Patents Assigned to Brandeis University
  • Patent number: 11111508
    Abstract: The invention features Cas9 fusion polypeptides. In one embodiment of the invention, Cas9 is fused to a SNAP tag that enhances Cas9's gene repair function.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: September 7, 2021
    Assignee: BRANDEIS UNIVERSITY
    Inventor: Nelson Lau
  • Patent number: 11104741
    Abstract: The present invention features an antibody mimetic, or an antigen binding fragment thereof, that specifically binds to an allosteric site of Aurora A kinase, therapeutic compositions comprising this antibody mimetic, and the use of the monobody to modulate Aurora A kinase for the treatment of cancer.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: August 31, 2021
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Dorothee Kern, Adelajda Zorba
  • Patent number: 11058093
    Abstract: Systems and methods for monitoring and controlling activities of Drosophila organisms are provided. In one aspect, a method includes acquiring, using a first activity detector, imaging data tracking movements of the Drosophila organisms, and acquiring, using a second activity detector, bioluminescence data corresponding to a neural activity of the Drosophila organisms. The method also includes correlating, using the acquired data, a behavioral activity and neural activity of the Drosophila organisms, and determining, using the correlation, an activity profile for the Drosophila organisms. The method further includes providing, based on the activity profile, a stimulation to the Drosophila organisms to control at least one of the behavior activity or the neural activity over a time period extendible to a nominal life cycle of the Drosophila organisms.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: July 13, 2021
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Fang Guo, Hyung-jae Jung, Michael Rosbash
  • Patent number: 11055304
    Abstract: The present disclosure includes systems and methods for performing a plurality of base statistical analysis on a dataset to yield multiple, different base statistics with respect to a first predetermined number of features. The dataset and the base statistics can be used to find a transformation that determines significant features while controlling a false discovery rate (FDR) to be below a target FDR threshold (?), wherein a second predetermined number of features are assumed to be independent from each other. Using the transformation, a composite index can be generated that represents a synthesis of the base statistics and a report can be generated that indicates at least the relative presence of the significant features in the dataset using the composite index.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: July 6, 2021
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Pengyu Hong, Yuanzhe Bei
  • Patent number: 11040108
    Abstract: This invention relates to a conjugate of formula (I): (A-Z1-)n-Q-Z2-D (I), wherein Z1, Z2, Q, A, D, and n are as described herein. This invention also relates to a pharmaceutical composition including a pharmaceutically acceptable carrier and a conjugate of formula (I). This invention also relates to a method making a conjugate of formula (I), and the use of the conjugate for treating cancerous conditions, modulating cell membrane microheterogeneity, stimulating an immunoresponse, and forming a network on or near the inner or outer surface of target cells.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: June 22, 2021
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Huaimin Wang, Bing Xu
  • Patent number: 10960397
    Abstract: Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: March 30, 2021
    Assignees: President and Fellows of Harvard College, Brandeis University
    Inventors: Seth Fraden, Hakim Boukellal, Yanwei Jia, Seila Selimovic, Amy Rowat, Jeremy Agresti, David A. Weitz
  • Patent number: 10942095
    Abstract: Microfluidic devices and methods for investigating crystallization and/or for controlling a reaction or a phase transition are disclosed. In one embodiment, the microfluidic device includes a reservoir layer; a membrane disposed on the reservoir layer; a wetting control layer disposed on the membrane; and a storage layer disposed on the wetting control layer, wherein the wetting control layer and the storage layer define a microfluidic channel comprising an upstream portion, a downstream portion, a first fluid path in communication with the upstream and the downstream portions, and a storage well positioned within the first fluid path, wherein the wetting control layer includes a fluid passageway in communication with the storage well and the membrane, and wherein the wetting control layer wets a first fluid introduced into the microfluidic channel, the first fluid comprising a hydrophilic, lipophilic, fluorophilic or gas phase as the continuous phase in the microfluidic channel.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: March 9, 2021
    Assignee: Brandeis University
    Inventors: Seth Fraden, Michael Heymann, Markus Ludwig
  • Patent number: 10899509
    Abstract: Described herein is a glass bottle configured to improve the mechanics of liquid flow and prevent drip initiation. Additionally, the glass bottle eliminates dripping during pouring to enable drip-free pouring. The dripping is prevented over a full range of pouring angles, which vary depending on the amount of liquid held in the glass bottle. A method of making the glass bottle and a method of enabling drip-free pouring using the glass bottle are also disclosed.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: January 26, 2021
    Assignee: BRANDEIS UNIVERSITY
    Inventor: Daniel Perlman
  • Patent number: 10888853
    Abstract: Provided herein are cinchonium betaine catalysts and methods of promoting asymmetric imine isomerization reactions using the same.
    Type: Grant
    Filed: January 12, 2020
    Date of Patent: January 12, 2021
    Assignee: Brandeis University
    Inventors: Xiao Zhou, Yongwei Wu, Li Deng
  • Patent number: 10881293
    Abstract: Systems and methods for surveying the sclera are provided. In some aspects, a method for generating a design for a prosthetic lens for an eye of a subject includes arranging an eye of a subject at a distance from a plurality of illumination sources and a plurality of imaging devices, projecting light onto the eye of the subject using the illumination sources, acquiring image data of the eye of the subject and the light using the plurality of imaging devices, generating a three dimensional map of the eye, including the sclera, using the image data; and designing, using the three dimensional map of the eye for the lens that fits over a cornea of the eye to engage the sclera and form a fluid pocket between the prosthetic lens that surrounds the cornea.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 5, 2021
    Assignee: Brandeis University
    Inventor: Hermann Wellenstein
  • Patent number: 10869516
    Abstract: Individuals with special needs often struggle to put on swim caps as they may lack dexterity, strength, or coordination to pull the cap over their ears. An improved swim cap to aid such wearers includes a swim cap body to encapsulate an upper head area and ears of a wearer, a first ring near a right ear area of the cap, and a second ring near a left ear area the body. A reinforcing band is attached on an interior of the swim cap body, wherein ends of the band connect to the first ring and the second ring. The rings allow for easy gripping of the swim cap to easily pull the cap over the wearer's head and ears.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: December 22, 2020
    Assignee: Brandeis University
    Inventor: Rebecka Lauren Sokoloff
  • Patent number: 10857243
    Abstract: The invention relates to an enzymatically responsive product that includes an amino acid residue conjugated to a magnetic particle, wherein the amino acid residue is phosphorylated or sulfated or comprises an ester-moiety linked via peptide bond. Compositions containing the enzymatically responsive product, and the use thereof for separating distinct types of mammalian cells (e.g., cancer cells from normal cells), for treating a cancerous condition, and imaging cancer cells are also disclosed.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: December 8, 2020
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Xuewen Du, Jie Zhou, Bing Xu
  • Patent number: 10836761
    Abstract: The present invention includes certain conchinine-derived phase-transfer catalysts of formula (I), compositions comprising the same, and methods of promoting asymmetric addition reactions using the same.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: November 17, 2020
    Assignee: Brandeis University
    Inventors: Yongwei Wu, Li Deng
  • Patent number: 10821097
    Abstract: The present invention relates to the use of DBH inhibitors (e.g., disulfiram and Nepicastat), and pharmaceutical compositions thereof, for treating subjects with certain types of memory loss, for instance memory loss associated with a neurodegenerative disease, disorder, or condition, such as Alzheimer's Disease.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: November 3, 2020
    Assignee: Brandeis University
    Inventor: John Lisman
  • Patent number: 10813972
    Abstract: Methods, compositions and kits for the prevention and treatment of mitochondrial dysfunction, mitochondrial DNA damage and genomic DNA damage are provided. The methods use the administration of palm fruit juice and/or compositions containing phenolic compounds present in palm fruit juice. The methods, compositions, and kits can be used to reduce DNA damage in subjects being treated with nucleoside reverse transcriptase inhibitors, such as patients having HIV or AIDS.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: October 27, 2020
    Assignees: MALAYSIAN PALM OIL BOARD, BRANDEIS UNIVERSITY
    Inventors: Adam E. Osborne, Lawrence J. Wangh, Kenneth C. Hayes, Ravigadevi Sambanthamurthi
  • Patent number: 10780150
    Abstract: Disclosed are oligonucleotides that binds specifically to HIV neutralizing monoclonal antibody 2G12 with a K4 value lower than 20 nM, the oligonucleotide comprising a predicted structure, at 37° C., having exactly one stem-loop whereby the loop comprises the nucleotide sequence of AACCNACGGANAAA (SEQ ID NO: 1), where N is a modified nucleoside base, and the stem includes at least 3 nucleotide base-pairs and one of the nucleotides in the stem includes a modified nucleoside base, wherein the modified nucleoside base has the structure -B-L-A where A is a branched-chain Man9 oligosaccharide, L is a linker molecule, and B is independently a pyrimidine or pyridine base linked to the sugar-phosphate backbone of the oligonucleotide. Immunogenic conjugates that include the oligonucleotide, and pharmaceutical compositions that include the oligonucleotide or the immunogenic conjugate are also disclosed.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: September 22, 2020
    Assignee: BRANDEIS UNIVERSITY
    Inventors: Isaac J. Krauss, Joel Sebastian Temme
  • Patent number: 10781471
    Abstract: The present invention encompasses the recognition that identification of alternative means to block RAS oncogenic signaling may be required for developing novel cancer therapies. Among other things, the present invention encompasses the recognition that targeting RAS palmitoylation can achieve effective therapy for RAS-related cancers. Furthermore, the present invention encompasses the recognition that reduction of ZDHHC9 level and/or activity can significantly reduce palmitoylation level of Ras protein. Among other things, the present invention encompasses the recognition that identification of agents that modulate expression and/or activity of ZDHHC9 can reduce palmitoylation level of Ras protein. In some embodiments, the present invention provides methods of treating a subject suffering from cancer by administering ZDHHC9 inhibition therapy.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 22, 2020
    Assignees: Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Brandeis University
    Inventor: Ruibao Ren
  • Publication number: 20200291380
    Abstract: Described herein are compounds and methods for tethering proteins. For example, dimers of Protein X listed in Table 1 are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization and can be used to treat neurodegenerative diseases (such as, for example, Parkinson's Disease, ALS, Alzheimer's Disease, Huntington's Disease, Epilepsy, Frontotemporal Dementia, and/or DMD), cancer, autoimmune disease, and/or Celiac disease.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Applicant: Brandeis University
    Inventors: Jeffrey N. Agar, Joseph Salisbury
  • Publication number: 20200283753
    Abstract: Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 10, 2020
    Applicant: Brandeis University
    Inventors: Jeffrey N. Agar, Joseph Salisbury
  • Patent number: 10738347
    Abstract: Provided herein are reagents and kits for detection of multiple target sequences in a single-tube, single-color assay, and methods of use thereof. In particular, multiplex assays are provided for the detection of Mycobacterium tuberculosis complex target sequences (e.g., katG, rpoB, inhA promotor, pncA, etc.).
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: August 11, 2020
    Assignee: Brandeis University
    Inventors: Lawrence J. Wangh, Kenneth E. Pierce, John E. Rice