Patents Assigned to Brigham and Women's Hospital
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Publication number: 20210246182Abstract: The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-I to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.Type: ApplicationFiled: September 14, 2020Publication date: August 12, 2021Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Richard T. LEE, Vincent SEGERS
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Patent number: 11083604Abstract: A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.Type: GrantFiled: January 18, 2019Date of Patent: August 10, 2021Assignees: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., DUKE UNIVERSITYInventors: Erik V. Mukerjee, Jane A. Leopold, Amanda Randles
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Patent number: 11083690Abstract: Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.Type: GrantFiled: July 31, 2019Date of Patent: August 10, 2021Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Tokitae LLCInventors: Shiyi Zhang, Andrew Bellinger, Carlo Giovanni Traverso, Robert S. Langer, Dean Liang Glettig, Lowell L. Wood, Jr., Philip A. Eckhoff
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Patent number: 11083780Abstract: This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas.Type: GrantFiled: July 20, 2016Date of Patent: August 10, 2021Assignees: The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Ali Khademosseini, Rahmi Oklu
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Publication number: 20210239615Abstract: The invention provides novel non-invasive in vitro methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.Type: ApplicationFiled: March 31, 2021Publication date: August 5, 2021Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Catherine Racowsky, Manqi Deng, Daniel Needleman
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Patent number: 11077056Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: GrantFiled: December 18, 2020Date of Patent: August 3, 2021Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacy Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, Jr., Philip A. Eckhoff
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Patent number: 11076875Abstract: In accordance with an aspect of the present disclosure, a tissue extraction device may include a bag having an interior and a plurality of cutting elements extending through the interior of the bag. The cutting elements can have a common end.Type: GrantFiled: May 11, 2018Date of Patent: August 3, 2021Assignee: The Brigham and Women's Hospital, Inc.Inventors: Frank Bonadio, Jon I. Einarsson, Jordan Smith, Alexander Isakov, Debasish Pradhan, Athar Anwar Solkar, Mangesh Ratnakar Patankar, Nikhil Katre, Tejas Chavan
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Patent number: 11058800Abstract: The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.Type: GrantFiled: February 8, 2017Date of Patent: July 13, 2021Assignees: Massachusetts Eye and Ear Infirmary, The Brigham and Women's Hospital, Inc.Inventors: Ali Khademhosseini, Nasim Annabi, Reza Dana, Ahmad Kheirkhah
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Patent number: 11058494Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit insider or next to the tissue mass. The system also includes a second sensor attached to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: GrantFiled: March 11, 2016Date of Patent: July 13, 2021Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Raphael Bueno, Jayender Jagadeesan, Ferenc A. Jolesz
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Publication number: 20210205492Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: ApplicationFiled: January 11, 2021Publication date: July 8, 2021Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Patent number: 11051851Abstract: The present disclosure provides devices and methods for insufflating abdomens of subjects under direct visualization. Such devices and methods, in some implementations, include features for cleaning the devices, and certain implementations of the methods permit procedures wherein it is not necessary to use a typical obturator to place a cannula, resulting in safer procedures.Type: GrantFiled: February 4, 2020Date of Patent: July 6, 2021Assignee: The Brigham and Women's Hospital, Inc.Inventor: Jon I. Einarsson
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Patent number: 11051892Abstract: An apparatus including a tendon-driven device such as an endoscope comprising a bendable body, a tendon attached to and extending a length of said body, and an actuator that will actuate said tendon based on a control signal from a controller. The controller is configured to send said control signal to said actuator and comprises a forward-kinematic-mapping unit that estimates an angular displacement, wherein the kinematic-mapping unit is configured for: providing a tension value of the tendon to obtain a desired angular displacement wherein the tension has a nonlinear relationship with the desired angular displacement based on information of friction where the tension is greater that would be calculated without including the effect of friction. The friction coefficient may be determined as it changes over time.Type: GrantFiled: September 19, 2014Date of Patent: July 6, 2021Assignees: Canon U.S.A., Inc., The Brigham and Women's Hospital, Inc.Inventors: Nobuhiko Hata, Takahisa Kato, Ichiro Okumura, Kiyoshi Takagi, Hidekazu Kose
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Patent number: 11040054Abstract: Provided herein are methods for the prevention and treatment of an abnormal tissue condition in the liver (e.g., liver cancer) of a subject, based on the administration of an inhibitor of a G protein-coupled estrogen receptor 1 (GPER1).Type: GrantFiled: November 14, 2017Date of Patent: June 22, 2021Assignee: The Brigham and Women's Hospital, Inc.Inventors: Wolfram Goessling, Saireudee Chaturantabut
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Publication number: 20210177750Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.Type: ApplicationFiled: February 12, 2021Publication date: June 17, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Womens's Hospital, Inc.Inventors: Andrew Bellinger, Shiyi Zhang, Carlo Giovanni Traverso, Robert S. Langer, Stacey Mo, Tyler Grant, Mousa Jafari, Dean Liang Glettig, Angela DiCiccio, Lowell L. Wood, JR., Philip A. Eckhoff
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Publication number: 20210177938Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.Type: ApplicationFiled: December 10, 2020Publication date: June 17, 2021Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Junwei Li, Thomas Wang, Ameya R. Kirtane, Yunhua Shi
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Publication number: 20210169827Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.Type: ApplicationFiled: January 28, 2021Publication date: June 10, 2021Applicants: THE BROAD INSTITUTE, INC., THE BRIGHAM & WOMEN'S HOSPITAL, INC., DANA-FARBER CANCER INSTITUTE, INC., Instituto Carlos Slim de la Salud, A.C.Inventors: Anna Greka, Moran Dvela-Levitt, Maria Alimova, Eric Lander, Todd R. Golub, Florence Wagner, Brian Chamberlain, Valeria Padovano, Joseph Growney
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Publication number: 20210171599Abstract: The present invention provides a method to identify and use compounds for the inhibition of abnormal or dysregulated hepatic glucose production that results in elevated blood glucose levels and associated metabolic disorders. The invention is based on the surprising discovery that the glucagon forms an obligate binding complex with aP2, which is necessary for activation of the glucagon G-coupled protein receptor.Type: ApplicationFiled: July 23, 2020Publication date: June 10, 2021Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Gokhan S. Hotamisligil, Ediz Calay, Amir Tirosh, Gurol Tuncman, Motohiro Sekiya
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Patent number: 11028176Abstract: The present disclosure provides, inter alia, anti-peripheral lymph node addressin antibodies and antigen binding fragments thereof. The present disclosure also provides compositions comprising drug-containing polymeric particles that mimic lymphocyte migration in vivo and can specifically deliver immunosuppressive or immunoregulatory drugs to lymphoid tissues and sites of chronic inflammation where T-cell activation and T-cell mediated injury are occurring; such compositions comprise the antibodies or antigen-binding fragments thereof described in the disclosure. The present disclosure also comprises antibody-drug conjugates and compositions comprising the antibody-drug conjugates. Methods of preparing and using these antibodies, antigen-binding fragments thereof, and compositions thereof are also provided.Type: GrantFiled: February 12, 2020Date of Patent: June 8, 2021Assignee: The Brigham and Women's Hospital, Inc.Inventor: Reza Abdi
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Patent number: 11027014Abstract: The technology described herein is directed to methods and compositions for the treatment of hypertension, e.g. pulmonary arterial hypertension, relating to inhibition of TGF?1, TGF?3, and/or GDF-15.Type: GrantFiled: January 29, 2019Date of Patent: June 8, 2021Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Lai-Ming Yung, Paul B. Yu
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Patent number: 11026947Abstract: The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).Type: GrantFiled: April 26, 2018Date of Patent: June 8, 2021Assignees: The Brigham and Women's Hospital, Inc., The United States of America, as Represented by the Secretary, Dept, of Health and Human ServicesInventors: Paul B. Yu, Wenwei Huang, Philip Edward Sanderson, Jian-Kang Jiang, Khalida Shamim, Wei Zheng, Xiuli Huang, Gregory Tawa, Arthur Lee, Asaf Alimardanov, Junfeng Huang