Patents Assigned to Caliper Life Sciences, Inc.
  • FLUIDIC DEVICES HAVING INCORPORATED ELECTRODES
    Publication number: 20110139274
    Abstract: The invention provides fluidic devices having incorporated electrodes, systems for using such devices, and methods for manufacturing such devices. The invention also provides fluidic devices configured to absorb joule heating within the device.
    Type: Application
    Filed: February 18, 2011
    Publication date: June 16, 2011
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventors: Colin B. Kennedy, Josh Molho, Alexander V. Dukhovny
  • Manipulation of Microparticles In Microfluidic Systems
    Publication number: 20110118139
    Abstract: An array of transportable particle sets is used in a microfluidic device for performing chemical reactions in the microfluidic device. The microfluidic device comprises a main channel and intersecting side channels, the main channel and side channels forming a plurality of intersections. The array of particle sets is disposed in the main channel, and the side channels are coupled to reagents. As the particle sets are transported through the intersections of the main channel and the side channels, reagents are flowed through the side channels into contact with each array member (or selected array members), thereby providing a plurality of chemical reactions in the microfluidic system.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 19, 2011
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventors: Tammy Burd Mehta, Anne R. Kopf-Sill, J. Wallace Parce, Andrea W. Chow, Luc J. Bousse, Michael R. Knapp, Theo T. Nikiforov, Steve Gallagher
  • Flow control of photo-polymerizable resin
    Patent number: 7932190
    Abstract: This invention provides methods and systems, e.g., to control the flow of photo-polymerizable resins. In the method, e.g., flow of a photo-polymerizable resin is restricted from illuminated resin exclusion regions on a substrate surface by precisely situated flow barriers. A system to control photo-polymerizable resin flow includes, e.g., a light source, a mask and a substrate.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: April 26, 2011
    Assignee: Caliper Life Sciences, Inc
    Inventors: Timothy B. Brown, Richard Kurth
  • Software for the display of chromatographic separation data
    Patent number: 7925451
    Abstract: Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that represent a series of measurements for multiple samples at a detection location over time can be displayed on a display device as a series of bands, the bands being arranged to resemble output from an electrophoresis gel. Additionally, the chromatographic separation data may be displayed in the form of measured intensity at the detection location versus time.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: April 12, 2011
    Assignee: Caliper Life Sciences, Inc.
    Inventor: Steven J. Gallagher
  • CHANNEL CROSS-SECTION GEOMETRY TO MANIPULATE DISPERSION RATES
    Publication number: 20110063943
    Abstract: The present invention provides novel methods for controlling/manipulating materials flowing in a fluidic device. In particular, the methods of the invention create and utilize differences between dispersion rates and/or average velocity of materials in order to manipulate the materials.
    Type: Application
    Filed: November 17, 2010
    Publication date: March 17, 2011
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventors: Andrea W. Chow, H. Garrett Wada
  • Methods for removing biological residue from capillary walls in microchannels
    Patent number: 7901621
    Abstract: Methods for removing a residue of one or more biological materials deposited on the walls of a microfluidic conduit in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid within the microfluidic conduit having residues of materials previously deposited on the walls thereof to adsorb to the materials and to remove such deposits from the walls of the microfluidic conduit.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: March 8, 2011
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Dean G. Hafeman, Aileen Zhou
  • PINCHING CHANNELS FOR FRACTIONATION OF FRAGMENTED SAMPLES
    Publication number: 20110036411
    Abstract: The invention provides a device, system, and method for isolating one or more sample components of a sample material following separation of the sample material into a plurality of sample components. The device includes first and second pinching channels, a separation channel extending between the first and second pinching channels, a collection leg that includes a collection well, and a waste leg, all of which are in fluid communication with a switching region. In the method, a sample material is separated into a plurality of separated components in the device, and one or more of the separated components are isolated in the collection well. The separated components are constrained and elongated in the switching region by first and second buffer streams.
    Type: Application
    Filed: July 26, 2010
    Publication date: February 17, 2011
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventors: JOSH MOLHO, HUI XU, JORGE J. ZANINOVICH
  • Analyte Injection System
    Publication number: 20110024296
    Abstract: This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separation of analytes from other sample constituents can be enhanced using skewing channel ITP.
    Type: Application
    Filed: October 11, 2010
    Publication date: February 3, 2011
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventors: Charles Park, Persefoni Kechagia, Michael Spaid, Morten Jensen, Irina G. Kazakova, Josh Molho
  • Method of holding a slide cassette for fluidic injection
    Patent number: 7867773
    Abstract: A system for holding a slide. The system includes a housing having a side wall and a top. The top includes a recess surrounded by an outer rim. The system also includes an inlet port in communication with the recess and an elevating mechanism capable of receiving the slide and for raising the slide toward the top of the housing to engage the slide with the outer rim to form an analytical cavity. Together these elements form an analytical cavity in which the assay may be performed.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: January 11, 2011
    Assignee: Caliper Life Sciences, Inc
    Inventors: Edward H. Thorne, IV, George Grubner
  • Priming module for microfluidic chips
    Patent number: 7867776
    Abstract: Methods and apparatuses for priming sample substrates such as DNA sipper chips are disclosed. According to one aspect of the present invention, a priming system that is suitable for priming a substrate which has a plurality of wells and at least one channel includes a base unit and a top unit. The base unit is arranged to accommodate, or support, the substrate. The top unit, which is substantially physically separate from the base unit, fits over the substrate when the substrate is held by the base unit. The top unit includes an adapter portion that interfaces with the substrate. Included in the adapter portion is a first cavity that is used to facilitate pressurizing a first well of the substrate when the adapter portion is interfaced with the substrate such that the first cavity is aligned with the first well.
    Type: Grant
    Filed: May 6, 2004
    Date of Patent: January 11, 2011
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Michael J. Kennedy, Alexander A. Gefter
  • Prevention of precipitate blockage in microfluidic channels
    Patent number: 7846392
    Abstract: The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular, the devices and methods of the invention utilize microchannels of specific cross-sectional configuration and of specific arrangement as well as application of AC current orthogonal to the direction of fluid flow, in order to prevent/ameliorate formation of precipitate blockages in microfluidic devices.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: December 7, 2010
    Assignee: Caliper Life Sciences, Inc.
    Inventor: Andrea W. Chow
  • Open-field serial to parallel converter
    Patent number: 7816148
    Abstract: Microfluidic devices and systems for affecting the serial to parallel conversion of materials introduced into the device or system. Material or materials to be converted from a serial orientation, e.g., a single channel, into a parallel orientation, e.g., multiple channels, are introduced into an open chamber or field in which containing flows of materials maintain the cohesiveness of the sample material plugs serially introduced into the open chamber. The sample material or materials are then redirected in the chamber toward and into a plurality of parallel channels that also communicate with the chamber.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: October 19, 2010
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Andreas Manz, Luc J. Bousse
  • Western Blot by Incorporating an Affinity Purification Zone
    Publication number: 20100233030
    Abstract: An upstream affinity purification region is used to bind one or more component of interest in a mixture of components prior to separating the mixture of components. Detection of the separated components and a released component of interest provide identification of the component of interest. In addition, post separation dilution is optionally used to improve detection of the mixture of components and the released component of interest. Microfluidic devices and systems suitable for performing such analyses are also provided.
    Type: Application
    Filed: May 21, 2010
    Publication date: September 16, 2010
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventors: Matthew B. Murphy, Robert S. Dubrow
  • Microfluidic device with controlled substrate conductivity
    Patent number: 7790116
    Abstract: A method to achieve controlled conductivity in microfluidic devices, and a device formed thereby. The method comprises forming a microchannel or a well in an insulating material, and ion implanting at least one region of the insulating material at or adjacent the microchannel or well to increase conductivity of the region.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: September 7, 2010
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Luc J. Bousse, Seth R. Stern, Richard J. McReynolds
  • Software for the Display of Chromatographic Separation Data
    Publication number: 20100198526
    Abstract: Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that represent a series of measurements for multiple samples at a detection location over time can be displayed on a display device as a series of bands, the bands being arranged to resemble output from an electrophoresis gel. Additionally, the chromatographic separation data may be displayed in the form of measured intensity at the detection location versus time.
    Type: Application
    Filed: April 16, 2010
    Publication date: August 5, 2010
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventor: Steven J. Gallagher
  • Total analyte quantitation
    Patent number: 7758737
    Abstract: Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and detect the individual analytes. Signal areas are summed for each individual analyte to quantitate the total analyte amount. Separate measurements of the total analyte sample are also used to determine total analyte concentration.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: July 20, 2010
    Assignee: Caliper Life Sciences, Inc.
    Inventor: Calvin Y. H. Chow
  • Microfluidic analytic detection assays, devices, and integrated systems
    Patent number: 7754150
    Abstract: Methods of detecting a component of interest, such as a protein, in a microfluidic system are provided. The methods include the use of a component-binding moiety specific to the component of interest, such as an antibody, to detect the component of interest. Also included are microfluidic devices and integrated systems for performing such assays, including devices utilizing flowable or fixed particle sets.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: July 13, 2010
    Assignee: Caliper Life Sciences, Inc.
    Inventors: H. Garrett Wada, Matthew B. Murphy
  • Electrode apparatus for use with a microfluidic device
    Patent number: 7727371
    Abstract: An electrode alignment apparatus may be used with a microfluidic device for accurate and repeatable alignment of electrode pins with reservoirs on the microfluidic device. The apparatus includes a base unit and an electrode block assembly that are moveable with respect to each other from an open position to a closed position. The electrode block assembly includes an interface array that is coupled to an interface array platform such that the interface array is moveable with respect to the interface array platform in three dimensions.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: June 1, 2010
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Colin B. Kennedy, Evelio Perez
  • SYSTEM FOR DIFFERENTIATING THE LENGTHS OF NUCLEIC ACIDS OF INTEREST IN A SAMPLE
    Publication number: 20100129896
    Abstract: Systems for differentiating the lengths of nucleic acids of interest in a sample are provided. The system includes a microfluidic device, a detector, and a software system. The microfluidic device includes an amplification microchannel or microchamber containing a reaction mixture under conditions that provide one or more amplicons of the nucleic acid of interest. The detector is integral with or proximal to the microfluidic device and is configured to detect the amplicons as one or more signals from a homogenous mixture. The software system interprets one or more coincidentally detected signals to indicate lengths of one or more individual nucleic acid molecules of interest, thereby differentiating the lengths of the nucleic acids of interest.
    Type: Application
    Filed: January 8, 2010
    Publication date: May 27, 2010
    Applicant: CALIPER LIFE SCIENCES, INC.
    Inventors: MICHAEL R. KNAPP, Jill M. Baker, Andrea W. Chow, Anne R. Kopf-Sill, Michael Spaid
  • Western blot by incorporating an affinity purification zone
    Patent number: 7723123
    Abstract: An upstream affinity purification region is used to bind one or more component of interest in a mixture of components prior to separating the mixture of components. Detection of the separated components and a released component of interest provide identification of the component of interest. In addition, post separation dilution is optionally used to improve detection of the mixture of components and the released component of interest. Microfluidic devices and systems suitable for performing such analyses are also provided.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: May 25, 2010
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Matthew B. Murphy, Robert S. Dubrow