Patents Assigned to Boehringer Mannheim
  • Patent number: 5908625
    Abstract: The invention relates to the use of thromboembolic proteins. These contain, as their only structural portion effecting thrombolytic activity, the protease domain of human tissue type plasminogen activator. These derivatives show reduced side effects, such as a reduction in bleeding while demonstrating remarkable in vivo efficacy. The effect is surprising, given their in vitro properties.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: June 1, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ulrich Kohnert, Anne Stern, Ulrich Martin, Stephan Fischer
  • Patent number: 5907047
    Abstract: This invention relates to a new biologically active compound as shown in formula (I) and its biologically active derivatives; whereas derivatives are produced by the reaction of formula (I) with nucleophiles.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: May 25, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Fritz Hansske, Olov Sterner, Marc Satadler, Heidrun Anke, Liesel Dorge, Rudong Shan
  • Patent number: 5906947
    Abstract: A method for the repeated transfer of liquids from one of several storage containers into a transfer container wherein protective tips are placed onto a tip of a pipette in order to avoid contamination.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: May 25, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Gerhard Bienhaus, Hans Lange, Thomas Walter
  • Patent number: 5902878
    Abstract: The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: May 11, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Heinz-Hartmut Seliger, Sibylle Berner, Klaus Muhlegger, Herbert Von Der Eltz, Hans-Georg Batz
  • Patent number: 5902821
    Abstract: A method of treatment using carvedilol is disclosed, wherein the carvedilol decreases the mortality caused by congestive heart failure in patients. The patients are titrated with low amounts of carvedilol, with the initial titration dosage being only 10 to 30% of the daily maintenance dose.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: May 11, 1999
    Assignee: Boehringer Mannheim Pharmaceuticals Corporation Smith Kline Corporation Limited Partnership No. 1
    Inventors: Mary Ann Lukas-Laskey, Robert Ruffolo, Jr., Neil Shusterman, Gisbert Sponer, Klaus Strein
  • Patent number: 5893364
    Abstract: An apparatus for light transport measurements on a test object with a measuring head which includes a contact surface for placing against an interface of the test object, light irradiation device with a light transmitter for irradiating light through the contact surface and an interface into the test object, and detection device with a light receiver for detecting light leaving the test object. The contact surface comprises at least one optically transparent light passage point for the light, on which a large number of rigid light-conducting elements are arranged, wherein an optical connection with a light transmitter or light receiver assigned to a light passage point is produced by the whole of the light-conducting elements of the light passage site.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: April 13, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans-Peter Haar, Matthias Essenpreis, Rainer Fritsche
  • Patent number: 5891687
    Abstract: A vector according to the invention with a positive selection possibility for cloning a DNA sequence into a host cell transformed with the vector, wherein the vector contains suitable restriction cleavage sites within a selection gene the functional expression of which is prevented by insertion of the foreign gene is characterized in that it contains a modified cap gene as the selection gene which codes for a CAP protein with modified DNA binding specificity the expression of which is lethal for adenylate-cyclase-positive host cells.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: April 6, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Daniel Schlieper, Harlad Sobek, Manfred Schmidt, Brigitte von Wilcken-Bergmann, Benno Muller-Hill
  • Patent number: 5888813
    Abstract: The invention concerns human monoclonal antibodies of the IgG isotype against human pancreatic islet cells which can be obtained by immortalizing human lymphocytes of prediabetics or diabetics, treating the culture supernatant of the immortalized cells with a conjugate of antibodies against human Fc .gamma. and a label, subsequently treating with human immunoglobulin, incubating with immobilized human pancreatic islet cells identifying an immortalized human cell culture which produces an antibody against pancreatic islet cells via determination of the label bound to the immobilized islet cells, isolating a human immortalized cell which produces this antibody, propagating this immortalized cell and isolating the monoclonal antibody produced by these cells.The invention also concerns a process for the isolation of an islet cell antigen to which such antibodies bind as well as a method for the determination of antibodies against an islet cell antigen of the pancreas.
    Type: Grant
    Filed: November 7, 1995
    Date of Patent: March 30, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Josef Endl, Michael Brandt, Herbert Jungfer, Winfried Albert, Rosemarie Kientsch-Engel, Werner Scherbaum, Wiltrud Richter, Thomas Eiermann
  • Patent number: 5888745
    Abstract: The present invention concerns a method for the determination of an analyte in a sample liquid using a metal complex capable of luminescence as an analyte-specific marker group for the production of a measuring signal in which an unspecific metal complex is additionally added as an interference elimination reagent which has a structure that is chemically related to the marker group.
    Type: Grant
    Filed: May 30, 1996
    Date of Patent: March 30, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Bernhard Eckert, Helmut Lenz, Norbert Franken, Hans-Peter Josel, Beatus Ofenloch-Hahnle
  • Patent number: 5888967
    Abstract: Described herein is a method of promoting osteogenesis in a patient in need thereof by administering a plasminogen activator which activates the zymogen plasminogen by cleavage between arginine 506 and valine 561 to form the serine protease plasmin.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: March 30, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Konrad Honold, Lothar Kling, Kurt Lang, Ulrike Leser
  • Patent number: 5886252
    Abstract: An instrument for determining a characteristic of a biological fluid or a control comprises a radiation-reflective surface, a first source for irradiating the surface, a first detector for detecting radiation reflected from the surface, and a mechanism for determining the characteristic based on the detected radiation. A slide holds a sample of the biological fluid or control the characteristic of which is to be determined. The slide has two opposed walls transparent to the radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent a second of the two opposed walls. A system is provided for supplying power and regulating supplied power from one of multiple power sources to the instrument.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: March 23, 1999
    Assignee: Boehringer Mannheim Corporation
    Inventors: George R. Lennert, Rick L. Collins, William J. Murphy
  • Patent number: 5885584
    Abstract: The invention concerns a process for improving the regeneration of oligodendrocytes, in particular of human oligodendrocytes, in which oligodendrocytes are treated in cell culture with nerve growth factor (NGF) or active fragments of NGF. Furthermore a composition is disclosed for treating diseases in which a demyelination of nerve fibres occurs which contains NGF or an active fragment thereof as the active substance, if desired, together with the usual pharmaceutical vehicles, auxiliary substances, fillers and diluents.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: March 23, 1999
    Assignees: Boehringer Mannheim GmbH, Max-Planck-Gesellschaft zur Forderung der Wissenschaften, E.V.
    Inventors: Hans-Hinrich Althaus, Jurgen Unger, Ilse Bartke
  • Patent number: 5882644
    Abstract: The invention relates to monoclonal antibodies, humanized monoclonal antibodies and functional derivatives thereof specific for the platelet-derived growth factor receptor .beta.. Methods of use of the antibody, particularly in ameliorating restenosis, are also provided.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: March 16, 1999
    Assignees: Protein Design Labs, Inc., Boehringer Mannheim GmbH
    Inventors: Chung Nan Chang, Nicholas F. Landolfi, Ulrich Martin
  • Patent number: 5879373
    Abstract: System for determining the properties of tissue parts of a living organism, comprising an optoelectronic measuring device (10) and an attachment device (20) which is opaque to light and surrounds a measuring window (28) through which determinations are carried out. The device (20) has one or several components (26) for reproducibly attaching the measuring device (10) in a direction toward a first surface of the tissue. Other subject matters of the invention are an attachment device (20) and a method for determining the properties of tissue parts with the aid of the claimed system.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: March 9, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Josef Roper, Dirk Bocker
  • Patent number: 5869001
    Abstract: A method and apparatus for the quantitative analysis of sample liquids. A sample is dried and irradiated with visible and/or infrared light. Light that is diffusely or specularly reflected from the sample and sample carrier is detected. and analysed.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: February 9, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Juergen Backhaus, Reinhold Mischler
  • Patent number: 5863740
    Abstract: The invention concerns interference-eliminating agents for avoiding unspecific interactions in immunoassays in which avidin or streptavidin or a derivative thereof are used as the interference-eliminating agents.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: January 26, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Rosemarie Kientsch-Engel, Frederic Donie, Michael Wiedmann
  • Patent number: 5862934
    Abstract: Packaging system for liquid reagents in which two or more vessels with holding areas are combined by pressing a plug-on plate onto the holding areas of the vessels. For this purpose the plug-on plate has two or more apertures the cross-section of which essentially corresponds to the cross-section of the holding areas of the vessels. Plug-on plate and/or holding areas of the vessels can have stop elements which, after the combination, hinder the separation vessels and plug-on plate.
    Type: Grant
    Filed: July 17, 1995
    Date of Patent: January 26, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Stephan Sattler, Albert Wohland, Hermann Erb
  • Patent number: 5863800
    Abstract: A systems for test elements used for clinical chemical analyses has several test elements, each of which is individually sealed to be impermeable to water vapor. The method provides for the removal of test elements and protects the test elements contained in it against effects from the outside.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: January 26, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Heino Eikmeier, Klaus-Dieter Sacherer, Joerg Schreiber, Wilfried Schmid, Hans-Juergen Kuhr
  • Patent number: 5858691
    Abstract: The invention concerns a method for the simultaneous colorimetric and electrochemical measurement of an analyte using an oxidizing enzyme and a chromogen A that accepts electrons from the enzyme which is characterized in that the chromogen A after reduction to A' reacts by coupling to a substance BX to form a colored substance A'B the concentratin of which is measured colorimetrically as a measure for the presence or amount of the analyte and in that an electrochemically measurable group X.sup.- is cleaved off during the coupling reaction the concentration of which is measured electrochemically as a measure for the amount of the analyte.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: January 12, 1999
    Assignee: Boehringer Mannheim GmbH
    Inventors: Joachim Hoenes, Holger Kotzan, Volker Unkrig, Michael Marouant
  • Patent number: D406895
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: March 16, 1999
    Assignee: Boehringer Mannheim Corporation
    Inventors: Nancy K. Byrd, Yani Deros, Patricia A. Hopkinson, Richard J. Kasle, Patrick F. McDermott, James R. Parker, Luis A. Pedraza, Timothy L. Ranney