Patents Assigned to California Institute Technology
  • Patent number: 11975824
    Abstract: A system and method for controlling a multi-rotor aircraft that implements the unconventional use of an odd number of rotors. The odd or auxiliary rotor is designed to be smaller in diameter than the remaining main rotors and accordingly generates a smaller unbalanced torque and pitch on the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque from the odd auxiliary rotor.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: May 7, 2024
    Assignees: California Institute of Technology, TooFon, Inc.
    Inventors: Morteza Gharib, Michael V. Ol, Christopher J. Dougherty
  • Publication number: 20240142528
    Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.
    Type: Application
    Filed: December 14, 2023
    Publication date: May 2, 2024
    Applicant: California Institute of Technology
    Inventors: Farshid ROUMI, Jamshid ROUMI
  • Patent number: 11969246
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Grant
    Filed: May 17, 2023
    Date of Patent: April 30, 2024
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Dvin I. Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
  • Publication number: 20240133051
    Abstract: Systems and methods for electrochemical hydrogen looping cells are described. Generating a pH swing can expedite carbon dioxide capture from oceanwater. Many embodiments implement electrochemical hydrogen looping cells that simultaneously produce acid via anodic hydrogen oxidation and base via cathodic hydrogen evolution to generate a pH change.
    Type: Application
    Filed: October 10, 2023
    Publication date: April 25, 2024
    Applicants: California Institute of Technology, The Regents of the University of California
    Inventors: Harry A. Atwater, Zachary Schiffer, Chengxiang Xiang, Shane Ardo
  • Publication number: 20240134061
    Abstract: Systems and methods for a global positioning system using Global Navigation Satellite System (GNSS) signals and Stokes Parameters in accordance with embodiments of the invention are illustrated. One embodiment includes a GNSS. The GNSS includes at least four satellites and a receiver. Each satellite includes at least one pair of antennas, and a transmitter configured to transmit GNSS positioning signals to a receiver. The receiver includes a memory containing a positioning application, and a processor comprising a set of one or more processors, the positioning application configures the processors to determine a position of the receiver by performing the steps of collecting horizontal and vertical linear components of transmitted GNSS positioning signals, computing Stokes parameters of collected GNSS signals, obtaining tuning parameters based on computed Stokes parameters, synthesizing new polarization signal using tuning parameters, and processing new polarization signal to obtain a position of the location.
    Type: Application
    Filed: October 18, 2023
    Publication date: April 25, 2024
    Applicant: California Institute of Technology
    Inventors: Kamal Oudrhiri, Javier Bosch-Lluis, Nereida Rodriguez Alvarez, Joan F. Munoz
  • Patent number: 11965191
    Abstract: The present disclosure relates to systems, methods and compositions provided herein that include a compound protease. The compound protease can contain a protease domain, a cut site for another enzyme and an association domain. In some embodiments, the compound protease is part of a protein circuit.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: April 23, 2024
    Assignee: California Institute of Technology
    Inventors: Xiaojing Gao, Lucy S. Chong, Michael Elowitz, Mark William Budde, Matthew Sun-min Kim
  • Patent number: 11965172
    Abstract: Described herein are embodiments relating to manipulation of populations and sex ratio in populations through DNA sequence modifications.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: April 23, 2024
    Assignee: California Institute of Technology
    Inventors: Bruce A. Hay, Georg Oberhofer, Tobin William Ivy
  • Patent number: 11965001
    Abstract: Provided herein are thermomer monomer, thermomer dimers, thermomer monomeric constructs, thermomer dimeric complexes, and related gene expression cassette vectors, cells, surfaces devices, compositions methods and systems, that provide a thermobioswitch suitable to control location and/or binding of cargo moiety of interest in a temperature regulated manner.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: April 23, 2024
    Assignee: California Institute of Technology
    Inventors: Dan I. Piraner, Mikhail Shapiro
  • Patent number: 11968848
    Abstract: An image sensor includes a first light sensor layer including light sensing cells configured to sense first light of an incident light and generate electrical signals based on the sensed first light, and a color filter array layer disposed on the first light sensor layer, and including color filters respectively facing the light sensing cells. The image sensor further includes a second light sensor layer disposed on the color filter array layer, and configured to sense second light of the incident light and generate an electrical signal based on the sensed second light. Each of the color filters includes a nanostructure including a first material having a first refractive index, and a second material having a second refractive index greater than the first refractive index, the first material and the second material being alternately disposed with a period.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: April 23, 2024
    Assignees: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Seunghoon Han, Kwanghee Lee, Yongwan Jin, Yongsung Kim, Changgyun Shin, Jeongyub Lee, Amir Arbabi, Andrei Faraon, Yu Horie
  • Publication number: 20240125649
    Abstract: Ultra-miniature spatial heterodyne spectrometers (SHSs) are presented. Ultra-miniature SHSs in accordance with the invention, comprise a beam-splitter and gratings configured to generate a fringe pattern for spectroscopic detection. Many embodiments include input optics and a sensor and are configured in a way to omit collimating optics and imaging optics from the SHS. Compared to conventional SHSs known in the art, the present invention enables fewer parts, significantly smaller and lighter SHSs, are more efficient and robust, and require less maintenance. Many embodiments are field-deployable, in that such embodiments can be deployed for hand held use in real-world or remote activities outside of research or diagnostic facilities.
    Type: Application
    Filed: August 4, 2023
    Publication date: April 18, 2024
    Applicant: California Institute of Technology
    Inventor: Seyedeh Sona Hosseini
  • Patent number: 11959856
    Abstract: Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: April 16, 2024
    Assignee: California Institute of Technology
    Inventors: Imran R. Malik, Xiomara Linnette Madero, Erika F. Garcia, Sheel Mukesh Shah, Axel Scherer
  • Patent number: 11957438
    Abstract: A non-invasive and convenient method and apparatus for approximation of left ventricular end diastolic pressure (LVEDP) can be used in both hospital/clinic environments and nursing home or home environments. The method and apparatus use non-invasive sensors and a new “cardiac triangle” computational method to obtain an approximation of LVEDP. The computational method uses hemodynamic and electrocardiogram (ECG) waveforms as input, which can be collected by a portable device or devices.
    Type: Grant
    Filed: August 18, 2023
    Date of Patent: April 16, 2024
    Assignee: California Institute of Technology
    Inventors: Morteza Gharib, Niema M. Pahlevan
  • Patent number: 11957910
    Abstract: Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having a spinal cord injury, a brain injury, or a neurological neuromotor disease are described.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: April 16, 2024
    Assignees: California Institute of Technology, University of Louisville Research Foundation, Inc., The Regents of the University of California
    Inventors: Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Joel W. Burdick, Susan J. Harkema, Jonathan Hodes, Yu-Chong Tai, Mandheerej S. Nandra, Claudia A. Angeli, Thomas Anthony Desautels
  • Patent number: 11959127
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: April 16, 2024
    Assignee: California Institute of Technology
    Inventors: Mikhail G. Shapiro, Dan Piraner, Mohamad H. Abedi, Brittany Moser, Audrey Lee-Gosselin
  • Patent number: 11958741
    Abstract: Apparatus and methods for facilitating an intramolecular reaction that occurs in single collisions of CO2 molecules (or their derivatives amenable to controllable acceleration, such as CO2+ ions) with a solid surface, such that molecular oxygen (or its relevant analogs, e.g., O2+ and O2? ions) is directly produced are provided. The reaction is driven by kinetic energy and is independent of surface composition and temperature. The methods and apparatus may be used to remove CO2 from Earth's atmosphere, while, in other embodiments, the methods and apparatus may be used to prevent the atmosphere's contamination with CO2 emissions. In yet other embodiments, the methods and apparatus may be used to obtain molecular oxygen in CO2-rich environments, such as to facilitate exploration of extraterrestrial bodies with CO2-rich atmospheres (e.g. Mars).
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: April 16, 2024
    Assignee: California Institute of Technology
    Inventors: Yunxi Yao, Konstantinos P. Giapis
  • Patent number: 11950887
    Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: April 9, 2024
    Assignee: California Institute of Technology
    Inventors: Aditya Rajagopal, Dominic Yurk, Yaser Abu-Mostafa, Alaina Ann Brinley Rajagopal
  • Publication number: 20240108303
    Abstract: The disclosure relates to systems and methods for noninvasively performing cardiac auscultation. In some implementations, a method includes: performing, using a BP cuff of a BP cuff system, a blood pressure measurement of a subject to obtain one or more blood pressure values corresponding to the subject; inflating, based on the one or more blood pressure values corresponding to the subject, the BP cuff to a subject specific pressure value; capturing, using the BP cuff system, while the BP cuff is inflated to the subject specific pressure value, a pulse pressure waveform signal associated with an artery of the subject; obtaining a sound waveform signal associated with a heart valve of the subject by filtering the pulse pressure waveform signal to extract sound components associated with the opening or closing of the heart valve; and analyzing the sound waveform signal to identify characteristics of the heart of the subject.
    Type: Application
    Filed: September 25, 2023
    Publication date: April 4, 2024
    Applicant: California Institute of Technology
    Inventors: Alessio TAMBORINI, Morteza GHARIB
  • Publication number: 20240109786
    Abstract: Provided herein are compositions, devices, electrochemical systems, and methods relating to lithium-rich iron sulfide lithium-ion battery cathodes. In one embodiment, a composition may be characterized by formula FX1: Liw-?AlxFezS2. In some embodiments, w may be greater than or equal to 2 and less than or equal to 2.5. In some embodiments, x may be greater than 0 and less than or equal to 0.5. In some embodiments, z may be greater than 0 and less than or equal to 1. In some embodiments, ? may be greater than or equal to 0 and less than w. In some embodiments, the composition may have a net charge of 0.
    Type: Application
    Filed: September 18, 2023
    Publication date: April 4, 2024
    Applicant: California Institute of Technology
    Inventors: Eshaan S. PATHERIA, Kimberly A. ROBB
  • Publication number: 20240110068
    Abstract: A thin oil film having parylene irregular dendritic-like columns extending from one side to another exhibits hydrophobic properties that can be used as a corrosion resistant coating or water-repellant, biofouling resistant surface. This parylene-in-oil layer can be paired with an adjacent layer of solid parylene that it overlays or underlays. The solid parylene cross polymerizes with the parylene dendrites, keeping them in place as well as the oil film. The parylene dendrites are fabricated by chemical vapor deposition (CVD) of parylene over the oil layer, the dendrites self-forming from the bottom to the top. Continued CVD over the dendrites can produce a top layer of solid parylene. Etching the solid parylene away can result in a water repellant, anti-biofouling surface.
    Type: Application
    Filed: October 2, 2023
    Publication date: April 4, 2024
    Applicant: California Institute of Technology
    Inventors: Yu-Chong Tai, Kuang-Ming Shang, Haixu Shen, Ningxuan Dai, David Q. Kong
  • Patent number: 11946066
    Abstract: Disclosed herein include methods, compositions, and systems suitable for use in delivering a polynucleotide to a target cell of a subject in need thereof. In some embodiments, a viral vector comprises a polynucleotide encoding nucleoprotein (N), phosphoprotein (P), matrix protein (M), RNA-dependent RNA polymerase (L), and one or more transgenes. The viral vector can comprise one or more of a conditionally stable fusion protein, a protease fusion protein, a degron fusion protein, and/or a glycoprotein derived of another species than the viral vector polynucleotide to enable control of viral vector transduction and/or replication.
    Type: Grant
    Filed: September 23, 2022
    Date of Patent: April 2, 2024
    Assignee: California Institute of Technology
    Inventors: Xiaojing Gao, Lucy S. Chong, Michael B. Elowitz, Matthew S-M Kim