Patents Assigned to Calysta, Inc.
  • Patent number: 11939567
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: October 28, 2021
    Date of Patent: March 26, 2024
    Assignee: Calysta, Inc.
    Inventors: Luan Thanh Nguyen, Joshua A. Silverman, Graham Ian Aylen
  • Patent number: 11795428
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating in a loop reactor which utilize substantially vertical flow zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: October 24, 2023
    Assignee: CALYSTA, INC.
    Inventors: Luan Thanh Nguyen, Joshua A. Silverman
  • Patent number: 11572539
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: February 7, 2023
    Assignee: Calysta, Inc.
    Inventors: Luan Thanh Nguyen, Joshua A. Silverman, Graham Ian Aylen
  • Patent number: 11480581
    Abstract: The present disclosure provides methods of identifying or certifying an animal that consumed a traceable diet comprising a C1 metabolizing microorganism.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: October 25, 2022
    Assignee: CALYSTA, INC.
    Inventors: Sungwon Lee, Allan LeBlanc
  • Patent number: 11332706
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: May 17, 2022
    Assignee: CALYSTA, INC.
    Inventors: Luan Thanh Nguyen, Arild Johannessen, Graham Ian Aylen, Joshua A. Silverman
  • Patent number: 11041159
    Abstract: The present disclosure provides nucleic acids and vectors for use with methanotrophic bacteria. Related host cells and methods for using such nucleic acids and vectors for expressing polypeptides or other genetic manipulation of methanotrophic bacteria are also provided.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: June 22, 2021
    Assignee: Calysta, Inc.
    Inventors: Renee M. Saville, Joshua Silverman, Jeremy Minshull, Jon Edward Ness, Effendi Leonard, Jana Stumpe, Mark Welch
  • Patent number: 11034930
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: June 15, 2021
    Assignee: CALYSTA, INC.
    Inventors: Luan Thanh Nguyen, Joshua A. Silverman, Graham Ian Aylen
  • Patent number: 10995316
    Abstract: The present disclosure provides compositions and methods for making and using methanotrophic proline auxotrophs.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: May 4, 2021
    Assignee: CALYSTA, INC.
    Inventor: Jana Stumpe
  • Patent number: 10889793
    Abstract: A fermenter can have at least one hollow fluid conduit disposed at least partially within a vessel. An external circumference of the hollow fluid conduit and an interior circumference of the vessel can define a downward flow path through which a multi-phase mixture including a liquid media and compressed gas substrate bubbles flows. An interior circumference of the hollow fluid conduit can defined an upward flow path which is in fluid communication with the downward flow path. The multi-phase liquid can flow through the upward flow path and exit the fermenter. Cooling may be provided in the hollow fluid conduit or the vessel. One or more backpressor generators can be used to maintain a backpressure on the fermenter. One or more fluid movers can be used to variously create an induced and/or forced flow in the downward and upward flow paths.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: January 12, 2021
    Assignee: CALYSTA, INC.
    Inventors: Joshua A. Silverman, Sol M. Resnick, Drew D. Regitsky
  • Patent number: 10889842
    Abstract: The present disclosure relates to recombinant microorganisms engineered for enhance production of a desired amino acid, as well as related biomass, and compositions which are useful, inter alia, as animal feed ingredients. The present invention also provides related methods.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: January 12, 2021
    Assignee: CALYSTA, INC.
    Inventors: Renee M. Saville, Joshua A. Silverman, Eric G. Luning, Brandon D. Doss, Lorraine Joan Giver, Sol M. Resnick, Drew D. Regitsky
  • Patent number: 10689610
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: June 23, 2020
    Assignee: Calysta, Inc.
    Inventors: Luan Thanh Nguyen, Joshua A. Silverman, Graham Ian Aylen
  • Patent number: 10570364
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: February 25, 2020
    Assignee: CALYSTA, INC.
    Inventors: Luan Thanh Nguyen, Arild Johannessen, Graham Ian Aylen, Joshua A. Silverman
  • Patent number: 10538730
    Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: January 21, 2020
    Assignee: CALYSTA, INC.
    Inventors: Luan Thanh Nguyen, Arild Johannessen, Graham Ian Aylen, Joshua A. Silverman
  • Patent number: 10480016
    Abstract: The present disclosure relates to genetically engineered microorganisms for biological oxidation of hydrocarbons, including production of alcohols from alkanes or epoxides from alkenes, and related methods and systems.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: November 19, 2019
    Assignee: Calysta, Inc.
    Inventors: Joshua A. Silverman, Drew D. Regitsky
  • Patent number: 10450548
    Abstract: The present disclosure provides non-naturally occurring c1 microorganisms useful for the production of lactate and related compositions, as well as methods for the biologically production of lactate. In specific embodiments, the present disclosure provides non-naturally occurring methanotrophic bacteria which are useful for producing lactate from c1 substrates.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: October 22, 2019
    Assignee: CALYSTA, INC.
    Inventors: Renee M. Saville, Sungwon Lee, Drew D. Regitsky, Sol M. Resnick, Joshua A. Silverman
  • Patent number: 10443060
    Abstract: The present disclosure provides nucleic acids and vectors for use with methanotrophic bacteria. Related host cells and methods for using such nucleic acids and vectors for expressing polypeptides or other genetic manipulation of methanotrophic bacteria are also provided. In one aspect, the present disclosure is directed to a non-naturally occurring nucleic acid molecule, comprising (1) a promoter that is functional in a methanotrophic bacterium, and (2) a native or altered methanol dehydrogenase (MDH) ribosomal binding sequence, provided that when the promoter is an MDH gene promoter, the nucleic acid comprises an altered MDH ribosomal binding sequence.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: October 15, 2019
    Assignee: CALYSTA, INC.
    Inventors: Renee M. Saville, Joshua Silverman, Jeremy Minshull, Jon Edward Ness, Effendi Leonard, Jana Stumpe, Mark Welch
  • Patent number: 10337043
    Abstract: The present disclosure relates to recombinant microorganisms engineered for enhanced production of a desired carbohydrate, as well as related biomass, and compositions which are useful, inter alia, as animal feed ingredients. The present disclosure also provides related methods.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: July 2, 2019
    Assignee: CALYSTA, INC.
    Inventors: Joshua A. Silverman, Lorraine Joan Giver, Jana Mueller, Renee M. Saville, Drew D. Regitsky
  • Patent number: 10273446
    Abstract: The present disclosure provides compositions and methods for using recombinant C1 metabolizing microorganisms capable of metabolizing sulfur containing compounds and other contaminants to biologically convert sour or acidic natural gas into high-value molecules, and to allow recovery of stranded oil.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: April 30, 2019
    Assignee: Calysta, Inc.
    Inventors: Howard Lam Ho Fong, John H Grate, Luan Nguyen, Joshua A. Silverman, Lisa Marie Newman, Lorraine Joan Giver, Drew D. Regitsky
  • Patent number: 10190123
    Abstract: The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate (e.g., glucose) as a primary or sole carbon source and methods for growing methanotrophic bacteria on the multi-carbon substrate.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: January 29, 2019
    Assignee: CALYSTA, INC.
    Inventors: Joshua A. Silverman, Effendi Leonard, Renee M. Saville
  • Patent number: 10113188
    Abstract: The present disclosure provides compositions and methods for biologically producing fatty acid derivatives, such as fatty alcohols, from recombinant C1 metabolizing microorganisms that utilize C1 substrates such as methane or natural gas as a feedstock.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: October 30, 2018
    Assignee: Calysta, Inc.
    Inventor: Joshua A. Silverman