Patents Assigned to California Institute Technology
  • Publication number: 20210013569
    Abstract: A phase shifter comprising an actuator coupled to a dielectric. When the dielectric is inserted into the waveguide in response to actuation by the actuator, the phase velocity of the incoming electromagnetic wave is decreased, resulting in a phase shift of the electromagnetic wave. A desired phase shift and a low insertion loss can be controlled by positioning of the dielectric and engineering the permittivity of the dielectric.
    Type: Application
    Filed: July 7, 2020
    Publication date: January 14, 2021
    Applicant: California Institute of Technology
    Inventors: Sofia Rahiminejad, Maria A. Del Pino, Cecile D. Jung-Kubiak, Theodore J. Reck, Goutam Chattopadhyay
  • Publication number: 20210010976
    Abstract: A photoacoustic imaging system is disclosed that includes an ergodic relay coupled optically to a light source configured to produce a light pulse and further coupled acoustically to a transducer. The ergodic relay is further configured to direct at least two PA signals to the transducer. Each of the at least two PA signals are produced at different positions within the field of view of the object to be imaged in response to illumination by a single light pulse. The transducer detects each of the at least two PA signals after each of at least two delays that correspond to the position at which each PA signal was produced.
    Type: Application
    Filed: May 10, 2018
    Publication date: January 14, 2021
    Applicant: California Institute of Technology
    Inventors: Lihong Wang, Yang Li, Lei Li
  • Patent number: 10888994
    Abstract: A compact, high torque actuator includes a brushless motor, motor control electronics, an inner hollow tube to transmit rotation of an output plate to the input end of the actuator, thus allowing two absolute magnetic encoders to read an absolute position of the input and output of the actuator. The actuator is sealed to operate in fluid environment at high pressures.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: January 12, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Matthew Gildner, Justin R Koch, Torkom A Pailevanian
  • Patent number: 10889863
    Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: January 12, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Emil P. Kartalov, Aditya Rajagopal, Axel Scherer, Mark D. Goldberg
  • Patent number: 10886691
    Abstract: A ring optical resonator is formed on a substrate. An outer circumferential surface of the resonator substantially confines one or more circumferential resonant optical modes. The resonator is positioned above a void formed in the substrate and is supported above the void by a portion of a material layer on the substrate that extends radially inward above the void from an outer circumferential edge of the void to the outer circumferential surface of the resonator. An optical waveguide can be integrally formed on the substrate and traverses a portion of the material layer above the void. The optical waveguide and the ring optical resonator are arranged and positioned so as to establish evanescent optical coupling between them. Q-factors of 108 or more have been achieved with a silica resonator and silicon nitride waveguide integrally formed on a silicon substrate.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: January 5, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Kerry Vahala, Kiyoul Yang, Dong Yoon Oh, Seung Hoon Lee
  • Patent number: 10881336
    Abstract: A solution containing a target molecule and a reference molecule is illuminated to obtain Raman signals. An optical metasurface is used as a diffractive optical element to split the Raman signal from the target molecule and the Raman signal from the reference molecule. The target and reference Raman signals can be detected at different locations with different photodetectors, and the target molecule concentration in the solution is determined by comparing the target and reference Raman signals.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: January 5, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Andrei Faraon, Amir Arbabi, Yu Horie
  • Patent number: 10883528
    Abstract: Systems and methods in accordance with embodiments of the invention operate to structurally interrelate two components using inserts made from metallic glass-based materials. In one embodiment, a method of structurally interrelating two components includes: forming an insert from a metallic glass-based composition; where the formed insert includes a metallic glass-based material; affixing the insert to a first component; and structurally interrelating the second component to the first component using the insert.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: January 5, 2021
    Assignee: California Institute of Technology
    Inventors: Douglas C. Hofmann, Samuel C. Bradford
  • Publication number: 20200409177
    Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
    Type: Application
    Filed: September 7, 2020
    Publication date: December 31, 2020
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Charles M.T. DeBoer, Mark S. Humayun
  • Patent number: 10876133
    Abstract: The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which is capable of down regulating the expression of a target gene through RNA interference. A variety of cells can be treated according to the methods of the invention including embryos, embryogenic stem cells, allowing for the generation of transgenic animals or animals constituted partly by the transduced cells that have a specific gene or a group of genes down regulated.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: December 29, 2020
    Assignee: California Institute of Technology
    Inventors: Carlos Lois-Caballe, David Baltimore, Xiao-Feng Qin
  • Patent number: 10876276
    Abstract: An atmospheric water generation system with high efficiency is based on a counter flowing heat exchanger including multiple cold channels, each cold channel surrounded by multiple hot channels. The hot and warm gases flow in opposite directions, allowing the cool dry air to contribute to cooling the warm humid air to the dew point. Thermoelectric or passive cooling of the warm humid air, and hydrophobic surfaces in a cyclone structure also contribute in increasing the efficiency of the water generation system.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: December 29, 2020
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, PWIL INC.
    Inventors: Harold Frank Greer, Peter Capak, Aria Anvar
  • Patent number: 10876118
    Abstract: In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: December 29, 2020
    Assignees: California Institute of Technology, The Regents of the University of California
    Inventors: Carlos Lois-Caballe, David Baltimore, Xiao-Feng Qin, Irvin S. Y. Chen, Dong Sung An
  • Publication number: 20200403837
    Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.
    Type: Application
    Filed: September 1, 2020
    Publication date: December 24, 2020
    Applicants: California Institute of Technology, Technische Universität Berlin
    Inventors: Philipp Walk, Babak Hassibi, Peter Jung
  • Publication number: 20200403664
    Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Applicants: California Institute of Technology, The Regents of the University of California, Technische Universität Berlin
    Inventors: Philipp Walk, Babak Hassibi, Peter Jung, Hamid Jafarkhani
  • Patent number: 10872679
    Abstract: Disclosed herein are methods and systems for analyzing visual data from multiple rounds of hybridization interactions where the same molecular target is detected by probes with different detectable labels. In particular, disclosed herein are methods and systems for analyzing sequential hybridization images for molecular profiling, where the images are obtained using multiplex fluorescence in situ hybridization (FISH).
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: December 22, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Long Cai, Ahmet F. Coskun
  • Patent number: 10872987
    Abstract: Barrier infrared detectors having structures configured to enhance the quantum efficiency, and methods of their manufacture are provided. In particular, device structures for constructing high-performance barrier infrared detectors using novel combinations of p-type and n-type absorber regions and contact regions are provided. The infrared detectors generally incorporate a “p+Bpnn+” structure. The detectors generally comprise, in sequence, a highly p-doped contact layer “p+”, an electron unipolar barrier “B”, a p-type absorber section “p”, and n-type absorber section “n”, and a highly n-doped contact layer “n+”.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: December 22, 2020
    Assignee: California Institute of Technology
    Inventors: David Z. Ting, Alexander Soibel, Arezou Khoshakhlagh, Sarath D. Gunapala
  • Publication number: 20200393668
    Abstract: An electro-mechanical device includes a payload of a magnet affixed to a mirror, and a coil assembly. The coil assembly has a body with wound electrically conducting wires and a payload aperture through which the payload travels. When voltage is applied to the coil assembly, current through the coil assembly generates a magnetic field resulting in a net upward force on the magnet that accelerates the payload to travel upward through the payload aperture for the mirror to block an optical pulse. As the magnet travels through the payload aperture, due to a magnetization direction of the magnet and a magnetic field in an upper portion of the coil assembly, the magnet experiences a net deceleration force that arrests the payload.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 17, 2020
    Applicants: California Institute of Technology, Massachusetts Institute of Technology
    Inventors: Richard Abbott, Peter Fritschel, Kavya Sreedhar
  • Patent number: 10866184
    Abstract: The present invention relates to methods, computer readable medium and systems for detecting and counting single nucleic acid molecules confined in nanoliter volumes using an unmodified camera, such as a cell phone camera. In particular, it identifies colorimetric amplification-indicator dyes that are compatible with the spectral sensitivity of standard mobile phones. The invention further provides an optimal ratiometric image-process for a selected dye to achieve a readout that is robust to lighting conditions and camera hardware and provides unambiguous quantitative results, even for colorblind users.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: December 15, 2020
    Assignee: California Institute of Technology
    Inventors: Rustem F. Ismagilov, Jesus Rodriguez Manzano, Mikhail Karymov, David A. Selck, Stefano Begolo, Erik B. Jue, Dmitriy V. Zhukov
  • Publication number: 20200388644
    Abstract: An image sensor includes a substrate, thin lenses disposed on a first surface of the substrate and configured to concentrate lights incident on the first surface, and light-sensing cells disposed on a second surface of the substrate, the second surface facing the first surface, and the light-sensing cells being configured to sense lights passing through the thin lenses, and generate electrical signals based on the sensed lights. A first thin lens and second thin lens of the thin lenses are configured to concentrate a first light and a second light, respectively, of the incident lights onto the light-sensing cells, the first light having a different wavelength than the second light.
    Type: Application
    Filed: August 21, 2020
    Publication date: December 10, 2020
    Applicants: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Amir ARBABI, Seunghoon HAN, Andrei FARAON, Hyeonsoo PARK
  • Publication number: 20200388811
    Abstract: Provided are separator systems for electrochemical systems providing electronic, mechanical and chemical properties useful for a variety of applications including electrochemical storage and conversion. Embodiments provide structural, physical and electrostatic attributes useful for managing and controlling dendrite formation and for improving the cycle life and rate capability of electrochemical cells including silicon anode based batteries, air cathode based batteries, redox flow batteries, solid electrolyte based systems, fuel cells, flow batteries and semisolid batteries. Disclosed separators include multilayer, porous geometries supporting excellent ion transport properties, providing a barrier to prevent dendrite initiated mechanical failure, shorting or thermal runaway, or providing improved electrode conductivity and improved electric field uniformity.
    Type: Application
    Filed: May 11, 2020
    Publication date: December 10, 2020
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: Farshid ROUMI
  • Patent number: 10857530
    Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: December 8, 2020
    Assignees: Umicore AG & Co. KG, California Institute of Technology
    Inventors: Adam M. Johns, T. Patrick Montgomery, Tonia S. Ahmed, Robert H. Grubbs, Richard L. Pederson