Patents Assigned to Boehringer Ingelheim Vetmedica, Inc.
  • PCV2 IMMUNOGENIC COMPOSITIONS AND METHODS OF PRODUCING SUCH COMPOSITIONS
    Publication number: 20130101621
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time-consuming extraction procedures required to separate and recover the recombinant protein from within the cells.
    Type: Application
    Filed: December 27, 2012
    Publication date: April 25, 2013
    Applicant: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • Method of preventing early infections
    Patent number: 8398970
    Abstract: The present invention relates inter alia to the use of a combination of a vaccine against Lawsonia intracellularis and an anti-Lawsonia antibiotic for the prevention or reduction of early, preferably fulminant Lawsonia intracellularis infections. The present invention relates particularly to the use of a live Lawsonia intracellularis vaccine in conjunction with an antibiotic that is effective against Lawsonia intracellularis, for the avoidance or reduction of early Lawsonia intracellularis infections in animals.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: March 19, 2013
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Ricarda Deitmer, Knut Elbers
  • Lawsonia vaccine and methods of use thereof
    Patent number: 8398994
    Abstract: The present invention provides improved vaccination methods for increased protection against ileitis. The methods provide for the vaccination of young animals, preferably piglets, between 10 and 26 days of age, vaccination of pregnant sows during the second or third stages of gestation, and a combination of these methods. Vaccination of the pregnant sows can occur using repeated and/or high doses of Lawsonia antigen prior to farrowing.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: March 19, 2013
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Jeremy Kroll, Michael Roof
  • Porcine reproductive and respiratory syndrome isolates and methods of use
    Patent number: 8383131
    Abstract: A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: February 26, 2013
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Michael Roof, Eric Vaughn, Wesley Johnson
  • EQUINE RHINITIS VACCINE
    Publication number: 20120237543
    Abstract: The disclosure provides for immunogenic compositions against Equine Rhinitis Virus, particularly Equine Rhinitis A and B Virus, and methods for their use and preparation. The immunogenic compositions, in alternate embodiments, also include other equine pathogens.
    Type: Application
    Filed: March 12, 2012
    Publication date: September 20, 2012
    Applicant: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Phillip Wayne HAYES, Kristina J. HENNESSY, Laurent VIEL, Andres DIAZ-MENDEZ
  • NOVEL H5 PROTEINS, NUCLEIC ACID MOLECULES AND VECTORS ENCODING FOR THOSE, AND THEIR MEDICINAL USE
    Publication number: 20120231027
    Abstract: The present invention relates to novel hemagglutinin H5 proteins, nucleic acids and vectors encoding for those as well as vaccines comprising any of such H5 proteins, nucleic acids or vectors encoding for those H5 proteins. Moreover, the present invention also relates to the medicinal use of any of such compositions in humans and animals.
    Type: Application
    Filed: May 21, 2012
    Publication date: September 13, 2012
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Eric VAUGHN, Paulino Carlos GONZALEZ-HERNANDEZ, Juergen DAEMMGEN
  • H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
    Patent number: 8202967
    Abstract: The present invention relates to novel hemagglutinin H5 proteins, nucleic acids and vectors encoding for those as well as vaccines comprising any of such H5 proteins, nucleic acids or vectors encoding for those H5 proteins. Moreover, the present invention also relates to the medicinal use of any of such compositions in humans and animals.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: June 19, 2012
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Eric Vaughn, Paulino Carlos Gonzalez-Hernandez, Juergen Däemmgen
  • COMPOSITIONS AND METHODS FOR VACCINATING CATTLE
    Publication number: 20120148620
    Abstract: The present invention relates to compositions, uses thereof, and methods of vaccinating cattle, particularly cows and heifers, against Leptospira borgpetersenii serovar hardjo (type hardjo-bovis) by using Leptospira interrogans serovar hardjo (type hardjoprajitno).
    Type: Application
    Filed: December 5, 2011
    Publication date: June 14, 2012
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventor: Carol L. RINEHART
  • MULTIVALENT PCV2 IMMUNOGENIC COMPOSITIONS AND METHODS OF PRODUCING SUCH COMPOSITIONS
    Publication number: 20120107348
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein.
    Type: Application
    Filed: January 9, 2012
    Publication date: May 3, 2012
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Michael Roof, Phillip Hayes, Marc Eichmeyer, Greg Nitzel
  • USE OF MYCOPLASMA BOVIS ANTIGEN
    Publication number: 20120093854
    Abstract: The present invention relates to combination vaccines and/or the combined use of immunogenic compositions for the treatment and/or prophylaxis of cattle against microbiological infections, wherein the infections are caused by M. bovis and at least one further cattle relevant pathogen. The combination vaccine as described herein comprises at least one M. bovis antigen, preferably the attenuated, avirulent M. bovis as provided herewith and one or more further immunologically active components effective for the treatment and/or prophylaxis of infections caused by a further pathogen of cattle.
    Type: Application
    Filed: October 22, 2009
    Publication date: April 19, 2012
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Michael Beck, Phillip Wayne Hayes, Jeffrey P. Knittel
  • Multivalent PCV2 immunogenic compositions and methods of producing such compositions
    Patent number: 8119143
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: February 21, 2012
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Michael Roof, Phillip Hayes, Marc Eichmeyer, Greg Nitzel
  • PCV2 IMMUNOGENIC COMPOSITIONS AND METHODS OF PRODUCING SUCH COMPOSITIONS
    Publication number: 20110274710
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time-consuming extraction procedures required to separate and recover the recombinant protein from within the cells.
    Type: Application
    Filed: July 25, 2011
    Publication date: November 10, 2011
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • PCV2 immunogenic compositions and methods of producing such compositions
    Patent number: 8025888
    Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time-consuming extraction procedures required to separate and recover the recombinant protein from within the cells.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: September 27, 2011
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • USE OF A PCV2 IMMUNOGENIC COMPOSITION FOR LESSENING CLINICAL SYMPTOMS IN PIGS
    Publication number: 20110217327
    Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
    Type: Application
    Filed: May 12, 2011
    Publication date: September 8, 2011
    Applicant: Boehringer Ingelheim Vetmedica, Inc
    Inventors: Michael Roof, Phillip Hayes, Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • Porcine Reproductive and Respiratory Syndrome Isolates and Methods of Use
    Publication number: 20110195088
    Abstract: A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.
    Type: Application
    Filed: April 13, 2011
    Publication date: August 11, 2011
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Michael Roof, Eric Vaughn, Wesley Johnson
  • PREVENTION AND TREATMENT OF SUB-CLINICAL PCVD
    Publication number: 20110182935
    Abstract: The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.
    Type: Application
    Filed: April 4, 2011
    Publication date: July 28, 2011
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Vicky Fachinger, Knut Elbers, Marion Kixmoeller, Francois-Xavier Orveillon, Isabelle von Richthofen, Axel Lischewski
  • WEST NILE VIRUS VACCINE
    Publication number: 20110159033
    Abstract: The invention provides for immunogenic compositions against West Nile Virus. The immunogenic compositions, in alternate embodiments, also include other equine pathogens. The West Nile Virus composition of the present invention advantageously provides for protection against North American Dominant West Nile Virus strains or isolates.
    Type: Application
    Filed: August 31, 2009
    Publication date: June 30, 2011
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Kristina J. Hennessy, Phillip Wayne Hayes
  • Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs
    Patent number: 7968285
    Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: June 28, 2011
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Michael Roof, Phillip Hayes, Marc Eichmeyer, Greg Nitzel, Merrill Schaeffer
  • MULTIVALENT VACCINE AGAINST PORCINE TESCHOVIRUS AND OTHER DISEASE CAUSING ORGANISMS IN SWINE
    Publication number: 20110150770
    Abstract: An immunogenic composition or vaccine, and method of treatment are provided by the present invention. The immunogenic composition is useful for treating, preventing, and lessening the severity of clinical symptoms associated with disease-causing organisms in swine, utilizing one or more Porcine Teschovirus antigen(s) along with an antigen of the other disease-causing organism in swine and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 9, 2010
    Publication date: June 23, 2011
    Applicant: BOEHRINGER INGELHEIM VETMEDICA, INC.
    Inventors: Elida BAUTISTA, Dianna M. Murphy JORDAN, Axel NEUBAUER, Abby Rae PATTERSON, Michael B. Roof, Eric M. VAUGHN, Joseph G. Victoria
  • TREATMENT OF PRDC IN PIGS
    Publication number: 20110129495
    Abstract: The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment, including a reduction in the severity of, duration of, and manifestations of, porcine respiratory disease complex (PRDC) in animals, preferably in pigs.
    Type: Application
    Filed: February 9, 2011
    Publication date: June 2, 2011
    Applicant: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Vicky Fachinger, Knut Elbers, Marion Kixmoeller, Francois-Xavier Orveillon, Isabelle von Richthofen, Axel Lischewski