Abstract: The present disclosure relates to, inter alia, improved methods for the treatment of solid tumors using embolic polymer microspheres, to embolic polymer microspheres that comprise a polymer and an inhibitor of the enzyme poly ADP ribose polymerase (PARP inhibitor) wherein the PARP inhibitor is held within the polymer microsphere and is elutable from the microsphere in aqueous media, and to methods of loading embolic polymer microspheres.

Abstract: Medical devices are disclosed having improved visualization of a portion of the medical device insertable into a patient's body while minimizing obstruction of fluid flow through a lumen of the device and while minimizing an increase in the outer diameter of the device attributable to the feature providing improved visualization. The device can include, for example, an imaging marker distal to lumen openings (exit ports), or, where the device comprises a tube, such as a metallic tube, an imaging marker embedded into a wall of the tube. Another embodiment includes attaching a marker to the surface on the inside of a lumen of a medical device without embedding the marker. Various alternative embodiments, methods and applications of using such devices are disclosed as well.

Abstract: A releasable coupling mechanism for coupling a delivery catheter and a dilator. The delivery catheter comprising a delivery catheter hub at the proximal end and the dilator comprising a dilator hub at the proximal end. The proximal end of the delivery catheter hub comprises a coupling member for releasably receiving a raised portion which is positioned at a distal end of the dilator hub. The coupling member has a pair of engagement members positioned on opposing sides of the coupling member and configured to releasably engage the raised portion. The delivery catheter hub further comprising at least one indicia on the housing. The indicia indicate an orientation of the delivery catheter hub such that the dilator hub disengages from the coupling member by simultaneously deflecting the pair of engagement members.

Abstract: The system can include a multi-lumen chamber can removably connected to and in fluid communication with a proximal end of a mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to include a first constituent in a first cavity. A first plunger can be internally positioned within the first lumen to control flow of the first constituent from the first cavity into the mixing lumen. The first cavity can terminate in a first port in fluid communication with the proximal end of the mixing lumen. The second lumen can be configured to include a second constituent. A second plunger can be internally positioned within the second lumen. The second lumen can terminate in a second port adjacent the first port and in fluid communication with the proximal end of the mixing lumen.

Abstract: A medical device may comprise a shaft, an articulation wire extending through at least a portion of the shaft, and a handle, including a handle body having an outer surface that defines a channel. A distal portion of the shaft may be received within a first portion of the channel. A distal portion of the articulation wire may be received within a second portion of the channel. A control member may be movable relative to the handle body to move the distal portion of the articulation wire relative to the distal portion of the shaft.

Abstract: An electrosurgical device for puncturing tissue comprises an electrically conductive elongate member which is capable of force transmission from a distal portion of the electrosurgical device to a proximal portion of the electrosurgical device to thereby provide tactile feedback to a user. The proximal portion comprises a handle or hub which includes an electrical connector configured to receive, in a releasable manner, an electrically conductive component operable to be electrically coupled to an energy source.

Abstract: An elongate steerable medical device includes a shaft and a handle assembly that is removably securable to the shaft. The shaft includes an elongate outer member and an elongate inner member that is disposed within the elongate outer member. The handle assembly includes a proximal handle, a spool that is slidingly secured to the handle body and a collet that is removably secured to the handle body. The spool is adapted to releasable secure the elongate inner member and the collet is adapted to releasably secure the elongate outer member.

Abstract: An electrosurgical device for puncturing tissue comprises an electrically conductive elongate member which is capable of force transmission from a distal portion of the electrosurgical device to a proximal portion of the electrosurgical device to thereby provide tactile feedback to a user. The proximal portion comprises a handle or hub which includes an electrical connector configured to receive, in a releasable manner, an electrically conductive component operable to be electrically coupled to an energy source.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system includes a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be removably connected to a proximal end of the mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to comprise a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The first lumen can terminate in a first port. The second lumen can be configured to include a second constituent. The second lumen can include a second plunger to distally move the second constituent and terminate in a second port. A vial adaptor can be included with a vial having a third constituent.

Abstract: A system for producing a mixture to deliver to a treatment site. A multi-lumen chamber can be connected to a proximal end of a mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can be configured to include a first constituent in a proximal portion of the first lumen and a second constituent in a distal portion of the first lumen. A first plunger can be internally positioned within the first lumen to distally move the first constituent into the distal portion to mix with the second constituent in a first state to form a first mixture. The first lumen can terminate in a first port. The second lumen is configured to include a third constituent. A second plunger is internally positioned within the second lumen to distally move the third constituent and the first mixture.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be connected to a proximal end of the mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can receive a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The second lumen can include a second constituent and a second plunger to distally move the second constituent and the first constituent in a second state. Distally moving the second plunger causes the first constituent and the second constituent to be mixed together within the mixing lumen to form the mixture.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a connector with a connector vent so that air in the connector is expellable therethrough. A multi-lumen chamber can be connected to a proximal end of the connector and include a first lumen aligned and adjacent a second lumen. The first lumen can be configured to include a first constituent in a proximal portion of the first lumen, a second constituent in a distal portion of the first lumen, and a first plunger internally positioned within the first lumen to distally move the first constituent into the distal portion to mix with the second constituent in a first state to form a first mixture. The second lumen is configured to include a third constituent and a second plunger rod internally positioned within the second to distally move the third constituent.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a first chamber with an inner cavity including a first constituent and an outer cavity concentric with the first cavity and including a second constituent. A partition can be openable and separate the first and second cavities. A second chamber can include a third constituent and be concentric with the first chamber. Moving the first chamber and/or the second chamber relative to the other can cause the partition to open so that the first constituent and the second constituent mix with each other to form a first mixture. Applying a force to the system can cause the first mixture and the third constituent to egress through distal portions of the first and second chambers and mix together to form the mixture for delivery to the treatment site.

Abstract: A system includes a connector with a central lumen. A multi-lumen chamber is removably connected to and in fluid communication with a proximal end of the central lumen. The multi-lumen chamber includes a first lumen aligned and adjacent a second lumen. The first lumen includes a first fluid in a proximal portion of the first lumen and a hydrophilic polymer in a distal portion of the first lumen, a first plunger rod within the first lumen to control flow of the first fluid into the distal portion to mix with the hydrophilic polymer in a first state to form a first mixture, and a first port. The second lumen includes a second fluid, a second plunger rod within the second lumen to distally move the second fluid and the first mixture in a second state, and a second port.

Abstract: Medical device packaging and methods for shaping/treating medical devices are disclosed. An example medical device package may include a carrier tube having a first end and a second end. The carrier tube may have an outer diameter adjacent to the first end. An intermediate tube may be coupled to the first end. The intermediate tube may have inner diameter larger than the outer diameter of the carrier tube. A retractable tube may be coupled to the intermediate tube. A clip may be secured to the carrier tube, the intermediate tube, or both.

Abstract: A medical device is adapted for use in assisting with mechanical thrombectomy. The medical device may include a housing that is adapted to be held within a user's hand and a pump that is secured within the housing. A fluid inlet is adapted to receive fluid that is pulled towards the pump and is fluidly coupled with the pump. A fluid outlet is adapted to expel fluid away from the pump and is fluidly coupled with the pump. As the pump is operated by the user, fluid is alternatively pulled into the fluid inlet and expelled through the fluid outlet. In some cases, the fluid may be blood or other bodily fluids.

Abstract: A suction device configured to simultaneously draw in fluid and expel fluid. The suction device may comprise a barrel defining a cavity and extending from a first end to a second end. A first fluid inlet may be adjacent the first end of the barrel and a second fluid inlet adjacent the second end of the barrel and a first fluid outlet may be adjacent the first end of the barrel and a second fluid outlet adjacent the second end of the barrel. A plunger may be slideably disposed within the cavity of the barrel with a handle assembly operably coupled thereto. A actuation of the handle assembly may be configured to move the plunger within the cavity between the first end and the second end of the barrel.

Abstract: Embodiments of a steerable catheter control system and methods are disclosed. The steerable catheter control system comprises a housing which defines an inner housing and a slide assembly which linearly translates within the inner housing. At least two control wires are positioned through the slide assembly wherein one of the at least two controls wires are indirectly coupled to the slide assembly via the direction reversing element. The steerable catheter control system further comprises a slack limiting element, coupled to at least one of the at least two control wires. The slack limiting element allows for frictional engagement of the control wire to limit slack. The control system includes a control knob for linearly translating the slide assembly, enabling the slide assembly to manipulate the control wires which causes a change in deflection of the steerable catheter.

Abstract: A medical device comprising a handle, a shaft extending from the handle, and an inflatable module at a distal portion of the shaft, the module including a camera, wherein the shaft includes a body defining a first channel extending between a first end configured to be in fluid communication with a fluid source, and a second end in fluid communication with the module, and wherein inflation of the module alters a viewing angle of the camera relative to an axis of the distal portion of the shaft.

Abstract: A medical system includes a medical device and an end cap. The medical device includes a handle, including an actuation device, and a shaft extending from the handle. A distal end of the shaft includes a tab, and the tab is movable based on movement of the actuation device. The end cap includes a modular camera assembly. The modular camera assembly includes a camera, a support, an arm, and a cavity. The tab is coupleable to the modular camera assembly via the cavity, and movement of the tab controls a position of the support and the camera.