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Tzu-Hao Cheng, Chia-Rung Lu, Tzu-Han Wang, Stanley N. Cohen
  • Remote center of motion mechanism and method of use
    Patent number: 9227326
    Abstract: According to one exemplary embodiment, a manipulator device includes a base, first and second linear slides, a drive link, a drive member, a driven member and an end effector. The elements of the manipulator device cooperate to constrain the end effector to rotate about a remote center of motion that is displaced from a proximal center of motion as the drive link moves a carriage of the second linear slide along an arcuate path.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: January 5, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Reuben D. Brewer, J. Kenneth Salisbury, Jr.
  • Imaging and evaluating embryos, oocytes, and stem cells
    Patent number: 9228931
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: January 5, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Connie C. Wong, Kevin E. Loewke, Thomas M. Baer, Rene A. Reijo-Pera, Barry Behr
  • Method of forming macro-structured high surface area transparent conductive oxide electrodes
    Patent number: 9227224
    Abstract: A method of forming a high surface area transparent conducting electrode is provided that includes depositing a transparent conducting thin film on a conductive substrate, where the transparent conducting thin film includes transparent conductive particles and a solution-based transparent conducting adhesive layer which serves to coat and bind together the transparent conducting particles, and heat treating the transparent conducting adhesion layer on the conductive substrate, where an increased surface area transparent conducting electrode is formed.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: January 5, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Arnold J. Forman, Zhebo Chen, Thomas F. Jaramillo
  • COMPOSITIONS AND METHODS TO TREAT LATENT VIRAL INFECTIONS
    Publication number: 20150376583
    Abstract: Viral infection is a persistent cause of human disease. Guided nuclease systems target the genomes of viral infections, rendering the viruses incapacitated.
    Type: Application
    Filed: July 2, 2015
    Publication date: December 31, 2015
    Applicant: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Stephen R. Quake, Jianbin Wang
  • Phased Whole Genome Genetic Risk In A Family Quartet
    Publication number: 20150370963
    Abstract: In an embodiment of the present invention, three novel human reference genome sequences were developed based on the most common population-specific DNA sequence (“major allele”). Methods were developed for their integration into interpretation pipelines for highthroughput whole genome sequencing.
    Type: Application
    Filed: April 13, 2012
    Publication date: December 24, 2015
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Frederick Dewey, Euan Ashley, Matthew Wheeler, Michael Snyder, Carlos Bustamante
  • MODULATION OF SYNAPTIC MAINTENANCE
    Publication number: 20150368325
    Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.
    Type: Application
    Filed: June 26, 2015
    Publication date: December 24, 2015
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ben A. Barres, Beth A. Stevens
  • MODULATION OF SYNAPTIC MAINTENANCE
    Publication number: 20150368326
    Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.
    Type: Application
    Filed: June 26, 2015
    Publication date: December 24, 2015
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ben A. Barres, Beth A. Stevens