Abstract: The present disclosure relates generally to the production of alcohols, and more specifically to biological platforms for the production of alcohols using monofunctional aldehyde dehydrogenases and monofunctional alcohol dehydrogenases.
Type:
Application
Filed:
May 27, 2016
Publication date:
October 11, 2018
Applicants:
The Regents of the University of California, Calysta, Inc.
Inventors:
Michelle C.Y. CHANG, Matthew DAVIS, Josh SILVERMAN, Drew REGITSKY
Abstract: The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate (e.g., glycerol) as a primary or sole carbon source and methods for growing methanotrophic bacteria on the multi-carbon substrate.
Type:
Grant
Filed:
December 6, 2017
Date of Patent:
July 3, 2018
Assignee:
CALYSTA, INC.
Inventors:
Joshua A. Silverman, Effendi Leonard, Renee M. Saville
Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
Type:
Grant
Filed:
October 19, 2015
Date of Patent:
May 15, 2018
Assignee:
Calysta, Inc.
Inventors:
Joshua A. Silverman, Sol M. Resnick, Michael Mendez
Abstract: The present disclosure provides compositions and methods for biologically producing fatty acid derivatives, such as fatty alcohols, from recombinant C1 metabolizing microorganisms that utilize C1 substrates such as methane or natural gas as a feedstock.
Abstract: The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate as a primary or sole carbon source and methods for growing methanotrophic bacteria on a multi-carbon substrate.
Type:
Grant
Filed:
October 24, 2013
Date of Patent:
December 19, 2017
Assignee:
Calysta, Inc.
Inventors:
Joshua A. Silverman, Effendi Leonard, Renee M. Saville
Abstract: The present disclosure relates to biosynthetic methods for producing propylene and to genetically engineered organisms having propylene biosynthesis capability.
Type:
Grant
Filed:
September 18, 2013
Date of Patent:
November 14, 2017
Assignee:
CALYSTA, INC.
Inventors:
Joshua A. Silverman, Thomas Joseph Purcell
Abstract: PFRs for running multiphasic processes are disclosed. The PFRs are single or multi-chamber devices having at least three types of regions (a liquid-contacting region, a gas-contacting region and a Ssquid-coSection region), and a porous substrate providing fluid communication at least between the liquid-contacting and gas-contacting regions. Removal of liquid from the porous substrate, such as by collecting the liquid as it flows off the bottom of the porous substrate in the Siquid-coSSection region or such as by evaporation of the liquid from the porous substrate in the evaporation region supports a continuous flow process. Methods of using the PFRs are also disclosed, for example methods of using the PFRs as photobioreactors for cultivating photosynthetic microorganisms, for producing fermentable sugars, for producing ethanol, for fermenting synthesis gas and producing single cell protein from natural gas.
Type:
Grant
Filed:
November 13, 2012
Date of Patent:
August 29, 2017
Assignee:
Calysta, Inc.
Inventors:
Marc Gregor Von Keitz, Jimmy Lee Gosse, Stefan Thust, Thomas Harwood
Abstract: Provided herein is an alkane-metabolizing cell that is unable to convert propionyl-CoA into methylmalonyl-CoA or 2-metylcitrate synthase. Depending on which enzymes are present in the cell, the cell can produce acrylate or a precursor for the same (e.g., propionate, 3-hydroxypropionyl-CoA, 3-hydroxypropionate, acrylyl-CoA) that can be readily converted to acrylate enzymatically (e.g., in the cell) or by chemical treatment. In one embodiment, the cell may contain a cytochrome P450 or alkane oxidase enzyme that allows the production of 3-hydroxypropionyl-CoA, which can be readily converted to 3-hydroxypropionate. In order to make such compounds, the cell may be grown in the presence of an odd-numbered chain alkane (e.g., pentane or heptane), although another odd-numbered chain alkane may be used. In another embodiment, the cell may contain acyl-CoA oxidase, enoyl-CoA hydratase, and hydrolase.
Type:
Grant
Filed:
October 17, 2012
Date of Patent:
May 23, 2017
Assignee:
Calysta, Inc.
Inventors:
Joshua A. Silverman, Tom Purcell, Jon Edward Ness, Effendi Leonard
Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
Type:
Grant
Filed:
July 30, 2015
Date of Patent:
August 9, 2016
Assignee:
Calysta, Inc.
Inventors:
Joshua A. Silverman, Sol M. Resnick, Michael Mendez, Renee M. Saville, Sungwon Lee, Luan Nguyen
Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.
Type:
Grant
Filed:
July 12, 2013
Date of Patent:
June 21, 2016
Assignee:
Calysta, Inc.
Inventors:
Joshua Silverman, Sol M. Resnick, Michael Mendez, Renee Saville, Sungwon Lee, Luan Nguyen
Abstract: The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate as a primary or sole carbon source and methods for growing methanotrophic bacteria on a multi-carbon substrate.
Type:
Application
Filed:
October 24, 2013
Publication date:
October 1, 2015
Applicant:
Calysta, Inc.
Inventors:
Joshua A. Silverman, Effendi Leonard, Renee M. Saville
Abstract: The present disclosure relates to biosynthetic methods for producing propylene and to genetically engineered organisms having propylene biosynthesis capability.
Type:
Application
Filed:
September 18, 2013
Publication date:
August 20, 2015
Applicant:
Calysta, Inc.
Inventors:
Joshua A. Silverman, Thomas Joseph Purcell