Abstract: Compositions and related kits and methods for treating a target site of a patient are described herein. The composition may include a hemostatic agent and a pH agent, for example. Methods of treatment include delivering and applying the hemostatic agent and the pH agent to a gastrointestinal system of a patient via a medical device to reduce bleeding of tissue in the gastrointestinal system.

Abstract: A medical device useful for cracking or cutting an intravascular lesion may include a monolithic blade or a blade assembly including a first terminal blade segment and a second terminal blade segment. The length of each of the first terminal blade segment and the second terminal blade segment, which may be defined at least in part by one or more flex points, may allow the first terminal blade segment and the second terminal blade segment to flex at least 30 degrees relative to a longitudinal axis when the monolithic blade is pressed against a lesion.

Abstract: The present disclosure relates generally to systems, devices, and methods for endoscopic suture termination. In some embodiments, a suture device may include an elongate member having a working channel and a suture channel, the elongate member having a proximal end and a distal end. The suture device may further include a suture extending through the suture channel, and a plurality of anchor components coupled to the suture, wherein the suture and the plurality of anchor components are deployable from the elongate member for engagement with a target tissue.

Abstract: In some aspects the present disclosure provides a radiopaque, reactive copolymer comprising at least one hydrophilic polymer segment having a plurality of hydrophilic polymer segment ends, a plurality of iodinated polymer segments covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated polymer segments. In other aspects, the present disclosure pertains to a system for forming a hydrogel composition that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, as well as to a crosslinked reaction product of the same. In further aspects, the present disclosure pertains to a method of treatment comprising administering to a subject a mixture that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, under conditions such that the nucleophilic compound and the radiopaque, reactive copolymer crosslink after administration.

Abstract: A medical device may include a handle and an end cap. The handle may include a first movable body and a stationary body. The end cap may include an outer portion, an inner portion disposed within the outer portion, and at least one biasing member. The outer portion may define a receptacle configured to contain a material. The inner portion may be proximal to the receptacle, within the outer portion, and coupled to the first movable body by at least one control element. The biasing member(s) may be disposed between a proximal face of the inner portion and a distal face of a proximal wall of the outer portion. Accordingly, movement of the first movable body relative to the stationary body moves the inner portion relative to the outer portion. Movement of the inner portion may be configured to deliver the material.

Abstract: This disclosure relates generally to medical devices, systems, and methods for locating devices and/or anatomy during medical procedures. More particularly, in some embodiments, the disclosure relates to medical device and/or anatomy locating devices, access devices, and systems and methods thereof, for use during, e.g., gastrojejunostomy procedures. In an aspect, a medical device locator may include an elongate member (such as sheath or guidewire) having a proximal end, a distal end, a longitudinal axis, and a length extending along the longitudinal axis. A location device may be disposed along the length of the elongate member.

Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes an inflatable member and at least one electrode for focal ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal.

Abstract: An implantable treatment device configured to facilitate removal thereof after tissue ingrowth into a portion thereof, such as into an enlarged region with a diameter greater than adjacent regions. A liner is positioned within a lumen of the treatment device, with a portion spaced from the enlarged region of the treatment device. A disruption zone in the liner facilitates controlled disruption of the liner's integrity to permit a portion of a removal device inserted within the liner to extend through the liner to interact with the treatment device. The treatment device may be part of a treatment system including a removal device with an enlarged region corresponding to the treatment device enlarged region. A method of treatment involves rupturing a rupture zone in a treatment device liner to allow a portion of a removal device to extend through the liner and into engagement with a portion of the treatment device.

Abstract: Medical devices and method for manufacturing medical devices are discloses. An example medical device may include a medical device body formed from one or more multi-melting point polymeric filaments. Each of the filaments may include a polymeric blend comprising a first block polymer and a second polymer. The polymeric blend may have a first melting point and a second melting point less than the first melting point. The medical device body may be heat set at a temperature within 10° C. of the second melting point.

Abstract: Intravascular imaging systems and methods for making and using intravascular imaging devices are disclosed. An example intravascular imaging device may comprise a catheter including an imaging device. A processor may be coupled to the catheter. The processor may be configured to process image data received from the imaging device. The processor may be configured to generate a calcium map. The calcium map may include an indicator of calcium depth to a vessel lumen surface, calcium distance to a center of the catheter, or both. A display unit may be coupled to the processor. The display unit may be configured to show a display including the calcium map.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device includes an ablation system. The ablation system may include an elongate shaft having a distal region. A plurality of ablation tines may be disposed at the distal region. Each of the ablation tines may include a tubular member having a flexible circuit disposed therein. The flexible circuit may include a substrate, one or more electrodes coupled to the substrate, and a temperature sensor coupled to the substrate and positioned adjacent to the one or more electrodes. The plurality of ablation tines may include a first ablation tine and a second ablation tine. A pair of bipolar electrodes may defined by a first electrode disposed at the first ablation tine and a second electrode disposed at the second ablation tine.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices, systems and methods for air/water and flushing valves. For example, an endoscopic valve of the present disclosure may include a valve stem with contiguous first and second channels and with first and second ports formed within a sidewall of the valve stem. A series of seals may be disposed around an outer surface of the valve stem proximal and distal to the first and second ports. A gating member may be slidably disposed within the proximal channel and a valve insert may be disposed between the proximal and distal channels.

Abstract: Various aspects of the present invention are directed towards apparatuses, systems, and methods that may include a blood pump. The blood pump may include an impeller assembly housing, an impeller assembly having an impeller configured to cause blood to flow through the pump, a motor housing, a motor configured to drive the impeller, and a pivotable housing connector.

Abstract: Devices, systems, and methods for a suction valve assembly for a medical device. The suction valve assembly includes a valve member with a valve shaft that slides within a valve well. The valve shaft includes one or more slits and is biased to expand outward and press against internal walls of the valve well.

Abstract: An example renal support pump includes a renal support device including an outer catheter shaft having a longitudinal axis and a distal end region coupled to a renal pump assembly, wherein the renal pump assembly includes a frame and an impeller assembly, wherein the impeller assembly is disposed within the frame, and wherein the impeller assembly is configured to rotate relative to the frame about the longitudinal axis of the catheter shaft.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include a magnetic drive system of a blood pump. The magnetic drive system may include a drive shaft coupled to an impeller, a driven magnet assembly coupled to at least one of the drive shaft and the impeller, and a driving coil assembly configured to drive the driven magnet assembly.

Abstract: The present disclosure provides to process intravascular ultrasound (IVUS) images from different runs through a vessel to generate a mapping between frames of each IVUS run and to generate a graphical user interface (GUI) to graphically present the IVUS runs in relationship to each other. In some examples, a vessel fiducial is identified in a frame of each IVUS run and one or both runs are offset in time, distance, and/or angle to align the frames with the identified vessel fiducial. Further, the disclosure provides to angularly align intravascular images to a viewing perspective of an external image of the vessel.

Abstract: Disclosed is a novel filter and delivery means. The device described within will not interfere with standard practice and tools used during standard surgical procedures and tools such as cannulas, clamps or dissection instruments including valve replacement sizing gages or other surgical procedures where the patient must be put on a heart-lung machine cross-clamping the aorta.

Abstract: The present disclosure provides to process intravascular ultrasound (IVUS) images from different runs through a vessel to generate a mapping between frames of each IVUS run and to generate a graphical user interface (GUI) to graphically present the IVUS runs in relationship to each other. In some examples, a vessel fiducial is identified in a frame of each IVUS run and one or both runs are offset in time, distance, and/or angle to align the frames with the identified vessel fiducial. Further, the disclosure provides to angularly align intravascular images to a viewing perspective of an external image of the vessel.

Abstract: The present disclosure provides devices and methods to process intravascular images of a vessel of one imaging modalities and to generate, extract and adapt features from another imaging modality to generate a hybrid image comprising features from both modalities. The disclosure provides devices and methods to train deep generative models to adapt domain specific features from one intravascular imaging modality (e.g., OCT, or the like) to another intravascular imaging modality (e.g., IVUS) and integrate the adapted features into the images from the other intravascular imaging modality.