Abstract: Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.

Abstract: A combination of urapidil and furosemide, e.g., in the form of an acid-addition salt, in the form of a physical admixture or in the form of two distinct components collectively constitutes an effective active ingredient in the treatment of hypertension. The combination is advantageously incorporated in a standard dosage form and administered by various routes to mammals afflicted with high blood pressure. By combining furosemide with urapidil on one of the noted forms, the maximum hypotensive activity of urapidil is increased, while the side effects and toxicity of urapidil are reduced.

Abstract: A catheter including a flexible hose attached to one end of a rigid tube through which fluid pressure may be applied to invert said hose from an invaginated position within said tube to an exserted position extending outwardly of said tube has formed at the distal of said hose a valve which remains closed when the hose is in the invaginated position and which opens with the hose in its exserted position. The valve is formed integrally by portions of the hose distal end by cutting the distal end along a plane extending obliquely of the axis of the hose and forming the distal end walls of the hose in an abutting configuration defining therebetween an orifice which tends to remain closed by abutment of the distal end walls against each other when the hose is in its invaginated position, and particularly when fluid pressure is applied within the tube, with the abutting wall portions between which said orifice is defined tending to separate to open the orifice when the hose is exserted from the tube.

Abstract: The title compound, prepared by nitrating .beta.-D-1-(6-amino-9H-purin-9-yl)-1-deoxyribofuranuronethylamide, is physiologically active and pharmacologically acceptable. It is useful for increasing coronary blood flow and is administrable, e.g., in the form of a medicament composition.

Abstract: Physiologically-active and pharmaceutically-acceptable 4-aminopyrazoles of each of the formulae ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, e.g., a hydrogen atom (--H), aliphatic hydrocarbyl, alicyclic hydrocarbyl, phenyl, substituted phenyl, phenalkyl or nuclearly-substituted phenalkyl.And their pharmacologically-acceptable acid-addition salts are synthesized by known procedures from available starting materials or from compounds which are made by analogy procedures from known compounds. The subject 4-aminopyrazoles and their pharmacologically-acceptable acid-addition salts are prepared in the form of medicament compositions and used as diuretics, saluretics and/or antihypertensives.

Abstract: 3-(5-Nitro-2-furyl)pyrazoles unsubstituted in the 5-position and 5-(5-nitro-2-furyl)pyrazoles unsubstituted in the 3-position are antimicrobials and disinfectants. The compounds are structurally represented by one of the formulae: ##STR1## wherein A is --CHO, --CN, --COOH, a protected or derived aldehyde group or a protected or derived carboxylic acid group;B is 5-nitro-2-furyl;R.sup.1 is --H, substituted or unsubstituted hydrocarbyl (saturated or unsaturated; acyclic, alicyclic or aromatic; or araliphatic); substituted or unsubstituted (cycloaliphatic or aromatic) heterocyclic or acyl (carboxylic or carbonic acid);R.sup.2 is --H; andn is a positive whole number of at most 2.

Abstract: An oral form of medicament releases active substance in the gastrointestinal tract at a constant rate.

Abstract: 2-[(O-ALKYLAROYLHYDRAZONO)PROPEN-1-YL]-5-NITROFURANS [1] ARE PREPARED BY CONDENSING 3-(5-NITRO-2-FURYL)ACRYLALDEHYDE [2] WITH AN O-ALKYLAROYL HYDRAZIDE [3]. Compounds [1] are bactericides, protozoacides and fungicides and are administrable to animals in therapeutically-acceptable compositions.

Abstract: Therapeutically-active and pharmacologically-acceptable N-acyl-N" -(3-amino-2-cyanoacryloyl)-formamidrazones and their pharmaceutically-acceptable acid-addition salts inhibit xanthine oxidase and are useful as the active ingredient in medicaments for the treatment of gout.

Abstract: A catheter including a flexible hose attached to one end of a rigid tube through which fluid pressure may be applied to invert said hose from an invaginated position within said tube to an exserted position extending outwardly of said tube has formed at the distal of said hose a valve which remains closed when the hose is in the invaginated position and which opens with the hose in its exserted position. The valve is formed integrally by portion of the hose distal end by cutting the distal end along a plane extending obliquely of the axis of the hose and forming the distal end walls of the hose in an abutting configuration defining therebetween an orifice which tends to remain closed by abutment of the distal end walls against each other when the hose is in its invaginated position, and particularly when fluid pressure is applied within the tube, with the abutting wall portions between which said orifice is defined tending to separate to open the orifice when the hose is exserted from the tube.

Abstract: 1,3-Diaryl-5-halogen-pyrazole-4-acetic acids and their derivatives with analgetic, antipyretic and antiphlogistic action are described.

Abstract: Pharmaceutically-acceptable compositions containing, as an active ingredient, at least one N-acylanilinobutyric acid have uses unrelated to the choleretic activity suggested in U.S. Pat. No. 3,780,095. Moreover, the further uses generally involve administration of smaller doses than would be required to obtain a choleretic effect.The new uses include: a) increasing the gastrointestinal enzyme secretion and b) tonicizing the cardiovascular system. The increase of the gastrointestinal enzyme secretion is applied in the treatment of different diseases such as treatment of sprue, treatment of indigestion, treatment of acute and chronic pancreatitis, therapy for degenerated intestine mucous membrane, treatment of stomach spasms, treatment of stomach ulcers, treatment of diseases where the application of an antigastrin is indicated. The tonicizing of the cardiovascular system is applied in, e.g.

Abstract: Therapeutically-active and pharmacologically-acceptable 1-amido-5-cyano-4(1H)-pyrimidinones and their pharmaceutically-acceptable acid addition salts inhibit xanthineoxidase and are useful as the active ingredient in medicaments for the treatment of gout. Such pyrimidinones are prepared by treating 2-(acyl) hydrazonomethyl-3-chloro or hydroxy-4-aza-2,4-pentadienenitriles with acid.

Abstract: 4,4-Diarylpiperidine compounds, preferably 4,4-diphenylpiperidine which are substituted or unsubstituted in the 1-position of the piperidine nucleus, such as 1-(lower alkyl)-4,4-diphenylpiperidines, 1-(lower alkyl)-4-phenyl-4-tolylpiperidines, and their substantially non-toxic, pharmaceutically-acceptable acid addition salts, are highly effective central nervous system (CNS) stimulants which are superior to known amphetamine-type stimulants. A novel and highly advantageous process of making such 4,4-diarylpiperidine compounds comprises reacting a 4-aryl-4-hydroxypiperidine compound which may be substituted in its 3-position by an aroyl group, with an aromatic hydrocarbon, in particular with benzene, in the presence of a Friedel-Crafts-type catalyst.

Abstract: Substituted hydrazino- and pyrazolo-aldopentoses and aldohexoses, which are useful as intermediates for preparing compounds, as compounds which lower the uric acid level in the blood, and as bactericides, are provided. The substituted hydrazino compounds also enter into chemical reactions which are not possible with their unsubstituted counterparts.

Abstract: 4,4-Diarylpiperidine compounds, preferably 4,4-diphenylpiperidine which are substituted or unsubstituted in the 1-position of the piperidine nucleus, such as 1-(lower alkyl)-4,4-diphenylpiperidines, 1-(lower alkyl)-4-phenyl-4-tolylpiperidines, and their substantially non-toxic, pharmaceutically-acceptable acid addition salts, are highly effective central nervous system (CNS) stimulants which are superior to known amphetamine-type stimulants. A novel and highly advantageous process of making such 4,4-diarylpiperidine compounds comprises reacting a 4-aryl-4-hydroxypiperidine compound which may be substituted in its 3-position by an aroyl group, with an aromatic hydrocarbon, in particular with benzene, in the presence of a Friedel-Crafts-type catalyst.

Abstract: A combination of a physiologically-active component which produces hemorrhagic gut and/or stomach lesions and a physiologically-active component which inhibits blood clotting, ingested by a rodent either concurrently or in either sequence, provides an effective rodenticide.

Abstract: 1,3-Diaryl-5-halogen-pyrazole-4-acetic acids and their derivatives with analgetic, antipyretic and antiphlogistic action are described.

Abstract: Insecticidal, fungicidal and bactericidal substituted formylazapentadienenitriles are prepared by hydrolyzing an azapentadienylidene ammonium salt of the formula ##EQU1##

Abstract: The reaction product of a carbohydrate such as a sugar, with an alkaline agent such as an alkali metal hydroxide solution has a high water retention power which is about as high as that of the neutral skin sugar fraction obtained by extraction of the stratum corneum and far superior to that of hygroscopic compounds such as glycerol, glycols, the water-soluble amino acid fraction of the skin and others which, although they attract water, permit rapid evaporation thereof.