Patents Assigned to Boehringer Ingelheim GmbH
  • Publication number: 20150136131
    Abstract: The invention relates to a system composed of an inhaler and a capsule, preferably intended for single use. The capsule contains a preferably powdered pharmaceutical preparation which, for inhalation, is expelled from the capsule through at least one hole. The capsule comprises as capsule elements a capsule cap and a capsule body, at least one of which comprises at least one prefabricated hole. The prefabricated hole in the capsule is sealed off in the transporting state of the system and is open in the usage state. The hole is exposed by actuation of a pulling mechanism. Prior to this the hole is closed off by a capsule receptacle or a film. In one embodiment the capsule may be present in two different states, for example in different insertion positions of the capsule elements. In the first state the prefabricated hole is closed off and in the second it is exposed. Also shown is an inhaler suitable as a disposable product, which is manufactured from thermoformed parts or from blister film.
    Type: Application
    Filed: May 17, 2013
    Publication date: May 21, 2015
    Applicant: Boehringer Ingelheim GmbH, Corporate Patents
    Inventors: Holger Holakovsky, Jessica Frentzel-Beyme, Stephen Terence Dunne, Jens Besseler, Claudius Weiler
  • Publication number: 20130236471
    Abstract: The present invention relates to anti-IL-36R binding compounds, in particular new anti-IL-36R antibodies and therapeutic and diagnostic methods and compositions for using the same.
    Type: Application
    Filed: November 14, 2012
    Publication date: September 12, 2013
    Applicant: Boehringer Ingelheim GmbH
    Inventors: Su-Ellen BROWN, Keith Canada, Lukasz Chlewicki, Michael Howell, Detlev Mennerich, Joseph Robert Woska, JR.
  • Publication number: 20120037157
    Abstract: An inhaler (1) including a blister strip (2) is proposed. The unused blister strip is stored in a spiral (16). After use, the blister strip is conveyed into another spiral (17). Both spirals share a common space within the inhaler and may be separated by a loose guiding element (18). The spirals and the guiding element may comprise protrusions (19) to reduce sliding friction. Additionally or alternatively, a lubricant (31) may be used to reduce friction.
    Type: Application
    Filed: December 14, 2009
    Publication date: February 16, 2012
    Applicants: VECTURA DELIVERY DEVICES LIMITED, BOEHRINGER INGELHEIM GMBH, CD PATENTS
    Inventors: Marc Rohrschneider, Manuel Krakowka, Herbert Wachtel, Nicholas John Campling, Duncan James Bradley, Tristian Roger Thornhill, Howard William Biddle, Matthew Sarkar, Stephen Eason, Graham Gibbins
  • Publication number: 20110094507
    Abstract: A passive inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (3) is proposed. The inhaler comprises an impaction element (31) onto which the air stream can impact together with entrained inhalation formulation for better deagglomeration. Alternatively, the inhaler comprises an oscillating and/or vibrating device (35) for better de-agglomeration of the inhalation formulation. Alternatively or additionally, the inhaler comprises one or two mixing means for generating swirls, preferably with opposite rotation directions.
    Type: Application
    Filed: December 29, 2008
    Publication date: April 28, 2011
    Applicants: Vectura Delivery Devices Limited, Boehringer Ingelheim GmbH, CD Patents
    Inventors: Herbert Wachtel, Quentin John Harmer, Matthew Neil Sarkar, Ivan Milivojevic
  • Publication number: 20110041841
    Abstract: A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler has a flow resistance of at least 75000 Pa1/2s/m3.
    Type: Application
    Filed: January 19, 2009
    Publication date: February 24, 2011
    Applicants: Vectura Delivery Devices Limited, Boehringer Ingelheim GmbH, CD Patents
    Inventors: Herbert Wachtel, Quentin John Harmer, Stephen William Eason
  • Patent number: 7758936
    Abstract: The present invention relates to a new pharmaceutical blister with reduced permeability to water vapor and gas. It is proposed according to the invention to coat conventional blisters with a silicon oxide-containing functional layer to protect against gases, water vapor and organic molecules.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: July 20, 2010
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Michael Spallek, Burkhard Metzger
  • Patent number: 7694676
    Abstract: An inhaler for inhaling powdered pharmaceutical compositions from capsules includes: a lower part; a plate which can be latched to the lower part and with which the lower part can be closed off; a capsule holder for receiving the capsules, this holder being adapted to be lowered into the lower part; a mouthpiece latchable to the plate; a lid which covers the mouthpiece in a closed position and latches it by means of a closure element, the lower part, the plate, the mouthpiece and the lid being hinged together by means of a single joint; and an actuating member which can be moved out a resting position and thereby interacts with at least one pin which can be made to pierce the capsule holder.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: April 13, 2010
    Assignee: Boehringer Ingelheim GmbH
    Inventor: Herbert Wachtel
  • Publication number: 20040143235
    Abstract: Foil bags are used as a primary packaging for liquids, the bags permitting the liquid to be taken therefrom without the application of a considerable amount of force. A container is provided for a medicinal liquid, the container being gas-tight and liquid-tight so that it is storable over many months. The container includes a collapsible foil bag on which a flange, which is stable in respect of shape, is disposed. The flange is designed for fitting onto a discharge connection member. The container can be disposed in a casing which is stable in respect of shape. The medicinal liquid does not come into contact with air and is protected from the effect of light. The medicinal liquid may be dispensed from the foil bag in many partial quantities over a prolonged period of time, with a respective partial amount thereof being converted into an aerosol by means of an atomizer.
    Type: Application
    Filed: January 12, 2004
    Publication date: July 22, 2004
    Applicant: Boehringer Ingelheim GmbH
    Inventors: Bernhard Freund, Dieter Hochrainer, Heinrich Kladders, Bernd Zierenberg, Joachim Eicher, Johannes Geser, Martin Essing, Holger Reinecke
  • Patent number: 6685691
    Abstract: Foil bags are used as a primary packaging for liquids, the bags permitting the liquid to be taken therefrom without the application of a considerable amount of force. A container is provided for a medicinal liquid, the container being gas-tight and liquid-tight so that it is storable over many months. The container includes a collapsible foil bag on which a flange, which is stable in respect of shape, is disposed. The flange is designed for fitting onto a discharge connection member. The container can be disposed in a casing which is stable in respect of shape. The medicinal liquid does not come into contact with air and is protected from the effect of light. The medicinal liquid may be dispensed from the foil bag in many partial quantities over a prolonged period of time, with a respective partial amount thereof being converted into an aerosol by means of an atomizer.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: February 3, 2004
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Bernhard Freund, Dieter Hochrainer, Heinrich Kladders, Bernd Zierenberg, Joachim Eicher, Johannes Geser, Martin Essing, Holger Reinecke
  • Patent number: 6465483
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group  wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: October 15, 2002
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Patent number: 6402055
    Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: June 11, 2002
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Joachim Jaeger, Pasquale Cirillo, Joachim Eicher, Johannes Geser, Bernhard Freund, Bernd Zierenberg
  • Patent number: 6180645
    Abstract: A compound of formula I wherein A denotes a benzo, indolo or thieno group; R1 denotes thienyl or the group wherein R7, R8 and R9 independently of one another may represent methyl, ethyl, propyl, phenyl or benzyl, while not more than 2 of the substituents can simultaneously represent phenyl or benzyl; R2, m, R3 and R4 are defined as in the specification, as well as pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: January 30, 2001
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Lösel, Otto Roos, Dietrich Arndts
  • Patent number: 6136819
    Abstract: Compound of general formula I ##STR1## wherein A denotes a benzo, indolo or thienyl group;B denotes the group --O--, --S-- or --CHR.sup.5 --, wherein R.sup.5 is hydrogen, (C.sub.1 -.sub.6)alkyl, phenyl or benzyl;R.sup.3 denotes 2- or 3-thienyl, (C.sub.4 -.sub.7)cycloalkyl, (C.sub.4 -.sub.6)cycloalkyl(C.sub.1 -.sub.5)alkyl or ##STR2## wherein R is (C.sub.1 -.sub.4)alkyl, hydroxy, --N.sub.3, halogen (F, Cl, Br, I), CF.sub.3 or (C.sub.1 -.sub.4)alkoxy,u is 0, 1, 2 or 3, andm, R.sup.2, R.sup.4, R.sup.7, R.sup.8 and R.sup.9 are as defined in the specification, as well as pharmaceutical preparations containing these compounds and the pharmaceutical use thereof.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: October 24, 2000
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Otto Roos, Walter Losel, Dietrich Arndts
  • Patent number: 6071939
    Abstract: A composition comprising diethyl (E)-4-[2-[(tert-butyloxycarbonyl)vinyl]phenyl-1,4-dihydro-2,6-dimethylpyri dine-3,5-dicarboxylate (lacidipine) and 4'-[[2-n-propyl-4-methyl-6 -(1-methylbenziimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2 -carboxylic acid (telmisartan) or a physiologically functional derivative thereof.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: June 6, 2000
    Assignees: Glaxo Group Limited, Boehringer Ingelheim GmbH
    Inventors: Giovanni Gaviraghi, Mauro Quartaroli
  • Patent number: 5964416
    Abstract: A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be partially or completely disposed within the hollow piston. The device is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol of a liquid medicament without the use of propellant gas.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: October 12, 1999
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Joachim Jaeger, Pasquale Cirillo, Joachim Eicher, Johannes Geser
  • Patent number: 5922878
    Abstract: The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein the group R.sup.2 is ##STR2## and R.sup.1, A, G, Y, Z and m have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: July 13, 1999
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Franz Esser, Gerd Schnorrenberg, Horst Dollinger, Brigit Jung, Erich Burger, Georg Speck
  • Patent number: 5767279
    Abstract: The present invention relates to new enantiomerically pure pyridylcycloalkylethylamines of formula 1a and 1b, the salts thereof as well as to methods of preparing them and their use as intermediate products.
    Type: Grant
    Filed: August 10, 1995
    Date of Patent: June 16, 1998
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Heinrich Schneider, Gerd-Rainer Bressler
  • Patent number: 5712397
    Abstract: The invention relates to new amino acid derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein the group R.sup.2 is ##STR2## and R.sup.1, A, G, Y, Z and m have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 27, 1998
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Franz Esser, Gerd Schnorrenberg, Horst Dollinger, Birgit Jung, Erich Burger, Georg Speck
  • Patent number: 5712273
    Abstract: The invention relates to new amino acid derivatives of general formula IR.sup.1 -R.sup.11 --A.sup.1 --B (I)and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, and whereinR.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.5 and R.sup.11 have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: January 27, 1998
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Gerd Schnorrenberg, Franz Esser, Horst Dollinger, Birgit Jung, Georg Speck, Erich Burger
  • Patent number: 5709305
    Abstract: A new dispenser for solid pharmaceutical preparations consists of a flat container with a removal well 3 which can be closed or opened by the flipping round of a closure member 5 with a convexity 6 engaging in the removal well 3.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: January 20, 1998
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Dieter Essig, Heribert Hausler, Hans-Dieter Ruthemann, Klaus-Dieter Eckert, Frank Landwehr, Thomas Zimmer, Dieter Berndt, Thomas Reiner, Gunter Horntrich, Reiner Reeg