Abstract: A cinch deployment system includes a delivery system and a releasable cinch including an inner tubular, a compressible gripper having a suture passage, the gripper positioned within the inner tubular housing, and a resilient structure biased to compress the gripper to reduce the size of the suture passage. The resilient structure has a first configuration in which the resilient structure is constrained from applying sufficient compression to the gripper to prevent movement of the gripper on the suture, and a second configuration in which sufficient compression is applied to secure the gripper on the suture. The resilient structure is moved from the first to the second configuration by movement of the retainer moved by the deployment system.

Abstract: A cryoablation catheter system comprises a cryoablation catheter having a shaft, a guidewire lumen member and an expandable balloon attached to the shaft and the guidewire lumen member, and an auxiliary device configured for use in combination with the cryoablation catheter, the auxiliary device including a location sensor configured to provide a sensor output indicative of a location of the location sensor within a localization volume responsive to a localization field. A user-accessible relative position indicator is located on one or both of the cryoablation catheter and the auxiliary device and is configured to provide an indication of a relative position of the cryoballoon and the location sensor.

Abstract: An endoscopic device includes a flexible shaft extending distally from a handle which, during use remains outside a living body, the shaft comprising a pull wire extending therethrough from the handle and a distal tip rotatably coupled to a distal end of the shaft, the distal tip comprising an imager directed distally from a distal face of the distal tip, the imager including a chip and a lens, a distal end of the pull wire being coupled to the distal tip in combination with an actuation mechanism coupled to a proximal end of the pull wire so that, actuation of the actuation mechanism, pulls the pull wire proximally through the shaft rotating the distal tip relative to the shaft to alter a field of view of the imager.

Abstract: A medical device may include an introducer sheath, having a distal and a proximal end and a lumen extending from the distal end to the proximal end. The introducer sheath may also include a tab formed at the distal end and extending distal to the lumen, and a frangible portion extending between the distal end and the proximal end.

Abstract: A replacement heart valve system may include a replacement heart valve implant including an expandable framework and a plurality of valve leaflets disposed within the expandable framework, and a filter element secured to the expandable framework and configured to be deployed downstream of the expandable framework, the filter element having a closed downstream end. A replacement heart valve system may include a filter element configured to be deployed across a native heart valve, wherein the filter element includes a lumen extending therethrough, and a replacement heart valve implant configured to be deployed within the lumen of the filter element. A method of treating a native heart valve may include deploying a filter element across the native heart valve, expanding an expandable balloon within the lumen of the filter element, and thereafter, deploying a replacement heart valve implant within the lumen of the filter element.

Abstract: According to one aspect, an apparatus for treating tissue may include an elongate tube. The elongate tube may include a slot extending longitudinally along a first side of the elongate tube, a first elongate jaw member on a first side of the slot, and a second elongate jaw member on a second side of the slot. The apparatus may also include a shaft coupled to the elongate tube along a second side of the elongate tube. The first elongate jaw member may be movably coupled to the shaft, such that the first elongate jaw member may be movable toward the second elongate jaw member to converge tissue walls within the slot and cut the tissue walls within the slot.

Abstract: A medical device may comprise a flexible sheath defining a lumen extending from a proximal end of the sheath to a distal end of the sheath. The sheath may include a piston slidably received within the lumen; an agent disposed in the lumen distal to the piston; and pneumatic fluid disposed in the lumen proximal of the piston. The device may also comprise handle at a proximal end of the sheath, the handle including: a plunger received in a reservoir, wherein the reservoir is in fluid communication with the lumen. The reservoir may contain pneumatic fluid. The handle may include a gear. An amount of rotation of the gear in a first direction may correspond to an amount that the plunger advances distally in the reservoir to displace pneumatic fluid. The displacement of the pneumatic fluid may advance the piston distally to deliver an amount of agent from the sheath.

Abstract: A vapor delivery device is provided that may include any of a number of features. One feature of the vapor delivery device is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate tissues of the prostate. The vapor delivery device can include a handle portion and a cartridge portion. The cartridge portion can be configured to be inserted into a lumen of the handle portion to align and position a vapor coil of the cartridge portion within a RF coil of the handle portion. Methods associated with use of the energy delivery probe are also covered.

Abstract: Example medical devices and methods for using the medical devices are disclosed. An example ultrasound medical device includes an elongate shaft having a distal end region, a housing coupled to the elongate shaft, a first ultrasound transducer coupled to the housing, and a second ultrasound transducer coupled to the housing. Further, the first ultrasound transducer is configured to generate a first ultrasound wave, the second ultrasound transducer is configured to generate a second ultrasound wave and the first ultrasound wave constructively interferes with the second ultrasound wave to generate a localized pressure wave in order to transmit energy to a target region.

Abstract: Tissue puncture devices, and systems and methods for accessing tissue (e.g., cardiovascular tissue) according to the present disclosure may include a tubular sheath extending along a longitudinal axis, the tubular sheath having a proximal end and a distal end, a needle disposed coaxially in the sheath, the needle having a proximal end and a distal end and being movable along the longitudinal axis of sheath, and a needle control mechanism disposed at the proximal end of the needle, the needle control mechanism being configured to lock the distal end of the needle in a first position retracted within the distal end of the sheath, and release the needle to an unlocked second position such that the distal end of the needle is extendable beyond the distal end of the sheath.

Abstract: A medical device includes a sensor, a processor, and non-transitory computer readable medium storing imaging instructions. The sensor captures a first raw image into a first frame of raw pixel values including a plurality of first pixel values that represent pixels of a first color and a plurality of second pixel values that represent pixels of a second color. The sensor captures a second raw image into a second frame of raw pixel values including a plurality of third pixel values that represent pixels of the second color and a plurality of fourth pixel values that represent pixels of a third color. The processor convolves the first frame of raw pixel values with the second frame of raw pixel values to generate a first extrapolated frame of pixel values in a YCrCb format and creates a processed image from the first extrapolated frame of pixel values.

Abstract: Stent delivery systems as well as methods for making and using stent delivery systems are disclosed. An example stent delivery system may include an elongate shaft including an inner member having a stent receiving region, a deployment sheath slidably disposed along the inner member, and an intermediate shaft disposed between the inner member and the deployment sheath. The intermediate shaft may have an outer diameter. A handle may be coupled to the elongate shaft. A rack member may be coupled to the deployment sheath. At least a region of the rack member may be configured to extend within the handle. The rack member may have an axial slot formed therein. At least a portion of the axial slot may have a width that is less than the outer diameter of the intermediate shaft.

Abstract: According to one aspect, a device may include a shaft having a distal end and a lumen, the lumen terminating in a distally-facing opening. An instrument may be inserted through the shaft and may extend through the lumen and out of opening. The device may further include an elevator for engaging the instrument. The elevator may include an actuator extending through at least a portion of the shaft; and a body may be coupled to the actuator. A portion of the body may be configured to extend within the lumen and to apply a force to the instrument and move the instrument into contact with a surface of the lumen when the actuator is moved.

Abstract: Various embodiments are generally directed to devices, systems, and methods for controlling the flow of fluids in endoscopic systems, such as endoscopic ultrasound (EUS) enabled endoscopes. Some embodiments are particularly directed to valve sets and/or valve interface mechanisms for controlling air, water, and/or suction flow through a valve well for an endoscopic system. Several embodiments are directed to user interface mechanisms and techniques for enabling an operator to interact with and control endoscope valves. Many embodiments are directed to mechanisms and techniques for translating interface input motion into valve control motions. In one or more embodiments, the valve sets and/or valve interface mechanisms may be disposable.

Abstract: Various embodiments are generally directed to devices, systems, and methods for controlling the flow of fluids in endoscopic systems, such as endoscopic ultrasound (EUS) enabled endoscopes. Some embodiments are particularly directed to valve sets and/or valve interface mechanisms for controlling air, water, and/or suction flow through a valve well for an endoscopic system. Several embodiments are directed to user interface mechanisms and techniques for enabling an operator to interact with and control endoscope valves. Many embodiments are directed to mechanisms and techniques for translating interface input motion into valve control motions. In one or more embodiments, the valve sets and/or valve interface mechanisms may be disposable.

Abstract: A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands.

Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing an intravascular device having a distal portion, inserting the device into the vascular lumen, positioning the distal portion in the vascular wall to at least partially surround the occlusion, and removing at least a portion of the surrounded occlusion from the lumen.

Abstract: According to an aspect, a medical device includes an elongate member, a first arm extending from the elongate member, a second arm extending from the elongate member, the second arm being configured to move with respect to the first arm, and a needle coupled to the elongate member, the needle being configured to move with respect to the elongate member.

Abstract: Aspects of positioning devices, methods, and systems are disclosed. An exemplary method comprises: moving a distal end of a tube into a body, the tube including a lumen and a shaft in the lumen, the shaft having a transducer; sending a first signal to the transducer; passing, with the transducer, in response to the first signal, a wave energy into the body; receiving, with the transducer, a reflected portion of the wave energy; generating, with the transducer, a second signal in response to the reflected portion of the wave energy; determining, with a processor, an indicia of the body in response to the second signal; and identifying, with the indicia, a targeted issue in the body; positioning the distal end of the tube at the targeted tissue in response to the indicia; and removing a portion of the targeted tissue with the distal end of the tube.

Abstract: A medical device may include an insertion portion longitudinally extending between a proximal end and a distal end. The insertion portion may define a channel extending therethrough. The medical device may further include a handle coupled to the proximal end of the insertion portion. The handle may further include an irrigation port in fluid communication with the channel and coupled to a source of irrigation fluid. Additionally, the handle may include an actuator and a pressurizer. Manipulation of the actuator may be configured to actuate the pressurizer to urge irrigation fluid distally through the channel.