Abstract: Methods, articles and systems that provide imagewise mapping or display of gene expression of a biosample, by contacting the biosample, such as a tissue slice or metacommunity, to a detector which captures material from the biosample and processes the captured material. In one embodiment the detector has an array of one or more capture sites at defined positions on the detector, each site carrying an immobilized capture oligonucleotide and a site-indexing oligonucleotide. The array captures mRNA from the biosample contacted thereto, and the captured mRNA is processed to form a sequenceable amount of amplified captured material which includes the site-indexing oligonucleotide, so that when sequenced, detection of the site-indexing oligonucleotide indicates the original capture location on the array, thereby mapping the sequenced material to its capture location and imaging display of gene expression distribution in the original biosample.

Abstract: A magazine for a firearm may include a cavity that is shaped to prevent the tip of the bullets in the cartridges from contacting the magazine when the firearm recoils. The magazine may also be configured so that the cartridges in the magazine exit the cavity at least approximately in the center of the magazine. The magazine may be configured to include a biasing mechanism that pushes the cartridges upward in the cavity. The biasing mechanism may be configured to allow the magazine to be compact, simple, and reliable.

Abstract: The present invention generally relates to mass spectrometry and related techniques, and in some cases, to determining single species using mass spectrometry. In certain instances, polymers such as DNA or RNA can also be sequenced. Certain embodiments of the invention relate to passing a polymer, such as DNA, RNA, a protein, a polypeptide, a polysaccharide, etc., through a pore and cleaving the polymer in sequence. For instance, the polymer may be cleaved using a laser or an electric field. In some embodiments, a property of at least one subunit of a polymer is determined using mass spectrometry. In some embodiments, a single ion (which may be a subunit of a polymer, or an ion based on another species) can be isolated in a mass spectrometer and a signal generated from the single ion.

Abstract: The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of collagen VI; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation.

Abstract: A method for surface engineering a metal substrate involves mixing precursor powders with a polymer binder to create a coating mix and coating the substrate with the coating mix. The substrate is then heated via induction heating, with the frequency and duration of the heating being controlled so as to cause a reaction of the precursor powders to create one or more types of ceramics or intermetallics, evaporate the polymer binder, melt a portion of the substrate, and cause the synthesized compounds to mix with the substrate and form a compositionally graded surface modification. The compound(s) created by the reactions are mixed with molten portion of the substrate and upon re-solidification of the substrate, are distributed at decreasing percentages along a depth of the substrate so that their content varies from 100% at a surface of the substrate to 0% at a defined depth of the substrate.

Abstract: In one exemplary embodiment, an apparatus includes a memory storing data and a processor performing operations. The apparatus generates or maintains an accumulation tree for the stored data—an ordered tree structure with a root node, leaf nodes and internal nodes. Each leaf node corresponds to a portion of the data. A depth of the tree remains constant. A bound on a degree of each internal node is a function of a number of leaf nodes of a subtree rooted at the internal node. Each node of the tree has an accumulation value. Accumulation values of the root and internal nodes are determined by hierarchically employing an accumulator over the accumulation values of the nodes lying one level below the node in question. The accumulation value of the root node is a digest for the tree.

Abstract: Methods and systems for removing volatile organic compounds from spent air are provided. The method can include oxidizing cumene in the presence of an oxidant to produce an oxidized product containing methanol and a spent air, separating the spent air from the oxidized product, contacting the spent air with an absorbent, an adsorbent, or a mixture thereof to remove at least a portion of any impurities in the spent air to produce a first purified air, and contacting the first purified air with a biological material to produce a treated air.

Abstract: Systems and methods for producing aromatic amines and removing phenol therefrom are provided. The method can include hydrogenating one or more aromatic nitro compounds to produce a reaction product comprising one or more aromatic amines, water, and phenol. The method can also include contacting the reaction product with one or more ion exchange materials to produce an aromatic amine product that contains less phenol than the reaction product. The one or more ion exchange materials can be solid, semi-solid, or a combination thereof.

Abstract: System and method for processing hydrocarbon. One or more embodiments of the method include combining a first hydrocarbon including a de-asphalted oil with a recycled hydrocarbon product to produce a combined hydrocarbon, cracking the combined hydrocarbon to produce a cracked hydrocarbon product, and recycling at least a portion of the cracked hydrocarbon product to provide the recycled hydrocarbon product, wherein the recycled hydrocarbon product comprises a cycle oil product, a naphtha product, or a combination thereof.

Abstract: The present invention provides a dual purpose roasting rack having opposed arms mounted to a roasting rack which are movable between two configurations. In the first configuration, the arms are substantially parallel to the base and food may be mounted on the roasting rack apparatus in a horizontal orientation. In the second configuration, the opposed arms sit substantially upright relative to the base and cooperate to enable food, such as poultry, to be cooked in a vertical orientation. The opposed arms may rotate between the two configurations and may interlock together while in the second configuration.

Abstract: This invention relates to a food processors and specifically to flexible blades for food processors. Disclosed is a rotatable, flexible cutting blade and a food processing apparatus using a rotatable, flexible cutting blade. The rotatable, flexible cutting blade is connected to a food processor drive mechanism and is comprised of one or more blade arms. The blade arms comprise a blade and a flexible portion where the flexible portion connects the blade to the drive mechanism via mechanical means. The blade arms start in a first position away from the plane orthogonal to the axis of rotation of the rotatable, flexible cutting blade. When the rotatable, flexible cutting blade is rotated at sufficient speeds, centrifugal forces cause the blades to move away from their first position. As the rotation slows, the blades return to their first position.

Abstract: A composition of matter that experiences an increase rate of radioactive emission is presented. The composition comprises a radioactive material and particles having affinity for Hydrogen or its isotopes. When exposed to Hydrogen, the composition's emission rate increases. Methods of production are also presented.

Abstract: Systems and methods for exchanging heat in a gasification system are provided. The method can include introducing one or more particulates and a heat transfer medium including a feed water, a deaerated feed water, or a combination thereof, to a first zone. The method can also include indirectly exchanging heat from the one or more particulates to the heat transfer medium within the first zone to provide an intermediate heat transfer medium and cooled particulates. The method can also include introducing at least a portion of the intermediate heat transfer medium and a syngas to a second zone. The method can also include indirectly exchanging heat from the syngas to the intermediate heat transfer medium within the second zone to provide a heat transfer medium product and a cooled syngas. The heat transfer medium product can include steam.

Abstract: The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes.

Abstract: The present invention provides a system for engaging a fluid flow. The system comprising one or more foil members operationally connected to a feedback control loop system. In one embodiment, the foil member is a hydrofoil member or an airfoil member. The foil members are configured for one or more degrees of freedom of oscillatory movement within the fluid flow. The feedback control loop system comprises a sensor system, actuator system, and a controller system. The feedback control loop system configured for actuating the foil members and thereby optimizing the operation of the foil members to attain one or more optimization objectives. In operation, the foil members are situated in the fluid flow and are manipulated to attain one or more optimization objectives.