Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
Type:
Application
Filed:
October 31, 2003
Publication date:
May 3, 2007
Applicant:
Cardiome Pharma Corp.
Inventors:
G.M. Barrett, Lewis Choi, Dough Chou, Grace Jung, Bertrand Plouvier, Yuzhong Liu, Jeff Zhu, Tao Sheng
Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
Type:
Application
Filed:
June 15, 2006
Publication date:
January 18, 2007
Applicant:
Cardiome Pharma Corp.
Inventors:
Grace Jung, James Yee, Doug Chou, Bertrand Plouvier
Abstract: Aminocycloalkyl cinnamide compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.
Type:
Application
Filed:
April 11, 2006
Publication date:
November 9, 2006
Applicant:
Cardiome Pharma Corp.
Inventors:
Gregory Beatch, Cindy Longley, Michael Walker, Richard Wall
Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
Type:
Application
Filed:
March 30, 2006
Publication date:
November 2, 2006
Applicant:
Cardiome Pharma Corp
Inventors:
Gregory Beatch, Bertrand Plouvier, Tao Sheng, Michael Walker, Richard Wall, Sandro Yong, Jeff Zhu, Alexander Zolotoy
Abstract: Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g. atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
Type:
Application
Filed:
August 9, 2004
Publication date:
September 7, 2006
Applicant:
Cardiome Pharma Corp.
Inventors:
David Fedida, Gregory Beatch, Alan Ezrin, Peter Orth
Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Type:
Grant
Filed:
September 29, 2003
Date of Patent:
September 5, 2006
Assignee:
Cardiome Pharma Corp.
Inventors:
Allen I Bain, Gregory N Beatch, Cindy J Longley, Bertrand M C Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L Yong, Jeff Jiqun Zhu, Alexander B Zolotoy
Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Type:
Application
Filed:
January 27, 2006
Publication date:
August 24, 2006
Applicant:
Cardiome Pharma Corp.
Inventors:
Gregory Beatch, Bertrand Plouvier, Tao Sheng, Michael Walker, Richard Wall, Sandro Yong, Jeff Zhu, Alexander Zolotoy
Abstract: The subject invention includes mutant voltage-gated ion channels that are open over a wide range of potential differences across membranes. The present invention also includes methods of use such mutant voltage-gated ion channels in cells with highly negative potential differences across their membranes. One preferred mutant voltage-gated ion channel is a channel with a mutation at the residue homologous to P513 in Kv1.5 and at least one mutation at one of the residues homologous to R400, R403, and R409 in Kv1.5.
Abstract: Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
Type:
Application
Filed:
August 9, 2004
Publication date:
June 22, 2006
Applicant:
Cardiome Pharma Corp.
Inventors:
David Fedida, Gregory Beatch, Alan Ezrin, Peter Orth, Christian Hesketh
Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Type:
Grant
Filed:
December 21, 2004
Date of Patent:
June 6, 2006
Assignee:
Cardiome Pharma Corp.
Inventors:
Gregory N. Beatch, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
Abstract: Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia. n=1–4; R1, R2, R3, R4, R5, R13, X and A are as in claim (1).
Type:
Grant
Filed:
March 3, 2000
Date of Patent:
May 30, 2006
Assignee:
Cardiome Pharma Corp.
Inventors:
Gregory N. Beatch, Cindy J. Longley, Michael J. A. Walker, Richard A. Wall
Abstract: Aminocycloalkyl compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.
Type:
Grant
Filed:
February 10, 2000
Date of Patent:
December 27, 2005
Assignee:
Cardiome Pharma Corp.
Inventors:
Gregory N. Beatch, Bertrand M. C. Plouvier, Michael J. A. Walker, Richard A. Wall, Alexander B. Zolotoy
Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Type:
Application
Filed:
December 21, 2004
Publication date:
September 22, 2005
Applicant:
Cardiome Pharma Corp.
Inventors:
Allen Bain, Gregory Beatch, Cindy Longley, Bertrand Plouvier, Tao Sheng, Michael Walker, Richard Wall, Sandro Yong, Jeff Zhu, Alexander Zolotoy
Abstract: Abstract of the Disclosure Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Type:
Application
Filed:
September 29, 2003
Publication date:
September 1, 2005
Applicant:
Cardiome Pharma Corp.
Inventors:
Allen Bain, Gregory Beatch, Cindy Longley, Bertrand Plouvier, Tao Sheng, Michael Walker, Richard Wall, Sandro Yong, Jeff Zhu, Alexander Zolotoy
Abstract: Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g. atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
Type:
Application
Filed:
August 9, 2004
Publication date:
June 2, 2005
Applicant:
Cardiome Pharma Corp.
Inventors:
David Fedida, Gregory Beatch, Alan Ezrin, Peter Orth
Abstract: Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
Type:
Application
Filed:
August 9, 2004
Publication date:
March 31, 2005
Applicant:
Cardiome Pharma Corp.
Inventors:
David Fedida, Gregory Beatch, Alan Ezrin, Peter Orth, Christian Hesketh
Abstract: The present invention discloses that a substituted acetic acid derivatives containing a N-alkylpiperazino moiety are useful as pro-libido agents for males and females, and may be used for the treatment of sexual dysfunction including impotence and to enhance sexual performance.
Abstract: Compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.
Type:
Grant
Filed:
June 9, 1999
Date of Patent:
May 14, 2002
Assignee:
Cardiome Pharma Corp.
Inventors:
Gregory N. Beatch, Lewis S. L. Choi, Clive P. Page, Bertrand M. C. Plouvier, Yuzhong Liu