Patents Assigned to Boehringer Ingelheim Pharma GmbH & Co. KG
  • Method for Improving the Ability of Patients Suffering from Lung Diseases to Participate In and Benefit from Pulmonary Rehabilitation Programs
    Publication number: 20070099949
    Abstract: A method for improving the ability of a patient suffering from a lung disease to participate in and benefit from a pulmonary rehabilitation program, the method comprising administering to the patient a therapeutically effective amount of a tiotropium salt.
    Type: Application
    Filed: August 31, 2006
    Publication date: May 3, 2007
    Applicants: Boehringer Ingelheim Pharma GmbH & Co. KG, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Bernd Disse, Steven Kesten, Theodore Witek
  • Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH) / prostatic hypertrophy
    Publication number: 20070099918
    Abstract: The present invention relates to the use of specific EGF-receptor antagonists for preparing a pharmaceutical composition for the prevention and/or treatment of benign prostatic hyperplasia and/or prostatic hypertrophy, a method for the treatment or prevention of benign prostatic hyperplasia/prostatic hypertrophy comprising administering an EGF-receptor antagonist of groups (A), (B) or (C), described herein optionally in combination with known compounds for the treatment of benign prostatic hyperplasia/prostatic hypertrophy, as well as associated pharmaceutical compositions.
    Type: Application
    Filed: December 12, 2006
    Publication date: May 3, 2007
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Thomas Singer, Stefan Platz, Florian Colbatzky
  • Use of bradycardiac substances in the treatment of myocardial diseases associated with hypertrophy and novel medicament combinations
    Patent number: 7208508
    Abstract: The present invention relates to the new use of bradycardiac substances such as a Ca++ channel blocker, beta-receptor blocker or if channel blocker, the if channel blockers being preferred, optionally in combination with a cardioactive substance for inducing the regression of myocardial diseases accompanied by hypertrophy, particularly for the treatment of idiopathic hypertrophic cardiomyopathies (HCM) in humans and domestic pets.
    Type: Grant
    Filed: April 7, 2001
    Date of Patent: April 24, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Juergen Daemmgen, Brian Guth, Randolph Seidler
  • Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide
    Patent number: 7189743
    Abstract: The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and 1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: March 13, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Norbert Hauel, Florian Colbatzky, Ulrich Busch
  • Powdered Medicaments Containing A Tiotropium Salt and Salmeterol Xinafoate
    Publication number: 20070031347
    Abstract: The invention relates to powdered preparations for inhalation containing a tiotropium salt and salmeterol xinafoate, processes for preparing them and their use in the preparation of a pharmaceutical composition for treating respiratory diseases, particularly for treating COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: October 2, 2006
    Publication date: February 8, 2007
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Mareke Hartig, Michael Trunk, Rainer Soyka, Peter Sieger, Hagen Graebner, Michael Walz
  • Pyrimidine derivatives
    Patent number: 7173028
    Abstract: The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterised by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: February 6, 2007
    Assignees: Boehringer Ingelheim Pharma GmbH & Co. KG, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Georg Dahmann, Frank Himmelsbach, Bernd Krist, Martin Lenter, Alexander Pautsch, Gisela Schnapp, Martin Steegmaier, Helmut Wittneben, Anthony S. Prokopowicz, Walter Spevak, Andreas Schoop, Steffen Steurer
  • New Process for the Production of Tiotropium Salts
    Publication number: 20070027320
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Application
    Filed: July 24, 2006
    Publication date: February 1, 2007
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Brandenburg, Waldemar Pfrengle
  • Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
    Patent number: 7169936
    Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: January 30, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus C. A. Van Meel, Ulrike Tontsch-Grunt
  • Trisubstituted pyrimidines
    Patent number: 7166599
    Abstract: The present invention relates to trisubstituted pyrimidines of formula wherein Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses in which ?-amyloid modulators have a therapeutic benefit, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: January 23, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Klaus Bornemann, Hans Briem, Cornelia Dorner-Ciossek, Katja Fechteler, Klaus Fuchs, Frank Himmelsbach, Klaus Klinder, Markus Kostka
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Patent number: 7166615
    Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 23, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Crystalline Micronisate, Process for the Manufacture Thereof and Use Thereof for the Preparation of a Medicament
    Publication number: 20070015785
    Abstract: The invention relates to a crystalline micronisate of (1 ?,2?,4?,5?,7?)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide, processes for preparing it and its use for preparing a pharmaceutical composition, particularly for preparing a pharmaceutical composition with an anticholinergic activity.
    Type: Application
    Filed: September 18, 2006
    Publication date: January 18, 2007
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Helmut Bender, Hagen Graebner, Konrad Schindler, Michael Trunk, Michael Walz
  • Resorbable Polyetheresters and Medicinal Implants Made Therefrom
    Publication number: 20070014848
    Abstract: The invention relates to the use of absorbable block copolymers with polyether and polyester units for preparing surgical implants which are suitable for the human or animal body, and the block copolymers in question. The block copolymers used according to the invention and those which are new according to the invention are characterised by high mechanical strength and rapid absorption kinetics.
    Type: Application
    Filed: July 13, 2006
    Publication date: January 18, 2007
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Berthold Buchholz, Anja Enderle
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Patent number: 7160901
    Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 9, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Process for making a non-nucleoside HIV-1 reverse transcriptase inhibitor
    Patent number: 7151174
    Abstract: The invention provides a process for making compounds of the general formula I: wherein R2, R4, R5, R11 and Q are defined as in claim 1. The compounds of the general formula I are effective inhibitors of HIV reverse transcriptase.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: December 19, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Oliver Meyer, Ingo Heddesheimer, Georg Zerban
  • Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
    Patent number: 7148249
    Abstract: The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: December 12, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Kley, Frank Hilberg, Armin Heckel, Gerald Juergen Roth, Thorsten Lehmann-Lintz, Ralf R. H. Lotz, Ulrike Tontsch-Grunt, Jacobus C. A. Van Meel
  • Medicaments comprising steroids and a novel anticholinergic
    Publication number: 20060276441
    Abstract: A pharmaceutical composition comprising: (a) a salt of formula 1 wherein: X? is an anion with a single negative charge; and (b) a steroid 2, processes for preparing such pharmaceutical composition, and their use in the treatment of respiratory complaints.
    Type: Application
    Filed: April 20, 2006
    Publication date: December 7, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rolf Banholzer, Helmut Meissner, Gerd Morschhaeuser, Michael Pieper, Gerald Pohl, Richard Reichl, Georg Speck, Christopher Meade, Michel Pairet
  • Continuous process for preparing dihydropyrones
    Patent number: 7141681
    Abstract: The invention relates to a continuous process for preparing dihydropyrones of general formula I, wherein the groups R1 and R2 have the meanings described herein.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: November 28, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Oliver Meyer, Markus Sauter, Mark Goehlich
  • Dihydroxymethylphenyl derivatives, processes for preparing them, and their use as pharmaceuticals
    Patent number: 7135500
    Abstract: A compound of formula 1 wherein the groups R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, and their use as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: November 14, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine
  • Method for the Administration of an Anticholinergic by Inhalation
    Publication number: 20060251586
    Abstract: An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1 ?{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 ?m, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 ?m to 500 ?m, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 ?{square root over (kPa)} min/L containing the inhalable powder.
    Type: Application
    Filed: June 28, 2006
    Publication date: November 9, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Bernd Zierenberg
  • Novel Crystalline Forms of Tiotropium Bromide
    Publication number: 20060246009
    Abstract: The invention relates to new crystalline forms of tiotropium bromide, processes for preparing them and their use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: May 1, 2006
    Publication date: November 2, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Sherry Morissette, Mark Tawa, Mark Oliveira