Abstract: The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method for cultivating large scale supplies of L. intracellularis, including both a novel isolate of L. intracellularis of European origin and a method of preparing a lyophilized product containing the attenuated European isolate as vaccine product.
Type:
Application
Filed:
July 15, 2004
Publication date:
February 10, 2005
Applicant:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Michael Roof, Jeremy Kroll, Jeffrey Knittel
Abstract: The invention includes kits for producing and using immunogenic compositions that include swine infertility and respiratory virus. The invention also includes vaccines and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Application
Filed:
May 6, 2004
Publication date:
October 21, 2004
Applicant:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Abstract: A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and an adjuvant. The adjuvant can include a cross-linked olefinically unsaturated carboxylic acid polymer which may have bioadhesive properties. The vaccine may also include antigens against other equine pathogens such as inactivated EHV-4 and inactivated A1 and/or A2 strains of equine influenza virus. Methods for protecting horses against diseases associated with EHV-1 and/or EHV-4 and methods of producing the equine herpesvirus vaccine are also provided.
Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Grant
Filed:
December 18, 2000
Date of Patent:
December 24, 2002
Assignees:
Regents of the University of Minnesota, South Dakota State University, Boehringer Ingelheim Vetmedica, Inc.
Inventors:
James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Grant
Filed:
January 31, 2000
Date of Patent:
June 5, 2001
Assignees:
Regents of the University of Minnesota, South Dakota State University, Boehringer Ingelheim Vetmedica, Inc.
Inventors:
James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Grant
Filed:
September 10, 1997
Date of Patent:
June 27, 2000
Assignee:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Abstract: A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.
Type:
Grant
Filed:
May 15, 1995
Date of Patent:
March 28, 2000
Assignee:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Danny W. Chladek, David E. Gorcyca, Louis L. Harris
Abstract: A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.
Type:
Grant
Filed:
August 15, 1996
Date of Patent:
November 23, 1999
Assignee:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Danny W. Chladek, David E. Gorcyca, Louis L. Harris
Abstract: A multi-dose applicator comprising a bottle locking assembly wherein a supply bottle can be quickly and easily attached or removed from the applicator by rotating a locking ring a fraction of a turn and wherein the plunger is flexible to allow for misalignment.
Type:
Grant
Filed:
November 12, 1997
Date of Patent:
February 2, 1999
Assignee:
Boehringer Ingelheim Vetmedica, Inc.
Inventors:
Dean Doying, Sr., Tom Kennedy, Wayne Cole, W. L. Eidson, Jack Zupan