Abstract: Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is produced by generating on a solid support an immobilized nucleic acid complement from a template, one of which comprises a detectable label; and amplifying the complement and the template to obtain a nucleic acid cluster on the support, the cluster having a substantially central location marked by the detectable label and a surrounding region comprising immobilized copies. Also disclosed are nucleotide sequence determination in nucleic acid clusters so produced, center position annotation in the clusters, assignment of sequence information to overlapping clusters, and related compositions and methods.

Abstract: A data logger device for in-situ measurement of one or more physical parameters comprising a power source; one or more sensors for measuring the one or more physical parameters; a data store for storing representations of at least some of the measured values of the one or more physical parameters; control logic arranged to write the representations of at least some of the measured values to the data store and arranged to read data from the data store during data transmission; an antenna; and a transmitter coupled to the antenna and configured to transmit the stored data by passive transmission. The physical parameter may be temperature. A processor may estimate basal body temperature by extrapolating from a plurality of temperature readings during a sleep period. The estimated basal temperature may be used to form an indication of ovulation.

Abstract: A method for forming an electronic device having a semiconducting active layer comprising a polymer, the method comprising aligning the chains of the polymer parallel to each other by bringing the polymer into a liquid-crystalline phase.

Abstract: In a thermocouple, a pair of thermoelements extend within a protective sheath. The thermoelements are spaced from the sheath by an insulator. The sheath comprises an outer sheath formed from a metal alloy adapted to provide mechanical support and corrosion resistance during use of the thermocouple, typically at elevated temperature. The sheath further comprises an inner sheath positioned between the outer sheath and the thermoelements and formed from a nickel-based alloy containing less than 10 wt % Cr, to prevent diffusion of Cr and/or Mn from the outer sheath to the thermoelements.

Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.

Abstract: The present invention relates to a multi-bit digital to analogue converter (DAC) and to a delta-sigma analogue to digital converter employing such a DAC. The DAC has a multi-bit input, a plurality of elements for processing an input signal received at the input and a selector for selecting, based on the input signal, one or more of the DAC elements to process the signal. The DAC has control means for controlling the selector such that if the input to the DAC is below a predetermined level for a predetermined period of time the selector is operative to select only a single one of the DAC elements to process the input signal. Also disclosed is a delta-sigma analogue to digital converter (ADC) employing such a DAC.

Abstract: Apparatus for controlling the generation of a DC signal at the output of a mixer, so that the DC signal is predictable, enabling a static offset compensation voltage to offset the DC signal. The apparatus comprises a mixer configured to receive a first and a second input signal, the mixer being such as to generate a first DC signal at the output of the mixer when the first and second input signals have the same frequency and a first relative phase, a phase detector for determining the relative phase of the first and second signals, and a phase modifier configured to modify the phase of the second signal relative to the first signal in dependence on the determination of the relative phase between the first and second signals such that the resulting DC signal at the output of the mixer is the first DC signal.

Abstract: A method of transmitting a plurality of signals from a transmitting station to a plurality of receiving stations in a transmission channel having a plurality of sub-channels, the method comprising: transmitting a first signal in a first sub-channel to a first receiving station; transmitting a second signal in a second sub-channel to a second receiving station; whereby the first and second signals are transmitted simultaneously.

Abstract: A white light emitting material comprising a polymer having an emitting polymer chain and at least one emitting end capping group.

Abstract: Managing access to a time-slotted communications medium by masking interrogatory codes that are contained in signals demarcating time slots of the medium and comparing the masked interrogatory codes against masked response codes. Access to the medium is dependent on the outcome of these comparisons.

Abstract: A method by which a transmitter and receiver synchronise. The transmitter and receiver are operable in accordance with a protocol which mandates that some transmissions are jittered. The method comprises the transmitter transmitting a pseudo-random seed to the receiver; determining a jitter value based on the pseudo-random seed; and transmitting a synchronisation packet to the receiver at a time determined by the jitter value. The receiver receives the pseudo-random seed from the transmitter; determines timing of a receive window for the synchronisation packet based on the pseudo-random seed; opens the receive window at the determined time; and receives the synchronisation packet within the receive window.

Abstract: A method of forming a polymer device including the steps (i) of depositing on a substrate a solution containing a polymer or oligomer and a crosslinking moiety, to form a layer, and, (ii) curing the layer formed in step (i) under conditions to form an insoluble crosslinked polymer, wherein the crosslinking moiety is present in step (i) in an amount in the range of from 0.05 mol % to 5 mol % based on the total number of moles or repeat units of the polymer or oligomer and the crosslinking moiety in the solution.

Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

Abstract: A display device comprising: a light switching unit comprising an array of pixels each operable to vary the transmission of light therethrough; and a backlight comprising a first series of regions of organic light-emissive material having a first emission color and a second series of regions of organic light-emissive material having a second emission color, each region of organic material being located so as to lie behind a plurality of pixels of the array in the viewing direction for backlighting those pixels; and at least one of the regions of organic light-emissive material being formed by a process of ink-jet deposition.

Abstract: A SRAM memory element comprises an influencing element which sets the state of the memory cells within the memory element on start-up to defined values. These defined values are set at the design stage such that on start-up the volatile memory contains firmware or other data. Dependent upon the implementation of the influencing element, the values of stored in the memory cells may be fixed or may subsequently be overwritten during operation of the device. The memory cell may comprise two cross-coupled inverters and the influencing element comprises at least one transistor arranged to connect the input to one of the inverters to ground or a power supply rail when voltage is applied to a controlling node of the transistor.

Abstract: In a camera apparatus, two SMA actuator subsystems each comprise two SMA wires connected between a camera unit and a support structure, hooked over a pivot element defining pivot axes that lie in a common plane along the optical axis. Differential contraction of the SMA wires drives rotation. The SMA actuator subsystems are opposed, but the SMA wires of each subsystem are fixed respectively to the camera unit and the support structure, reducing the height. A non-conductive substrate supporting conductive tracks electrically connected to the SMA actuator system is configured as a flexure arrangement between the camera unit and the support structure. The flexure arrangement is connected to the camera unit at a position in the common plane reducing lateral resistance to tilt. Use of an intermediate connector element allows the circuit board to be arranged in front of the intermediate connector inside the height of the lens system.

Abstract: Devices and methods of detecting a predetermined audio signal in audio signals are provided. A device includes a processor coupled to a clock signal generator, a power controller and an audio detector. The power controller controls a clock rate provided to the processor by the clock signal generator, to control the device to operate in a low power mode having a relatively low power consumption or in a normal power mode having a relatively high power consumption. The audio detector receives audio signals and detects, in the low power mode, probable presence of a predetermined audio signal in the audio signals. The power controller controls the device to switch from the low power mode to the normal power mode responsive to the detected presence of the predetermined audio signal by the audio detector.

Abstract: A method for displaying text including the steps of providing a text, arranging the text into a plurality of word clusters, wherein at least one selected word cluster of the plurality of word clusters includes at least two lines of words and each line of words includes at least two words, and emphasizing at least one word in the selected word cluster.

Abstract: A monomer for use in manufacturing a conjugated polymer, the monomer having a structure as shown formula (2): Ar1, Ar2 and Ar3 are independently selected from optionally substituted aryl or heteroaryl, X1 and X3 both independently comprise a leaving group capable of participating in polymerisation and Z represents a direct bond or an optionally substituted bridging atom.

Abstract: A method for interpreting timing information at a communication support entity operable to communicate wirelessly, includes the steps of: at a first time at the communication support entity, receiving an indicator of a predetermined form over a link from another communication support entity; receiving over the link data representing one or more relative times; interpreting each such relative time represented by the received data as indicating the absolute time that is offset after the first time by the respective relative time together optionally with a latency value; and determining in dependence on the received data the manner in which the communication support entity is to communicate wirelessly at that absolute time.