Abstract: Disclosed is a method of treating tumors capable of being treated with interferon by administering interferon and dipyridamole, or pharmaceutically acceptable salts thereof, in amounts sufficient to enhance the anti-tumor effect of interferon. Further disclosed is a pharmaceutical composition comprising interferon and dipyridamole.
Abstract: A process for producing trimethylene carbonate wherein 1,3-propanediol is reacted with diethylcarbonate in the presence of zinc powder, zinc oxide, tin powder, tin halide or an organo-tin compound, at an elevated temperature.
Type:
Grant
Filed:
June 17, 1992
Date of Patent:
May 18, 1993
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Klaus R. Muller, Berthold Buchholz, Joachim Hess
Abstract: Disclosed are new cyclic amine derivatives of the formula I ##STR1## wherein the substituents are defined in the specification. These compounds are useful as for treating sinus tachycardia.
Type:
Grant
Filed:
July 3, 1991
Date of Patent:
December 29, 1992
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Manfred Psiorz, Joachim Heider, Andreas Bomhard, Manfred Reiffen, Norbert Hauel, Klaus Noll, Berthold Narr, Christian Lillie, Walter Kobinger, Jurgen Dammgen
Abstract: The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.
Type:
Grant
Filed:
October 11, 1991
Date of Patent:
October 13, 1992
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Karl-Heinz Weber, Albrecht Harreus, Jorge Casals-Stenzel, Gojko Muacevic, Wolfgang Troger, Gerhard Walther
Abstract: A resorbable osteosynthesis device consisting of: 1) a resorbable plate, in which the side of the plate facing the bone is coated with calcium phosphate and/or hydroxyl apatite; and 2) preferably, a resorbable fixing device consisting of a threaded bolt which is optionally coated with calcium phosphate and/or hydroxyl apatite, and a nut which can be fitted onto the threaded bolt.
Type:
Grant
Filed:
September 15, 1989
Date of Patent:
April 28, 1992
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Jurgen Eitenmuller, Heinz Offergeld, Walter Michaeli
Abstract: The invention relates to a method of separation by liquid chromatography for preparing enantiomerically pure hetrazines, using cellulose triacetate as a stationary phase and a polar solvent as a mobile phase.
Abstract: The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1-C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably C1 or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.
Type:
Grant
Filed:
June 15, 1990
Date of Patent:
January 21, 1992
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Karl-Heinz Weber, Albrecht Harreus, Jorge Casals-Stenzel, Gojko Muacevic, Wolfgang Troger, Gerhard Walther
Abstract: Amino acid derivatives of general formula ##STR1## (the definitions of the various symbols being explained in the specification) are suitable for treating high blood pressure and for cardioprotection. The new compounds are prepared and used in the usual way.
Type:
Grant
Filed:
September 6, 1989
Date of Patent:
April 16, 1991
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Gerd Schnorrenberg, Otto Roos, Walter Losel, Ingrid Wiedemann, Wolfram Gaida, Wolfgang Hoefke, Dietrich Arndts, Ilse Streller
Abstract: Disclosed is a method of treating tumors capable of being treated with interferon which is comprised of interferon and dipyridamole, or pharmaceutically acceptable salts thereof, in amounts sufficient to enhance the anti-tumor effect of interferon. Further disclosed is a pharmaceutical composition comprised of interferon and dipyridamole.
Abstract: By using .alpha.-mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilization of fodder and the ratio of muscle to fat in favour of the proportion of muscle and protein.
Type:
Grant
Filed:
October 25, 1988
Date of Patent:
November 13, 1990
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Werner Bomann, Franz Esser, Ulrich Hamel, Helmut Stable
Abstract: Oxoquinazoline derivatives of formulae ##STR1## (the symbols are defined in the specification) are well-tolerated drugs for treating hyperuricaemia.
Abstract: This invention relates to a pharmaceutical dosage unit composition consisting essentially of a gelatin capsule containing (1) a disintegrating core comprising clonidine, said disintegrating core having a readily water-soluble coating, and (2) a plurality of non-disintegrating cores comprising clonidine, said non-disintegrating cores having a coating consisting of from 20 to 90 percent by weight of a water-insoluble film former and from 10 to 80 percent by weight of a water-soluble polymer, the diameter of each of the disintegrating and non-disintegrating cores being at least about 5 mm.
Type:
Grant
Filed:
April 27, 1984
Date of Patent:
March 25, 1986
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Herbert Stricker, Bernhard Freund, Heribert Harwalik, Karl L. Rominger, Siegfried Darda, Volkmar Haselbarth, Dietrich Arndts, Wolf D. Bechtel, Gerhard Bozler, Rolf Brickl, Peter Gruber
Abstract: This invention is directed to a method for the non-contact application of letters or symbols to the exterior surfaces of uncoated tablets or uncoated tablet cores, which comprises dotting color solution or suspension by means of an ink-jet printer in specific quantity in the form of discrete droplets of specific volume onto the exterior surfaces of the uncoated tablets or uncoated tablet cores.
Abstract: Compounds of the formula ##STR1## wherein A is phenyl; 4-hydroxy-phenyl; 2- or 3-thienyl; cyclohexyl; cyclohexen-1-yl; cyclohexa-1, 4-dien-1-yl; or 3,4-disubstituted phenyl, where the substituents may be identical to or different from each other and are selected from the group consisting of chlorine, hydroxyl or methoxy; andR is an aliphatic, cycloaliphatic; aromatic or heterocyclic group of diverse types;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antibiotics.
Type:
Grant
Filed:
September 21, 1982
Date of Patent:
June 25, 1985
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Bernd Wetzel, Wolfgang Reuter, Eberhard Woitun, Roland Maier, Uwe Lechner, Hanns Goeth, Rolf Werner