Patents Assigned to Capitalbio Corporation
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Patent number: 11666911Abstract: A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.Type: GrantFiled: December 14, 2020Date of Patent: June 6, 2023Assignee: Capitalbio CorporationInventors: Longtang Zheng, Lei Wang, Liang Bai, Xinying Zhou, Fei Wen, Yanan Wang, Xiang Chen, Tengfei Guo, Baolian Li, Li Ma, Jing Cheng
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Patent number: 11577240Abstract: A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.Type: GrantFiled: February 3, 2021Date of Patent: February 14, 2023Assignees: Capitalbio Corporation, West China Hospital of Sichuan UniversityInventors: Xinying Zhou, Lei Wang, Liang Bai, Tengfei Guo, Shuo Li, Baolian Li, Bin Zhuang, Xiang Chen, Hongju Guo, Xiaolei Zhao, Wanli Xing, Jing Cheng
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Patent number: 11565255Abstract: A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.Type: GrantFiled: February 5, 2021Date of Patent: January 31, 2023Assignees: Capitalbio Corporation, West China Hospital of Sichuan UniversityInventors: Liang Bai, Tengfei Guo, Lei Wang, Xinying Zhou, Juan Xin, Baolian Li, Li Ma, Libing Dong, Jing Cheng
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Patent number: 11396013Abstract: An integrated microfluidic chip, wherein at least one integrated reaction unit is provided on its substrate, and the integrated reaction unit comprises at least a sample cell (1), a mixing cell (2) and a reaction cell (3) connected through liquid channels (6). In one aspect, one end of the sample cell (1) is provided with a sample inlet (4), and the chip further comprises an internal air circulating system/circuit. One end of the internal air circulating system/circuit is connected with the mixing cell (2), while the other end comprises at least a first circulation branch circuit connected with the end of the sample cell (1) distal to the sample inlet (4).Type: GrantFiled: May 18, 2017Date of Patent: July 26, 2022Assignee: CAPITALBIO CORPORATIONInventors: Lei Wang, Yao Zhou, Wanli Xing, Hu Wang, Jing Cheng, Xiang Chen, Mingxian Lin
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Patent number: 11396020Abstract: In one aspect, the present disclosure provides an integrated microfluidic device for nucleic acid amplification and microarray detection. In one aspect, the device comprises: (1) a microchip configured to process reagents, comprising a plurality of reservoirs, channels, valves, and/or fluid interfaces; (2) an amplification chamber for PCR, carried out in a detachable tube assembled on the microchip through a joint; and (3) a microarray chamber comprising a microarray and a reaction chamber. In some embodiments, these features are interconnected to allow transportation of reagents for nucleic acid amplification and hybridization detection functions in a closed system. In one aspect, the integrate device herein overcomes the problem of contamination during the amplification and hybridization reactions.Type: GrantFiled: March 31, 2015Date of Patent: July 26, 2022Assignees: CapitalBio Corporation, Tsinghua UniversityInventors: Yan Liu, Guohao Zhang, Jiang Zhu, Zhengde Feng, Hongju Guo, Jian Gao, Wanli Xing, Jing Cheng
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Patent number: 11268631Abstract: A microfluidic valve provided herein is configured to mix or capable of mixing a sample and/or a reagent in addition to controlling liquid flow. In one embodiment, the microfluidic valve comprises a rotor (3) and one or more micro-structures (2) that move with the rotation of the rotor (3). In one embodiment, the one or more micro-structures (2) stir and/or mix content in a mixing chamber (5) formed by the rotor (3), a base (1), and a sleeve (4) of the microfluidic valve. A microfluidic chip or chip system comprising one or more of the microfluidic valves, and methods of use, are also provided.Type: GrantFiled: September 30, 2016Date of Patent: March 8, 2022Assignee: CAPITALBIO CORPORATIONInventors: Lei Wang, Yao Zhou, Hu Wang, Mingxian Lin, Tongjun Wang, Liang Bai, Guoliang Huang, Dong Wang, Wanli Xing
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Patent number: 10885673Abstract: In some aspects, the present disclosure relates to a method for identifying the type of the unit by camera.Type: GrantFiled: July 17, 2018Date of Patent: January 5, 2021Assignee: Capitalbio CorporationInventors: Yuan Xue, Guanbin Zhang, Cheng Chen, Kaijun Zhao, Jing Chen
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Patent number: 10758903Abstract: In one aspect, a microfluidic device for multiple reactions is provided, which comprises a reaction channel comprising multiple reaction chambers connected to a closed chamber or an elastic balloon outside of the microfluidic device, wherein a wall of the closed chamber is an elastic membrane; and a control channel comprising an elastic side wall, wherein the intersections between the side wall of the control channel with the reaction channel form multiple pneumatic microvalves. In another aspect, a method for conducting multiple reactions using the microfluidic device is provided, which comprises: a) filling the reaction chambers with a sample; and b) applying pressure to the control channel to expand the elastic side wall of the control channel, wherein the expanded elastic side wall forms a pneumatic microvalve that separates the reaction chambers.Type: GrantFiled: May 7, 2013Date of Patent: September 1, 2020Assignees: CAPITALBIO CORPORATION, TSINGHUA UNIVERSITYInventors: Jiaming Ye, Kaihuan Zhang, Wanli Xing, Jing Cheng
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Patent number: 10704092Abstract: Provided herein is a multi-sample and multi-locus method for analyzing a genetic locus. In particular, provided herein is a method for SNP detection and analysis based on high-throughput sequencing, comprising designing a probe, pre-amplification and biotin labeling, hybridization, ligation, barcode specific primer extension, sequencing and analyzing the SNP locus. A probe set is for the analysis is also provided.Type: GrantFiled: November 10, 2015Date of Patent: July 7, 2020Assignees: CAPITALBIO CORPORATION, TSINGHUA UNIVERSITYInventors: Dong Wang, Hui Wang, Yan Zhang, Guangxin Xiang, Yimin Sun, Wanli Xing, Jing Cheng
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Patent number: 10365213Abstract: Methods and devices use in two-color measurement systems. The methods and devices include methods of making corrections, methods of calculating correction factors, fluorescence scanners, and microarray chips. The said methods and devices enable a user to correct fluorescence intensities for errors caused by the occurrence of FRET and/or cross-talk when two fluorophores are used in two-color fluorescence arrays.Type: GrantFiled: June 11, 2008Date of Patent: July 30, 2019Assignee: CapitalBio CorporationInventors: Jiang Zhu, Cheng Deng, Guoliang Huang, Shukuan Xu, Jing Cheng
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Publication number: 20190185922Abstract: A method for labeling target molecules coupled to particles for the detection of the target molecules using a microarray chip, comprises: providing a functionalized microparticle, wherein the microparticle is coated with one or more functional group; providing a modification group on each of the target molecules to be detected to form modified target molecules; contacting the functionalized microparticle with the modified target molecules; coupling a luminophore to the complex between the functionalized microparticle and the modified target molecules, thereby directly or indirectly labeling each modified target molecules with the luminophore. By directly or indirectly labeling the target molecules with the luminophore, the method reduces the cost of fluorescence detection, and avoids PCR inhibition derived from traditional fluorescence labeling molecules.Type: ApplicationFiled: November 20, 2018Publication date: June 20, 2019Applicant: CapitalBio CorporationInventors: Yang Li, Guanbin Zhang, Di Jiang, Guangxin Xiang, Wanli Xing, Jing Cheng
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Patent number: 10309977Abstract: In some aspects, the present disclosure provides a biochip detecting device that comprises a first shell (2) connect to a second shell (1), and a rotatable support frame (5) of biochip possessing a detecting zone that holds one or more biochips, and a detector (7).Type: GrantFiled: September 25, 2015Date of Patent: June 4, 2019Assignee: CapitalBio CorporationInventors: Yuan Xue, Guanbin Zhang, Cheng Chen, Kaijun Zhao, Yu Dong, Jing Cheng
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Publication number: 20190143324Abstract: An integrated microfluidic chip, wherein at least one integrated reaction unit is provided on its substrate, and the integrated reaction unit comprises at least a sample cell (1), a mixing cell (2) and a reaction cell (3) connected through liquid channels (6). In one aspect, one end of the sample cell (1) is provided with a sample inlet (4), and the chip further comprises an internal air circulating system/circuit. One end of the internal air circulating system/circuit is connected with the mixing cell (2), while the other end comprises at least a first circulation branch circuit connected with the end of the sample cell (1) distal to the sample inlet (4).Type: ApplicationFiled: May 18, 2017Publication date: May 16, 2019Applicant: CAPITALBIO CORPORATIONInventors: Lei WANG, Yao ZHOU, Wanli XING, Hu WANG, Jing CHENG, Xiang CHEN, Mingxian LIN
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Patent number: 10274479Abstract: The present invention provides a microfluidic device and its use for cell motility classification. The microfluidic device comprises a fluid inlet, a sample inlet and a channel connecting the fluid inlet and the sample inlet, wherein the channel comprises at least two sections of different sizes, and the channel allows fluid flow from the fluid inlet to the sample inlet.Type: GrantFiled: June 1, 2012Date of Patent: April 30, 2019Assignee: CapitalBio CorporationInventors: Tian Qiu, Rui Ma, Chao Han, Lan Xie, Jing Cheng
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Publication number: 20190085393Abstract: Provided herein is a multi-sample and multi-locus method for analyzing a genetic locus. In particular, provided herein is a method for SNP detection and analysis based on high-throughput sequencing, comprising designing a probe, pre-amplification and biotin labeling, hybridization, ligation, barcode specific primer extension, sequencing and analyzing the SNP locus. A probe set is for the analysis is also provided.Type: ApplicationFiled: November 10, 2015Publication date: March 21, 2019Applicants: CapitalBio Corporation, Tsinghua UniversityInventors: Dong WANG, Hui WANG, Yan ZHANG, Guangxin XIANG, Yimin SUN, Wanli XING, Jing CHENG
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Publication number: 20180322659Abstract: In some aspects, the present disclosure relates to a method for identifying the type of the unit by camera.Type: ApplicationFiled: July 17, 2018Publication date: November 8, 2018Applicant: CapitalBio CorporationInventors: Yuan XUE, Guanbin ZHANG, Cheng CHEN, Kaijun ZHAO, Jing CHEN
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Patent number: 10099218Abstract: In one aspect, disclosed herein are methods for packaging biochips, including microfluidic chips. The method can comprise bonding a substrate and a cover slide, packaging the bonded chip, creating a vacuum in the package, and applying a pressure on the packaged chip. The method is particularly useful for minimizing bubble formation during low-cost and mass production of microfluidic chips.Type: GrantFiled: November 18, 2016Date of Patent: October 16, 2018Assignee: CAPITALBIO CORPORATIONInventors: Lei Wang, Xinying Zhou, Li Ma, Juan Xin, Mingxian Lin, Jinhai Feng
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Publication number: 20180266586Abstract: A microfluidic valve provided herein is configured to mix or capable of mixing a sample and/or a reagent in addition to controlling liquid flow. In one embodiment, the microfluidic valve comprises a rotor (3) and one or more micro-structures (2) that move with the rotation of the rotor (3). In one embodiment, the one or more micro-structures (2) stir and/or mix content in a mixing chamber (5) formed by the rotor (3), a base (1), and a sleeve (4) of the microfluidic valve. A microfluidic chip or chip system comprising one or more of the microfluidic valves, and methods of use, are also provided.Type: ApplicationFiled: September 30, 2016Publication date: September 20, 2018Applicant: CapitalBio CorporationInventors: Lei Wang, Yao Zhou, Hu Wang, Mingxian Lin, Tongjun Wang, Liang Bai, Guoliang Huang, Dong Wang, Wanli Xing
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Patent number: 10049464Abstract: In some aspects, the present disclosure relates to a method for identifying the type of the unit by camera.Type: GrantFiled: September 25, 2015Date of Patent: August 14, 2018Assignee: CapitalBio CorporationInventors: Yuan Xue, Guanbin Zhang, Cheng Chen, Kaijun Zhao, Jing Cheng
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Patent number: D869684Type: GrantFiled: February 7, 2018Date of Patent: December 10, 2019Assignees: CAPITALBIO CORPORATION, TSINGHUA UNIVERSITYInventors: Li Ma, Zixin Zhang, Guoliang Huang, Lei Wang, Xianbo Luo, Wanli Xing, Jing Cheng