Patents Assigned to Cardiome Pharma Corp.
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Publication number: 20110207730Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.Type: ApplicationFiled: December 16, 2010Publication date: August 25, 2011Applicant: Cardiome Pharma Corp.Inventors: Allen I. Bain, Gregory N. Beatch, Cindy J. Longley, Bertrand M.C. Plouvier, Tao Sheng, Michael J.A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
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Patent number: 7977373Abstract: Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing such prodrugs.Type: GrantFiled: March 31, 2005Date of Patent: July 12, 2011Assignee: Cardiome Pharma Corp.Inventors: Lewis Siu Leung Choi, Doug Ta Hung Chou, Allen W. Davidoff, Adewale Eniade, Bertrand M. C. Plouvier
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Publication number: 20110118329Abstract: Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds.Type: ApplicationFiled: October 7, 2010Publication date: May 19, 2011Applicant: CARDIOME PHARMA CORP.Inventors: Gregory N. Beatch, Alan M. Ezrin
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Patent number: 7875611Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.Type: GrantFiled: April 15, 2009Date of Patent: January 25, 2011Assignee: Cardiome Pharma Corp.Inventors: Allen I. Bain, Gregory N. Beatch, Cindy J. Longley, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
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Publication number: 20110004006Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.Type: ApplicationFiled: July 9, 2010Publication date: January 6, 2011Applicant: CARDIOME PHARMA CORP.Inventors: Grace Jung, Bertrand M. C. Plouvier, Yuzhong Liu, Jeff Jiqun Zhu, Tao Sheng, Anthony G. M. Barrett, Lewis Siu Leung Choi, Doug Ta Hung Chou
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Publication number: 20100273724Abstract: This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds.Type: ApplicationFiled: July 7, 2010Publication date: October 28, 2010Applicant: CARDIOME PHARMA CORP.Inventors: Elizabeth L. S. Cheu, Lewis Siu Leung Choi, Doug Ta Hung Chou, Allen W. Davidoff, Alan M. Ezrin, Grace Jung, Bertrand M.C. Plouvier, Aregahegn S. Yifru
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Patent number: 7820712Abstract: Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds.Type: GrantFiled: November 29, 2007Date of Patent: October 26, 2010Assignee: Cardiome Pharma Corp.Inventors: Gregory N. Beatch, Alan M. Ezrin
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Patent number: 7786119Abstract: This invention is directed to drug conjugates of certain ion channel modulating compounds having the following formula: wherein A, X, R1, R2, R3, R4, R5, LB, L and DM are defined herein, including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof. Pharmaceutical compositions and methods of use are also disclosed.Type: GrantFiled: March 31, 2005Date of Patent: August 31, 2010Assignee: Cardiome Pharma Corp.Inventors: Elizabeth L. S. Cheu, Lewis Siu Leung Choi, Doug Ta Hung Chou, Allen W. Davidoff, Alan M. Ezrin, Grace Jung, Bertrand M. C. Plouvier, Aregahegn S. Yifru
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Publication number: 20100217014Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.Type: ApplicationFiled: February 19, 2010Publication date: August 26, 2010Applicant: CARDIOME PHARMA CORP.Inventors: Grace Jung, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M. C. Plouvier
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Patent number: 7767830Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.Type: GrantFiled: March 23, 2007Date of Patent: August 3, 2010Assignee: Cardiome Pharma Corp.Inventors: Grace Jung, Bertrand M. C. Plouvier, Yuzhong Liu, Jeff Jiqun Zhu, Tao Sheng, Anthony G. M. Barrett, Lewis Siu Leung Choi, Doug Ta Hung Chou
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Patent number: 7754897Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.Type: GrantFiled: June 15, 2006Date of Patent: July 13, 2010Assignee: Cardiome Pharma Corp.Inventors: Grace Jung, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M. C. Plouvier
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Publication number: 20100152464Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.Type: ApplicationFiled: November 18, 2005Publication date: June 17, 2010Applicant: CARDIOME PHARMA CORP.Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
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Publication number: 20100152276Abstract: This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same.Type: ApplicationFiled: February 26, 2010Publication date: June 17, 2010Applicant: Cardiome Pharma Corp.Inventors: Doug Ta Hung Chou, Bertrand M. C. Plouvier, Peter Pang, James Gee Ken Yee, Jeffery Jerome Wheeler, Aregahegn S. Yifru, Allen W. Davidoff
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Publication number: 20100120890Abstract: Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.Type: ApplicationFiled: January 19, 2010Publication date: May 13, 2010Applicant: CARDIOME PHARMA CORP.Inventors: David Fedida, Gregory N. Beatch, Alan M. Ezrin, Peter M. R. Orth, Christian Hesketh
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Patent number: 7705036Abstract: This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same.Type: GrantFiled: October 13, 2006Date of Patent: April 27, 2010Assignee: Cardiome Pharma Corp.Inventors: Doug Ta Hung Chou, Bertrand M.C. Plouvier, Peter Pang, James Gee Ken Yee, Jeffrey Jerome Wheeler, Aregahegn S. Yifru, Allen W. Davidoff
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Patent number: 7687536Abstract: Aminocycloalkyl cinnamide compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.Type: GrantFiled: April 11, 2006Date of Patent: March 30, 2010Assignee: Cardiome Pharma Corp.Inventors: Gregory N. Beatch, Cindy J. Longley, Michael J. A. Walker, Richard A. Wall
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Patent number: 7674820Abstract: Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.Type: GrantFiled: August 9, 2004Date of Patent: March 9, 2010Assignee: Cardiome Pharma Corp.Inventors: David Fedida, Gregory N Beatch, Alan M Ezrin, Peter M R Orth, Christian Hesketh
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Publication number: 20100056603Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.Type: ApplicationFiled: March 26, 2009Publication date: March 4, 2010Applicant: CARDIOME PHARMA CORP.Inventors: Gregory N. Beatch, Bertrand M.C. Plouvier, Tao Sheng, Michael J.A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander R. Zolotoy
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Publication number: 20100029639Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.Type: ApplicationFiled: April 15, 2009Publication date: February 4, 2010Applicant: CARDIOME PHARMA CORP.Inventors: Allen I. Bain, Gregory N. Beatch, Cindy J. Longley, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
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Publication number: 20090270478Abstract: Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g., atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.Type: ApplicationFiled: March 20, 2009Publication date: October 29, 2009Applicant: CARDIOME PHARMA CORP.Inventors: David Fedida, Gregory N. Beatch, Alan M. Ezrin, Peter M.R. Orth